Gabrb3 (gamma-aminobutyric acid type A receptor subunit beta 3) - Rat Genome Database

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Gene: Gabrb3 (gamma-aminobutyric acid type A receptor subunit beta 3) Rattus norvegicus
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Symbol: Gabrb3
Name: gamma-aminobutyric acid type A receptor subunit beta 3
RGD ID: 2651
Description: Enables AP-2 adaptor complex binding activity; GABA-A receptor activity; and GABA-gated chloride ion channel activity. Involved in GABAergic synaptic transmission and response to auditory stimulus. Located in several cellular components, including inhibitory synapse; sperm head; and terminal bouton. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Biomarker of fetal alcohol spectrum disorder and status epilepticus. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; childhood absence epilepsy; developmental and epileptic encephalopathy 43; and heroin dependence. Orthologous to human GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GABA(A) receptor subunit beta-3; GABA-alpha receptor beta-3 subunit; GABAAR subunit beta-3; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3; Gamma-aminobutyric acid receptor beta 3; gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid receptor, subunit beta 3; gamma-aminobutyric acid type A receptor beta 3 subunit; testis gamma-aminobutyric acid receptor subunit beta 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81117,602,772 - 117,838,230 (+)NCBIGRCr8
mRatBN7.21108,467,047 - 108,702,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1108,296,124 - 108,698,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1113,838,572 - 114,068,957 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01122,311,079 - 122,541,470 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01115,559,397 - 115,789,792 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01113,034,251 - 113,265,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1112,976,770 - 113,265,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01114,042,551 - 114,275,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41109,047,399 - 109,277,756 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11109,125,741 - 109,356,099 (+)NCBI
Celera1102,635,270 - 102,866,355 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Gabrb3Ratalcohol dependence susceptibilityISOGABRB3 (Homo sapiens)405866351DNA:SNPs: :RGD 
Gabrb3Ratalcohol use disorder susceptibilityISOGABRB3 (Homo sapiens)405866342DNA:CA repeats: :(human)RGD 
Gabrb3Ratchildhood absence epilepsy  ISOGABRB3 (Homo sapiens)1601269DNA:SNPsRGD 
Gabrb3Ratfetal alcohol spectrum disorder sexual_dimorphismISOGabrb3 (Mus musculus)405866345in male mice only and mRNA:increased expression:frontal cortex:RGD 
Gabrb3Ratfetal alcohol spectrum disorder treatmentIEP 13432044 RGD 
Gabrb3Ratheroin dependence susceptibilityISOGABRB3 (Homo sapiens)405866341DNA:SNP:promoter:rs4906902(human)RGD 
Gabrb3Ratheroin dependence susceptibilityISOGABRB3 (Homo sapiens)5509583DNA:SNP::rs7165224(human)RGD 
Gabrb3RatSleep Initiation and Maintenance Disorders  ISOGABRB3 (Homo sapiens)1601268DNA:point mutation:exon:R192HRGD 
Gabrb3Ratstatus epilepticus  IEP 405866354protein:decreased expression more ...RGD 
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Gabrb3RatAngelman syndrome  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: Angelman syndromeClinVarPMID:24088041 more ...
Gabrb3Ratautism spectrum disorder  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:21844811 more ...
Gabrb3Ratautistic disorder  ISOGABRB3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:21681106 more ...
Gabrb3RatChildhood Absence Epilepsy 1  ISOGABRB3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11198279 more ...
Gabrb3RatChildhood Absence Epilepsy 5  ISOGABRB3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18514161 more ...
Gabrb3Ratchromosome 15q11.2 deletion syndrome  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 15q11-q13 duplication syndromeClinVarPMID:25741868 and PMID:31690835
Gabrb3Ratdevelopmental and epileptic encephalopathy 1  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 1ClinVarPMID:25741868
Gabrb3Ratdevelopmental and epileptic encephalopathy 43  ISOGABRB3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11742254 more ...
Gabrb3RatDevelopmental Disabilities  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:18514161 more ...
Gabrb3Ratepilepsy  ISOGABRB3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:20550555 more ...
Gabrb3Ratgeneralized epilepsy  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: Epileptic encephalopathyClinVarPMID:25741868 more ...
Gabrb3Ratgenetic disease  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:17576681 more ...
Gabrb3Ratintellectual disability  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868 more ...
