RGD Reference Report - GARLH Family Proteins Stabilize GABAA Receptors at Synapses. - Rat Genome Database

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GARLH Family Proteins Stabilize GABAA Receptors at Synapses.

Authors: Yamasaki, Tokiwa  Hoyos-Ramirez, Erika  Martenson, James S  Morimoto-Tomita, Megumi  Tomita, Susumu 
Citation: Yamasaki T, etal., Neuron. 2017 Mar 8;93(5):1138-1152.e6. doi: 10.1016/j.neuron.2017.02.023.
RGD ID: 13800541
Pubmed: PMID:28279354   (View Abstract at PubMed)
PMCID: PMC5347473   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuron.2017.02.023   (Journal Full-text)

Ionotropic neurotransmitter receptors mediate fast synaptic transmission by functioning as ligand-gated ion channels. Fast inhibitory transmission in the brain is mediated mostly by ionotropic GABAA receptors (GABAARs), but their essential components for synaptic localization remain unknown. Here, we identify putative auxiliary subunits of GABAARs, which we term GARLHs, consisting of LH4 and LH3 proteins. LH4 forms a stable tripartite complex with GABAARs and neuroligin-2 in the brain. Moreover, LH4 is required for the synaptic localization of GABAARs and inhibitory synaptic transmission in the hippocampus. Our findings propose GARLHs as the first identified auxiliary subunits for anion channels. These findings provide new insights into the regulation of inhibitory transmission and the molecular constituents of native anion channels in vivo.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Gabra1  (gamma-aminobutyric acid type A receptor subunit alpha 1)
Gabrb2  (gamma-aminobutyric acid type A receptor subunit beta 2)
Gabrb3  (gamma-aminobutyric acid type A receptor subunit beta 3)
Gabrg2  (gamma-aminobutyric acid type A receptor subunit gamma 2)
Lhfpl4  (LHFPL tetraspan subfamily member 4)
Nlgn2  (neuroligin 2)


Additional Information