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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621348
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wnt4
Name: Wnt family member 4
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wnt4increases expressionISOWnt4 (Mus musculus)6480464CTDNicotine results in increased expression of WNT4 mRNA; Nicotine results in increased expression of WNT4 proteinPMID:33640489 PMID:35411647
Wnt4multiple interactionsISOWnt4 (Mus musculus)6480464CTDCarbon Tetrachloride promotes the reaction [Nicotine results in increased expression of WNT4 mRNA]; Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of WNT4 protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of WNT4 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of WNT4 protein]PMID:33640489 PMID:35411647
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