Gabrb3Ratmyoepithelioma  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: Myoepithelial tumorClinVar 
Gabrb3RatNeurodevelopmental Disorders  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Gabrb3RatPrader-Willi syndrome  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: Prader-Willi syndromeClinVarPMID:28631899
Gabrb3Ratschizophrenia  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
Gabrb3RatSleep Initiation and Maintenance Disorders  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: InsomniaClinVarPMID:11742254 more ...
Gabrb3Ratsudden infant death syndrome  ISOGABRB3 (Homo sapiens)8554872ClinVar Annotator: match by term: SUDDEN INFANT DEATH SYNDROMEClinVarPMID:11742254 more ...
Gabrb3Ratvisual epilepsy  ISOGABRB3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18514161 more ...
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Original Reference(s)
Gabrb3RatAngelman syndrome  ISOGABRB3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15878204
Gabrb3Ratautism spectrum disorder  ISOGABRB3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22037176
Gabrb3Ratautistic disorder  ISOGABRB3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9545402 and PMID:11920158
Gabrb3RatBrain Injuries  ISOGABRB3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23159883
Gabrb3Ratchildhood absence epilepsy  ISOGABRB3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18514161
Gabrb3RatCraniofacial Abnormalities  ISOGABRB3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15878204
Gabrb3Ratepilepsy  ISOGABRB3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15878204 and PMID:29942082
Gabrb3RatIsodicentric Chromosome 15 Syndrome  ISOGABRB3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23663378
Gabrb3RatNeurodevelopmental Disorders  ISOGABRB3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29942082
Gabrb3RatSleep Initiation and Maintenance Disorders  ISOGABRB3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12189488
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Gabrb3Ratautism spectrum disorder  ISSGabrb3 (Mus musculus)13592920 MouseDO 
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Gabrb3RatChildhood Absence Epilepsy 5  ISOGABRB3 (Homo sapiens)7240710 OMIM 
Gabrb3Ratdevelopmental and epileptic encephalopathy 43  ISOGABRB3 (Homo sapiens)7240710 OMIM 

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Gabrb3Rat(1->4)-beta-D-glucan multiple interactionsISOGabrb3 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of GABRB3 mRNACTDPMID:36331819
Gabrb3Rat1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine increases expressionEXP 6480464chlorcyclizine results in increased expression of GABRB3 mRNACTDPMID:21058326
Gabrb3Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of GABRB3 mRNACTDPMID:29097150
Gabrb3Rat17beta-estradiol increases expressionISOGABRB3 (Homo sapiens)6480464Estradiol results in increased expression of GABRB3 mRNACTDPMID:16000229
Gabrb3Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:21394737
Gabrb3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOGabrb3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of GABRB3 mRNACTDPMID:21570461 and PMID:26377647
Gabrb3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of GABRB3 mRNACTDPMID:32109520
Gabrb3Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Gabrb3Rat3,3-bis(trifluoromethyl)bicyclo[2.2.1]heptane-2,2-dicarbonitrile affects bindingISOGABRB3 (Homo sapiens)64804643 more ...CTDPMID:16537435
Gabrb3Rat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of GABRB3 mRNACTDPMID:28522335
Gabrb3Rat3alpha-hydroxy-5beta-pregnan-20-one multiple interactionsISOGABRB3 (Homo sapiens)6480464Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form] more ...CTDPMID:29038840
Gabrb3Rat4,4'-sulfonyldiphenol decreases expressionISOGabrb3 (Mus musculus)6480464bisphenol S results in decreased expression of GABRB3 mRNACTDPMID:39298647
Gabrb3Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of GABRB3 mRNACTDPMID:36041667
Gabrb3Rat5-fluorouracil increases expressionISOGabrb3 (Mus musculus)6480464Fluorouracil results in increased expression of GABRB3 proteinCTDPMID:21296659
Gabrb3Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of GABRB3 mRNACTDPMID:36843608
Gabrb3Ratacetic acid affects expressionISOGabrb3 (Mus musculus)6480464Acetic Acid affects the expression of GABRB3 proteinCTDPMID:21296659
Gabrb3Ratall-trans-retinoic acid decreases expressionISOGABRB3 (Homo sapiens)6480464Tretinoin results in decreased expression of GABRB3 mRNACTDPMID:21934132
Gabrb3Ratall-trans-retinol increases expressionISOGABRB3 (Homo sapiens)6480464Vitamin A results in increased expression of GABRB3 mRNACTDPMID:17225872
Gabrb3Ratalpha-hexachlorocyclohexane multiple interactionsISOGABRB3 (Homo sapiens)6480464alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] and alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]CTDPMID:9316872
Gabrb3RatAlphaxolone multiple interactionsEXP 6480464alphaxalone promotes the reaction [Muscimol binds to GABRB3 protein]CTDPMID:8397295

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Biological Process
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Gabrb3Ratbrain development acts_upstream_of_or_withinISOGabrb3 (Mus musculus)1624291 PMID:16168624 and PMID:17983671RGDPMID:16168624 and PMID:17983671
Gabrb3Ratcellular response to histamine involved_inISSUniProtKB:P284721600115GO_REF:0000024UniProtGO_REF:0000024
Gabrb3Ratcellular response to histamine involved_inISOGABRB3 (Homo sapiens)1624291 PMID:18281286RGDPMID:18281286
Gabrb3Ratcellular response to zinc ion acts_upstream_of_or_withinISOGabrb3 (Mus musculus)1624291 PMID:12183328RGDPMID:12183328
Gabrb3Ratcerebellum development acts_upstream_of_or_withinISOGabrb3 (Mus musculus)1624291 PMID:17983671RGDPMID:17983671
Gabrb3Ratchloride transmembrane transport involved_inISOGABRB3 (Homo sapiens)1624291 PMID:22303015 more ...RGDPMID:22303015 more ...
