ARHGAP19 (Rho GTPase activating protein 19) - Rat Genome Database

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Gene: ARHGAP19 (Rho GTPase activating protein 19) Homo sapiens
Analyze
Symbol: ARHGAP19
Name: Rho GTPase activating protein 19
RGD ID: 1351019
HGNC Page HGNC:23724
Description: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Located in intracellular membrane-bounded organelle and plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DKFZp313K217; MGC138804; MGC138805; MGC14258; putative RhoGAP protein; rho GTPase-activating protein 19; rho-type GTPase-activating protein 19
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381097,222,179 - 97,292,637 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1097,222,173 - 97,292,673 (-)EnsemblGRCh38hg38GRCh38
GRCh371098,981,936 - 99,052,394 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361098,971,920 - 99,042,403 (-)NCBINCBI36Build 36hg18NCBI36
Build 341098,971,926 - 99,042,396NCBI
Celera1092,723,490 - 92,790,901 (-)NCBICelera
Cytogenetic Map10q24.1NCBI
HuRef1092,609,973 - 92,679,489 (-)NCBIHuRef
CHM1_11099,264,185 - 99,334,168 (-)NCBICHM1_1
T2T-CHM13v2.01098,103,011 - 98,172,839 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8619474   PMID:9110174   PMID:12477932   PMID:12693554   PMID:14702039   PMID:15164054   PMID:15489334   PMID:16344560   PMID:16385451   PMID:16713569   PMID:17454002   PMID:19322201  
PMID:21873635   PMID:22939629   PMID:23503679   PMID:24259668   PMID:27173435   PMID:28514442   PMID:29420299   PMID:31536960   PMID:32203420   PMID:32814053   PMID:32994395   PMID:33407571  
PMID:33961781   PMID:34296808   PMID:34299191   PMID:35271311   PMID:35944360   PMID:36543142   PMID:36931259   PMID:37267103   PMID:37827155  


Genomics

Comparative Map Data
ARHGAP19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381097,222,179 - 97,292,637 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1097,222,173 - 97,292,673 (-)EnsemblGRCh38hg38GRCh38
GRCh371098,981,936 - 99,052,394 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361098,971,920 - 99,042,403 (-)NCBINCBI36Build 36hg18NCBI36
Build 341098,971,926 - 99,042,396NCBI
Celera1092,723,490 - 92,790,901 (-)NCBICelera
Cytogenetic Map10q24.1NCBI
HuRef1092,609,973 - 92,679,489 (-)NCBIHuRef
CHM1_11099,264,185 - 99,334,168 (-)NCBICHM1_1
T2T-CHM13v2.01098,103,011 - 98,172,839 (-)NCBIT2T-CHM13v2.0
Arhgap19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391941,755,027 - 41,790,523 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1941,755,027 - 41,790,486 (-)EnsemblGRCm39 Ensembl
GRCm381941,766,588 - 41,802,084 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1941,766,588 - 41,802,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv371941,841,078 - 41,876,574 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361941,822,896 - 41,855,345 (-)NCBIMGSCv36mm8
Celera1942,565,944 - 42,601,293 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1935.19NCBI
Arhgap19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81250,519,703 - 250,566,705 (-)NCBIGRCr8
mRatBN7.21240,571,554 - 240,617,361 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,580,871 - 240,617,287 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1248,726,358 - 248,762,787 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01255,423,509 - 255,459,938 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01248,076,520 - 248,112,949 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01261,015,083 - 261,051,515 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1261,015,123 - 261,051,498 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01268,467,998 - 268,504,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1236,417,793 - 236,454,050 (-)NCBICelera
Cytogenetic Map1q54NCBI
Arhgap19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555073,403,846 - 3,471,884 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555073,400,273 - 3,471,943 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28109,138,192 - 109,209,490 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110109,143,512 - 109,214,816 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01093,845,870 - 93,917,842 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11097,340,568 - 97,412,538 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1097,340,568 - 97,412,538 (-)Ensemblpanpan1.1panPan2
