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ONTOLOGY REPORT - ANNOTATIONS

Term:exosomal secretion
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Accession:GO:1990182 term browser browse the term
Definition:The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
Synonyms:exact_synonym: exosomal secretory pathway;   extracellular vesicular exosome secretion;   multi-vesicular body fusion with plasma membrane;   secretion of exosome
 narrow_synonym: exosomal protein secretion
 never_in_taxon: NCBITaxon:4890 ! Ascomycota


show annotations for term's descendants           Sort by:
exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:19246649) RGD PMID:19246649 NCBI chr 5:13,975,198...13,993,391
Ensembl chr 5:9,192,100...9,210,731 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family involved_in ISO (PMID:15634213) RGD PMID:15634213 NCBI chr 8:74,118,922...74,141,760
Ensembl chr 8:65,222,949...65,246,525 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:23092844) RGD PMID:23092844 NCBI chr 8:82,663,373...82,717,267
Ensembl chr 8:73,782,694...73,847,829 		JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO MGI:4398911 (PMID:18617898) RGD PMID:18617898 NCBI chr13:33,904,710...33,950,100
Ensembl chr13:31,351,954...31,396,519 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in IEA
ISO		 GO_REF:0000107
(PMID:25392495)		 Ensembl
RGD		 PMID:25392495 GO_REF:0000107 NCBI chr 1:106,549,035...106,578,859
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
negative regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp9a ATPase phospholipid transporting 9A (putative) involved_in ISO (PMID:30947313) RGD PMID:30947313 NCBI chr 3:177,779,203...177,886,431
Ensembl chr 3:157,360,359...157,467,818 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
IEA		 (PMID:26911690)
GO_REF:0000107		 RGD
Ensembl		 PMID:26911690 GO_REF:0000107 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:26911690) RGD PMID:26911690 NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr13:23,421,758...23,446,848
Ensembl chr13:22,907,109...22,932,229 		JBrowse link
positive regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:24603074), (PMID:25392495)
(PMID:25392495)		 RGD PMID:24603074 PMID:25392495 NCBI chr 5:158,575,727...158,595,157
Ensembl chr 5:153,292,751...153,312,139 		JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 1:82,731,212...82,735,088
Ensembl chr 1:73,660,046...73,662,452 		JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate involved_in ISO
IEA		 (PMID:24105262)
GO_REF:0000107		 RGD
Ensembl		 PMID:24105262 GO_REF:0000107 NCBI chr10:106,237,988...106,256,174
Ensembl chr10:105,739,296...105,757,835 		JBrowse link
G Myo5b myosin Vb IMP RGD PMID:18984164 RGD:11533643 NCBI chr18:70,313,717...70,613,918
Ensembl chr18:68,038,759...68,338,745 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 8:122,469,223...122,524,993
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Sdc1 syndecan 1 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Sdc4 syndecan 4 involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 5:24,245,279...24,314,712
Ensembl chr 5:19,489,961...19,527,572 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in IMP PMID:24743145 BHF-UCL PMID:24743145 RGD:10054083 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Snf8 SNF8 subunit of ESCRT-II involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr10:81,481,054...81,493,430
Ensembl chr10:80,984,363...80,996,734 		JBrowse link
G Stam signal transducing adaptor molecule involved_in ISO (PMID:24105262) RGD PMID:24105262 NCBI chr17:82,028,779...82,074,717
Ensembl chr17:77,120,158...77,166,467 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO
IEA		 (PMID:22660413), (PMID:24105262)
GO_REF:0000107		 RGD
Ensembl		 PMID:22660413 PMID:24105262 GO_REF:0000107 NCBI chr 1:106,549,035...106,578,859
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A involved_in ISO
IEA		 UniProtKB:O75351 (PMID:22660413)
GO_REF:0000107		 RGD
Ensembl		 PMID:22660413 GO_REF:0000107 NCBI chr19:51,838,411...51,858,639
Ensembl chr19:34,934,961...34,948,887 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO UniProtKB:Q9UN37 (PMID:22660413) RGD PMID:22660413 NCBI chr13:23,421,758...23,446,848
Ensembl chr13:22,907,109...22,932,229 		JBrowse link
regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp3 charged multivesicular body protein 3 NOT|involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr 4:105,134,860...105,180,862
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
G Chmp6 charged multivesicular body protein 6 NOT|involved_in ISO (PMID:22660413) RGD PMID:22660413 NCBI chr10:105,690,400...105,696,070
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      vesicle-mediated transport 1652
        exocytosis 413
          exosomal secretion 23
            multivesicular body fusion to apical plasma membrane 0
            negative regulation of exosomal secretion 4
            positive regulation of exosomal secretion 15
            regulation of exosomal secretion + 19
Path 2
Term Annotations click to browse term
  biological_process 20546
    localization 5709
      establishment of localization 5057
        transport 4749
          secretion 1226
            secretion by cell 1030
              exocytosis 413
                exosomal secretion 23
                  multivesicular body fusion to apical plasma membrane 0
                  negative regulation of exosomal secretion 4
                  positive regulation of exosomal secretion 15
                  regulation of exosomal secretion + 19
paths to the root