Gabrb3Ratchloride transmembrane transport involved_inISOGabrb3 (Mus musculus)1624291 PMID:9108119RGDPMID:9108119
Gabrb3Ratchloride transmembrane transport involved_inIBAMGI:95621 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gabrb3Ratchloride transmembrane transport involved_inISOComplexPortal:CPX-21671600115GO_REF:0000114ComplexPortalGO_REF:0000114
Gabrb3Ratchloride transmembrane transport involved_inIEAGO:00052541600115GO_REF:0000108GOCGO_REF:0000108
Gabrb3Ratchloride transport involved_inIEAUniProtKB-KW:KW-08691600115GO_REF:0000043UniProtGO_REF:0000043
Gabrb3Ratcircadian sleep/wake cycle, REM sleep acts_upstream_of_or_withinISOGabrb3 (Mus musculus)1624291 PMID:12419540RGDPMID:12419540
Gabrb3Ratcochlea development involved_inISOGabrb3 (Mus musculus)1624291 PMID:17021187RGDPMID:17021187
Gabrb3Ratexploration behavior acts_upstream_of_or_withinISOGabrb3 (Mus musculus)1624291 PMID:17983671RGDPMID:17983671
Gabrb3Ratgamma-aminobutyric acid signaling pathway involved_inISOComplexPortal:CPX-29541600115GO_REF:0000114ComplexPortalGO_REF:0000114
Gabrb3Ratgamma-aminobutyric acid signaling pathway involved_inISOGABRB3 (Homo sapiens)1624291 PMID:26950270 more ...RGDPMID:26950270 more ...
Gabrb3Ratgamma-aminobutyric acid signaling pathway involved_inISSUniProtKB:P284721600115GO_REF:0000024UniProtGO_REF:0000024
Gabrb3Ratgamma-aminobutyric acid signaling pathway involved_inNAS 405650249PMID:34417930ComplexPortal 
Gabrb3Rathard palate development acts_upstream_of_or_withinISOGabrb3 (Mus musculus)1624291 PMID:12606284 more ...RGDPMID:12606284 more ...
Gabrb3Ratinhibitory postsynaptic potential involved_inISOGabrb3 (Mus musculus)1624291 PMID:19846622RGDPMID:19846622
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Cellular Component
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Gabrb3Ratcell surface is_active_inISOGabrb3 (Mus musculus)1624291 PMID:12183328RGDPMID:12183328
Gabrb3Ratchloride channel complex part_ofIEAUniProtKB-KW:KW-08691600115GO_REF:0000043UniProtGO_REF:0000043
Gabrb3Ratcytoplasm  IDA 1601272MMO:0000686RGD 
Gabrb3Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Gabrb3Ratcytoplasmic vesicle membrane located_inIEAUniProtKB-SubCell:SL-00891600115GO_REF:0000044UniProtGO_REF:0000044
Gabrb3Ratdendritic spine is_active_inISOGABRB3 (Homo sapiens)1624291 PMID:25025157RGDPMID:25025157
Gabrb3RatGABA-A receptor complex part_ofIPI 150521647PMID:18079275ComplexPortal 
Gabrb3RatGABA-A receptor complex part_ofIBAMGI:95621 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gabrb3RatGABA-A receptor complex part_ofISOGabrb3 (Mus musculus)1624291 PMID:9108119RGDPMID:9108119
Gabrb3RatGABA-A receptor complex part_ofISSUniProtKB:P284721600115GO_REF:0000024UniProtGO_REF:0000024
Gabrb3RatGABA-A receptor complex part_ofISOGABRB3 (Homo sapiens)1624291 PMID:22303015 more ...RGDPMID:22303015 more ...
