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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of dendritic spine development
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Accession:GO:0060999 term browser browse the term
Definition:Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


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positive regulation of dendritic spine development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24328732) Alzheimers_University_of_Toronto
Ensembl		 PMID:24328732 GO_REF:0000107 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G ARF1 ARF GTPase 1 ISO RGD PMID:23889934 RGD:8553918 NCBI chr 1:203,484,803...203,501,395
Ensembl chr 1:208,695,615...208,712,105 		JBrowse link
G C22H21orf91 chromosome 22 C21orf91 homolog involved_in ISO (PMID:27404227) UniProt PMID:27404227 NCBI chr21:4,524,103...4,554,496
Ensembl chr21:17,888,992...17,918,985 		JBrowse link
G CAMK1 calcium/calmodulin dependent protein kinase I involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:9,708,782...9,721,433
Ensembl chr 3:9,945,609...9,959,560 		JBrowse link
G CDKL5 cyclin dependent kinase like 5 ISO RGD PMID:23671101 RGD:12791021 NCBI chr  X:11,047,357...11,261,172
Ensembl chr  X:18,492,329...18,638,735 		JBrowse link
G CFL1 cofilin 1 ISO RGD PMID:25723479 RGD:11570400 NCBI chr11:61,215,092...61,218,628
Ensembl chr11:64,544,275...64,550,806 		JBrowse link
G CPEB3 cytoplasmic polyadenylation element binding protein 3 involved_in ISO (PMID:22153079) UniProt PMID:22153079 NCBI chr10:88,794,186...89,038,808
Ensembl chr10:92,320,240...92,506,089 		JBrowse link
G CREBBP CREB binding protein ISO RGD PMID:32206715 RGD:126848802 NCBI chr16:2,645,445...2,800,975
Ensembl chr16:3,820,519...3,974,206 		JBrowse link
G DLG5 discs large MAGUK scaffold protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:74,311,249...74,447,312
Ensembl chr10:76,972,573...77,110,115 		JBrowse link
G EIF4G2 eukaryotic translation initiation factor 4 gamma 2 ISO RGD PMID:22514323 RGD:10755512 NCBI chr11:10,961,216...10,973,210
Ensembl chr11:10,656,795...10,668,956 		JBrowse link
G FMR1 fragile X messenger ribonucleoprotein 1 involved_in ISO (PMID:18539120) UniProt PMID:18539120 NCBI chr  X:136,937,889...136,976,828
Ensembl chr  X:147,365,748...147,405,321 		JBrowse link
G FOXO6 forkhead box O6 involved_in ISO (PMID:23222102) ParkinsonsUK-UCL PMID:23222102 NCBI chr 1:40,659,371...40,681,778 JBrowse link
G GRN granulin precursor ISO RGD PMID:21813674 RGD:5509044 NCBI chr17:13,046,329...13,054,236
Ensembl chr17:13,211,784...13,219,609 		JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K ISO RGD PMID:24990929 RGD:10002784 NCBI chr 9:40,898,593...40,911,159
Ensembl chr 9:83,324,238...83,336,756 		JBrowse link
G IL2 interleukin 2 ISO RGD PMID:20225203 RGD:5147914 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G ITSN1 intersectin 1 ISO RGD PMID:19258322 RGD:13461864 NCBI chr21:20,009,385...20,266,835
Ensembl chr21:33,457,081...33,625,248 		JBrowse link
G LLPH LLP homolog, long-term synaptic facilitation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:22,777,107...22,784,862
Ensembl chr12:23,283,068...23,290,777 		JBrowse link
G LPAR1 lysophosphatidic acid receptor 1 ISO RGD PMID:16638019 RGD:2317707 NCBI chr 9:82,013,960...82,179,227
Ensembl chr 9:110,179,600...110,279,038 		JBrowse link
G MAPK6 mitogen-activated protein kinase 6 acts_upstream_of_or_within ISO (PMID:22508986) MGI PMID:22508986 NCBI chr15:30,946,218...31,007,987
Ensembl chr15:49,273,095...49,335,754 		JBrowse link
G MAPKAPK5 MAPK activated protein kinase 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22508986) Ensembl
MGI		 PMID:22508986 GO_REF:0000107 NCBI chr12:109,416,610...109,471,729
Ensembl chr12:112,812,769...112,863,595 		JBrowse link
G MECP2 methyl-CpG binding protein 2 ISO RGD PMID:24188180 RGD:12789443 NCBI chr  X:143,571,864...143,647,192
Ensembl chr  X:153,465,204...153,527,854 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO RGD PMID:21683721 RGD:10040994 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841 		JBrowse link
G NEURL1 neuralized E3 ubiquitin protein ligase 1 involved_in ISO (PMID:22153079) UniProt PMID:22153079 NCBI chr10:100,093,614...100,192,485 JBrowse link
