| 619921 | Rhoa | ras homolog family member A | ENCODES a protein that exhibits GDP binding; GTP binding; GTPase activity; INVOLVED IN GTP metabolic process; microtubule depolymerization; negative regulation of canonical NF-kappaB signal transduction; PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH acute myocardial infarction; asthma; Brain Injuries; FOUND IN axon; cytosol; dendrite; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-(-)-perillyl alcohol; 1-octadec-9-enoylglycero-3-phosphate | 8 | 117870548 | 117904303 | Rat | 694 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731060 | Rhoa | ras homolog family member A | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] | 9 | 108183359 | 108215142 | Mouse | 741 | symbol , old_gene_name , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1347797 | RHOA | ras homolog family member A | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] | 3 | 49359145 | 49411976 | Human | 745 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8805780 | Rhoa | ras homolog family member A | ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); alpha-beta T cell lineage commitment (ortholog); androgen receptor signaling pathway (ortholog); PARTICIPATES IN calcium signaling pa thway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); acute myocardial infarction (ortholog); alopecia (ortholog); FOUND IN apical junction complex (ortholog); axon (ortholog); cell cortex (ortholog) | NW_004955532 | 1300821 | 1347453 | Chinchilla | 281 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11748716 | RHOA | ras homolog family member A | ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); androgen receptor signaling pathway (ortholog); angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blo od pressure (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); acute myocardial infarction (ortholog); alopecia (ortholog); FOUND IN apical junction complex (ortholog); axon (ortholog); cell cortex (ortholog) | 3 | 49282009 | 49339887 | Bonobo | 275 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12222706 | RHOA | ras homolog family member A | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); GTPase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); androgen receptor signaling pathway (ortholog); angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); acute myocardial infarction (ortholog); alopecia (ortholog); FOUND IN apical junction complex (ortholog); axon (ortholog); cell cortex (ortholog) | 20 | 39824552 | 39888089 | Dog | 320 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 12568494 | Rhoa | ras homolog family member A | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); androgen receptor signaling pathway (ortholog); angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); acute myocardial infarction (ortholog); alopecia (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); dendritic spine (ortholog) | NW_004936529 | 1000050 | 1045655 | Squirrel | 273 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13900973 | RHOA | ras homolog family member A | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); GTPase activity (ortholog); INVOLVED IN embryonic cleavage; establishment or maintenance of actin cytoskeleton polarity; meiotic spindle organization; PARTICIPATES IN calcium signaling pathway via the calcium-sensing rec eptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); acute myocardial infarction (ortholog); alopecia (ortholog); FOUND IN cell cortex; cleavage furrow; meiotic spindle; INTERACTS WITH deoxynivalenol | | | | Pig | 353 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 18721266 | RHOA | ras homolog family member A | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); androgen receptor signaling pathway (ortholog); angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); acute myocardial infarction (ortholog); alopecia (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); dendritic spine (ortholog) | | | | Green Monkey | 272 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18928007 | Rhoa | ras homolog family member A | ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); alpha-beta T cell lineage commitment (ortholog); androgen receptor signaling pathway (ortholog); PARTICIPATES IN calcium signaling pa thway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); acute myocardial infarction (ortholog); alopecia (ortholog); FOUND IN apical junction complex (ortholog); axon (ortholog); cell cortex (ortholog) | | | | Naked Mole-Rat | 281 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155244050 | rhoa | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626040397 | Rhoa | ras homolog family member A | ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); alpha-beta T cell lineage commitment (ortholog); androgen receptor signaling pathway (ortholog); PARTICIPATES IN calcium signaling pa thway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); acute myocardial infarction (ortholog); alopecia (ortholog); FOUND IN apical junction complex (ortholog); axon (ortholog); cell cortex (ortholog) | | | | Black Rat | 281 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 284024563 | rhoa.2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155260155 | rhoa.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244049 | rhoa.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 10413421 | RHOA-IT1 | RHOA intronic transcript 1 | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna |
