WNT4 (Wnt family member 4) - Rat Genome Database

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Gene: WNT4 (Wnt family member 4) Sus scrofa
Analyze
Symbol: WNT4
Name: Wnt family member 4
RGD ID: 14065684
Description: ENCODES a protein that exhibits receptor ligand activity (ortholog); transcription corepressor activity (ortholog); INVOLVED IN adrenal gland development (ortholog); anatomical structure development (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH 46,XX Sex Reversal with Dysgenesis of Kidneys, Adrenals, and Lungs (ortholog); acute kidney failure (ortholog); Dwarfism (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: protein Wnt-4; wingless-related MMTV integration site 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1680,110,238 - 80,138,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,137,827 - 74,165,540 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
anatomical structure development  (ISO)
apoptotic signaling pathway  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cell differentiation  (ISO)
cell fate commitment  (IBA,ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to starvation  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
embryonic epithelial tube formation  (ISO)
epithelial to mesenchymal transition  (ISO)
female gonad development  (ISO)
female sex determination  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
gamete generation  (ISO)
hormone metabolic process  (ISO)
immature T cell proliferation in thymus  (ISO)
kidney development  (ISO)
kidney morphogenesis  (ISO)
liver development  (ISO)
male gonad development  (ISO)
mammary gland epithelium development  (ISO)
meiotic nuclear division  (ISO)
mesenchymal to epithelial transition  (ISO)
mesonephric tubule development  (ISO)
mesonephros development  (ISO)
metanephric nephron development  (ISO)
metanephric nephron morphogenesis  (ISO)
metanephric tubule formation  (ISO)
metanephros development  (ISO)
negative regulation of androgen biosynthetic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of male gonad development  (ISO)
negative regulation of steroid biosynthetic process  (ISO)
negative regulation of testicular blood vessel morphogenesis  (ISO)
negative regulation of testosterone biosynthetic process  (ISO)
negative regulation of wound healing  (ISO)
nephron development  (ISO)
neuron differentiation  (IBA)
non-canonical Wnt signaling pathway  (ISO)
non-canonical Wnt signaling pathway via MAPK cascade  (ISO)
oocyte development  (ISO)
paramesonephric duct development  (ISO)
pericyte cell differentiation  (ISO)
positive regulation of aldosterone biosynthetic process  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cortisol biosynthetic process  (ISO)
positive regulation of dermatome development  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of meiotic nuclear division  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of stress fiber assembly  (ISO)
regulation of cell-cell adhesion  (ISO)
renal vesicle formation  (ISO)
renal vesicle induction  (ISO)
response to benzoic acid  (ISO)
response to estradiol  (ISO)
response to retinoic acid  (ISO)
Sertoli cell differentiation  (ISO)
sex differentiation  (ISO)
smooth muscle cell differentiation  (ISO)
somatotropin secreting cell differentiation  (ISO)
T cell differentiation in thymus  (ISO)
tertiary branching involved in mammary gland duct morphogenesis  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)
tube morphogenesis  (ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
WNT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1680,110,238 - 80,138,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,137,827 - 74,165,540 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,117,313 - 22,143,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl122,117,313 - 22,143,969 (-)EnsemblGRCh38hg38GRCh38
GRCh37122,443,806 - 22,469,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,316,385 - 22,342,106 (-)NCBINCBI36hg18NCBI36
Build 34122,191,504 - 22,214,916NCBI
Celera120,766,732 - 20,792,452 (-)NCBI
Cytogenetic Map1p36.12NCBI
HuRef120,687,456 - 20,707,677 (-)NCBIHuRef
CHM1_1122,556,295 - 22,576,527 (-)NCBICHM1_1
T2T-CHM13v2.0121,941,071 - 21,966,860 (-)NCBI
Wnt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,004,946 - 137,026,812 (+)NCBIGRCm39mm39
GRCm39 Ensembl4137,004,800 - 137,027,037 (+)Ensembl
GRCm384137,277,635 - 137,299,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,277,489 - 137,299,726 (+)EnsemblGRCm38mm10GRCm38
MGSCv374136,833,550 - 136,852,694 (+)NCBIGRCm37mm9NCBIm37
MGSCv364136,549,711 - 136,568,855 (+)NCBImm8
Celera4135,495,983 - 135,515,320 (+)NCBICelera
Cytogenetic Map4D3NCBI
Wnt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,513,573 - 149,535,415 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5149,514,018 - 149,532,859 (+)Ensembl
Rnor_6.05155,649,238 - 155,668,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,649,217 - 155,672,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,405,855 - 159,424,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,064,371 - 156,083,198 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15156,074,409 - 156,093,237 (+)NCBI
Celera5147,911,190 - 147,930,012 (+)NCBICelera
Cytogenetic Map5q36NCBI
Wnt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,319,446 - 2,344,989 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,319,446 - 2,344,740 (-)NCBIChiLan1.0ChiLan1.0
WNT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,252,344 - 22,264,858 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,255,056 - 22,268,801 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0121,310,228 - 21,335,985 (-)NCBIMhudiblu_PPA_v0panPan3
WNT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,112,045 - 77,129,702 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,101,300 - 77,127,111 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,605,854 - 73,632,899 (+)NCBI
ROS_Cfam_1.0277,660,017 - 77,687,063 (+)NCBI
ROS_Cfam_1.0 Ensembl277,659,490 - 77,687,070 (+)Ensembl
UMICH_Zoey_3.1274,480,520 - 74,507,565 (+)NCBI
UNSW_CanFamBas_1.0275,489,331 - 75,516,389 (+)NCBI
UU_Cfam_GSD_1.0276,493,182 - 76,520,234 (+)NCBI
Wnt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,798,680 - 41,823,413 (-)NCBI
SpeTri2.0NW_0049364747,623,462 - 7,635,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,517,391 - 110,543,802 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,517,564 - 110,541,203 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660335,754,333 - 5,781,060 (-)NCBIVero_WHO_p1.0
Wnt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247646,921,811 - 6,933,392 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247646,913,027 - 6,934,650 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium
Low 7 2 5 2 10 1 1
Below cutoff 2 3 10 1