ARHGAP19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12810,556,278 - 10,621,032 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2810,739,777 - 10,803,940 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02810,878,208 - 10,943,056 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2810,878,126 - 10,942,986 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12810,539,879 - 10,604,434 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02810,601,086 - 10,665,164 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02810,741,124 - 10,805,093 (-)NCBIUU_Cfam_GSD_1.0
Arhgap19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721336,309,480 - 36,357,895 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366362,348,589 - 2,398,500 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366362,348,613 - 2,394,914 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114108,666,228 - 108,739,098 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214118,276,957 - 118,282,335 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1990,396,061 - 90,469,716 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl990,334,674 - 90,469,609 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604851,288,111 - 51,364,238 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247378,886,986 - 8,982,650 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247378,887,036 - 8,982,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARHGAP19
34 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3		 pathogenic
GRCh38/hg38 10q23.33-24.2(chr10:92626680-97755102)x1 copy number loss See cases [RCV000052564] Chr10:92626680..97755102 [GRCh38]
Chr10:94386437..99514859 [GRCh37]
Chr10:94376417..99504849 [NCBI36]
Chr10:10q23.33-24.2		 pathogenic
GRCh38/hg38 10q23.33-24.32(chr10:93181201-101356779)x1 copy number loss See cases [RCV000052565] Chr10:93181201..101356779 [GRCh38]
Chr10:94940958..103116536 [GRCh37]
Chr10:94930948..103106526 [NCBI36]
Chr10:10q23.33-24.32		 pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3		 pathogenic
GRCh38/hg38 10q24.1(chr10:96601018-97382040)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053561]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053561]|See cases [RCV000053561] Chr10:96601018..97382040 [GRCh38]
Chr10:98360775..99141797 [GRCh37]
Chr10:98350765..99131787 [NCBI36]
Chr10:10q24.1		 pathogenic
GRCh37/hg19 10q24.1(chr10:98941691-99153357)x3 copy number gain See cases [RCV000240430] Chr10:98941691..99153357 [GRCh37]
Chr10:10q24.1		 uncertain significance
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1		 pathogenic|drug response
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3		 pathogenic
NM_032900.6(ARHGAP19):c.1421C>T (p.Thr474Met) single nucleotide variant not specified [RCV004314351] Chr10:97229200 [GRCh38]
Chr10:98988957 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.667C>T (p.Arg223Trp) single nucleotide variant not specified [RCV004301007] Chr10:97259575 [GRCh38]
Chr10:99019332 [GRCh37]
Chr10:10q24.1		 uncertain significance
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
GRCh37/hg19 10q23.32-24.2(chr10:93908171-101809723)x1 copy number loss See cases [RCV000512315] Chr10:93908171..101809723 [GRCh37]
Chr10:10q23.32-24.2		 pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3		 pathogenic
GRCh37/hg19 10q24.1(chr10:98974462-99135215)x3 copy number gain not provided [RCV000737280] Chr10:98974462..99135215 [GRCh37]
Chr10:10q24.1		 benign
GRCh37/hg19 10q24.1(chr10:98903394-99097191)x1 copy number loss not provided [RCV000749794] Chr10:98903394..99097191 [GRCh37]
Chr10:10q24.1		 benign
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q24.1(chr10:98873648-99006083)x3 copy number gain not provided [RCV000845625] Chr10:98873648..99006083 [GRCh37]
Chr10:10q24.1		 uncertain significance
GRCh37/hg19 10q24.1-24.2(chr10:99027360-99300723)x1 copy number loss not provided [RCV002472884] Chr10:99027360..99300723 [GRCh37]
Chr10:10q24.1-24.2		 uncertain significance
NM_032900.6(ARHGAP19):c.28G>C (p.Glu10Gln) single nucleotide variant not specified [RCV004230850] Chr10:97292600 [GRCh38]