| 1597692 | Rhoa-ps1 | ras homolog family member A, pseudogene 1 | ENCODES a pseudogene that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred) | X | 23147741 | 23148772 | Rat | 5 | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 285832000 | rhoa.2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12418032 | LOC100688385 | transforming protein RhoA-like | | 4 | 65257708 | 65258934 | Dog | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 11876289 | LOC100975029 | transforming protein RhoA-like | | 6 | 89693477 | 89694051 | Bonobo | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 12692124 | LOC101959358 | transforming protein RhoA-like | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN skeletal muscle satellite cell migration (ortholog); wound healing, spreading of cells (ortholog); FOUND IN cleavage furrow (inferred); plasma membrane (inferred) | NW_004936590 | 844835 | 845422 | Squirrel | 9 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12595352 | LOC101971159 | transforming protein RhoA-like | | NW_004936693 | 35613 | 37005 | Squirrel | | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12307914 | LOC102152444 | transforming protein RhoA-like | | 4 | 32922135 | 32923562 | Dog | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 626111459 | LOC116888480 | transforming protein RhoA-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 626061168 | LOC116902777 | transforming protein RhoA-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 18916174 | LOC101701485 | transforming protein RhoA pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18936786 | LOC101710891 | transforming protein RhoA pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18740718 | LOC103240118 | transforming protein RhoA pseudogene | | | | | Green Monkey | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 18925372 | LOC101710482 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (inferred); INVOLVED IN negative regulation of Rho protein signal transduction (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); protein homooligomerization (inferred); FOUND IN Cul3-RING u biquitin ligase complex (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 7 | name | gene, protein-coding, MODEL [RefSeq] |
| 18903222 | LOC101710854 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (inferred); INVOLVED IN negative regulation of Rho protein signal transduction (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); protein homooligomerization (inferred); FOUND IN Cul3-RING u biquitin ligase complex (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 8 | name | gene, protein-coding, MODEL [RefSeq] |
| 11722262 | LOC100981597 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3-like | ENCODES a protein that exhibits ubiquitin-protein transferase activity (inferred); INVOLVED IN negative regulation of Rho protein signal transduction (inferred); proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); protein homooligomerization (inferred); FOUND IN Cul3-RING u biquitin ligase complex (inferred) | 10 | 43451160 | 43452331 | Bonobo | 6 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12566063 | LOC101968371 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2-like | | NW_004936469 | 26189026 | 26189991 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 18907383 | LOC101700341 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18923311 | LOC101721743 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18910296 | LOC106008940 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 14040628 | LOC110260792 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 pseudogene | | | | | Pig | | name | gene, pseudo, MODEL [RefSeq] |
| 3590 | Rock2 | Rho-associated coiled-coil containing protein kinase 2 | ENCODES a protein that exhibits endopeptidase activator activity (ortholog); protease binding (ortholog); protein kinase activity (ortholog); INVOLVED IN positive regulation of cardiac muscle hypertrophy; positive regulation of connective tissue growth factor production; positive regulation of conne ctive tissue replacement; PARTICIPATES IN chemokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; Wnt signaling pathway; ASSOCIATED WITH Left Ventricular Hypertrophy; primary biliary cholangitis; Animal Disease Models (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytoplasmic ribonucleoprotein granule (ortholog); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 6 | 45407823 | 45502773 | Rat | 354 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1605997 | LAMTOR1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | Enables GTPase binding activity and protein-membrane adaptor activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of TORC1 signaling; and regulation of cholesterol tra nsport. Located in lysosome. Part of FNIP-folliculin RagC/D GAP. Is active in Ragulator complex and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025] | 11 | 72097292 | 72103297 | Human | 141 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1303132 | Plekhg5 | pleckstrin homology and