Bad (BCL2-associated agonist of cell death) - Rat Genome Database

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Gene: Bad (BCL2-associated agonist of cell death) Rattus norvegicus
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Symbol: Bad
Name: BCL2-associated agonist of cell death
RGD ID: 620103
Description: Enables 14-3-3 protein binding activity; protein kinase B binding activity; and protein phosphatase 2B binding activity. Involved in several processes, including cellular response to chromate; positive regulation of granulosa cell apoptotic process; and response to anesthetic. Located in cytosol and mitochondrion. Used to study several diseases, including Parkinsonism; diabetic neuropathy; gastric ulcer; impotence; and middle cerebral artery infarction. Biomarker of several diseases, including artery disease (multiple); brain ischemia; obesity; traumatic brain injury; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human BAD (BCL2 associated agonist of cell death); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endometrial cancer pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bad_v1; Bad_v2; bcl-2 associated death agonist; bcl-2-binding component 6; bcl-xL/Bcl-2-associated death promoter; bcl2 antagonist of cell death; Bcl2-antagonist of cell death; BCL2-associated agonist of cell death, variant 1; BCL2-associated agonist of cell death, variant 2; bcl2-associated death promoter; MGC72439
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,562,719 - 213,572,034 (+)NCBIGRCr8
mRatBN7.21204,133,502 - 204,142,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,131,501 - 204,142,823 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,484,073 - 212,493,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,579,167 - 219,588,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,270,220 - 212,279,142 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,198,516 - 222,207,459 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,198,534 - 222,207,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,189,271 - 229,198,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,617,373 - 209,626,292 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,775,802 - 209,784,722NCBI
Celera1201,667,864 - 201,676,765 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
BadRatacute kidney failure treatmentIEP 10053672 RGD 
BadRatAlzheimer's disease treatmentISORGD:73306210053639 RGD 
BadRatAlzheimer's disease  ISORGD:73554110053642protein:increased expression:temporal cortex, membraneRGD 
BadRatamyotrophic lateral sclerosis disease_progressionISORGD:73306213506907 RGD 
BadRatBrain Injuries  IEP 2292694mRNA, protein:increased expression:cerebral cortexRGD 
BadRatbrain ischemia  IEP 10053716 RGD 
BadRatbrain ischemia  IEP 2292681protein:decreased serine phosphorylation:brainRGD 
BadRatbreast cancer disease_progressionISORGD:7355412292674 RGD 
BadRatBurns  IEP 2292697protein:increased expression:neutrophilRGD 
BadRatCardiomegaly treatmentIDA 10053646associated with HypertensionRGD 
BadRatChemical and Drug Induced Liver Injury treatmentIDA 10053709 RGD 
BadRatChronic Pancreatitis severityIEP 10053701 RGD 
BadRatcolon cancer treatmentIDA 10053668 RGD 
BadRatDiabetic Cardiomyopathies treatmentIDA 10053697associated with Diabetes Mellitus, ExperimentalRGD 
BadRatDiabetic Cystopathy treatmentIDA 10053664associated with Diabetes Mellitus, ExperimentalRGD 
BadRatdiabetic neuropathy treatmentIDA 10053667associated with Diabetes Mellitus, ExperimentalRGD 
BadRatendometrial cancer disease progressionISORGD:73554113432164protein:altered expression:endometrium (human)RGD 
BadRatExperimental Diabetes Mellitus  IDA 2292685protein:increased expression, decreased phosphorylation, altered activity:testisRGD 
