Gabrb3 (gamma-aminobutyric acid type A receptor subunit beta 3) - Rat Genome Database

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Gene: Gabrb3 (gamma-aminobutyric acid type A receptor subunit beta 3) Rattus norvegicus
Analyze
Symbol: Gabrb3
Name: gamma-aminobutyric acid type A receptor subunit beta 3
RGD ID: 2651
Description: Enables AP-2 adaptor complex binding activity; GABA-A receptor activity; and GABA-gated chloride ion channel activity. Involved in GABAergic synaptic transmission and response to auditory stimulus. Located in several cellular components, including inhibitory synapse; sperm head; and terminal bouton. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Biomarker of fetal alcohol spectrum disorder and status epilepticus. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; childhood absence epilepsy; developmental and epileptic encephalopathy 43; and heroin dependence. Orthologous to human GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GABA(A) receptor subunit beta-3; GABA-alpha receptor beta-3 subunit; GABAAR subunit beta-3; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3; Gamma-aminobutyric acid receptor beta 3; gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid receptor, subunit beta 3; gamma-aminobutyric acid type A receptor beta 3 subunit; testis gamma-aminobutyric acid receptor subunit beta 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81117,602,772 - 117,838,230 (+)NCBIGRCr8
mRatBN7.21108,467,047 - 108,702,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1108,296,124 - 108,698,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1113,838,572 - 114,068,957 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01122,311,079 - 122,541,470 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01115,559,397 - 115,789,792 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01113,034,251 - 113,265,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1112,976,770 - 113,265,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01114,042,551 - 114,275,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41109,047,399 - 109,277,756 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11109,125,741 - 109,356,099 (+)NCBI
Celera1102,635,270 - 102,866,355 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3-bis(trifluoromethyl)bicyclo[2.2.1]heptane-2,2-dicarbonitrile  (ISO)
3-chloropropane-1,2-diol  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-hexachlorocyclohexane  (ISO)
Alphaxolone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
bicuculline  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromochloroacetic acid  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clozapine  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
delta-hexachlorocyclohexane  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazepam  (EXP,ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etomidate  (ISO)
felbamate  (ISO)
fipronil  (ISO)
flumazenil  (ISO)
flunitrazepam  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gamma-aminobutyric acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
haloperidol  (EXP)
kainic acid  (ISO)
L-methionine  (ISO)
lanthanum atom  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methylmercury chloride  (ISO)
midazolam  (ISO)
muscimol  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
oleamide  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
pentobarbital  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picrotoxin  (ISO)
picrotoxinin  (ISO)
propofol  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tert-Butylbicyclophosphorothionate  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zolpidem  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Atomic force microscopy reveals the stoichiometry and subunit arrangement of the alpha4beta3delta GABA(A) receptor. Barrera NP, etal., Mol Pharmacol. 2008 Mar;73(3):960-7. doi: 10.1124/mol.107.042481. Epub 2007 Dec 13.
2. Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function. Bianchi MT and Macdonald RL, J Physiol 2002 Oct 1;544(Pt 1):3-18.
3. Functional characterization of the new human GABA(A) receptor mutation beta3(R192H). Buhr A, etal., Hum Genet. 2002 Aug;111(2):154-60. Epub 2002 Jul 16.
4. The brefeldin A-inhibited GDP/GTP exchange factor 2, a protein involved in vesicular trafficking, interacts with the beta subunits of the GABA receptors. Charych EI, etal., J Neurochem 2004 Jul;90(1):173-89.
5. Association analysis of GABRB3 promoter variants with heroin dependence. Chen CH, etal., PLoS One. 2014 Jul 15;9(7):e102227. doi: 10.1371/journal.pone.0102227. eCollection 2014.
6. GABAA Receptors and the Diversity in their Structure and Pharmacology. Chua HC and Chebib M, Adv Pharmacol. 2017;79:1-34. doi: 10.1016/bs.apha.2017.03.003. Epub 2017 May 2.
7. Association of gephyrin with synaptic and extrasynaptic GABAA receptors varies during development in cultured hippocampal neurons. Danglot L, etal., Mol Cell Neurosci. 2003 Jun;23(2):264-78.
8. Association of GABRG3 with alcohol dependence. Dick DM, etal., Alcohol Clin Exp Res. 2004 Jan;28(1):4-9. doi: 10.1097/01.ALC.0000108645.54345.98.
9. Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization. Feng HJ and Macdonald RL, J Neurophysiol 2004 Sep;92(3):1577-85. Epub 2004 May 19.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GABAA receptors: structure, function, pharmacology, and related disorders. Ghit A, etal., J Genet Eng Biotechnol. 2021 Aug 21;19(1):123. doi: 10.1186/s43141-021-00224-0.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. Kasugai Y, etal., Eur J Neurosci. 2010 Dec;32(11):1868-88. doi: 10.1111/j.1460-9568.2010.07473.x. Epub 2010 Nov 14.
14. Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Kittler JT, etal., Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14871-6. Epub 2005 Sep 28.
15. Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer. Laverty D, etal., Nature. 2019 Jan;565(7740):516-520. doi: 10.1038/s41586-018-0833-4. Epub 2019 Jan 2.
16. Heroin addiction in African Americans: a hypothesis-driven association study. Levran O, etal., Genes Brain Behav. 2009 Jul;8(5):531-40. Epub 2009 Jun 20.
17. Identification and characterization of a novel splice variant of beta3 subunit of GABA(A) receptor in rat testis and spermatozoa. Li SF, etal., Int J Biochem Cell Biol. 2005 Feb;37(2):350-60.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Changes in excitatory and inhibitory receptor expression and network activity during induction and establishment of epilepsy in the rat Reduced Intensity Status Epilepticus (RISE) model. Needs HI, etal., Neuropharmacology. 2019 Nov 1;158:107728. doi: 10.1016/j.neuropharm.2019.107728. Epub 2019 Jul 26.
20. Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors. Neelands TR and Macdonald RL, Mol Pharmacol. 1999 Sep;56(3):598-610. doi: 10.1124/mol.56.3.598.
21. D2 dopamine receptor and GABA(A) receptor beta3 subunit genes and alcoholism. Noble EP, etal., Psychiatry Res. 1998 Nov 16;81(2):133-47. doi: 10.1016/s0165-1781(98)00084-5.
22. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. Nusser Z, etal., J Neurosci. 1998 Mar 1;18(5):1693-703.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
25. Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn. Polgár E and Todd AJ, Neuroscience. 2008 Sep 22;156(1):193-202. doi: 10.1016/j.neuroscience.2008.07.009. Epub 2008 Jul 10.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry.PG - 241-57 Saha S, etal., Mol Cell Neurosci 2001 Jan;17(1):241-57.
30. Deletion of TLR-4 attenuates fetal alcohol exposure-induced gene expression and social interaction deficits. Shukla PK, etal., Alcohol. 2018 Dec;73:73-78. doi: 10.1016/j.alcohol.2018.04.004. Epub 2018 Apr 18.
31. Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Smith KR, etal., Mol Cell Neurosci. 2010 Aug;44(4):330-41. doi: 10.1016/j.mcn.2010.04.004. Epub 2010 Apr 22.
32. Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. Tunc-Ozcan E, etal., Alcohol Clin Exp Res. 2013 Nov;37(11):1986-95. doi: 10.1111/acer.12183. Epub 2013 Jun 13.
33. A GABRB3 promoter haplotype associated with childhood absence epilepsy impairs transcriptional activity. Urak L, etal., Hum Mol Genet. 2006 Aug 15;15(16):2533-41. Epub 2006 Jul 11.
34. The GABAA receptor beta 3 subunit gene: characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7. Wagstaff J, etal., Genomics 1991 Dec;11(4):1071-8.
35. Early continuous white noise exposure alters l-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit glutamate receptor 2 and gamma-aminobutyric acid type a receptor subunit beta3 protein expression in rat auditory cortex. Xu J, etal., J Neurosci Res. 2010 Feb 15;88(3):614-9. doi: 10.1002/jnr.22232.
36. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Yamasaki T, etal., Neuron. 2017 Mar 8;93(5):1138-1152.e6. doi: 10.1016/j.neuron.2017.02.023.
37. GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. Ymer S, etal., EMBO J 1989 Jun;8(6):1665-70.
Additional References at PubMed
PMID:2540033   PMID:8382702   PMID:9039914   PMID:9108119   PMID:11528422   PMID:12522165   PMID:16537435   PMID:16979397   PMID:17021187   PMID:17317750   PMID:18281286   PMID:19179335  
PMID:19617557   PMID:19846622   PMID:21474450   PMID:21735059   PMID:22215379   PMID:22303015   PMID:22396422   PMID:23205938   PMID:24500446   PMID:24909990   PMID:24992900   PMID:25489750  
PMID:26950270   PMID:27129275   PMID:27140694   PMID:29706582   PMID:32383536  


Genomics

Comparative Map Data
Gabrb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81117,602,772 - 117,838,230 (+)NCBIGRCr8
mRatBN7.21108,467,047 - 108,702,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1108,296,124 - 108,698,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1113,838,572 - 114,068,957 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01122,311,079 - 122,541,470 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01115,559,397 - 115,789,792 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01113,034,251 - 113,265,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1112,976,770 - 113,265,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01114,042,551 - 114,275,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41109,047,399 - 109,277,756 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11109,125,741 - 109,356,099 (+)NCBI
Celera1102,635,270 - 102,866,355 (+)NCBICelera
Cytogenetic Map1q22NCBI
GABRB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381526,543,552 - 26,773,763 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1526,543,552 - 26,939,539 (-)EnsemblGRCh38hg38GRCh38
GRCh371526,788,699 - 27,018,910 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361524,339,786 - 24,570,020 (-)NCBINCBI36Build 36hg18NCBI36
Build 341524,342,555 - 24,570,020NCBI
Celera154,950,603 - 5,179,865 (-)NCBICelera
Cytogenetic Map15q12NCBI
HuRef154,917,779 - 5,148,361 (-)NCBIHuRef
CHM1_11526,738,348 - 26,968,576 (-)NCBICHM1_1
T2T-CHM13v2.01524,283,987 - 24,515,087 (-)NCBIT2T-CHM13v2.0
Gabrb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39757,240,266 - 57,478,550 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl757,069,440 - 57,478,550 (+)EnsemblGRCm39 Ensembl
GRCm38757,590,518 - 57,828,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl757,419,692 - 57,828,802 (+)EnsemblGRCm38mm10GRCm38
MGSCv37764,845,904 - 65,084,172 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36757,458,398 - 57,696,666 (+)NCBIMGSCv36mm8
Celera754,911,328 - 55,150,383 (+)NCBICelera
Cytogenetic Map7B5NCBI
cM Map733.53NCBI
Gabrb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555332,573,599 - 2,938,952 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555332,879,437 - 2,938,952 (+)NCBIChiLan1.0ChiLan1.0
GABRB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2168,504,014 - 8,732,012 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11512,144,864 - 12,373,305 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0153,129,481 - 3,357,495 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11523,981,359 - 24,201,975 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1523,981,359 - 24,058,357 (-)Ensemblpanpan1.1panPan2
GABRB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1333,878,948 - 34,101,987 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl333,878,904 - 34,097,764 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha336,567,998 - 36,799,821 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0334,213,315 - 34,437,878 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl334,213,156 - 34,436,244 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1333,753,749 - 33,985,358 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0334,016,414 - 34,241,830 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0334,163,761 - 34,395,684 (+)NCBIUU_Cfam_GSD_1.0
Gabrb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640122,077,313 - 122,344,190 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647139,791,613 - 40,187,923 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647139,791,633 - 40,193,049 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1140,566,540 - 140,905,623 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11140,566,443 - 140,906,516 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GABRB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12655,319,667 - 55,543,116 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2655,471,907 - 55,538,855 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605438,152,669 - 38,377,691 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabrb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624896966,487 - 1,173,625 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624896962,253 - 1,173,842 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabrb3