Gabrb3RatGABA-A receptor complex part_ofISSUniProtKB:P630801600115GO_REF:0000024UniProtGO_REF:0000024
Gabrb3RatGABA-A receptor complex part_ofISSComplexPortal:CPX-85711600115GO_REF:0000114ComplexPortalGO_REF:0000114
Gabrb3RatGABA-A receptor complex part_ofISSComplexPortal:CPX-2801600115GO_REF:0000114ComplexPortalGO_REF:0000114
Gabrb3RatGABA-A receptor complex part_ofISOComplexPortal:CPX-21671600115GO_REF:0000114ComplexPortalGO_REF:0000114
Gabrb3RatGABA-ergic synapse located_inIEAARBA:ARBA000270961600115GO_REF:0000117UniProtGO_REF:0000117
Gabrb3RatGABA-ergic synapse is_active_inISOGabrb3 (Mus musculus)1624291 PMID:12522165RGDPMID:12522165
Gabrb3RatGABA-ergic synapse is_active_inIDA 13702464PMID:21073549SynGO 
Gabrb3Ratinhibitory synapse located_inIDA 8553984PMID:20417281MGI 
Gabrb3Ratmembrane located_inIEAInterPro:IPR002289 more ...1600115GO_REF:0000002InterProGO_REF:0000002
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Molecular Function
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Gabrb3RatAP-2 adaptor complex binding  IPIAp2m1 (Rattus norvegicus)1601273 RGD 
Gabrb3Ratchloride channel activity  IDA 727440 RGD 
Gabrb3Ratchloride channel activity enablesIEAUniProtKB-KW:KW-08691600115GO_REF:0000043UniProtGO_REF:0000043
Gabrb3Ratextracellular ligand-gated monoatomic ion channel activity enablesIEAInterPro:IPR006202 and InterPro:IPR0367341600115GO_REF:0000002InterProGO_REF:0000002
Gabrb3RatGABA-A receptor activity  IDA 728451 RGD 
Gabrb3RatGABA-A receptor activity  TAS 625528 RGD 
Gabrb3RatGABA-A receptor activity enablesIBAMGI:95621 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gabrb3RatGABA-A receptor activity enablesIEAInterPro:IPR0022891600115GO_REF:0000002InterProGO_REF:0000002
Gabrb3RatGABA-A receptor activity enablesISOGabrb3 (Mus musculus)1624291 PMID:9108119RGDPMID:9108119
Gabrb3RatGABA-A receptor activity enablesISOGABRB3 (Homo sapiens)1624291 PMID:14993607 more ...RGDPMID:14993607 more ...
Gabrb3RatGABA-A receptor activity enablesIDA 405650343PMID:10462548UniProt 
Gabrb3RatGABA-A receptor activity  IDA 727440 RGD 
Gabrb3RatGABA-A receptor activity  IDA 1358699 RGD 
Gabrb3RatGABA-gated chloride ion channel activity enablesISOGABRB3 (Homo sapiens)1624291 PMID:22303015 more ...RGDPMID:22303015 more ...
Gabrb3RatGABA-gated chloride ion channel activity contributes_toISOGabrb3 (Mus musculus)1624291 PMID:27129275RGDPMID:27129275
Gabrb3RatGABA-gated chloride ion channel activity enablesISOGabrb3 (Mus musculus)1624291 PMID:9108119RGDPMID:9108119
Gabrb3RatGABA-gated chloride ion channel activity enablesISSUniProtKB:P284721600115GO_REF:0000024UniProtGO_REF:0000024
Gabrb3RatGABA-gated chloride ion channel activity contributes_toISSUniProtKB:P630801600115GO_REF:0000024UniProtGO_REF:0000024
Gabrb3RatGABA-gated chloride ion channel activity enablesIDA 405650343PMID:10462548UniProt 
Gabrb3Ratidentical protein binding enablesISOGABRB3 (Homo sapiens)1624291UniProtKB:P28472 more ...RGDPMID:16537435 and PMID:24909990
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Reference Title
Reference Citation
1. Atomic force microscopy reveals the stoichiometry and subunit arrangement of the alpha4beta3delta GABA(A) receptor. Barrera NP, etal., Mol Pharmacol. 2008 Mar;73(3):960-7. doi: 10.1124/mol.107.042481. Epub 2007 Dec 13.
2. Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function. Bianchi MT and Macdonald RL, J Physiol 2002 Oct 1;544(Pt 1):3-18.
3. Functional characterization of the new human GABA(A) receptor mutation beta3(R192H). Buhr A, etal., Hum Genet. 2002 Aug;111(2):154-60. Epub 2002 Jul 16.
4. The brefeldin A-inhibited GDP/GTP exchange factor 2, a protein involved in vesicular trafficking, interacts with the beta subunits of the GABA receptors. Charych EI, etal., J Neurochem 2004 Jul;90(1):173-89.
5. Association analysis of GABRB3 promoter variants with heroin dependence. Chen CH, etal., PLoS One. 2014 Jul 15;9(7):e102227. doi: 10.1371/journal.pone.0102227. eCollection 2014.
6. GABAA Receptors and the Diversity in their Structure and Pharmacology. Chua HC and Chebib M, Adv Pharmacol. 2017;79:1-34. doi: 10.1016/bs.apha.2017.03.003. Epub 2017 May 2.
7. Association of gephyrin with synaptic and extrasynaptic GABAA receptors varies during development in cultured hippocampal neurons. Danglot L, etal., Mol Cell Neurosci. 2003 Jun;23(2):264-78.
8. Association of GABRG3 with alcohol dependence. Dick DM, etal., Alcohol Clin Exp Res. 2004 Jan;28(1):4-9. doi: 10.1097/01.ALC.0000108645.54345.98.
9. Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization. Feng HJ and Macdonald RL, J Neurophysiol 2004 Sep;92(3):1577-85. Epub 2004 May 19.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GABAA receptors: structure, function, pharmacology, and related disorders. Ghit A, etal., J Genet Eng Biotechnol. 2021 Aug 21;19(1):123. doi: 10.1186/s43141-021-00224-0.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. Kasugai Y, etal., Eur J Neurosci. 2010 Dec;32(11):1868-88. doi: 10.1111/j.1460-9568.2010.07473.x. Epub 2010 Nov 14.
14. Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Kittler JT, etal., Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14871-6. Epub 2005 Sep 28.
15. Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer. Laverty D, etal., Nature. 2019 Jan;565(7740):516-520. doi: 10.1038/s41586-018-0833-4. Epub 2019 Jan 2.
16. Heroin addiction in African Americans: a hypothesis-driven association study. Levran O, etal., Genes Brain Behav. 2009 Jul;8(5):531-40. Epub 2009 Jun 20.
17. Identification and characterization of a novel splice variant of beta3 subunit of GABA(A) receptor in rat testis and spermatozoa. Li SF, etal., Int J Biochem Cell Biol. 2005 Feb;37(2):350-60.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Changes in excitatory and inhibitory receptor expression and network activity during induction and establishment of epilepsy in the rat Reduced Intensity Status Epilepticus (RISE) model. Needs HI, etal., Neuropharmacology. 2019 Nov 1;158:107728. doi: 10.1016/j.neuropharm.2019.107728. Epub 2019 Jul 26.
20. Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors. Neelands TR and Macdonald RL, Mol Pharmacol. 1999 Sep;56(3):598-610. doi: 10.1124/mol.56.3.598.