BadRatExperimental Diabetes Mellitus  IDA 5131482protein:decreased serine phosphorylation:corneaRGD 
BadRatExperimental Mammary Neoplasms treatmentIDA 10053670 RGD 
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Original Reference(s)
BadRatintellectual disability  ISORGD:7355418554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
BadRatleukocyte adhesion deficiency 3  ISORGD:7355418554872ClinVar Annotator: match by term: Leukocyte adhesion deficiency 3ClinVarPMID:28492532
BadRatmultiple endocrine neoplasia type 1  ISORGD:7355418554872ClinVar Annotator: match by term: Multiple endocrine neoplasia, type 1ClinVarPMID:17065424|PMID:215689|PMID:23321498|PMID:28492532
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BadRatleukemia  ISORGD:73554111554173CTD Direct Evidence: marker/mechanismCTDPMID:12970779
BadRatProstatic Neoplasms  ISORGD:73554111554173CTD Direct Evidence: marker/mechanismCTDPMID:17542986|PMID:19593445
BadRattransient cerebral ischemia  ISORGD:73554111554173CTD Direct Evidence: marker/mechanismCTDPMID:12629175

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Original Reference(s)
BadRat(+)-epicatechin-3-O-gallate increases expressionISORGD:7355416480464epicatechin gallate results in increased expression of BAD proteinCTDPMID:21945981
BadRat(-)-Arctigenin multiple interactionsISORGD:7355416480464Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of BAD protein]CTDPMID:25380086
BadRat(-)-Arctigenin increases expressionISORGD:7355416480464arctigenin results in increased expression of BAD mRNACTDPMID:25922263
BadRat(-)-Arctigenin decreases phosphorylationISORGD:7355416480464arctigenin results in decreased phosphorylation of BAD proteinCTDPMID:25380086
BadRat(R,R,R)-alpha-tocopherol increases expressionEXP 6480464alpha-Tocopherol results in increased expression of BAD mRNACTDPMID:26332274
BadRat(S)-nicotine decreases expressionISORGD:7355416480464Nicotine results in decreased expression of BAD mRNACTDPMID:18247414
BadRat(S)-nicotine decreases phosphorylationEXP 6480464Nicotine results in decreased phosphorylation of BAD proteinCTDPMID:20447445
BadRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expressionEXP 6480464o,p'-DDT analog results in decreased expression of BAD mRNA; o,p'-DDT results in decreased expression of more ...CTDPMID:22937105
BadRat1,3-Dinitropyrene increases phosphorylationISORGD:73306264804641,3-dinitropyrene results in increased phosphorylation of BAD proteinCTDPMID:17240030
BadRat1,3-Dinitropyrene decreases phosphorylationISORGD:73306264804641,3-dinitropyrene results in decreased phosphorylation of BAD proteinCTDPMID:17240030
BadRat1,8-cineole increases expressionISORGD:7355416480464Eucalyptol results in increased expression of BAD mRNACTDPMID:36331666
BadRat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile increases expressionEXP 6480464Citalopram results in increased expression of BAD mRNACTDPMID:28467792
BadRat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISORGD:73306264804642,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAD protein]CTDPMID:23911879
BadRat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISORGD:73306264804641-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAD proteinCTDPMID:23911879
BadRat1-nitropyrene increases phosphorylationISORGD:73306264804641-nitropyrene results in increased phosphorylation of BAD proteinCTDPMID:17240030
BadRat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of BAD mRNACTDPMID:16940010
BadRat17beta-estradiol multiple interactionsEXP 6480464[Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of BAD mRNA; Estradiol more ...CTDPMID:14659978|PMID:20732338
BadRat17beta-estradiol increases expressionISORGD:7330626480464Estradiol results in increased expression of BAD mRNACTDPMID:39298647