Chr10:99052357 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.719G>A (p.Arg240His) single nucleotide variant not specified [RCV004193317] Chr10:97259523 [GRCh38]
Chr10:99019280 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.985G>T (p.Ala329Ser) single nucleotide variant not specified [RCV004196680] Chr10:97246280 [GRCh38]
Chr10:99006037 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.1178T>C (p.Ile393Thr) single nucleotide variant not specified [RCV004206700] Chr10:97243975 [GRCh38]
Chr10:99003732 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.661A>G (p.Lys221Glu) single nucleotide variant not specified [RCV004095131] Chr10:97259581 [GRCh38]
Chr10:99019338 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.269G>T (p.Gly90Val) single nucleotide variant not specified [RCV004117331] Chr10:97265913 [GRCh38]
Chr10:99025670 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.1093A>G (p.Thr365Ala) single nucleotide variant not specified [RCV004071526] Chr10:97244060 [GRCh38]
Chr10:99003817 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.442A>G (p.Ser148Gly) single nucleotide variant not specified [RCV004165971] Chr10:97263591 [GRCh38]
Chr10:99023348 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.236T>C (p.Leu79Pro) single nucleotide variant not specified [RCV004117655] Chr10:97265946 [GRCh38]
Chr10:99025703 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.191A>G (p.Asn64Ser) single nucleotide variant not specified [RCV004083354] Chr10:97265991 [GRCh38]
Chr10:99025748 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.1220G>T (p.Arg407Leu) single nucleotide variant not specified [RCV004178867] Chr10:97235281 [GRCh38]
Chr10:98995038 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.960G>C (p.Leu320Phe) single nucleotide variant not specified [RCV004106054] Chr10:97246305 [GRCh38]
Chr10:99006062 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.344C>T (p.Ser115Phe) single nucleotide variant not specified [RCV004279508] Chr10:97264885 [GRCh38]
Chr10:99024642 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.317G>A (p.Arg106Gln) single nucleotide variant not specified [RCV004276884] Chr10:97265865 [GRCh38]
Chr10:99025622 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.1252G>A (p.Ala418Thr) single nucleotide variant not specified [RCV004268526] Chr10:97235249 [GRCh38]
Chr10:98995006 [GRCh37]
Chr10:10q24.1		 uncertain significance
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3		 pathogenic
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3		 pathogenic
NM_032900.6(ARHGAP19):c.582T>G (p.His194Gln) single nucleotide variant not specified [RCV004358842] Chr10:97263451 [GRCh38]
Chr10:99023208 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.47C>G (p.Ser16Cys) single nucleotide variant not specified [RCV004361498] Chr10:97292581 [GRCh38]
Chr10:99052338 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.1138G>A (p.Val380Ile) single nucleotide variant not specified [RCV004365277] Chr10:97244015 [GRCh38]
Chr10:99003772 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.961C>T (p.His321Tyr) single nucleotide variant not provided [RCV003422783] Chr10:97246304 [GRCh38]
Chr10:99006061 [GRCh37]
Chr10:10q24.1		 likely benign
GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3 copy number gain not provided [RCV003484798] Chr10:42709645..100834951 [GRCh37]
Chr10:10q11.21-24.2		 pathogenic
GRCh37/hg19 10q23.31-24.2(chr10:90796994-100067505)x1 copy number loss not specified [RCV003986861] Chr10:90796994..100067505 [GRCh37]
Chr10:10q23.31-24.2		 pathogenic
GRCh37/hg19 10q23.33-24.2(chr10:94283369-101820913)x1 copy number loss not specified [RCV003986912] Chr10:94283369..101820913 [GRCh37]
Chr10:10q23.33-24.2		 pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:95078198-135427143)x3 copy number gain not specified [RCV003986893] Chr10:95078198..135427143 [GRCh37]
Chr10:10q23.33-26.3		 pathogenic
NM_032900.6(ARHGAP19):c.29A>C (p.Glu10Ala) single nucleotide variant not specified [RCV004422439] Chr10:97292599 [GRCh38]
Chr10:99052356 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.143A>C (p.Lys48Thr) single nucleotide variant not specified [RCV004422437] Chr10:97266039 [GRCh38]