1 to 20 of 37 rows
PMID:2540033   PMID:8382702   PMID:9039914   PMID:9108119   PMID:11528422   PMID:12522165   PMID:16537435   PMID:16979397   PMID:17021187   PMID:17317750   PMID:18281286   PMID:19179335  
PMID:19617557   PMID:19846622   PMID:21474450   PMID:21735059   PMID:22215379   PMID:22303015   PMID:22396422   PMID:23205938   PMID:24500446   PMID:24909990   PMID:24992900   PMID:25489750  
PMID:26950270   PMID:27129275   PMID:27140694   PMID:29706582   PMID:32383536  



Gabrb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81117,602,772 - 117,838,230 (+)NCBIGRCr8
mRatBN7.21108,467,047 - 108,702,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1108,296,124 - 108,698,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1113,838,572 - 114,068,957 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01122,311,079 - 122,541,470 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01115,559,397 - 115,789,792 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01113,034,251 - 113,265,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1112,976,770 - 113,265,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01114,042,551 - 114,275,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41109,047,399 - 109,277,756 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11109,125,741 - 109,356,099 (+)NCBI
Celera1102,635,270 - 102,866,355 (+)NCBICelera
Cytogenetic Map1q22NCBI
GABRB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381526,543,552 - 26,773,763 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1526,543,552 - 26,939,539 (-)EnsemblGRCh38hg38GRCh38
GRCh371526,788,699 - 27,018,910 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361524,339,786 - 24,570,020 (-)NCBINCBI36Build 36hg18NCBI36
Build 341524,342,555 - 24,570,020NCBI
Celera154,950,603 - 5,179,865 (-)NCBICelera
Cytogenetic Map15q12NCBI
HuRef154,917,779 - 5,148,361 (-)NCBIHuRef
CHM1_11526,738,348 - 26,968,576 (-)NCBICHM1_1
T2T-CHM13v2.01524,283,987 - 24,515,087 (-)NCBIT2T-CHM13v2.0
Gabrb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39757,240,266 - 57,478,550 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl757,069,440 - 57,478,550 (+)EnsemblGRCm39 Ensembl
GRCm38757,590,518 - 57,828,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl757,419,692 - 57,828,802 (+)EnsemblGRCm38mm10GRCm38
MGSCv37764,845,904 - 65,084,172 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36757,458,398 - 57,696,666 (+)NCBIMGSCv36mm8
Celera754,911,328 - 55,150,383 (+)NCBICelera
Cytogenetic Map7B5NCBI
cM Map733.53NCBI
Gabrb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555332,573,599 - 2,938,952 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555332,879,437 - 2,938,952 (+)NCBIChiLan1.0ChiLan1.0
GABRB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2168,504,014 - 8,732,012 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11512,144,864 - 12,373,305 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0153,129,481 - 3,357,495 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11523,981,359 - 24,201,975 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1523,981,359 - 24,058,357 (-)Ensemblpanpan1.1panPan2
GABRB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1333,878,948 - 34,101,987 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl333,878,904 - 34,097,764 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha336,567,998 - 36,799,821 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0334,213,315 - 34,437,878 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl334,213,156 - 34,436,244 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1333,753,749 - 33,985,358 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0334,016,414 - 34,241,830 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0334,163,761 - 34,395,684 (+)NCBIUU_Cfam_GSD_1.0
Gabrb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640122,077,313 - 122,344,190 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647139,791,613 - 40,187,923 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647139,791,633 - 40,193,049 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1140,566,540 - 140,905,623 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11140,566,443 - 140,906,516 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GABRB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12655,319,667 - 55,543,116 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2655,471,907 - 55,538,855 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605438,152,669 - 38,377,691 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabrb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624896966,487 - 1,173,625 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624896962,253 - 1,173,842 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Gabrb3
1485 total Variants