BadRat17beta-estradiol decreases expressionISORGD:7355416480464Estradiol results in decreased expression of BAD mRNACTDPMID:23373633
BadRat1H-pyrazole multiple interactionsEXP 6480464[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BAD mRNACTDPMID:16610055

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Biological Process
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BadRatADP metabolic process involved_inISSUniProtKB:Q613371600115GO_REF:0000024UniProtGO_REF:0000024
BadRatADP metabolic process involved_inISORGD:7330621624291 PMID:18223655RGDPMID:18223655
BadRatapoptotic process involved_inISORGD:7355411624291 PMID:19667065RGDPMID:19667065
BadRatapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
BadRatapoptotic process involved_inIEAInterPro:IPR0188681600115GO_REF:0000002InterProGO_REF:0000002
BadRatapoptotic signaling pathway acts_upstream_of_or_withinISORGD:7330621624291MGI:2675966|MGI:3029528 PMID:11717309, PMID:12931191, PMID:15231831RGDPMID:11717309|PMID:12931191|PMID:15231831
BadRatATP metabolic process involved_inISSUniProtKB:Q613371600115GO_REF:0000024UniProtGO_REF:0000024
BadRatATP metabolic process involved_inISORGD:7330621624291 PMID:18223655RGDPMID:18223655
BadRatcellular response to chromate  IEP 5128585 RGD 
BadRatcellular response to hypoxia involved_inISORGD:7355411624291 PMID:20810912RGDPMID:20810912
BadRatcellular response to lipid involved_inISORGD:7330621624291 PMID:18223655RGDPMID:18223655
BadRatcellular response to mechanical stimulus involved_inISORGD:7355411624291 PMID:19593445RGDPMID:19593445
BadRatcellular response to nicotine involved_inISSUniProtKB:Q929341600115GO_REF:0000024UniProtGO_REF:0000024
BadRatcellular response to nicotine involved_inISORGD:7355411624291 PMID:18676776RGDPMID:18676776
BadRatcerebral cortex development  IEP 2315711 RGD 
BadRatcytokine-mediated signaling pathway acts_upstream_of_or_withinISORGD:7330621624291 PMID:14967141RGDPMID:14967141
BadRatepithelial cell proliferation acts_upstream_of_or_withinISORGD:7330621624291 PMID:9176392RGDPMID:9176392
BadRatextrinsic apoptotic signaling pathway involved_inISORGD:7355411624291 PMID:18852119RGDPMID:18852119
BadRatextrinsic apoptotic signaling pathway involved_inIBAMGI:1096330|PANTHER:PTN002004009|UniProtKB:Q929341600115GO_REF:0000033GO_CentralGO_REF:0000033
BadRatextrinsic apoptotic signaling pathway in absence of ligand acts_upstream_of_or_withinISORGD:7330621624291MGI:1890081 PMID:12115603, PMID:12431371, PMID:12944463, PMID:14967141RGDPMID:12115603|PMID:12431371|PMID:12944463|PMID:14967141
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Cellular Component
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BadRatBAD-BCL-2 complex part_ofISORGD:7355411624291 PMID:9463381RGDPMID:9463381
BadRatcytoplasm located_inISORGD:120929021624291 PMID:21716255RGDPMID:21716255
BadRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
BadRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
BadRatcytoplasm located_inISORGD:7330621624291 PMID:11146504, PMID:21546903, PMID:21716255RGDPMID:11146504|PMID:21546903|PMID:21716255
BadRatcytosol  IDA 2311439MMO:0000679RGD 
BadRatcytosol is_active_inIBAMGI:1096330|PANTHER:PTN002004009|RGD:620103|UniProtKB:Q929341600115GO_REF:0000033GO_CentralGO_REF:0000033
BadRatcytosol located_inISORGD:7330621624291 PMID:11980919, PMID:12142566RGDPMID:11980919|PMID:12142566
BadRatcytosol located_inISORGD:7355411624291 PMID:20700721RGDPMID:20700721
BadRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
BadRatmitochondrial outer membrane located_inISSUniProtKB:Q929341600115GO_REF:0000024UniProtGO_REF:0000024
BadRatmitochondrial outer membrane located_inIEAUniProtKB-KW:KW-10001600115GO_REF:0000043UniProtGO_REF:0000043
BadRatmitochondrial outer membrane located_inIEAUniProtKB-SubCell:SL-01721600115GO_REF:0000044UniProtGO_REF:0000044
BadRatmitochondrial outer membrane located_inISORGD:7355411624291 PMID:20700721RGDPMID:20700721
BadRatmitochondrion  IDA 407574370MMO:0000679RGD 
BadRatmitochondrion located_inISORGD:7330621624291 PMID:12931191RGDPMID:12931191
BadRatmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
BadRatmitochondrion is_active_inIBAMGI:1096330|PANTHER:PTN002004009|RGD:620103|UniProtKB:Q929341600115GO_REF:0000033GO_CentralGO_REF:0000033
BadRatmitochondrion located_inISORGD:7355411624291 RGDGO_REF:0000052
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Molecular Function
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BadRat14-3-3 protein binding  IDA 10053724 RGD 
BadRatcysteine-type endopeptidase activator activity enablesISORGD:7330621624291 PMID:19915011RGDPMID:19915011
BadRatcysteine-type endopeptidase activator activity enablesISSUniProtKB:Q613371600115GO_REF:0000024UniProtGO_REF:0000024
BadRatcysteine-type endopeptidase activator activity involved in apoptotic process enablesIBAMGI:1096330|PANTHER:PTN002004009|UniProtKB:Q929341600115GO_REF:0000033GO_CentralGO_REF:0000033
BadRatlipid binding enablesISSUniProtKB:Q929341600115GO_REF:0000024UniProtGO_REF:0000024
BadRatlipid binding enablesISORGD:7355411624291 PMID:19667065RGDPMID:19667065
BadRatphospholipid binding enablesISSUniProtKB:Q929341600115GO_REF:0000024UniProtGO_REF:0000024
BadRatphospholipid binding enablesISORGD:7355411624291 PMID:21081150RGDPMID:21081150
BadRatprotein binding  IPIRGD:620717625527 RGD 
BadRatprotein binding enablesIPIUniProtKB:Q6288110047225PMID:17998337UniProt 
BadRatprotein binding enablesISORGD:7355411624291UniProtKB:O43521|UniProtKB:O60238|UniProtKB:P03495|UniProtKB:P05067|UniProtKB:P07384|UniProtKB:P10415|UniProtKB:P17361|UniProtKB:P27348|UniProtKB:P31946|UniProtKB:P31947|UniProtKB:P35609|UniProtKB:P61981|UniProtKB:P62258|UniProtKB:P63104|UniProtKB:Q04917|UniProtKB:Q07817|UniProtKB:Q07817-1|UniProtKB:Q15323|UniProtKB:Q92843|UniProtKB:Q9NQS1 PMID:10949025, PMID:11526496, PMID:15131699, PMID:15694340, PMID:16189514, PMID:17446862, PMID:17485524, PMID:17979178, PMID:19427857, PMID:19427863, PMID:19667065, PMID:20005908, PMID:20179209, more ...RGDPMID:10949025|PMID:11526496|PMID:15131699|PMID:15694340|PMID:16189514|PMID:17446862|PMID:17485524|PMID:17979178|PMID:19427857|PMID:19427863|PMID:19667065|PMID:20005908|PMID:20179209|PMID:20603619|PMID:20936779|PMID:21081150|PMID:21900206|PMID:21988832|PMID:22000515|PMID:23397142|PMID:24008843|PMID:24255178|PMID:25241761|PMID:25416956|PMID:26871637|PMID:28514442|PMID:29997244|PMID:31467278|PMID:31515488|PMID:31980649|PMID:32296183|PMID:32814053|PMID:33961781|PMID:36931259|PMID:37398436|PMID:9388232|PMID:9463381|PMID:9973195
BadRatprotein binding enablesISORGD:7330621624291PR:P10417|PR:P28028|PR:P31750|PR:P63087|PR:P68254|PR:P70345|PR:Q60739|PR:Q64373|PR:Q8R5H6|UniProtKB:O08734|UniProtKB:P10415|UniProtKB:P10417|UniProtKB:P52792|UniProtKB:P63104|UniProtKB:Q07817-1|UniProtKB:Q0VBL6|UniProtKB:Q64373|UniProtKB:Q64373-1|UniProtKB:Q9CQV8 PMID:11697890, PMID:11723239, PMID:12115603, PMID:12931191, PMID:12944463, PMID:15694340, PMID:15710493, PMID:16697956, PMID:17289999, PMID:17941720, PMID:18223655, PMID:19915011, PMID:21095239, more ...RGDPMID:11697890|PMID:11723239|PMID:12115603|PMID:12931191|PMID:12944463|PMID:15694340|PMID:15710493|PMID:16697956|PMID:17289999|PMID:17941720|PMID:18223655|PMID:19915011|PMID:21095239|PMID:21546903|PMID:23332762|PMID:26949185|PMID:7834748
BadRatprotein binding  IPIRGD:620525633263 RGD 
BadRatprotein binding  IPIRGD:619982306032 RGD 
BadRatprotein binding  IPIRGD:22001579942 RGD 
BadRatprotein kinase B binding  IPIRGD:20811579942 RGD 
