Wnt4 (Wnt family member 4) - Rat Genome Database

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Gene: Wnt4 (Wnt family member 4) Ictidomys tridecemlineatus
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Symbol: Wnt4
Name: Wnt family member 4
RGD ID: 12613896
Description: ENCODES a protein that exhibits frizzled binding (inferred); receptor ligand activity (inferred); signaling receptor binding (inferred); INVOLVED IN anatomical structure development (ortholog); apoptotic signaling pathway (ortholog); branching involved in ureteric bud morphogenesis (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH 46,XX Sex Reversal with Dysgenesis of Kidneys, Adrenals, and Lungs (ortholog); acute kidney failure (ortholog); Dwarfism (ortholog); FOUND IN cytoplasm (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,798,680 - 41,823,413 (-)NCBI
SpeTri2.0NW_0049364747,623,462 - 7,635,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEA)
anatomical structure development  (IEA,ISO)
apoptotic signaling pathway  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
branching morphogenesis of an epithelial tube  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell differentiation  (IEA,ISO)
cell fate commitment  (IEA,ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to starvation  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEA)
embryonic epithelial tube formation  (IEA,ISO)
epithelial to mesenchymal transition  (IEA)
female gonad development  (IEA,ISO)
female sex determination  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
gamete generation  (IEA,ISO)
hormone metabolic process  (IEA,ISO)
immature T cell proliferation in thymus  (IEA,ISO)
kidney development  (IEA)
kidney morphogenesis  (IEA,ISO)
liver development  (IEA)
male gonad development  (IEA,ISO)
mammary gland epithelium development  (IEA)
meiotic nuclear division  (IEA,ISO)
mesenchymal to epithelial transition  (IEA,ISO)
mesonephric tubule development  (IEA,ISO)
mesonephros development  (IEA)
metanephric nephron development  (IEA,ISO)
metanephric nephron morphogenesis  (IEA,ISO)
metanephric tubule formation  (IEA,ISO)
metanephros development  (IEA,ISO)
negative regulation of androgen biosynthetic process  (IEA)
negative regulation of apoptotic signaling pathway  (IEA,ISO)
negative regulation of cell differentiation  (IEA,ISO)
negative regulation of cell migration  (IEA)
negative regulation of fibroblast growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of male gonad development  (IEA)
negative regulation of steroid biosynthetic process  (IEA)
negative regulation of testicular blood vessel morphogenesis  (IEA)
negative regulation of testosterone biosynthetic process  (IEA)
negative regulation of transcription, DNA-templated  (IEA)
negative regulation of wound healing  (IEA)
nephron development  (IEA,ISO)
non-canonical Wnt signaling pathway  (IEA,ISO)
non-canonical Wnt signaling pathway via MAPK cascade  (IEA)
oocyte development  (IEA,ISO)
paramesonephric duct development  (IEA,ISO)
pericyte cell differentiation  (IEA,ISO)
positive regulation of aldosterone biosynthetic process  (IEA)
positive regulation of bone mineralization  (IEA)
positive regulation of collagen biosynthetic process  (IEA)
positive regulation of cortisol biosynthetic process  (IEA)
positive regulation of dermatome development  (IEA)
positive regulation of focal adhesion assembly  (IEA)
positive regulation of GTPase activity  (IEA)
positive regulation of meiotic nuclear division  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of stress fiber assembly  (IEA)
positive regulation of transcription, DNA-templated  (IEA,ISO)
regulation of cell-cell adhesion  (IEA,ISO)
renal vesicle formation  (IEA,ISO)
renal vesicle induction  (IEA,ISO)
response to benzoic acid  (ISO)
response to estradiol  (ISO)
response to retinoic acid  (ISO)
Sertoli cell differentiation  (IEA,ISO)
sex differentiation  (IEA,ISO)
smooth muscle cell differentiation  (IEA,ISO)
somatotropin secreting cell differentiation  (IEA,ISO)
T cell differentiation in thymus  (IEA,ISO)
tertiary branching involved in mammary gland duct morphogenesis  (IEA,ISO)
thyroid-stimulating hormone-secreting cell differentiation  (IEA,ISO)
tube morphogenesis  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Wnt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,798,680 - 41,823,413 (-)NCBI
SpeTri2.0NW_0049364747,623,462 - 7,635,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,117,313 - 22,143,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl122,117,313 - 22,143,969 (-)EnsemblGRCh38hg38GRCh38
GRCh37122,443,806 - 22,469,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,316,385 - 22,342,106 (-)NCBINCBI36hg18NCBI36
Build 34122,191,504 - 22,214,916NCBI
Celera120,766,732 - 20,792,452 (-)NCBI
Cytogenetic Map1p36.12NCBI
HuRef120,687,456 - 20,707,677 (-)NCBIHuRef
CHM1_1122,556,295 - 22,576,527 (-)NCBICHM1_1
T2T-CHM13v2.0121,941,071 - 21,966,860 (-)NCBI
Wnt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,004,946 - 137,026,812 (+)NCBIGRCm39mm39
GRCm39 Ensembl4137,004,800 - 137,027,037 (+)Ensembl
GRCm384137,277,635 - 137,299,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,277,489 - 137,299,726 (+)EnsemblGRCm38mm10GRCm38
MGSCv374136,833,550 - 136,852,694 (+)NCBIGRCm37mm9NCBIm37
MGSCv364136,549,711 - 136,568,855 (+)NCBImm8
Celera4135,495,983 - 135,515,320 (+)NCBICelera
Cytogenetic Map4D3NCBI
Wnt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,513,573 - 149,535,415 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5149,514,018 - 149,532,859 (+)Ensembl
Rnor_6.05155,649,238 - 155,668,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,649,217 - 155,672,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,405,855 - 159,424,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,064,371 - 156,083,198 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15156,074,409 - 156,093,237 (+)NCBI
Celera5147,911,190 - 147,930,012 (+)NCBICelera
Cytogenetic Map5q36NCBI
Wnt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,319,446 - 2,344,989 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,319,446 - 2,344,740 (-)NCBIChiLan1.0ChiLan1.0
WNT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,252,344 - 22,264,858 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,255,056 - 22,268,801 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0121,310,228 - 21,335,985 (-)NCBIMhudiblu_PPA_v0panPan3
WNT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,112,045 - 77,129,702 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,101,300 - 77,127,111 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,605,854 - 73,632,899 (+)NCBI
ROS_Cfam_1.0277,660,017 - 77,687,063 (+)NCBI
ROS_Cfam_1.0 Ensembl277,659,490 - 77,687,070 (+)Ensembl
UMICH_Zoey_3.1274,480,520 - 74,507,565 (+)NCBI
UNSW_CanFamBas_1.0275,489,331 - 75,516,389 (+)NCBI
UU_Cfam_GSD_1.0276,493,182 - 76,520,234 (+)NCBI
WNT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1680,110,238 - 80,138,165 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,137,827 - 74,165,540 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,517,391 - 110,543,802 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,517,564 - 110,541,203 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660335,754,333 - 5,781,060 (-)NCBIVero_WHO_p1.0
Wnt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247646,921,811 - 6,933,392 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247646,913,027 - 6,934,650 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021734143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_021734143   ⟹   XP_021589818
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505841,798,680 - 41,823,413 (-)NCBI
SpeTri2.0NW_0049364747,623,462 - 7,635,416 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_021589818 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3282370 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_021589818   ⟸   XM_021734143
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000806 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000000720 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000806 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt4 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
NCBI Gene Wnt4 ENTREZGENE
PANTHER PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT4PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt I3LXD3_ICTTR UniProtKB/TrEMBL