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:45
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000020099, ENSRNOT00000065223
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847121834139Rat

1 to 10 of 54 rows
D1Arb10  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81117,834,041 - 117,834,434 (+)Marker Load Pipeline
mRatBN7.21108,698,333 - 108,698,726 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,737 - 113,265,129NCBIRnor6.0
Rnor_5.01114,274,416 - 114,274,808UniSTSRnor5.0
RGSC_v3.41109,277,128 - 109,277,521RGDRGSC3.4
RGSC_v3.41109,277,129 - 109,277,521UniSTSRGSC3.4
RGSC_v3.11109,355,471 - 109,355,864RGD
Celera1102,865,724 - 102,866,120UniSTS
FHH x ACI Map155.58RGD
FHH x ACI Map155.58UniSTS
Cytogenetic Map1q22UniSTS
D1Rat268  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81117,823,451 - 117,823,600 (+)Marker Load Pipeline
mRatBN7.21108,687,741 - 108,687,892 (+)MAPPERmRatBN7.2
Rnor_6.01113,254,147 - 113,254,295NCBIRnor6.0
Rnor_5.01114,263,826 - 114,263,974UniSTSRnor5.0
RGSC_v3.41109,266,538 - 109,266,687RGDRGSC3.4
RGSC_v3.41109,266,539 - 109,266,687UniSTSRGSC3.4
RGSC_v3.11109,344,881 - 109,345,030RGD
Celera1102,855,134 - 102,855,282UniSTS
SHRSP x BN Map153.79UniSTS
SHRSP x BN Map153.79RGD
Cytogenetic Map1q22UniSTS
D1Mco65  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,687,678 - 108,687,892 (+)MAPPERmRatBN7.2
Rnor_6.01113,254,084 - 113,254,295NCBIRnor6.0
Rnor_5.01114,263,763 - 114,263,974UniSTSRnor5.0
RGSC_v3.41109,266,476 - 109,266,687UniSTSRGSC3.4
Celera1102,855,071 - 102,855,282UniSTS
Cytogenetic Map1q22UniSTS
D1Mco64  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,580,284 - 108,580,484 (+)MAPPERmRatBN7.2
Rnor_6.01113,146,686 - 113,146,883NCBIRnor6.0
Rnor_5.01114,156,365 - 114,156,562UniSTSRnor5.0
RGSC_v3.41109,159,076 - 109,159,273UniSTSRGSC3.4
Celera1102,747,697 - 102,747,894UniSTS
Cytogenetic Map1q22UniSTS
D1Wox53  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81117,834,215 - 117,834,459 (+)Marker Load Pipeline
mRatBN7.21108,698,507 - 108,698,751 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,911 - 113,265,154NCBIRnor6.0
Rnor_5.01114,274,590 - 114,274,833UniSTSRnor5.0
RGSC_v3.41109,277,303 - 109,277,546UniSTSRGSC3.4
Celera1102,865,898 - 102,866,145UniSTS
Cytogenetic Map1q22UniSTS
RH138257  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,682,588 - 108,682,830 (+)MAPPERmRatBN7.2
Rnor_6.01113,248,993 - 113,249,234NCBIRnor6.0
Rnor_5.01114,258,672 - 114,258,913UniSTSRnor5.0
RGSC_v3.41109,261,385 - 109,261,626UniSTSRGSC3.4
Celera1102,849,987 - 102,850,228UniSTS
Cytogenetic Map1q22UniSTS
AW531506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,653,215 - 108,653,385 (+)MAPPERmRatBN7.2
Rnor_6.01113,219,620 - 113,219,789NCBIRnor6.0
Rnor_5.01114,229,299 - 114,229,468UniSTSRnor5.0
RGSC_v3.41109,232,012 - 109,232,181UniSTSRGSC3.4
Celera1102,820,616 - 102,820,785UniSTS
RH 3.4 Map1967.01UniSTS
Cytogenetic Map1q22UniSTS
BE113547  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,661,984 - 108,662,136 (+)MAPPERmRatBN7.2
Rnor_6.01113,228,389 - 113,228,540NCBIRnor6.0
Rnor_5.01114,238,068 - 114,238,219UniSTSRnor5.0
RGSC_v3.41109,240,781 - 109,240,932UniSTSRGSC3.4
Celera1102,829,385 - 102,829,536UniSTS
RH 3.4 Map1965.91UniSTS
Cytogenetic Map1q22UniSTS
GDB:192789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,698,188 - 108,698,446 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,592 - 113,264,849NCBIRnor6.0
Rnor_5.01114,274,271 - 114,274,528UniSTSRnor5.0
RGSC_v3.41109,276,984 - 109,277,241UniSTSRGSC3.4
Celera1102,865,579 - 102,865,836UniSTS
Cytogenetic Map1q22UniSTS
RH11160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,698,508 - 108,698,648 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,912 - 113,265,051NCBIRnor6.0
Rnor_5.01114,274,591 - 114,274,730UniSTSRnor5.0
RGSC_v3.41109,277,304 - 109,277,443UniSTSRGSC3.4
Celera1102,865,899 - 102,866,042UniSTS
Cytogenetic Map1q22UniSTS
D1Wox53  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81117,834,215 - 117,834,458 (+)Marker Load Pipeline
mRatBN7.21108,698,507 - 108,698,750 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,911 - 113,265,153NCBIRnor6.0
Rnor_5.01114,274,590 - 114,274,832UniSTSRnor5.0
RGSC_v3.41109,277,303 - 109,277,545UniSTSRGSC3.4
Celera1102,865,898 - 102,866,144UniSTS
Cytogenetic Map1q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 44 112 64 61 32 25 32 5 180 91 93 41 60 29



Ensembl Acc Id: ENSRNOT00000077594   ⟹   ENSRNOP00000071680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,455,915 - 108,698,961 (+)Ensembl
Rnor_6.0 Ensembl1113,034,266 - 113,265,364 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077877   ⟹   ENSRNOP00000073384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,296,124 - 108,698,961 (+)Ensembl