RhoGEF domain containing G5 | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN endothelial cell chemotaxis (ortholog); endothelial cell migration (ortholog); positive regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH autosomal dominant distal hered itary motor neuronopathy 14 (ortholog); autosomal recessive distal hereditary motor neuronopathy 4 (ortholog); Charcot-Marie-Tooth disease recessive intermediate C (ortholog); FOUND IN cell-cell junction (ortholog); cytoplasm (ortholog); endocytic vesicle (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; azoxystrobin | 5 | 167860730 | 167904229 | Rat | 131 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2319924 | Lamtor1l1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1 | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); molecular adaptor activity (ortholog); protein-membrane adaptor activity (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cholesterol homeostasis (ortholog); endosomal transport (orthol og); FOUND IN late endosome membrane; membrane raft; lysosomal membrane (ortholog) | X | 38446140 | 38447189 | Rat | 45 | old_gene_name | gene, protein-coding, INFERRED [RefSeq] |
| 735210 | Arhgef25 | Rho guanine nucleotide exchange factor 25 | ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); ASSOCIATED WITH prostate cancer (ortholog); FOUND IN myofibril (ortholog); plasma membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 64891260 | 64898382 | Rat | 80 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1601833 | ARHGEF25 | Rho guanine nucleotide exchange factor 25 | Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] | 12 | 57610116 | 57617245 | Human | 82 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 735078 | Lamtor1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | ENCODES a protein that exhibits GTPase binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to nutrient levels (ortholog); cholesterol homeostasis (ortholog ); PARTICIPATES IN mTOR signaling pathway; FOUND IN late endosome membrane; membrane raft; FNIP-folliculin RagC/D GAP (ortholog); INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A | 1 | 165684001 | 165689698 | Rat | 136 | old_gene_name , ensembl_full_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1622333 | Lamtor1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | Enables protein-membrane adaptor activity. Involved in several processes, including lysosome localization; positive regulation of intracellular signal transduction; and regulation of receptor recycling. Is active in lysosomal membrane. Is expressed in several structures, including adipose tissue; al imentary system; early conceptus; nervous system; and reproductive system. Orthologous to human LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 101555044 | 101561110 | Mouse | 172 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 620424 | Rock1 | Rho-associated coiled-coil containing protein kinase 1 | ENCODES a protein that exhibits small GTPase binding; protein serine/threonine kinase activity (ortholog); Rho-dependent protein serine/threonine kinase activity (ortholog); INVOLVED IN cytoskeleton organization; positive regulation of gene expression; response to transforming growth factor beta; PA RTICIPATES IN E-cadherin signaling pathway; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH Left Ventricular Hypertrophy; acute promyelocytic leukemia (ortholog); basal cell carcinoma (ortholog); FOUND IN synapse; cytoplasmic stress granule (ortholog); cytoskeleton (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 18 | 1387360 | 1509218 | Rat | 367 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 734041 | Mcf2l | mcf.2 transforming sequence-like | Enables 1-phosphatidylinositol binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within Rho protein signal transduction and positive regulation of transcription by RNA polymerase II. Located in lamellipodium and membrane. Is expressed in several structures, includi ng brain; liver; retina; right atrium; and testis. Orthologous to human MCF2L (MCF.2 cell line derived transforming sequence like). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 12923806 | 13070502 | Mouse | 167 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1604271 | MRI1 | methylthioribose-1-phosphate isomerase 1 | This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016] | 19 | 13764522 | 13774282 | Human | 84 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1550862 | Plekhg5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | This gene encodes a protein belonging to the Rho guanine exchange factor (GEF) family of proteins, which activate GTPases by replacing GDP with GTP. This family member is a RhoA GEF that plays a role in endothelial cell migration and tube formation. It is required for angiogenesis and may function i n neuronal cell differentiation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013] | 4 | 152156890 | 152199855 | Mouse | 137 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 734056 | ARHGEF11 | Rho guanine nucleotide exchange factor 11 | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] | 1 | 156934840 | 157046903 | Human | 93 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1619220 | Arhgef25 | Rho guanine nucleotide exchange factor 25 | Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance. Located in myofibril and plasma membrane. Is expressed in several structures, including brain; eye; gut; metanephros; and otocyst. Orthologous to human ARHGEF25 (Rho guanine nucleotide exchange factor 25). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 127018390 | 127025952 | Mouse | 80 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1347079 | KCTD10 | potassium channel tetramerization domain containing 10 | The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [ provided by RefSeq, Dec 2015] | 12 | 109448655 | 109477300 | Human | 99 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1591979 | Kctd10 | potassium channel tetramerization domain containing 10 | ENCODES a protein that exhibits identical protein binding (ortholog); Notch binding (ortholog); INVOLVED IN angiogenesis (ortholog); heart development (ortholog); negative regulation of Notch signaling pathway (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); MKS complex (ortholog) ; nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil | 12 | 47890777 | 47909391 | Rat | 95 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1614050 | Kctd10 | potassium channel tetramerisation domain containing 10 | Predicted to enable Notch binding activity and identical protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Acts upstream of or within angiogenesis; heart development; and negative regulation of Notch signaling pathway. Part of MKS complex. Is expressed in c lavicle; mandible; maxilla; midgut; and rib. Orthologous to human KCTD10 (potassium channel tetramerization domain containing 10). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 114501633 | 114518566 | Mouse | 111 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8888349 | Kctd10 | potassium channel tetramerization domain containing 10 | ENCODES a protein that exhibits identical protein binding (ortholog); Notch binding (ortholog); INVOLVED IN angiogenesis (ortholog); heart development (ortholog); negative regulation of Notch signaling pathway (ortholog); FOUND IN MKS complex (ortholog); nucleoplasm (ortholog) | NW_004955455 | 9032697 | 9064827 | Chinchilla | 13 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11673955 | KCTD10 | potassium channel tetramerization domain containing 10 | ENCODES a protein that exhibits identical protein binding (ortholog); Notch binding (ortholog); INVOLVED IN angiogenesis (ortholog); heart development (ortholog); negative regulation of Notch signaling pathway (ortholog); FOUND IN MKS complex (ortholog); nucleoplasm (ortholog) | 12 | 107025380 | 107054118 | Bonobo | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12058759 | KCTD10 | potassium channel tetramerization domain containing 10 | ENCODES a protein that exhibits identical protein binding (inferred); Notch binding (inferred); INVOLVED IN angiogenesis (ortholog); heart development (ortholog); negative regulation of Notch signaling pathway (ortholog); FOUND IN MKS complex (ortholog) | 26 | 17592157 | 17625384 | Dog | 20 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12576970 | Kctd10 | potassium channel tetramerization domain containing 10 | ENCODES a protein that exhibits identical protein binding (inferred); Notch binding (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN angiogenesis (ortholog); heart development (ortholog); negative regulation of Notch signaling pathway (ortholog); FOUND IN MKS complex (ortho log) | NW_004936769 | 1171725 | 1197497 | Squirrel | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14213422 | KCTD10 | potassium channel tetramerization domain containing 10 | ENCODES a protein that exhibits identical protein binding (inferred); Notch binding (inferred); INVOLVED IN angiogenesis (ortholog); heart development (ortholog); negative regulation of Notch signaling pathway (ortholog); FOUND IN MKS complex (ortholog) | | | | Pig | 20 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18547298 | KCTD10 | potassium channel tetramerization domain containing 10 | ENCODES a protein that exhibits identical protein binding (inferred); Notch binding (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN angiogenesis (ortholog); heart development (ortholog); negative regulation of Notch signaling pathway (ortholog); FOUND IN MKS complex (ortho log) | | | | Green Monkey | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18911862 | Kctd10 | potassium channel tetramerization domain containing 10 | ENCODES a protein that exhibits identical protein binding (ortholog); Notch binding (ortholog); INVOLVED IN angiogenesis (ortholog); heart development (ortholog); negative regulation of Notch signaling pathway (ortholog); FOUND IN MKS complex (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 21 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626081749 | Kctd10 | potassium channel tetramerization domain containing 10 | ENCODES a protein that exhibits identical protein binding (ortholog); Notch binding (ortholog); INVOLVED IN angiogenesis (ortholog); heart development (ortholog); negative regulation of Notch signaling pathway (ortholog); FOUND IN MKS complex (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 13 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 