1485 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:45
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000020099, ENSRNOT00000065223
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847121834139Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat

Markers in Region
D1Arb10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,698,333 - 108,698,726 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,737 - 113,265,129NCBIRnor6.0
Rnor_5.01114,274,416 - 114,274,808UniSTSRnor5.0
RGSC_v3.41109,277,128 - 109,277,521RGDRGSC3.4
RGSC_v3.41109,277,129 - 109,277,521UniSTSRGSC3.4
RGSC_v3.11109,355,471 - 109,355,864RGD
Celera1102,865,724 - 102,866,120UniSTS
FHH x ACI Map155.58UniSTS
FHH x ACI Map155.58RGD
Cytogenetic Map1q22UniSTS
D1Rat268  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,687,741 - 108,687,892 (+)MAPPERmRatBN7.2
Rnor_6.01113,254,147 - 113,254,295NCBIRnor6.0
Rnor_5.01114,263,826 - 114,263,974UniSTSRnor5.0
RGSC_v3.41109,266,538 - 109,266,687RGDRGSC3.4
RGSC_v3.41109,266,539 - 109,266,687UniSTSRGSC3.4
RGSC_v3.11109,344,881 - 109,345,030RGD
Celera1102,855,134 - 102,855,282UniSTS
SHRSP x BN Map153.79RGD
SHRSP x BN Map153.79UniSTS
Cytogenetic Map1q22UniSTS
D1Mco65  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,687,678 - 108,687,892 (+)MAPPERmRatBN7.2
Rnor_6.01113,254,084 - 113,254,295NCBIRnor6.0
Rnor_5.01114,263,763 - 114,263,974UniSTSRnor5.0
RGSC_v3.41109,266,476 - 109,266,687UniSTSRGSC3.4
Celera1102,855,071 - 102,855,282UniSTS
Cytogenetic Map1q22UniSTS
D1Mco64  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,580,284 - 108,580,484 (+)MAPPERmRatBN7.2
Rnor_6.01113,146,686 - 113,146,883NCBIRnor6.0
Rnor_5.01114,156,365 - 114,156,562UniSTSRnor5.0
RGSC_v3.41109,159,076 - 109,159,273UniSTSRGSC3.4
Celera1102,747,697 - 102,747,894UniSTS
Cytogenetic Map1q22UniSTS
D1Wox53  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,698,507 - 108,698,751 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,911 - 113,265,154NCBIRnor6.0
Rnor_5.01114,274,590 - 114,274,833UniSTSRnor5.0
RGSC_v3.41109,277,303 - 109,277,546UniSTSRGSC3.4
Celera1102,865,898 - 102,866,145UniSTS
Cytogenetic Map1q22UniSTS
RH138257  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,682,588 - 108,682,830 (+)MAPPERmRatBN7.2
Rnor_6.01113,248,993 - 113,249,234NCBIRnor6.0
Rnor_5.01114,258,672 - 114,258,913UniSTSRnor5.0
RGSC_v3.41109,261,385 - 109,261,626UniSTSRGSC3.4
Celera1102,849,987 - 102,850,228UniSTS
Cytogenetic Map1q22UniSTS
AW531506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,653,215 - 108,653,385 (+)MAPPERmRatBN7.2
Rnor_6.01113,219,620 - 113,219,789NCBIRnor6.0
Rnor_5.01114,229,299 - 114,229,468UniSTSRnor5.0
RGSC_v3.41109,232,012 - 109,232,181UniSTSRGSC3.4
Celera1102,820,616 - 102,820,785UniSTS
RH 3.4 Map1967.01UniSTS
Cytogenetic Map1q22UniSTS
BE113547  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,661,984 - 108,662,136 (+)MAPPERmRatBN7.2
Rnor_6.01113,228,389 - 113,228,540NCBIRnor6.0
Rnor_5.01114,238,068 - 114,238,219UniSTSRnor5.0
RGSC_v3.41109,240,781 - 109,240,932UniSTSRGSC3.4
Celera1102,829,385 - 102,829,536UniSTS
RH 3.4 Map1965.91UniSTS
Cytogenetic Map1q22UniSTS
GDB:192789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,698,188 - 108,698,446 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,592 - 113,264,849NCBIRnor6.0
Rnor_5.01114,274,271 - 114,274,528UniSTSRnor5.0
RGSC_v3.41109,276,984 - 109,277,241UniSTSRGSC3.4
Celera1102,865,579 - 102,865,836UniSTS
Cytogenetic Map1q22UniSTS
RH11160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,698,508 - 108,698,648 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,912 - 113,265,051NCBIRnor6.0
Rnor_5.01114,274,591 - 114,274,730UniSTSRnor5.0
RGSC_v3.41109,277,304 - 109,277,443UniSTSRGSC3.4
Celera1102,865,899 - 102,866,042UniSTS
Cytogenetic Map1q22UniSTS
D1Wox53  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21108,698,507 - 108,698,750 (+)MAPPERmRatBN7.2
Rnor_6.01113,264,911 - 113,265,153NCBIRnor6.0
Rnor_5.01114,274,590 - 114,274,832UniSTSRnor5.0
RGSC_v3.41109,277,303 - 109,277,545UniSTSRGSC3.4
Celera1102,865,898 - 102,866,144UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 44 112 64 61 32 25 32 5 180 91 93 41 60 29

Sequence


Ensembl Acc Id: ENSRNOT00000077594   ⟹   ENSRNOP00000071680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,455,915 - 108,698,961 (+)Ensembl
Rnor_6.0 Ensembl1113,034,266 - 113,265,364 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077877   ⟹   ENSRNOP00000073384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,296,124 - 108,698,961 (+)Ensembl
Rnor_6.0 Ensembl1113,034,266 - 113,264,982 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079348   ⟹   ENSRNOP00000070416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,410,949 - 108,455,986 (+)Ensembl