Chr10:99025796 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.472C>T (p.Leu158Phe) single nucleotide variant not specified [RCV004422441] Chr10:97263561 [GRCh38]
Chr10:99023318 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.922T>C (p.Phe308Leu) single nucleotide variant not specified [RCV004422443] Chr10:97256323 [GRCh38]
Chr10:99016080 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.386T>C (p.Ile129Thr) single nucleotide variant not specified [RCV004422440] Chr10:97264843 [GRCh38]
Chr10:99024600 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.546G>A (p.Met182Ile) single nucleotide variant not specified [RCV004422442] Chr10:97263487 [GRCh38]
Chr10:99023244 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.1106C>T (p.Thr369Met) single nucleotide variant not specified [RCV004422436] Chr10:97244047 [GRCh38]
Chr10:99003804 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.956G>T (p.Arg319Ile) single nucleotide variant not specified [RCV004666775] Chr10:97246309 [GRCh38]
Chr10:99006066 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.1063C>T (p.Arg355Trp) single nucleotide variant not specified [RCV004657749] Chr10:97244090 [GRCh38]
Chr10:99003847 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.1195C>G (p.Gln399Glu) single nucleotide variant not specified [RCV004657755] Chr10:97235306 [GRCh38]
Chr10:98995063 [GRCh37]
Chr10:10q24.1		 uncertain significance
NM_032900.6(ARHGAP19):c.1246A>G (p.Lys416Glu) single nucleotide variant not specified [RCV004657768] Chr10:97235255 [GRCh38]
Chr10:98995012 [GRCh37]
Chr10:10q24.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:7887
Count of miRNA genes:1471
Interacting mature miRNAs:2022
Transcripts:ENST00000316676, ENST00000355366, ENST00000358308, ENST00000358531, ENST00000371027, ENST00000453547, ENST00000466484, ENST00000487035, ENST00000492211, ENST00000493068
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597367929GWAS1464003_Hrisk-taking behaviour QTL GWAS1464003 (human)1e-15risk-taking behaviour109723843897238439Human
597386969GWAS1483043_Hblood osmolality measurement QTL GWAS1483043 (human)0.0000005blood molecular composition trait (VT:0010931)plasma osmolality (CMO:0002923)109728613397286134Human
597481370GWAS1577444_Hneutrophil count QTL GWAS1577444 (human)2e-67neutrophil quantity (VT:0000222)blood neutrophil count (CMO:0000030)109724150197241502Human
596961372GWAS1080891_Hmetabolic syndrome QTL GWAS1080891 (human)8e-10metabolic syndrome109726585497265855Human
597329747GWAS1425821_Hneuroticism measurement, cognitive function measurement QTL GWAS1425821 (human)8e-11neuroticism measurement, cognitive function measurement109722900297229003Human
597533812GWAS1629886_Hbody height QTL GWAS1629886 (human)4e-08body height (VT:0001253)body height (CMO:0000106)109724441497244415Human
597342384GWAS1438458_Hbody mass index QTL GWAS1438458 (human)1e-08body mass indexbody mass index (BMI) (CMO:0000105)109722969797229698Human
597060924GWAS1156998_Hmetabolic syndrome QTL GWAS1156998 (human)8e-10metabolic syndrome109726585497265855Human
597290548GWAS1386622_Hlymphocyte measurement, neutrophil measurement QTL GWAS1386622 (human)8e-14lymphocyte measurement, neutrophil measurement109722969797229698Human
597466897GWAS1562971_Hbody mass index QTL GWAS1562971 (human)2e-09body mass indexbody mass index (BMI) (CMO:0000105)109724150197241502Human
2314551GLUCO52_HGlucose level QTL 52 (human)1.4Glucose level1077605006103605006Human
597098691GWAS1194765_Hbody mass index QTL GWAS1194765 (human)3e-09body mass indexbody mass index (BMI) (CMO:0000105)109722969797229698Human
597425295GWAS1521369_Hlymphocyte:monocyte ratio QTL GWAS1521369 (human)4e-11leukocyte quantity (VT:0000217)109724831197248312Human
597458984GWAS1555058_Hneutrophil-to-lymphocyte ratio QTL GWAS1555058 (human)5e-09neutrophil-to-lymphocyte ratio109726439797264398Human
596956099GWAS1075618_Hlymphocyte measurement, neutrophil measurement QTL GWAS1075618 (human)8e-14lymphocyte measurement, neutrophil measurement109722969797229698Human
596986572GWAS1106091_Hleukocyte count QTL GWAS1106091 (human)4e-08leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)109724361897243619Human