G NLGN1 neuroligin 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15681343 GO_REF:0000107 RGD:8553420 NCBI chr 3:170,416,885...171,333,094
Ensembl chr 3:178,810,253...179,503,756 		JBrowse link
G NLGN2 neuroligin 2 ISO RGD PMID:15681343 RGD:8553420 NCBI chr17:7,438,853...7,454,014 JBrowse link
G NLGN3 neuroligin 3 ISO RGD PMID:15681343 RGD:8553420 NCBI chr  X:60,413,098...60,439,359
Ensembl chr  X:70,469,764...70,496,526 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:22509272 RGD:7174739 NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269 		JBrowse link
G PALM paralemmin involved_in ISO (PMID:18287537) UniProt PMID:18287537 NCBI chr19:386,417...427,178
Ensembl chr19:693,853...713,465 		JBrowse link
G PBRM1 polybromo 1 ISO RGD PMID:31723243 RGD:150340632 NCBI chr 3:52,487,083...52,626,418
Ensembl chr 3:53,718,051...53,850,146 		JBrowse link
G PPP1R9A protein phosphatase 1 regulatory subunit 9A ISO RGD PMID:12052877 RGD:1299363 NCBI chr 7:86,863,919...87,251,634
Ensembl chr 7:100,455,357...100,833,220 		JBrowse link
G PSEN1 presenilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876 		JBrowse link
G RAC1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (PMID:25865668) MGI PMID:25865668 NCBI chr 7:7,039,379...7,068,866 JBrowse link
G SHANK1 SH3 and multiple ankyrin repeat domains 1 involved_in ISO PMID:18287537 UniProt PMID:18287537 RGD:8553517 NCBI chr19:47,623,474...47,684,476
Ensembl chr19:56,526,577...56,580,442 		JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 involved_in ISO (PMID:21795692) BHF-UCL PMID:21795692 NCBI chr22:30,951,866...30,973,608 JBrowse link
G TSC2 TSC complex subunit 2 ISO RGD PMID:16595860 RGD:11568665 NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569 		JBrowse link
G ZMYND8 zinc finger MYND-type containing 8 ISO RGD PMID:24117785 RGD:8554267 NCBI chr20:43,540,819...43,701,322
Ensembl chr20:44,624,487...44,772,032 		JBrowse link
positive regulation of dendritic spine morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTR2 actin related protein 2 ISO RGD PMID:23441206 RGD:11530033 NCBI chr2A:65,289,675...65,333,219
Ensembl chr2A:66,413,011...66,456,857 		JBrowse link
G ACTR3 actin related protein 3 ISO RGD PMID:23441206 RGD:11530033 NCBI chr2B:827,184...900,424
Ensembl chr2B:114,373,392...114,445,729 		JBrowse link
G AFDN afadin, adherens junction formation factor ISO RGD PMID:22948147 RGD:13838731 NCBI chr 6:165,778,026...165,923,685
Ensembl chr 6:170,775,904...170,882,784 		JBrowse link
G BAIAP2 BAR/IMD domain containing adaptor protein 2 ISO RGD PMID:15673667 RGD:9684988 NCBI chr17:75,460,491...75,542,700
Ensembl chr17:81,187,021...81,269,714 		JBrowse link
G CAMK2B calcium/calmodulin dependent protein kinase II beta involved_in ISO PMID:12873385 UniProt PMID:12873385 RGD:8553829 NCBI chr 7:44,930,859...45,040,078
Ensembl chr 7:45,001,267...45,110,342 		JBrowse link
G CAPRIN1 cell cycle associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:34,023,981...34,079,335
Ensembl chr11:33,902,072...33,957,134 		JBrowse link
G CAPRIN2 caprin family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:55,529,976...55,575,375
Ensembl chr12:58,157,568...58,202,690 		JBrowse link
G CASK calcium/calmodulin dependent serine protein kinase ISO RGD PMID:18606847 RGD:11576294 NCBI chr  X:33,967,329...34,374,385
Ensembl chr  X:41,659,295...42,066,570 		JBrowse link
G CUX2 cut like homeobox 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:108,600,286...108,975,588
Ensembl chr12:112,175,555...112,311,221 		JBrowse link
G DBN1 drebrin 1 involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:19174472 GO_REF:0000107 GO_REF:0000118 RGD:10398809 NCBI chr 5:172,758,316...172,774,974
Ensembl chr 5:179,820,791...179,836,872 		JBrowse link
G DBNL drebrin like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:44,753,062...44,775,717
Ensembl chr 7:44,824,608...44,845,891 		JBrowse link
G DHX36 DEAH-box helicase 36 involved_in ISO PMID:23651854 UniProt PMID:23651854 RGD:13792545 NCBI chr 3:151,331,468...151,382,406
Ensembl chr 3:158,885,541...158,935,871 		JBrowse link
G DNM1L dynamin 1 like ISO RGD PMID:19605646 RGD:7800727 NCBI chr12:53,476,553...53,541,421
Ensembl chr12:56,077,504...56,142,376 		JBrowse link
G EEF2K eukaryotic elongation factor 2 kinase ISO RGD PMID:20427644 RGD:10401235 NCBI chr16:16,443,579...16,526,061