Sequence


Reference Sequences
RefSeq Acc Id: NM_001170828   ⟹   NP_001164299
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1680,110,247 - 80,123,362 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005656037   ⟹   XP_005656094
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1680,110,238 - 80,138,162 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013988775   ⟹   XP_013844229
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1680,110,238 - 80,138,165 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001164299 (Get FASTA)   NCBI Sequence Viewer  
  XP_005656094 (Get FASTA)   NCBI Sequence Viewer  
  XP_013844229 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACZ92038 (Get FASTA)   NCBI Sequence Viewer  
  ADC38897 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013844229   ⟸   XM_013988775
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005656094   ⟸   XM_005656037
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001164299   ⟸   NM_001170828
- UniProtKB: D3JCV7 (UniProtKB/TrEMBL)
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003521 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015058508 UniProtKB/TrEMBL
  ENSSSCG00025065740 UniProtKB/TrEMBL
  ENSSSCG00040071896 UniProtKB/TrEMBL
  ENSSSCG00045031599 UniProtKB/TrEMBL
  ENSSSCG00050075378 UniProtKB/TrEMBL
  ENSSSCG00055029352 UniProtKB/TrEMBL
  ENSSSCG00060060240 UniProtKB/TrEMBL
  ENSSSCG00065073330 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000003822 ENTREZGENE
  ENSSSCP00000003822.3 UniProtKB/TrEMBL
  ENSSSCP00015031546.1 UniProtKB/TrEMBL
  ENSSSCP00015031642.1 UniProtKB/TrEMBL
  ENSSSCP00015031724.1 UniProtKB/TrEMBL
  ENSSSCP00025039544.1 UniProtKB/TrEMBL
  ENSSSCP00025039591.1 UniProtKB/TrEMBL
  ENSSSCP00040044204.1 UniProtKB/TrEMBL
  ENSSSCP00040044243.1 UniProtKB/TrEMBL
  ENSSSCP00045037455.1 UniProtKB/TrEMBL
  ENSSSCP00045037527.1 UniProtKB/TrEMBL
  ENSSSCP00045037579.1 UniProtKB/TrEMBL
  ENSSSCP00050045172.1 UniProtKB/TrEMBL
  ENSSSCP00055046596.1 UniProtKB/TrEMBL
  ENSSSCP00055046612.1 UniProtKB/TrEMBL
  ENSSSCP00055046632.1 UniProtKB/TrEMBL
  ENSSSCP00060035611.1 UniProtKB/TrEMBL
  ENSSSCP00065044435.1 UniProtKB/TrEMBL
  ENSSSCP00065044451.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003912 ENTREZGENE
  ENSSSCT00000003912.4 UniProtKB/TrEMBL
  ENSSSCT00015078230.1 UniProtKB/TrEMBL
  ENSSSCT00015078469.1 UniProtKB/TrEMBL
  ENSSSCT00015078606.1 UniProtKB/TrEMBL
  ENSSSCT00025090250.1 UniProtKB/TrEMBL
  ENSSSCT00025090364.1 UniProtKB/TrEMBL
  ENSSSCT00040098857.1 UniProtKB/TrEMBL
  ENSSSCT00040098924.1 UniProtKB/TrEMBL
  ENSSSCT00045053849.1 UniProtKB/TrEMBL
  ENSSSCT00045053937.1 UniProtKB/TrEMBL
  ENSSSCT00045054000.1 UniProtKB/TrEMBL
  ENSSSCT00050103343.1 UniProtKB/TrEMBL
  ENSSSCT00055058250.1 UniProtKB/TrEMBL
  ENSSSCT00055058268.1 UniProtKB/TrEMBL
  ENSSSCT00055058289.1 UniProtKB/TrEMBL
  ENSSSCT00060082212.1 UniProtKB/TrEMBL
  ENSSSCT00065100965.1 UniProtKB/TrEMBL
  ENSSSCT00065101007.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt4 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
KEGG Report ssc:100327037 UniProtKB/TrEMBL
NCBI Gene WNT4 ENTREZGENE
PANTHER PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT4PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A8D0PBX9_PIG UniProtKB/TrEMBL
  A0A8D0PCV7_PIG UniProtKB/TrEMBL
  A0A8D0PGU0_PIG UniProtKB/TrEMBL
  A0A8D0UYS3_PIG UniProtKB/TrEMBL
  A0A8D1FXY6_PIG UniProtKB/TrEMBL
  A0A8D1IX75_PIG UniProtKB/TrEMBL
  A0A8D1L682_PIG UniProtKB/TrEMBL
  D3JCV7 ENTREZGENE, UniProtKB/TrEMBL
  D3K5L9_PIG UniProtKB/TrEMBL
UniProt Secondary F1STZ7 UniProtKB/TrEMBL
  I3LRC0 UniProtKB/TrEMBL
VGNC ID VGNC:94972 ENTREZGENE