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ONTOLOGY REPORT - ANNOTATIONS


Term:extracellular exosome biogenesis
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Accession:GO:0097734 term browser browse the term
Definition:The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
Synonyms:exact_synonym: exosome assembly or secretion;   exosome biogenesis;   exosome production
 related_synonym: ILV assembly;   intraluminal vesicle assembly


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extracellular exosome biogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:25392495) RGD PMID:25392495 NCBI chr 5:159,512,208...159,531,631
Ensembl chr 5:159,512,285...159,531,637
JBrowse link
exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:19246649) RGD PMID:19246649 NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339
JBrowse link
G Rab11a RAB11a, member RAS oncogene family involved_in ISO (PMID:15634213) RGD PMID:15634213 NCBI chr 8:70,192,975...70,215,719
Ensembl chr 8:70,192,975...70,215,719
JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:23092844) RGD PMID:23092844 NCBI chr 8:79,722,334...79,776,228
Ensembl chr 8:79,722,334...79,776,221
JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO MGI:4398911 (MGI:4367682|PMID:18617898) RGD PMID:18617898 MGI:4367682 NCBI chr13:36,257,220...36,274,144
Ensembl chr13:36,257,112...36,290,531
JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (MGI:5770036|PMID:25392495) RGD PMID:25392495 MGI:5770036 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
JBrowse link
extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd34 CD34 molecule involved_in ISO
ISS
(PMID:21835908)
GO_REF:0000024
RGD
UniProt
PMID:21835908 GO_REF:0000024 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
negative regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp9a ATPase phospholipid transporting 9A (putative) involved_in ISO
IEA
(PMID:30947313)
GO_REF:0000107
RGD
Ensembl
PMID:30947313 GO_REF:0000107 NCBI chr 3:165,405,588...165,511,104
Ensembl chr 3:165,412,803...165,477,771
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO (PMID:26911690) RGD PMID:26911690 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:26911690) RGD PMID:26911690 NCBI chr 4:119,910,461...119,963,065
Ensembl chr 4:119,910,478...119,959,173
JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr13:26,825,261...26,850,460
Ensembl chr13:26,825,261...26,850,460
JBrowse link
positive regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:24603074), (PMID:25392495)
(MGI:5770036|PMID:25392495)
RGD PMID:24603074 PMID:25392495 MGI:5770036 NCBI chr 5:159,512,208...159,531,631
Ensembl chr 5:159,512,285...159,531,637
JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 1:65,540,808...65,543,708
Ensembl chr 1:65,541,322...65,543,707
JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr10:109,638,944...109,657,460
Ensembl chr10:109,638,767...109,657,456
JBrowse link
G Myo5b myosin Vb IMP RGD PMID:18984164 RGD:11533643 NCBI chr18:70,426,865...70,729,985
Ensembl chr18:70,427,007...70,729,030
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 4:119,910,461...119,963,065
Ensembl chr 4:119,910,478...119,959,173
JBrowse link
G Sdc1 syndecan 1 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Sdc4 syndecan 4 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Sdcbp syndecan binding protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 5:19,471,664...19,498,499
Ensembl chr 5:19,471,664...19,498,485
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in IMP PMID:24743145 BHF-UCL PMID:24743145 RGD:10054083 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Snf8 SNF8 subunit of ESCRT-II involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr10:83,856,331...83,868,621
Ensembl chr10:83,856,280...83,868,598
JBrowse link
G Stam signal transducing adaptor molecule involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr17:81,209,795...81,256,111
Ensembl chr17:81,209,867...81,255,808
JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:22660413), (PMID:24105262) RGD PMID:22660413 PMID:24105262 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A involved_in ISO UniProtKB:O75351 (PMID:22660413) RGD PMID:22660413 NCBI chr19:39,230,050...39,243,298
Ensembl chr19:39,229,754...39,243,496
JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO UniProtKB:Q9UN37 (PMID:22660413) RGD PMID:22660413 NCBI chr13:26,825,261...26,850,460
Ensembl chr13:26,825,261...26,850,460
JBrowse link
positive regulation of extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Sdc1 syndecan 1 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Sdc4 syndecan 4 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Sdcbp syndecan binding protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 5:19,471,664...19,498,499
Ensembl chr 5:19,471,664...19,498,485
JBrowse link
regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp3 charged multivesicular body protein 3 NOT|involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 4:99,449,213...99,496,156
Ensembl chr 4:99,449,111...99,494,423
JBrowse link
G Chmp6 charged multivesicular body protein 6 NOT|involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr10:109,073,678...109,079,348
Ensembl chr10:109,073,678...109,079,348
JBrowse link
regulation of extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Stam signal transducing adaptor molecule involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr17:81,209,795...81,256,111
Ensembl chr17:81,209,867...81,255,808
JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19633
    cellular process 18481
      cellular component organization or biogenesis 6709
        cellular component biogenesis 3276
          extracellular vesicle biogenesis 26
            extracellular exosome biogenesis 24
              exosomal secretion + 23
              extracellular exosome assembly + 7
paths to the root