597198246GWAS1294320_Hleukocyte count QTL GWAS1294320 (human)4e-08leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)109724361897243619Human

Markers in Region
STS-F10974  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371098,982,106 - 98,982,187UniSTSGRCh37
Build 361098,972,096 - 98,972,177RGDNCBI36
Celera1092,723,666 - 92,723,747RGD
Cytogenetic Map10q24.1UniSTS
HuRef1092,610,149 - 92,610,230UniSTS
GeneMap99-GB4 RH Map10455.78UniSTS
RH102738  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371098,983,345 - 98,983,490UniSTSGRCh37
Build 361098,973,335 - 98,973,480RGDNCBI36
Celera1092,724,905 - 92,725,050RGD
Cytogenetic Map10q24.1UniSTS
HuRef1092,611,388 - 92,611,533UniSTS
GeneMap99-GB4 RH Map10461.29UniSTS
D10S2453  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371098,989,970 - 98,990,132UniSTSGRCh37
Build 361098,979,960 - 98,980,122RGDNCBI36
Celera1092,731,530 - 92,731,692RGD
HuRef1092,618,013 - 92,618,175UniSTS
ARHGAP19__4358  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371098,985,022 - 98,985,634UniSTSGRCh37
Build 361098,975,012 - 98,975,624RGDNCBI36
Celera1092,726,582 - 92,727,194RGD
HuRef1092,613,065 - 92,613,677UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1949 465 2270 7304 6470 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001204300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA427792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC082250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC114490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI830638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD743029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB069205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ338460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LS482313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U79256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000358308   ⟹   ENSP00000351058
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1097,222,176 - 97,292,673 (-)Ensembl
Ensembl Acc Id: ENST00000358531   ⟹   ENSP00000351333
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1097,222,179 - 97,292,637 (-)Ensembl
Ensembl Acc Id: ENST00000371027   ⟹   ENSP00000360066
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1097,225,309 - 97,270,664 (-)Ensembl
Ensembl Acc Id: ENST00000466484   ⟹   ENSP00000473667
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1097,259,430 - 97,292,635 (-)Ensembl
Ensembl Acc Id: ENST00000487035
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1097,222,180 - 97,256,515 (-)Ensembl
Ensembl Acc Id: ENST00000492211   ⟹   ENSP00000473327
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1097,222,173 - 97,292,623 (-)Ensembl
Ensembl Acc Id: ENST00000493068
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1097,265,380 - 97,292,637 (-)Ensembl
RefSeq Acc Id: NM_001204300   ⟹   NP_001191229
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381097,222,179 - 97,292,637 (-)NCBI
GRCh371098,981,930 - 99,052,430 (-)ENTREZGENE
HuRef1092,609,973 - 92,679,489 (-)ENTREZGENE
CHM1_11099,264,185 - 99,334,168 (-)NCBI
T2T-CHM13v2.01098,103,011 - 98,172,839 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001256423   ⟹   NP_001243352
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381097,222,179 - 97,270,657 (-)NCBI
GRCh371098,981,930 - 99,052,430 (-)NCBI
HuRef1092,609,973 - 92,679,489 (-)NCBI
CHM1_11099,264,185 - 99,312,567 (-)NCBI
T2T-CHM13v2.01098,103,011 - 98,153,392 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032900   ⟹   NP_116289
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381097,222,179 - 97,292,637 (-)NCBI
GRCh371098,981,930 - 99,052,430 (-)ENTREZGENE
Build 361098,971,920 - 99,042,403 (-)NCBI Archive
Celera1092,723,490 - 92,790,901 (-)RGD
HuRef1092,609,973 - 92,679,489 (-)ENTREZGENE
CHM1_11099,264,185 - 99,334,168 (-)NCBI
T2T-CHM13v2.01098,103,011 - 98,172,839 (-)NCBI
Sequence:
RefSeq Acc Id: NP_116289   ⟸   NM_032900
- Peptide Label: isoform 1
