Cnot2 (CCR4-NOT transcription complex, subunit 2) - Rat Genome Database

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Gene: Cnot2 (CCR4-NOT transcription complex, subunit 2) Rattus norvegicus
Analyze
Symbol: Cnot2
Name: CCR4-NOT transcription complex, subunit 2
RGD ID: 1311672
Description: Predicted to enable transcription corepressor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Predicted to be involved in several processes, including negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of RNA metabolic process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2); PARTICIPATES IN microRNA pathway; RNA degradation pathway; INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CCR4-NOT transcription complex subunit 2; LOC299805
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8754,016,447 - 54,117,511 (-)NCBIGRCr8
mRatBN7.2752,130,445 - 52,222,338 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl752,130,441 - 52,223,575 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx754,037,151 - 54,128,665 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0756,240,245 - 56,331,759 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0756,018,227 - 56,109,741 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0759,526,105 - 59,617,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl759,527,124 - 59,587,385 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0759,537,579 - 59,628,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4755,823,982 - 55,880,812 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1755,844,724 - 55,901,542 (-)NCBI
Celera748,914,667 - 48,971,519 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cnot2Ratgenetic disease  ISOCNOT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
Cnot2RatIntellectual Developmental Disorder with Nasal Speech, Dysmorphic Facies, and Variable Skeletal Anomalies  ISOCNOT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual developmental disorder with nasal speech more ...ClinVarPMID:25741868 more ...
Cnot2RatNeurodevelopmental Disorders  ISOCNOT2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cnot2RatIntellectual Developmental Disorder with Nasal Speech, Dysmorphic Facies, and Variable Skeletal Anomalies  ISOCNOT2 (Homo sapiens)7240710 OMIM 

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cnot2Rat(-)-epigallocatechin 3-gallate multiple interactionsISOCNOT2 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CNOT2 mRNACTDPMID:22079256
Cnot2Rat(-)-epigallocatechin 3-gallate multiple interactionsISOCnot2 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [1 and 3-dichloro-2-propanol results in increased expression of CNOT2 protein]CTDPMID:30092300
Cnot2Rat1,2-dimethylhydrazine multiple interactionsISOCnot2 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CNOT2 mRNACTDPMID:22206623
Cnot2Rat1,2-dimethylhydrazine decreases expressionISOCnot2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CNOT2 mRNACTDPMID:22206623
Cnot2Rat1,3-dichloropropan-2-ol increases expressionISOCnot2 (Mus musculus)64804641 and 3-dichloro-2-propanol results in increased expression of CNOT2 proteinCTDPMID:30092300
Cnot2Rat1,3-dichloropropan-2-ol multiple interactionsISOCnot2 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [1 and 3-dichloro-2-propanol results in increased expression of CNOT2 protein]CTDPMID:30092300
Cnot2Rat17beta-estradiol decreases expressionISOCNOT2 (Homo sapiens)6480464Estradiol results in decreased expression of CNOT2 mRNACTDPMID:19167446
Cnot2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCNOT2 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of CNOT2 mRNACTDPMID:22298810
Cnot2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCnot2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CNOT2 mRNACTDPMID:21570461
Cnot2Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of CNOT2 mRNACTDPMID:21346803
Cnot2Rat3,4-methylenedioxymethamphetamine decreases expressionISOCnot2 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of CNOT2 mRNACTDPMID:26251327
Cnot2Rat3-phenylprop-2-enal decreases expressionISOCNOT2 (Homo sapiens)6480464cinnamaldehyde results in decreased expression of CNOT2 mRNACTDPMID:19524605
Cnot2Rat4,4'-diaminodiphenylmethane increases expressionISOCnot2 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of CNOT2 mRNACTDPMID:18648102
Cnot2Rat4,4'-sulfonyldiphenol multiple interactionsISOCNOT2 (Homo sapiens)6480464[bisphenol S co-treated with Fulvestrant] results in decreased methylation of CNOT2 geneCTDPMID:31601247
Cnot2Rat4-phenylbutyric acid decreases expressionISOCNOT2 (Homo sapiens)64804644-phenylbutyric acid results in decreased expression of CNOT2 mRNACTDPMID:14583596
Cnot2Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of CNOT2 mRNACTDPMID:30047161
Cnot2Rataflatoxin B1 decreases methylationISOCNOT2 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of CNOT2 geneCTDPMID:27153756
Cnot2Rataristolochic acid A decreases expressionISOCNOT2 (Homo sapiens)6480464aristolochic acid I results in decreased expression of CNOT2 mRNACTDPMID:33212167
Cnot2RatAroclor 1254 decreases expressionISOCNOT2 (Homo sapiens)6480464Chlorodiphenyl (54% Chlorine) results in decreased expression of CNOT2 mRNACTDPMID:16934159
Cnot2RatAroclor 1254 decreases expressionISOCnot2 (Mus musculus)6480464Chlorodiphenyl (54% Chlorine) results in decreased expression of CNOT2 mRNACTDPMID:23650126