BadRatprotein kinase binding enablesISORGD:7355411624291UniProtKB:Q86V86 PMID:17270021RGDPMID:17270021
BadRatprotein kinase binding enablesIBAPANTHER:PTN002004009|RGD:620103|UniProtKB:Q929341600115GO_REF:0000033GO_CentralGO_REF:0000033
BadRatprotein phosphatase 2B binding  IPIRGD:33821579942 RGD 
BadRatprotein phosphatase binding enablesIBAMGI:1096330|PANTHER:PTN002004009|RGD:6201031600115GO_REF:0000033GO_CentralGO_REF:0000033
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RGD Manual Annotations


  
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Original Reference(s)
BadRatendometrial cancer pathway   ISORGD:73554113432162 RGD 
BadRatintrinsic apoptotic pathway   ISORGD:7355412314029 RGD 
BadRatintrinsic apoptotic pathway   ISS 1579966 RGD 
BadRatintrinsic apoptotic pathway   ISORGD:7330621579966 RGD 

Imported Annotations - SMPDB

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BadRatadenosine signaling pathway  ISORGD:73554110402751 SMPDBSMP:00320
BadRatadenosine signaling pathway  ISORGD:73554110402751 SMPDBSMP:00321

Imported Annotations - KEGG (archival)

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Imported Annotations - PID (archival)

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BadRatceramide signaling pathway  ISORGD:7355416484113 PIDPID:200119
BadRatinsulin-like growth factor signaling pathway  ISORGD:7355416484113 PIDPID:200100
BadRatphosphatidylinositol 3-kinase-Akt signaling pathway   ISORGD:7355416484113 PIDPID:200197

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Reference Title
Reference Citation
1. Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia. Abe T, etal., Brain Res. 2004 May 29;1009(1-2):159-68.
2. Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway. Ain R, etal., J Endocrinol. 2005 May;185(2):253-63.
3. Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53. Banu SK, etal., Toxicol Appl Pharmacol. 2011 Mar 15;251(3):253-66. Epub 2011 Jan 22.
4. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. Berquin IM, etal., J Clin Invest. 2007 Jul;117(7):1866-75.
5. pERK, pAkt and pBad: a possible role in cell proliferation and sustained cellular survival during tumorigenesis and tumor progression in ENU induced transplacental glioma rat model. Bhaskara VK, etal., Neurochem Res. 2006 Sep;31(9):1163-70. Epub 2006 Aug 31.
6. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Bishayee A, etal., Int J Cancer. 2013 Sep 1;133(5):1054-63. doi: 10.1002/ijc.28108. Epub 2013 Mar 29.
7. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Calon F, etal., Neuron. 2004 Sep 2;43(5):633-45.
8. Bad expression predicts outcome in patients treated with tamoxifen. Cannings E, etal., Breast Cancer Res Treat. 2007 Apr;102(2):173-9. Epub 2006 Sep 27.
9. Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes. Ciccarelli R, etal., Mol Pharmacol. 2007 May;71(5):1369-80. Epub 2007 Feb 9.
10. Regulation of BAD protein by PKA, PKCdelta and phosphatases in adult rat cardiac myocytes subjected to oxidative stress. Cieslak D and Lazou A, Mol Cells. 2007 Oct 31;24(2):224-31.
11. Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling. Clark CJ, etal., J Neurochem. 2007 Aug;102(4):1024-34.
12. Cloning and expression of the programmed cell death regulator Bad in the rat brain. D'Agata V, etal., Neurosci Lett 1998 Feb 27;243(1-3):137-40.
13. Bad and Bid - potential background players in preneoplastic to neoplastic shift in human endometrium. Driak D, etal., Neoplasma. 2014;61(4):411-5. doi: 10.4149/neo_2014_050.
14. Sequential in-office vitreous aspirates demonstrate vitreous matrix metalloproteinase 9 levels correlate with the amount of subretinal fluid in eyes with wet age-related macular degeneration. Ecker SM, etal., Mol Vis. 2012;18:1658-67. Epub 2012 Jun 20.