- UniProtKB: Q14CB8 (UniProtKB/Swiss-Prot),   Q8NF34 (UniProtKB/Swiss-Prot),   Q8N9X1 (UniProtKB/Swiss-Prot),   Q68DG6 (UniProtKB/Swiss-Prot),   Q5T462 (UniProtKB/Swiss-Prot),   Q5T460 (UniProtKB/Swiss-Prot),   Q5J8M2 (UniProtKB/Swiss-Prot),   Q14CF2 (UniProtKB/Swiss-Prot),   B4DZR1 (UniProtKB/Swiss-Prot),   A1XCP1 (UniProtKB/Swiss-Prot),   Q8TEK1 (UniProtKB/Swiss-Prot),   A0A2X0U4I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001191229   ⟸   NM_001204300
- Peptide Label: isoform 2
- UniProtKB: A0A2X0U4I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001243352   ⟸   NM_001256423
- Peptide Label: isoform 3
- UniProtKB: A0A2X0U4I8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000360066   ⟸   ENST00000371027
Ensembl Acc Id: ENSP00000473667   ⟸   ENST00000466484
Ensembl Acc Id: ENSP00000473327   ⟸   ENST00000492211
Ensembl Acc Id: ENSP00000351333   ⟸   ENST00000358531
Ensembl Acc Id: ENSP00000351058   ⟸   ENST00000358308
Protein Domains
Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q14CB8-F1-model_v2 AlphaFold Q14CB8 1-494 view protein structure

Promoters
RGD ID:7218305
Promoter ID:EPDNEW_H14898
Type:initiation region
Name:ARHGAP19_3
Description:Rho GTPase activating protein 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14899  EPDNEW_H14900  EPDNEW_H14901  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381097,222,398 - 97,222,458EPDNEW
RGD ID:7218307
Promoter ID:EPDNEW_H14899
Type:initiation region
Name:ARHGAP19_2
Description:Rho GTPase activating protein 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14898  EPDNEW_H14900  EPDNEW_H14901  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381097,265,937 - 97,265,997EPDNEW
RGD ID:7218309
Promoter ID:EPDNEW_H14900
Type:initiation region
Name:ARHGAP19_4
Description:Rho GTPase activating protein 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14898  EPDNEW_H14899  EPDNEW_H14901  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381097,270,657 - 97,270,717EPDNEW
RGD ID:7218311
Promoter ID:EPDNEW_H14901
Type:initiation region
Name:ARHGAP19_1
Description:Rho GTPase activating protein 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14898  EPDNEW_H14899  EPDNEW_H14900  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381097,292,637 - 97,292,697EPDNEW
RGD ID:6814944
Promoter ID:HG_MRA:2148
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:U79256
Position:
Human AssemblyChrPosition (strand)Source
Build 361098,972,051 - 98,972,551 (-)MPROMDB
RGD ID:6787367
Promoter ID:HG_KWN:10736
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000316676,   ENST00000358308,   ENST00000393817,   NM_032900,   OTTHUMT00000049650,   UC001KMY.2,   UC009XVI.1,   UC009XVJ.1,   UC009XVK.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361099,042,061 - 99,042,561 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23724 AgrOrtholog
COSMIC ARHGAP19 COSMIC
Ensembl Genes ENSG00000213390 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000358308 ENTREZGENE
  ENST00000358308.7 UniProtKB/Swiss-Prot
  ENST00000358531 ENTREZGENE
  ENST00000358531.9 UniProtKB/Swiss-Prot
  ENST00000371027 ENTREZGENE
  ENST00000371027.5 UniProtKB/Swiss-Prot
  ENST00000466484.1 UniProtKB/TrEMBL
  ENST00000492211.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000213390 GTEx
HGNC ID HGNC:23724 ENTREZGENE
Human Proteome Map ARHGAP19 Human Proteome Map
InterPro ARHGAP19_RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:84986 UniProtKB/Swiss-Prot
NCBI Gene 84986 ENTREZGENE
OMIM 611587 OMIM
PANTHER RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO GTPASE-ACTIVATING PROTEIN 19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134917415 PharmGKB
PROSITE RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2X0U4I8 ENTREZGENE, UniProtKB/TrEMBL
  A1XCP1 ENTREZGENE
  B4DZR1 ENTREZGENE
  Q14CB8 ENTREZGENE
  Q14CF2 ENTREZGENE
  Q5J8M2 ENTREZGENE
  Q5T460 ENTREZGENE
  Q5T462 ENTREZGENE
  Q68DG6 ENTREZGENE
  Q8N9X1 ENTREZGENE
  Q8NF34 ENTREZGENE
  Q8TEK1 ENTREZGENE
  R4GMS4_HUMAN UniProtKB/TrEMBL
  R4GNI4_HUMAN UniProtKB/TrEMBL
  RHG19_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A1XCP1 UniProtKB/Swiss-Prot
  B4DZR1 UniProtKB/Swiss-Prot
  Q14CF2 UniProtKB/Swiss-Prot
  Q5J8M2 UniProtKB/Swiss-Prot
  Q5T460 UniProtKB/Swiss-Prot
  Q5T462 UniProtKB/Swiss-Prot
  Q68DG6 UniProtKB/Swiss-Prot
  Q8N9X1 UniProtKB/Swiss-Prot
  Q8NF34 UniProtKB/Swiss-Prot
  Q8TEK1 UniProtKB/Swiss-Prot