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Biological Process
1 to 17 of 17 rows

  
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cnot2Ratbiological_process  ND 159840701/2016: no relevant rat dataRGD 
Cnot2Ratnegative regulation of intracellular estrogen receptor signaling pathway involved_inISOCNOT2 (Homo sapiens)1624291 PMID:16778766RGDPMID:16778766
Cnot2Ratnegative regulation of intracellular estrogen receptor signaling pathway involved_inIEAUniProtKB:Q9NZN8 and ensembl:ENSP000002291951600115GO_REF:0000107EnsemblGO_REF:0000107
Cnot2Ratnegative regulation of transcription by RNA polymerase II involved_inISOCNOT2 (Homo sapiens)1624291 PMID:14707134 and PMID:16712523RGDPMID:14707134 and PMID:16712523
Cnot2Ratnegative regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q9NZN8 and ensembl:ENSP000002291951600115GO_REF:0000107EnsemblGO_REF:0000107
Cnot2Ratnuclear-transcribed mRNA poly(A) tail shortening involved_inIBAFB:FBgn0017550 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cnot2Ratpositive regulation of cytoplasmic mRNA processing body assembly involved_inISOCNOT2 (Homo sapiens)1624291 PMID:21299754RGDPMID:21299754
Cnot2Ratpositive regulation of cytoplasmic mRNA processing body assembly involved_inIEAUniProtKB:Q9NZN8 and ensembl:ENSP000002291951600115GO_REF:0000107EnsemblGO_REF:0000107
Cnot2Ratregulation of DNA-templated transcription involved_inIEAInterPro:IPR0072821600115GO_REF:0000002InterProGO_REF:0000002
Cnot2Ratregulation of stem cell population maintenance involved_inISOCnot2 (Mus musculus)1624291 PMID:22367759RGDPMID:22367759
Cnot2Ratregulation of stem cell population maintenance involved_inIBAFB:FBgn0017550 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cnot2Ratregulation of stem cell population maintenance involved_inIEAUniProtKB:Q9NZN8 and ensembl:ENSP000002291951600115GO_REF:0000107EnsemblGO_REF:0000107
Cnot2Ratregulation of stem cell population maintenance involved_inIEAARBA:ARBA000262961600115GO_REF:0000117UniProtGO_REF:0000117
Cnot2Ratregulation of stem cell population maintenance involved_inIEAUniProtKB:Q8C5L3 and ensembl:ENSMUSP000001009021600115GO_REF:0000107EnsemblGO_REF:0000107
Cnot2Ratregulation of stem cell population maintenance involved_inISOCNOT2 (Homo sapiens)1624291 PMID:22367759RGDPMID:22367759
Cnot2Rattrophectodermal cell differentiation involved_inISOCnot2 (Mus musculus)1624291 PMID:22367759RGDPMID:22367759
Cnot2Rattrophectodermal cell differentiation involved_inIEAUniProtKB:Q8C5L3 and ensembl:ENSMUSP000001009021600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cnot2RatCCR4-NOT complex part_ofISOCNOT2 (Homo sapiens)1624291 PMID:19558367RGDPMID:19558367
Cnot2RatCCR4-NOT complex part_ofIEAUniProtKB:Q9NZN8 and ensembl:ENSP000002291951600115GO_REF:0000107EnsemblGO_REF:0000107
Cnot2RatCCR4-NOT core complex part_ofIEAInterPro:IPR0401681600115GO_REF:0000002InterProGO_REF:0000002
Cnot2RatCCR4-NOT core complex part_ofIBAPANTHER:PTN000595684 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cnot2Ratcytoplasm located_inISOCNOT2 (Homo sapiens)1624291 PMID:21299754RGDPMID:21299754
Cnot2Ratcytoplasm located_inIEAUniProtKB:Q9NZN8 and ensembl:ENSP000002291951600115GO_REF:0000107EnsemblGO_REF:0000107
Cnot2Ratcytosol located_inIEAUniProtKB:Q9NZN8 and ensembl:ENSP000002291951600115GO_REF:0000107EnsemblGO_REF:0000107
Cnot2Ratcytosol located_inISOCNOT2 (Homo sapiens) and UniProtKB:Q9NZN8-11624291 RGDGO_REF:0000052
Cnot2Ratnucleoplasm located_inIEAUniProtKB:Q9NZN8 and ensembl:ENSP000002291951600115GO_REF:0000107EnsemblGO_REF:0000107
Cnot2Ratnucleoplasm located_inISOCNOT2 (Homo sapiens) and UniProtKB:Q9NZN8-11624291 RGDGO_REF:0000052
Cnot2RatP-body is_active_inIBAMGI:2385261 and PANTHER:PTN0005956841600115GO_REF:0000033GO_CentralGO_REF:0000033
Cnot2Ratplasma membrane located_inIEAUniProtKB:Q9NZN8 and ensembl:ENSP000002291951600115GO_REF:0000107EnsemblGO_REF:0000107
Cnot2Ratplasma membrane located_inISOCNOT2 (Homo sapiens) and UniProtKB:Q9NZN8-11624291 RGDGO_REF:0000052
1 to 13 of 13 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cnot2Ratpoly(A)-specific ribonuclease activity contributes_toISOCNOT2 (Homo sapiens)1624291 PMID:21299754RGDPMID:21299754
Cnot2Ratpoly(A)-specific ribonuclease activity contributes_toIEAUniProtKB:Q9NZN8 and ensembl:ENSP000002291951600115GO_REF:0000107EnsemblGO_REF:0000107
Cnot2Ratprotein binding enablesISOCNOT2 (Homo sapiens)1624291UniProtKB:A5YKK6 more ...RGDPMID:10637334 more ...
Cnot2Rattranscription corepressor binding enablesISOCNOT2 (Homo sapiens)1624291 PMID:16712523RGDPMID:16712523
Cnot2Rattranscription corepressor binding enablesIEAUniProtKB:Q9NZN8 and ensembl:ENSP000002291951600115GO_REF:0000107EnsemblGO_REF:0000107