15. Modulation of apoptosis in the mouse brain after morphine treatments and morphine withdrawal. Emeterio EP, etal., J Neurosci Res. 2006 May 15;83(7):1352-61. doi: 10.1002/jnr.20812.
16. Edaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BAD. Fan J, etal., Int J Neurosci. 2012 Nov;122(11):665-74. doi: 10.3109/00207454.2012.707714. Epub 2012 Aug 21.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Protective effect of cyanidin-3-O-beta-D-glucopyranoside fraction from mulberry fruit pigment against oxidative damage in streptozotocin-induced diabetic rat bladder. Ha US, etal., Neurourol Urodyn. 2013 Jun;32(5):493-9. doi: 10.1002/nau.22334. Epub 2012 Nov 5.
20. Functional characterization of two splice variants of rat bad and their interaction with Bcl-w in sympathetic neurons.PG - 97-106 Hamner S, etal., Mol Cell Neurosci 2001 Jan;17(1):97-106.
1 to 20 of 98 rows
PMID:7834748   PMID:9176392   PMID:9388232   PMID:10407019   PMID:11146504   PMID:11717309   PMID:11980919   PMID:12115603   PMID:12142566   PMID:12431371   PMID:12472766   PMID:12477932  
PMID:12531534   PMID:12761242   PMID:12838582   PMID:12931191   PMID:12944463   PMID:14967141   PMID:15231831   PMID:15451022   PMID:15469889   PMID:15896972   PMID:15978696   PMID:16087293  
PMID:16116448   PMID:16446153   PMID:16565486   PMID:16603546   PMID:16937528   PMID:17080661   PMID:17270021   PMID:17289999   PMID:17555943   PMID:17940884   PMID:18223655   PMID:18387192  
PMID:18402937   PMID:18614015   PMID:18640115   PMID:18676776   PMID:18779656   PMID:18832722   PMID:18852119   PMID:18936092   PMID:19171933   PMID:19593445   PMID:19667065   PMID:19885947  
PMID:19915011   PMID:20651836   PMID:20700721   PMID:20810912   PMID:20850791   PMID:21081150   PMID:21095239   PMID:21546903   PMID:21716255   PMID:21789211   PMID:21818658   PMID:22006182  
PMID:22099262   PMID:25072152   PMID:27690136   PMID:30911955   PMID:31784847   PMID:34315852  



Bad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,562,719 - 213,572,034 (+)NCBIGRCr8
mRatBN7.21204,133,502 - 204,142,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,131,501 - 204,142,823 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,484,073 - 212,493,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,579,167 - 219,588,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,270,220 - 212,279,142 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,198,516 - 222,207,459 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,198,534 - 222,207,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,189,271 - 229,198,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,617,373 - 209,626,292 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,775,802 - 209,784,722NCBI
Celera1201,667,864 - 201,676,765 (+)NCBICelera
Cytogenetic Map1q43NCBI
BAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,269,828 - 64,284,704 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1164,269,830 - 64,284,704 (-)EnsemblGRCh38hg38GRCh38
GRCh371164,037,300 - 64,052,176 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,793,878 - 63,808,740 (-)NCBINCBI36Build 36hg18NCBI36
Build 341163,793,877 - 63,808,740NCBI
Celera1161,364,184 - 61,379,075 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,365,093 - 60,379,900 (-)NCBIHuRef
CHM1_11163,920,295 - 63,935,173 (-)NCBICHM1_1
T2T-CHM13v2.01164,259,856 - 64,274,668 (-)NCBIT2T-CHM13v2.0
Bad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,919,229 - 6,929,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,919,229 - 6,929,267 (+)EnsemblGRCm39 Ensembl
GRCm38196,941,861 - 6,951,905 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,941,861 - 6,951,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37197,016,345 - 7,026,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,008,899 - 7,018,937 (+)NCBIMGSCv36mm8
Celera196,718,946 - 6,728,897 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.1NCBI
Bad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,795,676 - 20,809,245 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,795,585 - 20,809,039 (+)NCBIChiLan1.0ChiLan1.0
BAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,497,028 - 65,511,872 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,542,163 - 66,557,017 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,626,981 - 59,641,824 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,971,808 - 62,986,304 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,971,808 - 62,986,257 (-)Ensemblpanpan1.1panPan2
BAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,781,335 - 52,791,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,781,921 - 52,791,405 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,388,992 - 51,398,261 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,826,736 - 53,836,956 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,827,323 - 53,836,575 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,929,992 - 52,939,466 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,505,744 - 52,514,998 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,289,648 - 53,298,901 (+)NCBIUU_Cfam_GSD_1.0
Bad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,481,976 - 8,491,335 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,924,789 - 4,933,368 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,924,349 - 4,933,683 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,830,920 - 7,842,863 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,831,192 - 7,842,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,897,866 - 6,909,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,949,717 - 9,964,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,949,762 - 9,964,432 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038107,289,663 - 107,305,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476722,026,133 - 22,037,277 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476722,025,721 - 22,037,283 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Bad
34 total Variants

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:77
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000028712, ENSRNOT00000067068
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 84 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat

1 to 10 of 84 rows
RH134341  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21204,142,556 - 204,142,747 (+)MAPPERmRatBN7.2
Rnor_6.01222,207,187 - 222,207,377NCBIRnor6.0
Rnor_5.01229,198,039 - 229,198,229UniSTSRnor5.0
RGSC_v3.41209,626,026 - 209,626,216UniSTSRGSC3.4
Celera1201,676,499 - 201,676,689UniSTS
RH 3.4 Map11509.7UniSTS
Cytogenetic Map1q43UniSTS
AW530352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21204,132,630 - 204,132,782 (+)MAPPERmRatBN7.2
Rnor_6.01222,197,261 - 222,197,412NCBIRnor6.0
Rnor_5.01229,188,115 - 229,188,266UniSTSRnor5.0
RGSC_v3.41209,616,152 - 209,616,303UniSTSRGSC3.4
Celera1201,666,631 - 201,666,782UniSTS
RH 3.4 Map11521.1UniSTS
Cytogenetic Map1q43UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000028712   ⟹   ENSRNOP00000028712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1204,131,501 - 204,142,823 (+)Ensembl
Rnor_6.0 Ensembl1222,198,534 - 222,207,453 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101503   ⟹   ENSRNOP00000096573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1204,133,489 - 204,142,599 (+)Ensembl
RefSeq Acc Id: NM_022698   ⟹   NP_073189
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,563,114 - 213,572,033 (+)NCBI
mRatBN7.21204,133,904 - 204,142,823 (+)NCBI
Rnor_6.01222,198,534 - 222,207,453 (+)NCBI
Rnor_5.01229,189,271 - 229,198,306 (+)NCBI
RGSC_v3.41209,617,373 - 209,626,292 (+)RGD
Celera1201,667,864 - 201,676,765 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230896   ⟹   XP_006230958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,562,719 - 213,572,034 (+)NCBI
mRatBN7.21204,133,502 - 204,142,828 (+)NCBI
Rnor_6.01222,198,516 - 222,207,454 (+)NCBI
Rnor_5.01229,189,271 - 229,198,306 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230897   ⟹   XP_006230959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,563,260 - 213,572,034 (+)NCBI
mRatBN7.21204,134,068 - 204,142,829 (+)NCBI
Rnor_6.01222,198,708 - 222,207,459 (+)NCBI
Rnor_5.01229,189,271 - 229,198,306 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230898   ⟹   XP_006230960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,563,369 - 213,572,034 (+)NCBI
mRatBN7.21204,134,068 - 204,142,828 (+)NCBI
Rnor_6.01222,198,712 - 222,207,458 (+)NCBI
