TNFAIP1 (TNF alpha induced protein 1) - Rat Genome Database

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Gene: TNFAIP1 (TNF alpha induced protein 1) Canis lupus familiaris
Analyze
Symbol: TNFAIP1
Name: TNF alpha induced protein 1
RGD ID: 12066550
Description: ENCODES a protein that exhibits cyclin binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN positive regulation of DNA replication (ortholog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred); cytoplasm (inferred); endosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,588,009 - 42,597,961 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,588,112 - 42,595,596 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,744,941 - 41,754,881 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,407,163 - 43,417,110 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,407,185 - 43,417,107 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,191,412 - 42,201,351 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,482,639 - 42,492,584 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,559,687 - 42,569,626 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TNFAIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,588,009 - 42,597,961 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,588,112 - 42,595,596 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha941,744,941 - 41,754,881 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,407,163 - 43,417,110 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,407,185 - 43,417,107 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,191,412 - 42,201,351 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,482,639 - 42,492,584 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,559,687 - 42,569,626 (+)NCBIUU_Cfam_GSD_1.0
TNFAIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,335,761 - 28,347,009 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,335,602 - 28,347,009 (+)EnsemblGRCh38hg38GRCh38
GRCh371726,662,787 - 26,674,035 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361723,686,913 - 23,698,160 (+)NCBINCBI36Build 36hg18NCBI36
Build 341723,686,912 - 23,698,160NCBI
Celera1723,524,290 - 23,535,780 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1722,870,942 - 22,882,432 (+)NCBIHuRef
CHM1_11726,725,440 - 26,736,930 (+)NCBICHM1_1
T2T-CHM13v2.01729,277,609 - 29,288,860 (+)NCBIT2T-CHM13v2.0
Tnfaip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,413,676 - 78,427,122 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,413,676 - 78,427,158 (-)EnsemblGRCm39 Ensembl
GRCm381178,522,850 - 78,536,270 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,522,850 - 78,536,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv371178,336,352 - 78,349,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,339,043 - 78,352,389 (-)NCBIMGSCv36mm8
Celera1188,154,923 - 88,168,333 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Tnfaip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,915,824 - 63,930,514 (-)NCBIGRCr8
mRatBN7.21063,417,774 - 63,432,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,417,775 - 63,432,466 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,050,427 - 68,065,093 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,555,758 - 67,570,424 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,025,275 - 63,039,976 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,791,002 - 65,805,693 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,791,003 - 65,805,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,837,922 - 65,853,370 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,632,189 - 64,646,879 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,647,455 - 64,660,389 (-)NCBI
Celera1062,394,329 - 62,409,019 (-)NCBICelera
Cytogenetic Map10q25NCBI
Tnfaip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,786,015 - 4,799,274 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,786,015 - 4,799,376 (-)NCBIChiLan1.0ChiLan1.0
TNFAIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21936,111,643 - 36,122,935 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,992,035 - 38,003,328 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,427,448 - 28,438,826 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,929,788 - 28,941,278 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,929,788 - 28,941,278 (-)Ensemblpanpan1.1panPan2
Tnfaip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560241,613,977 - 41,625,942 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,491,925 - 4,503,645 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,491,915 - 4,503,887 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFAIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,616,916 - 44,629,934 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,616,840 - 44,626,330 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21246,529,322 - 46,538,741 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNFAIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,102,499 - 22,111,739 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1622,102,531 - 22,115,451 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660758,014,614 - 8,026,413 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfaip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624786939,605 - 952,675 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624786939,619 - 952,698 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TNFAIP1
117 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 16 6 6 11 10 6
Low 1 6 6 6 6 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000029628   ⟹   ENSCAFP00000027535
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl942,588,112 - 42,595,596 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845012326   ⟹   ENSCAFP00845009635
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl943,407,185 - 43,417,107 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845012374   ⟹   ENSCAFP00845009674
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl943,407,185 - 43,415,074 (+)Ensembl
RefSeq Acc Id: XM_038486388   ⟹   XP_038342316
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1942,191,412 - 42,201,351 (+)NCBI
RefSeq Acc Id: XM_038548226   ⟹   XP_038404154
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0942,559,687 - 42,569,626 (+)NCBI
RefSeq Acc Id: XM_038612191   ⟹   XP_038468119
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0942,482,639 - 42,492,584 (+)NCBI
RefSeq Acc Id: XM_038677449   ⟹   XP_038533377
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0943,407,163 - 43,417,110 (+)NCBI
RefSeq Acc Id: XM_548281   ⟹   XP_548281
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1942,588,009 - 42,597,961 (+)NCBI
Dog10K_Boxer_Tasha941,744,941 - 41,754,881 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_548281   ⟸   XM_548281
- UniProtKB: A0A8C0T9F1 (UniProtKB/TrEMBL),   A0A8C0KHF8 (UniProtKB/TrEMBL),   A0A8I3NFW8 (UniProtKB/TrEMBL),   A0A8C0KFZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000027535   ⟸   ENSCAFT00000029628
RefSeq Acc Id: XP_038342316   ⟸   XM_038486388
RefSeq Acc Id: XP_038468119   ⟸   XM_038612191
RefSeq Acc Id: XP_038533377   ⟸   XM_038677449
- UniProtKB: A0A8C0T9F1 (UniProtKB/TrEMBL),   A0A8C0KHF8 (UniProtKB/TrEMBL),   A0A8I3NFW8 (UniProtKB/TrEMBL),   A0A8C0KFZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038404154   ⟸   XM_038548226
- UniProtKB: A0A8C0KFZ5 (UniProtKB/TrEMBL),   A0A8C0KHF8 (UniProtKB/TrEMBL),   A0A8C0T9F1 (UniProtKB/TrEMBL),   A0A8I3NFW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845009635   ⟸   ENSCAFT00845012326
RefSeq Acc Id: ENSCAFP00845009674   ⟸   ENSCAFT00845012374
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018663 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013883 UniProtKB/TrEMBL
  ENSCAFG00040020100 UniProtKB/TrEMBL
  ENSCAFG00845006938 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029628.5 UniProtKB/TrEMBL
  ENSCAFT00030025736.1 UniProtKB/TrEMBL
  ENSCAFT00040037151.1 UniProtKB/TrEMBL
  ENSCAFT00845012326 ENTREZGENE
  ENSCAFT00845012326.1 UniProtKB/TrEMBL
  ENSCAFT00845012374.1 UniProtKB/TrEMBL
InterPro BACURD1-3 UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/TrEMBL
KEGG Report cfa:491161 UniProtKB/TrEMBL
NCBI Gene TNFAIP1 ENTREZGENE
PANTHER BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 2 UniProtKB/TrEMBL
  PTHR11145 UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
UniProt A0A8C0KFZ5 ENTREZGENE
  A0A8C0KHF8 ENTREZGENE
  A0A8C0T9F1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NFW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RTN3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:47648 ENTREZGENE