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cnot2RatmicroRNA pathway   ISOCNOT2 (Homo sapiens)9850101 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cnot2RatRNA degradation pathway  IEA 6907045 KEGGrno:03018

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes. Wahle E and Winkler GS, Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):561-70. doi: 10.1016/j.bbagrm.2013.01.003. Epub 2013 Jan 19.
PMID:12477932   PMID:14707134   PMID:16712523   PMID:16778766   PMID:19558367   PMID:19946888   PMID:21299754   PMID:22367759  



Cnot2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8754,016,447 - 54,117,511 (-)NCBIGRCr8
mRatBN7.2752,130,445 - 52,222,338 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl752,130,441 - 52,223,575 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx754,037,151 - 54,128,665 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0756,240,245 - 56,331,759 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0756,018,227 - 56,109,741 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0759,526,105 - 59,617,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl759,527,124 - 59,587,385 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0759,537,579 - 59,628,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4755,823,982 - 55,880,812 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1755,844,724 - 55,901,542 (-)NCBI
Celera748,914,667 - 48,971,519 (-)NCBICelera
Cytogenetic Map7q22NCBI
CNOT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381270,243,018 - 70,354,993 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1270,243,002 - 70,354,993 (+)EnsemblGRCh38hg38GRCh38
GRCh371270,636,798 - 70,748,773 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361268,923,044 - 69,035,040 (+)NCBINCBI36Build 36hg18NCBI36
Build 341268,923,488 - 69,033,960NCBI
Celera1270,300,448 - 70,412,447 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1267,686,934 - 67,798,932 (+)NCBIHuRef
CHM1_11270,606,077 - 70,718,081 (+)NCBICHM1_1
T2T-CHM13v2.01270,222,411 - 70,334,463 (+)NCBIT2T-CHM13v2.0
Cnot2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910116,321,065 - 116,418,891 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10116,321,066 - 116,417,416 (-)EnsemblGRCm39 Ensembl
GRCm3810116,485,160 - 116,581,900 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10116,485,161 - 116,581,511 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710115,922,217 - 116,018,567 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610115,889,276 - 115,985,621 (-)NCBIMGSCv36mm8
Celera10118,426,741 - 118,523,052 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1064.76NCBI
Cnot2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540510,451,414 - 10,547,229 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540510,451,414 - 10,547,229 (+)NCBIChiLan1.0ChiLan1.0
CNOT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21078,258,520 - 78,370,806 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11278,255,483 - 78,367,205 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01267,753,703 - 67,865,375 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11270,520,722 - 70,633,149 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1270,520,722 - 70,633,149 (+)Ensemblpanpan1.1panPan2
CNOT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11012,057,269 - 12,174,405 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1012,009,762 - 12,172,427 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1011,995,863 - 12,112,451 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01012,188,879 - 12,305,324 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1012,141,268 - 12,305,312 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11012,055,404 - 12,171,985 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01012,302,721 - 12,419,265 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01012,426,002 - 12,542,252 (+)NCBIUU_Cfam_GSD_1.0
Cnot2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494546,069,715 - 46,170,762 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365457,938,934 - 8,042,117 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365457,938,934 - 8,040,409 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNOT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl534,426,394 - 34,549,310 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1534,470,911 - 34,548,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2537,132,108 - 37,207,783 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNOT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11165,823,294 - 65,932,588 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1165,861,353 - 65,934,042 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037179,752,841 - 179,862,945 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnot2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475027,430,575 - 27,529,081 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475027,433,671 - 27,529,545 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cnot2
208 total Variants