Rnor_5.01229,189,271 - 229,198,306 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089714   ⟹   XP_038945642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,562,719 - 213,572,034 (+)NCBI
mRatBN7.21204,133,502 - 204,142,824 (+)NCBI
RefSeq Acc Id: XM_063272784   ⟹   XP_063128854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,562,719 - 213,565,037 (+)NCBI
RefSeq Acc Id: XR_010057342
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,562,719 - 213,570,840 (+)NCBI
RefSeq Acc Id: NP_073189   ⟸   NM_022698
- UniProtKB: O70256 (UniProtKB/Swiss-Prot),   Q9JHX1 (UniProtKB/Swiss-Prot),   O35147 (UniProtKB/Swiss-Prot),   A6HZK1 (UniProtKB/TrEMBL),   A0A8I6AQN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230958   ⟸   XM_006230896
- Peptide Label: isoform X1
- UniProtKB: A6HZK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230960   ⟸   XM_006230898
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006230959   ⟸   XM_006230897
- Peptide Label: isoform X3
- UniProtKB: A6HZK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028712   ⟸   ENSRNOT00000028712

Name Modeler Protein Id AA Range Protein Structure
AF-O35147-F1-model_v2 AlphaFold O35147 1-205 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 26 of 26 rows
Database
Acc Id
Source(s)
BIND 133989
  133990
BioCyc Gene G2FUF-56577 BioCyc
Ensembl Genes ENSRNOG00000021147 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028712 ENTREZGENE
  ENSRNOT00000101503 ENTREZGENE
IMAGE_CLONE IMAGE:5598682 IMAGE-MGC_LOAD
InterPro BAD UniProtKB/Swiss-Prot
KEGG Report rno:64639 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72439 IMAGE-MGC_LOAD
NCBI Gene 64639 ENTREZGENE
PANTHER BCL2-ASSOCIATED AGONIST OF CELL DEATH UniProtKB/Swiss-Prot
  PTHR28540 UniProtKB/Swiss-Prot
Pfam Bcl-2_BAD UniProtKB/Swiss-Prot
PhenoGen Bad PhenoGen
RatGTEx ENSRNOG00000021147 RatGTEx
UniProt A0A8I6AQN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UKI4 ENTREZGENE, UniProtKB/TrEMBL
  A6HZK0 ENTREZGENE, UniProtKB/TrEMBL
  A6HZK1 ENTREZGENE, UniProtKB/TrEMBL
  BAD_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  O70256 ENTREZGENE
  Q6P7C5_RAT UniProtKB/TrEMBL
  Q9JHX1 ENTREZGENE
UniProt Secondary O70256 UniProtKB/Swiss-Prot
  Q9JHX1 UniProtKB/Swiss-Prot
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-28 Bad  BCL2-associated agonist of cell death  Bad_v2  BCL2-associated agonist of cell death, variant 2  Data merged from RGD:728344 737654 PROVISIONAL
2018-08-28 Bad  BCL2-associated agonist of cell death  Bad_v1  BCL2-associated agonist of cell death, variant 1  Data merged from RGD:728296 737654 PROVISIONAL
2009-11-05 Bad  BCL2-associated agonist of cell death  Bad  Bcl2-antagonist of cell death  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-01 Bad  Bcl2-antagonist of cell death  Bad  bcl2-associated death promoter  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Bad_v1  bcl-2 associated death agonist, variant 1    bcl-2 associated death agonist,variant 1  Name updated 1299863 APPROVED
2004-12-14 Bad_v2  bcl-2 associated death agonist, variant 2      Symbol and Name status set to approved 1299863 APPROVED
2004-12-14 Bad  bcl2-associated death promoter    bcl-2 associated death agonist  Name updated 1299863 APPROVED
2002-08-07 Bad  bcl-2 associated death agonist      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_domains contains a Bcl-2 homology 3(BH3) domain 625527
gene_domains contains a Bcl2 homology 3(BH3) -domain 625527
gene_expression expressed in several brain regions, liver, and spleen 625527
gene_expression mRNA expressed in several brain regions, liver, and spleen 625527
gene_expression mRNA expressed in several brain regions, liver, and spleen 625527
gene_physical_interaction both variants interact with Bcl-w 625527
gene_physical_interaction interacts with Bcl-w 625527
gene_process links growth factor receptor signaling and apoptotic pathways 625527
gene_product a BH3-only proapoptotic Bcl-2 family member 625527
gene_product member of the Bcl-2 family of proteins 727627
gene_transcript two splice variants observed with differences only in C-terminal from alternative usage of downstream splice acceptor in the fourth exon 625527
gene_transcript usage of downstream splice acceptor in the fourth exon results in translation of a part of 3-UTR giving rise to a unique C-terminal 625527