735189 | Kctd13 | potassium channel tetramerization domain containing 13 | ENCODES a protein that exhibits protein domain specific binding; identical protein binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN positive regulation of DNA replication; cell migration (ortholog); negative regulation of Rho protein signal transduction (o rtholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); spondylocostal dysostosis 5 (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); nuclear body (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3H-1,2-dithiole-3-thione | 1 | 190965073 | 190983381 | Rat | 89 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1332528 | Kctd13 | potassium channel tetramerisation domain containing 13 | Enables identical protein binding activity. Involved in negative regulation of Rho protein signal transduction and positive regulation of synaptic transmission. Predicted to be located in nuclear body. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, in cluding central nervous system; genitourinary system; and retina. Orthologous to human KCTD13 (potassium channel tetramerization domain containing 13). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 126528051 | 126544781 | Mouse | 142 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1345683 | KCTD13 | potassium channel tetramerization domain containing 13 | Enables identical protein binding activity and small GTPase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of Rho protein signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; and stress fiber assembly. Located in nuclear body. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 29906339 | 29926226 | Human | 95 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8771723 | Kctd13 | potassium channel tetramerization domain containing 13 | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN cell migration (ortholog); negative regulation of Rho protein signal transduction (ortholog); neural precursor ce ll proliferation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); spondylocostal dysostosis 5 (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | NW_004955493 | 7039027 | 7055798 | Chinchilla | 31 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11785840 | KCTD13 | potassium channel tetramerization domain containing 13 | ENCODES a protein that exhibits protein domain specific binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN cell migration (ortholog); neural precursor cell proliferation (ortholog); positive regulation of DNA replication (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); spondylocostal dysostosis 5 (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog) | | | | Bonobo | 31 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12342941 | KCTD13 | potassium channel tetramerization domain containing 13 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN neural precursor cell proliferation (ortholog); positive regulation of DNA replication (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); sp ondylocostal dysostosis 5 (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nuclear body (inferred); nucleoplasm (inferred); INTERACTS WITH bisphenol A | 6 | 17945541 | 17959421 | Dog | 37 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12601305 | Kctd13 | potassium channel tetramerization domain containing 13 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN neural precursor cell proliferation (ortholog); positive regulation of DNA replication (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); sp ondylocostal dysostosis 5 (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nuclear body (inferred); nucleoplasm (inferred) | NW_004936501 | 12544899 | 12557485 | Squirrel | 37 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14190102 | KCTD13 | potassium channel tetramerization domain containing 13 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN neural precursor cell proliferation (ortholog); positive regulation of DNA replication (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); sp ondylocostal dysostosis 5 (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nuclear body (inferred); nucleoplasm (inferred) | | | | Pig | 36 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18459088 | KCTD13 | potassium channel tetramerization domain containing 13 | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN neural precursor cell proliferation (ortholog); positive regulation of DNA replication (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); sp ondylocostal dysostosis 5 (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); nuclear body (inferred); nucleoplasm (inferred) | | | | Green Monkey | 37 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625973960 | Kctd13 | potassium channel tetramerization domain containing 13 | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN cell migration (ortholog); negative regulation of Rho protein signal transduction (ortholog); neural precursor ce ll proliferation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 30 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 3877 | Tnfaip1 | TNF alpha induced protein 1 | ENCODES a protein that exhibits cyclin binding; identical protein binding (ortholog); small