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:124
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000066396
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 40 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat

1 to 10 of 40 rows
RH144030  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2752,138,261 - 52,138,425 (+)MAPPERmRatBN7.2
Rnor_6.0759,533,922 - 59,534,085NCBIRnor6.0
Rnor_5.0759,545,396 - 59,545,559UniSTSRnor5.0
RGSC_v3.4755,827,349 - 55,827,512UniSTSRGSC3.4
Celera748,918,034 - 48,918,197UniSTS
RH 3.4 Map7481.5UniSTS
Cytogenetic Map7q22UniSTS
RH140338  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2752,149,611 - 52,149,762 (+)MAPPERmRatBN7.2
Rnor_6.0759,545,272 - 59,545,422NCBIRnor6.0
Rnor_5.0759,556,746 - 59,556,896UniSTSRnor5.0
RGSC_v3.4755,838,699 - 55,838,849UniSTSRGSC3.4
Celera748,929,384 - 48,929,534UniSTS
RH 3.4 Map7503.6UniSTS
Cytogenetic Map7q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 21 of 21 rows
RefSeq Transcripts NM_001399553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC136231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 21 of 21 rows

Ensembl Acc Id: ENSRNOT00000066396   ⟹   ENSRNOP00000061277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl752,134,908 - 52,191,729 (-)Ensembl
Rnor_6.0 Ensembl759,530,568 - 59,587,385 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085836   ⟹   ENSRNOP00000075690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl752,131,074 - 52,221,608 (-)Ensembl
Rnor_6.0 Ensembl759,532,641 - 59,547,174 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091427   ⟹   ENSRNOP00000074023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl752,136,860 - 52,221,617 (-)Ensembl
Rnor_6.0 Ensembl759,527,124 - 59,587,382 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100132   ⟹   ENSRNOP00000078367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl752,130,594 - 52,221,611 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104908   ⟹   ENSRNOP00000084380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl752,130,441 - 52,221,617 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114739   ⟹   ENSRNOP00000077944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl752,130,443 - 52,221,617 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118688   ⟹   ENSRNOP00000095291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl752,130,594 - 52,223,575 (-)Ensembl
RefSeq Acc Id: NM_001399553   ⟹   NP_001386482
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,107,960 (-)NCBI
mRatBN7.2752,130,445 - 52,221,966 (-)NCBI
RefSeq Acc Id: NM_001399554   ⟹   NP_001386483
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,107,960 (-)NCBI
mRatBN7.2752,130,445 - 52,221,966 (-)NCBI
RefSeq Acc Id: NM_001399555   ⟹   NP_001386484
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,107,960 (-)NCBI
mRatBN7.2752,130,445 - 52,221,966 (-)NCBI
RefSeq Acc Id: NM_001399556   ⟹   NP_001386485
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,107,960 (-)NCBI
mRatBN7.2752,130,445 - 52,221,966 (-)NCBI
RefSeq Acc Id: XM_006241369   ⟹   XP_006241431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,130,453 - 52,222,327 (-)NCBI
Rnor_6.0759,526,105 - 59,617,297 (-)NCBI
Rnor_5.0759,537,579 - 59,628,786 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594741   ⟹   XP_017450230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,130,448 - 52,222,327 (-)NCBI
Rnor_6.0759,526,105 - 59,617,307 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078717   ⟹   XP_038934645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,107,312 (-)NCBI
mRatBN7.2752,130,453 - 52,221,318 (-)NCBI
RefSeq Acc Id: XM_039078720   ⟹   XP_038934648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,130,453 - 52,222,326 (-)NCBI
RefSeq Acc Id: XM_039078728   ⟹   XP_038934656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,131,062 - 52,222,328 (-)NCBI
RefSeq Acc Id: XM_039078730   ⟹   XP_038934658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,131,062 - 52,222,327 (-)NCBI
RefSeq Acc Id: XM_039078732   ⟹   XP_038934660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,117,511 (-)NCBI
mRatBN7.2752,131,062 - 52,222,328 (-)NCBI
RefSeq Acc Id: XM_039078735   ⟹   XP_038934663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,030,719 (-)NCBI
mRatBN7.2752,131,062 - 52,145,999 (-)NCBI
