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ONTOLOGY REPORT - ANNOTATIONS

Term:extracellular exosome biogenesis
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Accession:GO:0097734 term browser browse the term
Definition:The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
Synonyms:exact_synonym: exosome assembly or secretion;   exosome biogenesis;   exosome production
 related_synonym: ILV assembly;   intraluminal vesicle assembly


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extracellular exosome biogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:25392495) RGD PMID:25392495 NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139 		JBrowse link
exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:19246649) RGD PMID:19246649 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family involved_in ISO (PMID:15634213) RGD PMID:15634213 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:23092844) RGD PMID:23092844 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829 		JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO MGI:4398911 (MGI:4367682|PMID:18617898) RGD PMID:18617898 MGI:4367682 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (MGI:5770036|PMID:25392495) RGD PMID:25392495 MGI:5770036 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd34 CD34 molecule involved_in ISO
ISS		 (PMID:21835908)
GO_REF:0000024		 RGD
UniProt		 PMID:21835908 GO_REF:0000024 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832 		JBrowse link
negative regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp9a ATPase phospholipid transporting 9A (putative) involved_in ISO (PMID:30947313) RGD PMID:30947313 NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO (PMID:26911690) RGD PMID:26911690 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:26911690) RGD PMID:26911690 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr13:22,907,105...22,932,200
Ensembl chr13:22,907,109...22,932,229 		JBrowse link
positive regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:24603074), (PMID:25392495)
(MGI:5770036|PMID:25392495)		 RGD PMID:24603074 PMID:25392495 MGI:5770036 NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139 		JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452 		JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate involved_in ISO
IEA		 (PMID:24105262)
GO_REF:0000107		 RGD
Ensembl		 PMID:24105262 GO_REF:0000107 NCBI chr10:105,739,617...105,757,838
Ensembl chr10:105,739,296...105,757,835 		JBrowse link
G Myo5b myosin Vb IMP RGD PMID:18984164 RGD:11533643 NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Sdc1 syndecan 1 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Sdc4 syndecan 4 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in IMP PMID:24743145 BHF-UCL PMID:24743145 RGD:10054083 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Snf8 SNF8 subunit of ESCRT-II involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr10:80,984,337...80,996,724
Ensembl chr10:80,984,363...80,996,734 		JBrowse link
G Stam signal transducing adaptor molecule involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr17:77,120,235...77,166,173
Ensembl chr17:77,120,158...77,166,467 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:22660413), (PMID:24105262) RGD PMID:22660413 PMID:24105262 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A involved_in ISO UniProtKB:O75351 (PMID:22660413) RGD PMID:22660413 NCBI chr19:34,934,999...34,948,267
Ensembl chr19:34,934,961...34,948,887 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO UniProtKB:Q9UN37 (PMID:22660413) RGD PMID:22660413 NCBI chr13:22,907,105...22,932,200
Ensembl chr13:22,907,109...22,932,229 		JBrowse link
positive regulation of extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Sdc1 syndecan 1 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Sdc4 syndecan 4 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572 		JBrowse link
regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp3 charged multivesicular body protein 3 NOT|involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
G Chmp6 charged multivesicular body protein 6 NOT|involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
regulation of extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Stam signal transducing adaptor molecule involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr17:77,120,235...77,166,173
Ensembl chr17:77,120,158...77,166,467 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      cellular component organization or biogenesis 6620
        cellular component biogenesis 3380
          extracellular vesicle biogenesis 26
            extracellular exosome biogenesis 24
              exosomal secretion + 23
              extracellular exosome assembly + 7
paths to the root