Ensembl chr16:22,537,518...22,596,091 		JBrowse link
G EPHB2 EPH receptor B2 ISO RGD PMID:21364901 RGD:127285794 NCBI chr 1:21,895,961...22,107,649
Ensembl chr 1:22,912,570...23,047,118 		JBrowse link
G GPRASP3 G protein-coupled receptor associated sorting protein family member 3 involved_in ISO (PMID:21199326) UniProt PMID:21199326 NCBI chr  X:91,944,691...91,978,289 JBrowse link
G IL1RAPL1 interleukin 1 receptor accessory protein like 1 involved_in ISO (PMID:21940441) BHF-UCL PMID:21940441 NCBI chr  X:21,180,693...22,548,122
Ensembl chr  X:28,950,521...30,109,286 		JBrowse link
G ITPKA inositol-trisphosphate 3-kinase A acts_upstream_of_or_within ISO PMID:19890013 MGI PMID:19890013 RGD:8553536 NCBI chr15:20,434,532...20,444,389
Ensembl chr15:38,675,600...38,684,779 		JBrowse link
G KALRN kalirin RhoGEF kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19625617) Ensembl
MGI		 PMID:19625617 GO_REF:0000107 NCBI chr 3:121,138,136...121,828,723
Ensembl chr 3:128,225,413...128,720,441 		JBrowse link
G LRP8 LDL receptor related protein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:52,515,534...52,600,390
Ensembl chr 1:54,114,909...54,199,452 		JBrowse link
G MAPRE3 microtubule associated protein RP/EB family member 3 ISO RGD PMID:31092585 RGD:597538596 NCBI chr2A:26,970,010...27,026,223
Ensembl chr2A:27,102,780...27,115,223 		JBrowse link
G MARCKS myristoylated alanine rich protein kinase C substrate ISO RGD PMID:16202710 RGD:9685333 NCBI chr 6:111,647,847...111,653,821 JBrowse link
G MFN1 mitofusin 1 ISO RGD PMID:19605646 RGD:7800727 NCBI chr 3:176,378,175...176,423,943
Ensembl chr 3:184,552,108...184,596,763 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:19605646 RGD:7800727 NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase ISO RGD PMID:19605646 RGD:7800727 NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358 		JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:2,584,349...2,676,928
Ensembl chr17:2,590,007...2,680,994 		JBrowse link
G PAK3 p21 (RAC1) activated kinase 3 ISO RGD PMID:18481281 RGD:7775053 NCBI chr  X:100,060,647...100,345,491
Ensembl chr  X:110,672,664...110,797,992 		JBrowse link
G PTPRD protein tyrosine phosphatase receptor type D involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:8,113,171...10,420,732
Ensembl chr 9:8,288,569...8,831,227 		JBrowse link
G RELN reelin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:95,464,285...95,984,813
Ensembl chr 7:108,208,344...108,728,037 		JBrowse link
G SLC30A1 solute carrier family 30 member 1 ISO RGD PMID:25319628 RGD:11057402 NCBI chr 1:187,139,544...187,147,113 JBrowse link
G SRCIN1 SRC kinase signaling inhibitor 1 ISO RGD PMID:31092585 RGD:597538596 NCBI chr17:18,666,094...18,742,015
Ensembl chr17:18,942,084...19,015,744 		JBrowse link
G STAU2 staufen double-stranded RNA binding protein 2 ISO RGD PMID:16418534 RGD:10043163 NCBI chr 8:69,958,735...70,283,591
Ensembl chr 8:71,606,583...71,929,167 		JBrowse link
G TIAM1 TIAM Rac1 associated GEF 1 ISO RGD PMID:16474385 RGD:10043325 NCBI chr21:17,483,273...17,925,301
Ensembl chr21:30,868,308...31,016,883 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19317
    developmental process 6680
      positive regulation of developmental process 1472
        positive regulation of dendritic spine development 69
          positive regulation of dendritic spine morphogenesis 33
Path 2
Term Annotations click to browse term
  biological_process 19317
    developmental process 6680
      anatomical structure development 6261
        multicellular organism development 5028
          system development 4369
            nervous system development 2737
              neurogenesis 2028
                generation of neurons 1753
                  neuron differentiation 1668
                    neuron development 1370
                      neuron projection development 1202
                        dendrite development 332
                          dendritic spine development 139
                            regulation of dendritic spine development 90
                              positive regulation of dendritic spine development 69
                                positive regulation of dendritic spine morphogenesis 33
paths to the root