Rnor_6.0 Ensembl1112,976,770 - 113,021,942 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081831   ⟹   ENSRNOP00000071478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,467,112 - 108,698,961 (+)Ensembl
Rnor_6.0 Ensembl1113,034,227 - 113,265,364 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082310   ⟹   ENSRNOP00000069990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1113,033,098 - 113,033,228 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113752   ⟹   ENSRNOP00000085111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,467,741 - 108,698,961 (+)Ensembl
RefSeq Acc Id: NM_017065   ⟹   NP_058761
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,603,460 - 117,834,669 (+)NCBI
mRatBN7.21108,467,741 - 108,698,961 (+)NCBI
Rnor_6.01113,034,251 - 113,265,364 (+)NCBI
Rnor_5.01114,042,551 - 114,275,043 (+)NCBI
RGSC_v3.41109,047,399 - 109,277,756 (+)RGD
Celera1102,635,270 - 102,866,355 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101122   ⟹   XP_038957050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,602,772 - 117,838,230 (+)NCBI
mRatBN7.21108,467,047 - 108,702,522 (+)NCBI
RefSeq Acc Id: XM_039101126   ⟹   XP_038957054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,603,736 - 117,838,230 (+)NCBI
mRatBN7.21108,468,017 - 108,702,522 (+)NCBI
RefSeq Acc Id: NP_058761   ⟸   NM_017065
- Peptide Label: precursor
- UniProtKB: P63079 (UniProtKB/Swiss-Prot),   A6KD41 (UniProtKB/TrEMBL),   A0A0G2K131 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070416   ⟸   ENSRNOT00000079348
Ensembl Acc Id: ENSRNOP00000069990   ⟸   ENSRNOT00000082310
Ensembl Acc Id: ENSRNOP00000071680   ⟸   ENSRNOT00000077594
Ensembl Acc Id: ENSRNOP00000073384   ⟸   ENSRNOT00000077877
Ensembl Acc Id: ENSRNOP00000071478   ⟸   ENSRNOT00000081831
RefSeq Acc Id: XP_038957050   ⟸   XM_039101122
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0J9 (UniProtKB/TrEMBL),   A6KD40 (UniProtKB/TrEMBL),   A0A0G2K131 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957054   ⟸   XM_039101126
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K131 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085111   ⟸   ENSRNOT00000113752
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63079-F1-model_v2 AlphaFold P63079 1-473 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2651 AgrOrtholog
BioCyc Gene G2FUF-59441 BioCyc
Ensembl Genes ENSRNOG00000060599 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055014837 UniProtKB/Swiss-Prot
  ENSRNOG00060000098 UniProtKB/Swiss-Prot
  ENSRNOG00065003735 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077594.2 UniProtKB/TrEMBL
  ENSRNOT00000077877.2 UniProtKB/TrEMBL
  ENSRNOT00000079348.2 UniProtKB/TrEMBL
  ENSRNOT00000081831.2 UniProtKB/TrEMBL
  ENSRNOT00000113752.1 UniProtKB/Swiss-Prot
  ENSRNOT00055025431 UniProtKB/Swiss-Prot
  ENSRNOT00060000138 UniProtKB/Swiss-Prot
  ENSRNOT00065005454 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAAb_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24922 UniProtKB/Swiss-Prot
NCBI Gene 24922 ENTREZGENE
PANTHER GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gabrb3 PhenoGen
PRINTS GABAARBETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060599 RatGTEx
  ENSRNOG00055014837 RatGTEx
  ENSRNOG00060000098 RatGTEx
  ENSRNOG00065003735 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JXV3_RAT UniProtKB/TrEMBL
  A0A0G2K0J9 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K131 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K5D4_RAT UniProtKB/TrEMBL
  A6KD40 ENTREZGENE, UniProtKB/TrEMBL
  A6KD41 ENTREZGENE, UniProtKB/TrEMBL
  GBRB3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5XPT5_RAT UniProtKB/TrEMBL
UniProt Secondary P15433 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabrb3  gamma-aminobutyric acid type A receptor subunit beta 3  Gabrb3  gamma-aminobutyric acid type A receptor beta 3 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabrb3  gamma-aminobutyric acid type A receptor beta 3 subunit  Gabrb3  gamma-aminobutyric acid (GABA) A receptor, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Gabrb3  gamma-aminobutyric acid (GABA) A receptor, beta 3  Gabrb3  gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gabrb3  gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3    gamma-aminobutyric acid receptor, subunit beta 3  Name updated 1299863 APPROVED
2002-06-10 Gabrb3  Gamma-aminobutyric acid receptor beta 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to both cytoplasmic and subsynaptic sites of NTS neurons 625528
gene_expression mRNA is expressed in high amounts in nucleus tractus solitarii and protein expression is seen in many areas of the medulla like cuneate, gracile, olivary and spinal trigeminal nuclei 625528
gene_process may mediate inhibitory GABA responses in nucleus tractus solitarii (NTS) in the brain 625528