Calm1 (calmodulin 1) - Rat Genome Database

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Gene: Calm1 (calmodulin 1) Ictidomys tridecemlineatus
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Symbol: Calm1
Name: calmodulin 1
RGD ID: 12566003
Description: ENCODES a protein that exhibits adenylate cyclase binding (ortholog); calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); calcium-mediated signaling (ortholog); establishment of protein localization to membrane (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); cannabis abuse (ortholog); catecholaminergic polymorphic ventricular tachycardia (ortholog); FOUND IN cytoplasm (ortholog); DAPK1-calmodulin complex (ortholog); growth cone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: calmodulin; calmodulin-1; LOC101967074
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864014,480,463 - 14,488,619 (-)NCBI
SpeTri2.0NW_00493648817,580,425 - 17,588,480 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
autophagosome membrane docking  (IEA)
calcium-mediated signaling  (ISO)
detection of calcium ion  (IEA)
establishment of protein localization to membrane  (ISO)
establishment of protein localization to mitochondrial membrane  (ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO)
mitochondrion-endoplasmic reticulum membrane tethering  (IEA)
negative regulation of calcium ion export across plasma membrane  (IEA)
negative regulation of calcium ion transmembrane transporter activity  (IEA)
negative regulation of high voltage-gated calcium channel activity  (IEA)
negative regulation of ryanodine-sensitive calcium-release channel activity  (IEA)
organelle localization by membrane tethering  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagic cell death  (ISO)
positive regulation of cyclic-nucleotide phosphodiesterase activity  (IEA)
positive regulation of DNA binding  (IEA,ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphoprotein phosphatase activity  (IEA)
positive regulation of protein dephosphorylation  (IEA)
positive regulation of ryanodine-sensitive calcium-release channel activity  (IEA)
potassium ion transmembrane transport  (ISO)
protein autophosphorylation  (ISO)
regulation of calcium-mediated signaling  (IEA)
regulation of cardiac muscle cell action potential  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of cyclase activity  (IEA)
regulation of cytokinesis  (IEA)
regulation of heart rate  (IEA)
regulation of high voltage-gated calcium channel activity  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IEA)
regulation of response to tumor cell  (ISO)
regulation of ryanodine-sensitive calcium-release channel activity  (IEA,ISO)
regulation of synaptic vesicle endocytosis  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (IEA)
substantia nigra development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adenosine monophosphate-activated protein kinase (AMPK) signaling pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
glycogen degradation pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
insulin responsive facilitative sugar transporter mediated glucose transport pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
N-cadherin signaling pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
p38 MAPK signaling pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
type II interferon signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

Genomics

Comparative Map Data
Calm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864014,480,463 - 14,488,619 (-)NCBI
SpeTri2.0NW_00493648817,580,425 - 17,588,480 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1490,396,502 - 90,408,268 (+)EnsemblGRCh38hg38GRCh38
GRCh381490,396,502 - 90,408,268 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371490,862,846 - 90,874,612 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361489,933,126 - 89,944,363 (+)NCBINCBI36hg18NCBI36
Build 341489,933,129 - 89,944,148NCBI
Celera1470,910,477 - 70,921,767 (+)NCBI
Cytogenetic Map14q32.11NCBI
HuRef1471,038,153 - 71,049,443 (+)NCBIHuRef
CHM1_11490,801,276 - 90,812,578 (+)NCBICHM1_1
Calm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912100,165,694 - 100,176,083 (+)NCBIGRCm39mm39
GRCm39 Ensembl12100,165,694 - 100,176,073 (+)Ensembl
GRCm3812100,199,435 - 100,209,824 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12100,199,435 - 100,209,814 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712101,437,751 - 101,448,016 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612100,600,591 - 100,610,856 (+)NCBImm8
Celera12101,426,181 - 101,436,442 (+)NCBICelera
Cytogenetic Map12ENCBI
Calm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26119,487,691 - 119,495,759 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl6119,487,621 - 119,498,227 (+)Ensembl
Rnor_6.06124,217,241 - 124,225,292 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6124,217,241 - 124,225,292 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06133,444,207 - 133,452,258 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46124,477,601 - 124,485,669 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16124,481,414 - 124,491,549 (+)NCBI
Celera6117,015,915 - 117,023,918 (+)NCBICelera
Cytogenetic Map6q32NCBI
Calm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543812,842,437 - 12,854,028 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543812,842,437 - 12,854,028 (+)NCBIChiLan1.0ChiLan1.0
CALM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11490,367,086 - 90,378,361 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,121,687 - 52,131,135 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01471,015,099 - 71,026,322 (+)NCBIMhudiblu_PPA_v0panPan3
CALM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1861,398,231 - 61,408,874 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl861,398,244 - 61,406,195 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha860,978,989 - 60,989,622 (+)NCBI
ROS_Cfam_1.0861,672,887 - 61,680,835 (+)NCBI
ROS_Cfam_1.0 Ensembl861,672,892 - 61,683,535 (+)Ensembl
UMICH_Zoey_3.1861,353,922 - 61,364,539 (+)NCBI
UNSW_CanFamBas_1.0861,402,765 - 61,413,376 (+)NCBI
UU_Cfam_GSD_1.0861,731,734 - 61,739,644 (+)NCBI
CALM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7112,154,880 - 112,171,744 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17112,160,823 - 112,171,754 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27118,728,008 - 118,738,940 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12468,133,446 - 68,145,117 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2468,133,428 - 68,145,180 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605355,415,057 - 55,426,335 (+)NCBIVero_WHO_p1.0
Calm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473412,030,264 - 12,041,682 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013356831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010003700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_013356831   ⟹   XP_013212285
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864014,480,463 - 14,488,619 (-)NCBI
SpeTri2.0NW_00493648817,580,425 - 17,588,480 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013212285 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3260523 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013212285   ⟸   XM_013356831
- Sequence:
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000016340 UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000014633 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000016342 UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
NCBI Gene Calm1 ENTREZGENE
Pfam EF-hand_7 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt I3MRD3_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Calm1  calmodulin 1  LOC101967074  calmodulin  Symbol and/or name change 5135510 APPROVED
2017-07-13 LOC101967074  calmodulin  Calm1  calmodulin 1  Symbol and/or name change 5135510 APPROVED