Rnor_6.0 Ensembl1113,034,266 - 113,264,982 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079348   ⟹   ENSRNOP00000070416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,410,949 - 108,455,986 (+)Ensembl
Rnor_6.0 Ensembl1112,976,770 - 113,021,942 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081831   ⟹   ENSRNOP00000071478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,467,112 - 108,698,961 (+)Ensembl
Rnor_6.0 Ensembl1113,034,227 - 113,265,364 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082310   ⟹   ENSRNOP00000069990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1113,033,098 - 113,033,228 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113752   ⟹   ENSRNOP00000085111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,467,741 - 108,698,961 (+)Ensembl
RefSeq Acc Id: NM_017065   ⟹   NP_058761
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,603,460 - 117,834,669 (+)NCBI
mRatBN7.21108,467,741 - 108,698,961 (+)NCBI
Rnor_6.01113,034,251 - 113,265,364 (+)NCBI
Rnor_5.01114,042,551 - 114,275,043 (+)NCBI
RGSC_v3.41109,047,399 - 109,277,756 (+)RGD
Celera1102,635,270 - 102,866,355 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101122   ⟹   XP_038957050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,602,772 - 117,838,230 (+)NCBI
mRatBN7.21108,467,047 - 108,702,522 (+)NCBI
RefSeq Acc Id: XM_039101126   ⟹   XP_038957054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,603,736 - 117,838,230 (+)NCBI
mRatBN7.21108,468,017 - 108,702,522 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_058761 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957050 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957054 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41180 (Get FASTA)   NCBI Sequence Viewer  
  AAU93411 (Get FASTA)   NCBI Sequence Viewer  
  CAA33495 (Get FASTA)   NCBI Sequence Viewer  
  EDL86447 (Get FASTA)   NCBI Sequence Viewer  
  EDL86448 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000085111
  ENSRNOP00000085111.1
GenBank Protein P63079 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_058761   ⟸   NM_017065
- Peptide Label: precursor
- UniProtKB: P63079 (UniProtKB/Swiss-Prot),   A6KD41 (UniProtKB/TrEMBL),   A0A0G2K131 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070416   ⟸   ENSRNOT00000079348
Ensembl Acc Id: ENSRNOP00000069990   ⟸   ENSRNOT00000082310
Ensembl Acc Id: ENSRNOP00000071680   ⟸   ENSRNOT00000077594
Ensembl Acc Id: ENSRNOP00000073384   ⟸   ENSRNOT00000077877
Name Modeler Protein Id AA Range Protein Structure
AF-P63079-F1-model_v2 AlphaFold P63079 1-473 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-59441 BioCyc
Ensembl Genes ENSRNOG00000060599 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000113752 ENTREZGENE
  ENSRNOT00000113752.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot
  GABAAb_rcpt UniProtKB/Swiss-Prot
  Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
KEGG Report rno:24922 UniProtKB/Swiss-Prot
NCBI Gene 24922 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PhenoGen Gabrb3 PhenoGen
PRINTS GABAARBETA UniProtKB/Swiss-Prot
  GABAARECEPTR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060599 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A0A0G2JXV3_RAT UniProtKB/TrEMBL
  A0A0G2K0J9 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K131 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K5D4_RAT UniProtKB/TrEMBL
  A6KD40 ENTREZGENE, UniProtKB/TrEMBL
  A6KD41 ENTREZGENE, UniProtKB/TrEMBL
  GBRB3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5XPT5_RAT UniProtKB/TrEMBL
UniProt Secondary P15433 UniProtKB/Swiss-Prot
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Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabrb3  gamma-aminobutyric acid type A receptor subunit beta 3  Gabrb3  gamma-aminobutyric acid type A receptor beta 3 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabrb3  gamma-aminobutyric acid type A receptor beta 3 subunit  Gabrb3  gamma-aminobutyric acid (GABA) A receptor, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Gabrb3  gamma-aminobutyric acid (GABA) A receptor, beta 3  Gabrb3  gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gabrb3  gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3    gamma-aminobutyric acid receptor, subunit beta 3  Name updated 1299863 APPROVED
2002-06-10 Gabrb3  Gamma-aminobutyric acid receptor beta 3      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_cellular_localization localizes to both cytoplasmic and subsynaptic sites of NTS neurons 625528
gene_expression mRNA is expressed in high amounts in nucleus tractus solitarii and protein expression is seen in many areas of the medulla like cuneate, gracile, olivary and spinal trigeminal nuclei 625528
gene_process may mediate inhibitory GABA responses in nucleus tractus solitarii (NTS) in the brain 625528