BAD (BCL2 associated agonist of cell death) - Rat Genome Database

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Gene: BAD (BCL2 associated agonist of cell death) Canis lupus familiaris
Analyze
Symbol: BAD
Name: BCL2 associated agonist of cell death
RGD ID: 12092902
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); protein kinase B binding (ortholog); protein phosphatase 2B binding (ortholog); INVOLVED IN positive regulation of apoptotic process; positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; apoptotic signaling pathway (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endometrial cancer pathway; ASSOCIATED WITH acute kidney failure (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytoplasm; BAD-BCL-2 complex (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BCL2-antagonist of cell death; bcl2-associated agonist of cell death
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,781,335 - 52,791,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,781,921 - 52,791,405 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,388,992 - 51,398,261 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,826,736 - 53,836,956 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,827,323 - 53,836,575 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,929,992 - 52,939,466 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,505,744 - 52,514,998 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,289,648 - 53,298,901 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ADP metabolic process  (IEA)
apoptotic process  (IEA)
apoptotic signaling pathway  (IEA,ISO)
ATP metabolic process  (IEA)
cellular response to chromate  (ISO)
cellular response to hypoxia  (IBA,IEA)
cellular response to lipid  (IEA)
cellular response to mechanical stimulus  (IEA)
cellular response to nicotine  (IEA)
cerebral cortex development  (ISO)
cytokine-mediated signaling pathway  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IBA,IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
glucose catabolic process  (IEA,ISO)
glucose homeostasis  (IEA,ISO)
intrinsic apoptotic signaling pathway  (IBA,IEA)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
pore complex assembly  (IEA)
positive regulation of apoptotic process  (IEA,IMP)
positive regulation of B cell differentiation  (IEA,ISO)
positive regulation of epithelial cell proliferation  (IEA)
positive regulation of granulosa cell apoptotic process  (ISO)
positive regulation of insulin secretion  (IEA)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IEA)
positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (IEA,IMP)
positive regulation of mitochondrial membrane potential  (IEA)
positive regulation of proteolysis  (IEA)
positive regulation of release of cytochrome c from mitochondria  (IEA)
positive regulation of T cell differentiation  (IEA,ISO)
positive regulation of type B pancreatic cell development  (IEA)
regulation of apoptotic process  (IEA,ISO)
regulation of mitochondrial membrane permeability  (IBA,IEA)
release of cytochrome c from mitochondria  (IBA,IEA,ISO)
response to amino acid  (ISO)
response to benzene  (ISO)
response to calcium ion  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hormone  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to oleic acid  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)
type B pancreatic cell proliferation  (IEA)

Cellular Component
BAD-BCL-2 complex  (IEA,ISO)
cytoplasm  (IEA,IMP)
cytosol  (IBA,IEA)
mitochondrial outer membrane  (IEA)
mitochondrion  (IBA,IEA)