GTPase binding (ortholog); INVOLVED IN positive regulation of DNA replication; cell migration (ortholog); immune response (ortholog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); FOUND IN Cul3-RING ubiq uitin ligase complex (ortholog); cytoplasm (ortholog); endosome (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 10 | 63915824 | 63930514 | Rat | 118 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1346510 | TNFAIP1 | TNF alpha induced protein 1 | This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008] | 17 | 28335761 | 28347009 | Human | 110 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1550978 | Tnfaip1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | Predicted to enable cyclin binding activity; identical protein binding activity; and small GTPase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of Rho protein signal transduction; posi tive regulation of DNA replication; and stress fiber assembly. Predicted to be located in endosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in brain; heart valve; peripheral nerve; sensory organ; and skeleton. Orthologous to human TNFAIP1 (TNF alpha induced protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 78413676 | 78427122 | Mouse | 140 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8728209 | Tnfaip1 | TNF alpha induced protein 1 | ENCODES a protein that exhibits cyclin binding (ortholog); identical protein binding (ortholog); small GTPase binding (ortholog); INVOLVED IN cell migration (ortholog); immune response (ortholog); negative regulation of Rho protein signal transduction (ortholog); ASSOCIATED WITH Diabetic Nephropathi es (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); endosome (ortholog) | NW_004955481 | 4786015 | 4799376 | Chinchilla | 26 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11682867 | TNFAIP1 | TNF alpha induced protein 1 | ENCODES a protein that exhibits cyclin binding (ortholog); INVOLVED IN positive regulation of DNA replication (ortholog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); endosome (inferred) | 17 | 28427448 | 28438826 | Bonobo | 36 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12066550 | TNFAIP1 | TNF alpha induced protein 1 | ENCODES a protein that exhibits cyclin binding (ortholog); INVOLVED IN positive regulation of DNA replication (ortholog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); endosome (inferred) | 9 | 42588009 | 42597961 | Dog | 35 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12639618 | Tnfaip1 | TNF alpha induced protein 1 | ENCODES a protein that exhibits cyclin binding (ortholog); INVOLVED IN positive regulation of DNA replication (ortholog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); endosome (inferred) | NW_004936538 | 4491915 | 4503887 | Squirrel | 36 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13973280 | TNFAIP1 | TNF alpha induced protein 1 | ENCODES a protein that exhibits cyclin binding (ortholog); INVOLVED IN positive regulation of DNA replication (ortholog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); endosome (inferred) | | | | Pig | 35 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18425366 | TNFAIP1 | TNF alpha induced protein 1 | ENCODES a protein that exhibits cyclin binding (ortholog); INVOLVED IN positive regulation of DNA replication (ortholog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); endosome (inferred) | | | | Green Monkey | 36 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18902053 | Tnfaip1 | TNF alpha induced protein 1 | ENCODES a protein that exhibits cyclin binding (ortholog); INVOLVED IN positive regulation of DNA replication (ortholog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); endosome (inferred) | | | | Naked Mole-Rat | 36 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626158547 | Tnfaip1 | TNF alpha induced protein 1 | ENCODES a protein that exhibits cyclin binding (ortholog); identical protein binding (ortholog); small GTPase binding (ortholog); INVOLVED IN cell migration (ortholog); immune response (ortholog); negative regulation of Rho protein signal transduction (ortholog); ASSOCIATED WITH Diabetic Nephropathi es (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); endosome (ortholog) | | | | Black Rat | 26 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1350163 | PPP1R12A | protein phosphatase 1 regulatory subunit 12A | Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatas e Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] | 12 | 79773563 | 79935460 | Human | 281 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735071 | Rhoal1 | ras homolog family member A like 1 | ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); PARTICIPATES IN chemokine mediated signaling pathway; colorectal cancer pathway; endocytosis pathway; FOUND IN cleavage furrow (inferred); plasma membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride | 4 | 96581411 | 96582783 | Rat | 20 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1623323 | Rhoay-ps1 | ras homolog A translocated to the Y, pseudogene 1 | | Y | 2095313 | 2096205 | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1623322 | Rhoay-ps2 | ras homolog A translocated to the Y, pseudogene 2 | | Y | 3747034 | 3747810 | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1623321 | Rhoay-ps3 | ras homolog A translocated to the Y, pseudogene 3 | | Y | 873536 | 874468 | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1315839 | RIPOR2 | RHO family interacting cell polarization regulator 2 | This gene encodes an atypical inhibitor of the small G protein RhoA. Inhibition of RhoA activity by the encoded protein mediates myoblast fusion and polarization of T cells and neutrophils. The encoded protein is a component of hair cell stereocilia that is essential for hearing. A splice site mutat ion in this gene results in hearing loss in human patients. [provided by RefSeq, Sep 2016] | 6 | 24804284 | 25042168 | Human | 222 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1607091 | AAMP | angio associated migratory cell protein | The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014] | 2 | 218264129 | 218270137 | Human | 80 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1315077 | ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and do es not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008] | 4 | 36005404 | 36244784 | Human | 140 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1343283 | ARHGAP17 | Rho GTPase activating protein 17 | RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004] | 16 | 24919389 | 25015369 | Human | 109 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1351019 | ARHGAP19 | Rho GTPase activating protein 19 | Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 1 7454002]).[supplied by OMIM, Mar 2008] | 10 | 97222179 | 97292637 | Human | 82 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1322105 | ARHGAP26 | Rho GTPase activating protein 26 | Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase act ivating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017] | 5 | 142770377 | 143229011 | Human | 167 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1605412 | ARHGAP32 | Rho GTPase activating protein 32 | RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008] | 11 | 128965060 | 129279632 | Human | 112 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3500508 | ARHGAP42 | Rho GTPase activating protein 42 | This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017] | 11 | 100687288 | 100993941 | Human | 97 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1349829 | ARHGAP6 | Rho GTPase activating protein 6 | This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, a nd another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | X | 11137544 | 11665920 | Human | 108 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1315873 | ARHGEF15 | Rho guanine nucleotide exchange factor 15 | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vasc ular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010] | 17 | 8310241 | 8322511 | Human | 89 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1312400 | ARHGEF19 | Rho guanine nucleotide exchange factor 19 | Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).[supplied by OMIM, Dec 2008] | 1 | 16197854 | 16212652 | Human | 111 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1321712 | ARHGEF3 | Rho guanine nucleotide exchange factor 3 | Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 3 | 56727420 | 57079268 | Human | 136 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1317623 | CCM2 | CCM2 scaffold protein | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. T he protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009] | 7 | 44999746 | 45076470 | Human | 203 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1353387 | CGNL1 | cingulin like 1 | This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in associati on of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011] | 15 | 57376505 | 57550717 | Human | 122 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1344953 | GMIP | GEM interacting protein | This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. A lternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] | 19 | 19629476 | 19643657 | Human | 84 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1312823 | NET1 | neuroepithelial cell transforming 1 | This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012] | 10 | 5412557 | 5459056 | Human | 156 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 11554295 | PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014] | 8 | 8317736 | 8386439 | Human | 137 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1318093 | RHPN2 | rhophilin Rho GTPase binding protein 2 | This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009] | 19 | 32978592 | 33064888 | Human | 106 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1316447 | SCAI | suppressor of cancer cell invasion | This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010] | 9 | 124942608 | 125143528 | Human | 78 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1316657 | TIAM1 | TIAM Rac1 associated GEF 1 | This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017] | 21 | 31118418 | 31559087 | Human | 244 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1343957 | VAV3 | vav guanine nucleotide exchange factor 3 | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] | 1 | 107571161 | 107965180 | Human | 200 | description | gene, protein-coding, REVIEWED [RefSeq] |
