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ONTOLOGY REPORT - ANNOTATIONS

Term:extracellular vesicle biogenesis
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Accession:GO:0140112 term browser browse the term
Definition:The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.
Synonyms:exact_synonym: extracellular vesicle assembly


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extracellular vesicle biogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrdc1 arrestin domain containing 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:27462458)		 UniProt
RGD		 PMID:27462458 GO_REF:0000024 NCBI chr 3:7,735,002...7,742,195
Ensembl chr 3:7,735,011...7,742,197 		JBrowse link
G Arrdc4 arrestin domain containing 4 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5804712|PMID:27462458)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:27462458 GO_REF:0000024 GO_REF:0000107 MGI:5804712 NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290 		JBrowse link
exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:19246649) RGD PMID:19246649 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family involved_in ISO (PMID:15634213) RGD PMID:15634213 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:23092844) RGD PMID:23092844 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829 		JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO MGI:4398911 (MGI:4367682|PMID:18617898) RGD PMID:18617898 MGI:4367682 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (MGI:5770036|PMID:25392495) RGD PMID:25392495 MGI:5770036 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd34 CD34 molecule involved_in ISO
ISS		 (PMID:21835908)
GO_REF:0000024		 RGD
UniProt		 PMID:21835908 GO_REF:0000024 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832 		JBrowse link
extracellular exosome biogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:25392495) RGD PMID:25392495 NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139 		JBrowse link
negative regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp9a ATPase phospholipid transporting 9A (putative) involved_in ISO (PMID:30947313) RGD PMID:30947313 NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO (PMID:26911690) RGD PMID:26911690 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:26911690) RGD PMID:26911690 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr13:22,907,105...22,932,200
Ensembl chr13:22,907,109...22,932,229 		JBrowse link
positive regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:24603074), (PMID:25392495)
(MGI:5770036|PMID:25392495)		 RGD PMID:24603074 PMID:25392495 MGI:5770036 NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139 		JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452 		JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate involved_in ISO
IEA		 (PMID:24105262)
GO_REF:0000107		 RGD
Ensembl		 PMID:24105262 GO_REF:0000107 NCBI chr10:105,739,617...105,757,838
Ensembl chr10:105,739,296...105,757,835 		JBrowse link
G Myo5b myosin Vb IMP RGD PMID:18984164 RGD:11533643 NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Sdc1 syndecan 1 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Sdc4 syndecan 4 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in IMP PMID:24743145 BHF-UCL PMID:24743145 RGD:10054083 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Snf8 SNF8 subunit of ESCRT-II involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr10:80,984,337...80,996,724
Ensembl chr10:80,984,363...80,996,734 		JBrowse link
G Stam signal transducing adaptor molecule involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr17:77,120,235...77,166,173
Ensembl chr17:77,120,158...77,166,467 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:22660413), (PMID:24105262) RGD PMID:22660413 PMID:24105262 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A involved_in ISO
IEA		 UniProtKB:O75351 (PMID:22660413)
GO_REF:0000107		 RGD
Ensembl		 PMID:22660413 GO_REF:0000107 NCBI chr19:34,934,999...34,948,267
Ensembl chr19:34,934,961...34,948,887 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO UniProtKB:Q9UN37 (PMID:22660413) RGD PMID:22660413 NCBI chr13:22,907,105...22,932,200
Ensembl chr13:22,907,109...22,932,229 		JBrowse link
positive regulation of extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Sdc1 syndecan 1 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Sdc4 syndecan 4 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572 		JBrowse link
regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp3 charged multivesicular body protein 3 NOT|involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
G Chmp6 charged multivesicular body protein 6 NOT|involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
regulation of extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Stam signal transducing adaptor molecule involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr17:77,120,235...77,166,173
Ensembl chr17:77,120,158...77,166,467 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19748
    cellular process 18161
      cellular component organization or biogenesis 6791
        cellular component biogenesis 3350
          extracellular vesicle biogenesis 26
            extracellular exosome biogenesis + 24
            extracellular microvesicle biogenesis 0
paths to the root