References
Additional References at PubMed
PMID:21781600   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,781,335 - 52,791,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,781,921 - 52,791,405 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,388,992 - 51,398,261 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,826,736 - 53,836,956 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,827,323 - 53,836,575 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,929,992 - 52,939,466 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,505,744 - 52,514,998 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,289,648 - 53,298,901 (+)NCBIUU_Cfam_GSD_1.0
BAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,269,828 - 64,284,704 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1164,269,830 - 64,284,704 (-)EnsemblGRCh38hg38GRCh38
GRCh371164,037,300 - 64,052,176 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,793,878 - 63,808,740 (-)NCBINCBI36Build 36hg18NCBI36
Build 341163,793,877 - 63,808,740NCBI
Celera1161,364,184 - 61,379,075 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,365,093 - 60,379,900 (-)NCBIHuRef
CHM1_11163,920,295 - 63,935,173 (-)NCBICHM1_1
T2T-CHM13v2.01164,259,856 - 64,274,668 (-)NCBIT2T-CHM13v2.0
Bad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,919,229 - 6,929,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,919,229 - 6,929,267 (+)EnsemblGRCm39 Ensembl
GRCm38196,941,861 - 6,951,905 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,941,861 - 6,951,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37197,016,345 - 7,026,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,008,899 - 7,018,937 (+)NCBIMGSCv36mm8
Celera196,718,946 - 6,728,897 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.1NCBI
Bad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,562,719 - 213,572,034 (+)NCBIGRCr8
mRatBN7.21204,133,502 - 204,142,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,131,501 - 204,142,823 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,484,073 - 212,493,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,579,167 - 219,588,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,270,220 - 212,279,142 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,198,516 - 222,207,459 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,198,534 - 222,207,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,189,271 - 229,198,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,617,373 - 209,626,292 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,775,802 - 209,784,722NCBI
Celera1201,667,864 - 201,676,765 (+)NCBICelera
Cytogenetic Map1q43NCBI
Bad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,795,676 - 20,809,245 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,795,585 - 20,809,039 (+)NCBIChiLan1.0ChiLan1.0
BAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,497,028 - 65,511,872 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,542,163 - 66,557,017 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,626,981 - 59,641,824 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,971,808 - 62,986,304 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,971,808 - 62,986,257 (-)Ensemblpanpan1.1panPan2
Bad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,481,976 - 8,491,335 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,924,789 - 4,933,368 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,924,349 - 4,933,683 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,830,920 - 7,842,863 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,831,192 - 7,842,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,897,866 - 6,909,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,949,717 - 9,964,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,949,762 - 9,964,432 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038107,289,663 - 107,305,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476722,026,133 - 22,037,277 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476722,025,721 - 22,037,283 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BAD
157 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 3 18 2 2 2 1 12 8 10 4
Low 2 4 4 4 4 5 6 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001031820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005631061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005631062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005631063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022405079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038423456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038423457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038423458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038423459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038423460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ127247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000038335   ⟹   ENSCAFP00000034035
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1852,781,921 - 52,791,405 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845054387   ⟹   ENSCAFP00845042735
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1853,827,323 - 53,836,575 (+)Ensembl
RefSeq Acc Id: NM_001031820   ⟹   NP_001026990
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11852,781,921 - 52,791,405 (+)NCBI
Dog10K_Boxer_Tasha1851,388,992 - 51,398,261 (+)NCBI
ROS_Cfam_1.01853,827,323 - 53,836,575 (+)NCBI
UMICH_Zoey_3.11852,929,992 - 52,939,466 (+)NCBI
UNSW_CanFamBas_1.01852,505,744 - 52,514,998 (+)NCBI
UU_Cfam_GSD_1.01853,289,648 - 53,298,901 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038423456   ⟹   XP_038279384
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01853,826,913 - 53,836,956 (+)NCBI
RefSeq Acc Id: XM_038423457   ⟹   XP_038279385
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01853,827,095 - 53,836,956 (+)NCBI
RefSeq Acc Id: XM_038423458   ⟹   XP_038279386
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01853,826,736 - 53,836,956 (+)NCBI
RefSeq Acc Id: XM_038423459   ⟹   XP_038279387
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01853,827,134 - 53,836,956 (+)NCBI
RefSeq Acc Id: XM_038423460   ⟹   XP_038279388
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01853,827,079 - 53,836,956 (+)NCBI
RefSeq Acc Id: NP_001026990   ⟸   NM_001031820
- UniProtKB: Q45KI9 (UniProtKB/TrEMBL),   A0A8C0N2N7 (UniProtKB/TrEMBL),   F1PK10 (UniProtKB/TrEMBL),   A0A8C0KNS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000034035   ⟸   ENSCAFT00000038335
RefSeq Acc Id: XP_038279386   ⟸   XM_038423458
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N2N7 (UniProtKB/TrEMBL),   F1PK10 (UniProtKB/TrEMBL),   A0A8C0KNS8 (UniProtKB/TrEMBL),   Q45KI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038279384   ⟸   XM_038423456
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N2N7 (UniProtKB/TrEMBL),   F1PK10 (UniProtKB/TrEMBL),   A0A8C0KNS8 (UniProtKB/TrEMBL),   Q45KI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038279388   ⟸   XM_038423460
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N2N7 (UniProtKB/TrEMBL),   F1PK10 (UniProtKB/TrEMBL),   A0A8C0KNS8 (UniProtKB/TrEMBL),   Q45KI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038279385   ⟸   XM_038423457
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N2N7 (UniProtKB/TrEMBL),   F1PK10 (UniProtKB/TrEMBL),   A0A8C0KNS8 (UniProtKB/TrEMBL),   Q45KI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038279387   ⟸   XM_038423459
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N2N7 (UniProtKB/TrEMBL),   F1PK10 (UniProtKB/TrEMBL),   A0A8C0KNS8 (UniProtKB/TrEMBL),   Q45KI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845042735   ⟸   ENSCAFT00845054387


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014488 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011540 UniProtKB/TrEMBL
  ENSCAFG00040013648 UniProtKB/TrEMBL
  ENSCAFG00845030649 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000038335.3 UniProtKB/TrEMBL
  ENSCAFT00030021344.1 UniProtKB/TrEMBL
  ENSCAFT00040025200.1 UniProtKB/TrEMBL
  ENSCAFT00040025270.1 UniProtKB/TrEMBL
  ENSCAFT00845054387 ENTREZGENE
  ENSCAFT00845054387.1 UniProtKB/TrEMBL
InterPro BAD UniProtKB/TrEMBL
KEGG Report cfa:483763 UniProtKB/TrEMBL
NCBI Gene BAD ENTREZGENE
PANTHER BCL2-ASSOCIATED AGONIST OF CELL DEATH UniProtKB/TrEMBL
  PTHR28540 UniProtKB/TrEMBL
Pfam Bcl-2_BAD UniProtKB/TrEMBL
UniProt A0A8C0KNS8 ENTREZGENE
  A0A8C0N2N7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SI24_CANLF UniProtKB/TrEMBL
  F1PK10 ENTREZGENE
  Q45KI9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1PK10 UniProtKB/TrEMBL
VGNC ID VGNC:38362 ENTREZGENE