BAD (BCL2 associated agonist of cell death) - Rat Genome Database

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Gene: BAD (BCL2 associated agonist of cell death) Sus scrofa
Analyze
Symbol: BAD
Name: BCL2 associated agonist of cell death
RGD ID: 13912444
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); lipid binding (ortholog); phospholipid binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity (ortholog); ADP metabolic process (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endometrial cancer pathway; ASSOCIATED WITH acute kidney failure (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN BAD-BCL-2 complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bcl2-associated agonist of cell death
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,830,920 - 7,842,863 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,831,192 - 7,842,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,897,866 - 6,909,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Pancreatitis  (ISO)
colon cancer  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Cystopathy  (ISO)
diabetic neuropathy  (ISO)
endometrial cancer  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Seizures  (ISO)
gastric ulcer  (ISO)
glaucoma  (ISO)
Hemorrhagic Shock  (ISO)
high grade glioma  (ISO)
hypertension  (ISO)
hypothyroidism  (ISO)
impotence  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
intermittent claudication  (ISO)
leukemia  (ISO)
leukocyte adhesion deficiency 3  (ISO)
Liver Reperfusion Injury  (ISO)
lung non-small cell carcinoma  (ISO)
macular degeneration  (ISO)
middle cerebral artery infarction  (ISO)
morphine withdrawal syndrome  (ISO)
multiple endocrine neoplasia type 1  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
pancreatic cancer  (ISO)
Parkinsonism  (ISO)
prostate carcinoma  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
Sepsis  (ISO)
Small-For-Size Syndrome  (ISO)
Spinal Cord Reperfusion Injury  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
traumatic brain injury  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity  (ISO)
ADP metabolic process  (ISO)
apoptotic process  (IEA)
apoptotic signaling pathway  (ISO)
ATP metabolic process  (ISO)
cellular response to chromate  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipid  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to nicotine  (ISO)
cerebral cortex development  (ISO)
cytokine-mediated signaling pathway  (ISO)
epithelial cell proliferation  (ISO)
extrinsic apoptotic signaling pathway  (IBA)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
glucose catabolic process  (ISO)
glucose homeostasis  (ISO)
intrinsic apoptotic signaling pathway  (IBA)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of apoptotic process  (ISO)
pore complex assembly  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of B cell differentiation  (ISO)
positive regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of granulosa cell apoptotic process  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of type B pancreatic cell development  (ISO)
regulation of apoptotic process  (ISO)
regulation of cysteine-type endopeptidase activity  (ISO)
regulation of mitochondrial membrane permeability  (IBA)
release of cytochrome c from mitochondria  (IBA,ISO)
response to amino acid  (ISO)
response to anesthetic  (ISO)
response to benzene  (ISO)
response to calcium ion  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hormone  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to oleic acid  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
response to wortmannin  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)
type B pancreatic cell proliferation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,830,920 - 7,842,863 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,831,192 - 7,842,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,897,866 - 6,909,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,269,828 - 64,284,704 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1164,269,830 - 64,284,704 (-)EnsemblGRCh38hg38GRCh38
GRCh371164,037,300 - 64,052,176 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,793,878 - 63,808,740 (-)NCBINCBI36Build 36hg18NCBI36
Build 341163,793,877 - 63,808,740NCBI
Celera1161,364,184 - 61,379,075 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,365,093 - 60,379,900 (-)NCBIHuRef
CHM1_11163,920,295 - 63,935,173 (-)NCBICHM1_1
T2T-CHM13v2.01164,259,856 - 64,274,668 (-)NCBIT2T-CHM13v2.0
Bad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,919,229 - 6,929,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,919,229 - 6,929,267 (+)EnsemblGRCm39 Ensembl
GRCm38196,941,861 - 6,951,905 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,941,861 - 6,951,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37197,016,345 - 7,026,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,008,899 - 7,018,937 (+)NCBIMGSCv36mm8
Celera196,718,946 - 6,728,897 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.1NCBI
Bad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,562,719 - 213,572,034 (+)NCBIGRCr8
mRatBN7.21204,133,502 - 204,142,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,131,501 - 204,142,823 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,484,073 - 212,493,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,579,167 - 219,588,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,270,220 - 212,279,142 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,198,516 - 222,207,459 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,198,534 - 222,207,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,189,271 - 229,198,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,617,373 - 209,626,292 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,775,802 - 209,784,722NCBI
Celera1201,667,864 - 201,676,765 (+)NCBICelera
Cytogenetic Map1q43NCBI
Bad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,795,676 - 20,809,245 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,795,585 - 20,809,039 (+)NCBIChiLan1.0ChiLan1.0
BAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,497,028 - 65,511,872 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,542,163 - 66,557,017 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,626,981 - 59,641,824 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,971,808 - 62,986,304 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,971,808 - 62,986,257 (-)Ensemblpanpan1.1panPan2
BAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,781,335 - 52,791,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,781,921 - 52,791,405 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,388,992 - 51,398,261 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,826,736 - 53,836,956 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,827,323 - 53,836,575 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,929,992 - 52,939,466 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,505,744 - 52,514,998 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,289,648 - 53,298,901 (+)NCBIUU_Cfam_GSD_1.0
Bad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,481,976 - 8,491,335 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,924,789 - 4,933,368 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,924,349 - 4,933,683 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,949,717 - 9,964,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,949,762 - 9,964,432 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038107,289,663 - 107,305,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476722,026,133 - 22,037,277 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476722,025,721 - 22,037,283 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BAD
453 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000063471   ⟹   ENSSSCP00000042395
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl27,830,920 - 7,842,863 (+)Ensembl
RefSeq Acc Id: XM_021082883   ⟹   XP_020938542
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.127,831,192 - 7,842,864 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020938542 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000042395.3
  ENSSSCP00025047853.1
  ENSSSCP00045034097.1
  ENSSSCP00070039924.1
RefSeq Acc Id: XP_020938542   ⟸   XM_021082883
- UniProtKB: A0A4X1VGM0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000042395   ⟸   ENSSSCT00000063471


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013033 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00025076792 UniProtKB/TrEMBL
  ENSSSCG00045028591 UniProtKB/TrEMBL
  ENSSSCG00070023715 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000063471.3 UniProtKB/TrEMBL
  ENSSSCT00025106530.1 UniProtKB/TrEMBL
  ENSSSCT00045049009.1 UniProtKB/TrEMBL
  ENSSSCT00070047318.1 UniProtKB/TrEMBL
InterPro BAD UniProtKB/TrEMBL
NCBI Gene BAD ENTREZGENE
PANTHER BCL2-ASSOCIATED AGONIST OF CELL DEATH UniProtKB/TrEMBL
  PTHR28540 UniProtKB/TrEMBL
Pfam Bcl-2_BAD UniProtKB/TrEMBL
UniProt A0A287AEF3_PIG UniProtKB/TrEMBL
  A0A4X1VGM0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85743 ENTREZGENE