RefSeq Acc Id: XM_063263224   ⟹   XP_063119294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,016,447 - 54,057,225 (-)NCBI
RefSeq Acc Id: XM_063263225   ⟹   XP_063119295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,030,621 - 54,117,511 (-)NCBI
RefSeq Acc Id: XM_063263226   ⟹   XP_063119296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,030,621 - 54,117,511 (-)NCBI
1 to 30 of 32 rows
Protein RefSeqs NP_001386482 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386483 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386484 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386485 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241431 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450230 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934645 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934648 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934656 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934658 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934660 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934663 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119294 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119295 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119296 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87653 (Get FASTA)   NCBI Sequence Viewer  
  EDM16655 (Get FASTA)   NCBI Sequence Viewer  
  EDM16656 (Get FASTA)   NCBI Sequence Viewer  
  EDM16658 (Get FASTA)   NCBI Sequence Viewer  
  EDM16662 (Get FASTA)   NCBI Sequence Viewer  
  EDM16665 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061277
  ENSRNOP00000061277.1
  ENSRNOP00000074023.2
  ENSRNOP00000075690.2
  ENSRNOP00000077944
  ENSRNOP00000077944.1
  ENSRNOP00000078367
  ENSRNOP00000078367.1
  ENSRNOP00000084380
1 to 30 of 32 rows
1 to 5 of 22 rows
1 to 5 of 22 rows
RefSeq Acc Id: XP_006241431   ⟸   XM_006241369
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AJD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450230   ⟸   XM_017594741
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZXR1 (UniProtKB/TrEMBL),   A6IGN2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074023   ⟸   ENSRNOT00000091427
Ensembl Acc Id: ENSRNOP00000061277   ⟸   ENSRNOT00000066396
Ensembl Acc Id: ENSRNOP00000075690   ⟸   ENSRNOT00000085836
NOT2/NOT3/NOT5 C-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K717-F1-model_v2 AlphaFold A0A0G2K717 1-540 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-34033 BioCyc
Ensembl Genes ENSRNOG00000004909 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066396 ENTREZGENE
  ENSRNOT00000066396.3 UniProtKB/TrEMBL
  ENSRNOT00000085836.2 UniProtKB/TrEMBL
  ENSRNOT00000091427.2 UniProtKB/TrEMBL
  ENSRNOT00000100132 ENTREZGENE
  ENSRNOT00000100132.1 UniProtKB/TrEMBL
  ENSRNOT00000104908 ENTREZGENE
  ENSRNOT00000104908.1 UniProtKB/TrEMBL
  ENSRNOT00000114739 ENTREZGENE
  ENSRNOT00000114739.1 UniProtKB/TrEMBL
  ENSRNOT00000118688.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.1020 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7313082 IMAGE-MGC_LOAD
InterPro CCR4-NOT_su2/3/5_N_sf UniProtKB/TrEMBL
  NOT UniProtKB/TrEMBL
  Not2/3/5 UniProtKB/TrEMBL
MGC_CLONE MGC:105588 IMAGE-MGC_LOAD
NCBI Gene 299805 ENTREZGENE
PANTHER PTHR23326 UniProtKB/TrEMBL
Pfam NOT2_3_5 UniProtKB/TrEMBL
PhenoGen Cnot2 PhenoGen
RatGTEx ENSRNOG00000004909 RatGTEx
UniProt A0A0G2K717_RAT UniProtKB/TrEMBL
  A0A0G2KB82 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y9U2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZKS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXR1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJD1 ENTREZGENE, UniProtKB/TrEMBL
  A6IGN0 ENTREZGENE, UniProtKB/TrEMBL
  A6IGN1 ENTREZGENE, UniProtKB/TrEMBL
  A6IGN2 ENTREZGENE, UniProtKB/TrEMBL
  A6IGN5 ENTREZGENE, UniProtKB/TrEMBL
  A6IGP0 ENTREZGENE, UniProtKB/TrEMBL
  A6IGP1 ENTREZGENE, UniProtKB/TrEMBL
  A6IGP2 ENTREZGENE, UniProtKB/TrEMBL
  Q5PPJ8_RAT UniProtKB/TrEMBL
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Cnot2  CCR4-NOT transcription complex, subunit 2  Cnot2_predicted  CCR4-NOT transcription complex, subunit 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cnot2_predicted  CCR4-NOT transcription complex, subunit 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED