FMR1 (FMRP translational regulator 1) - Rat Genome Database

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Gene: FMR1 (FMRP translational regulator 1) Pan paniscus
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Symbol: FMR1
Name: FMRP translational regulator 1
RGD ID: 11985828
Description: ENCODES a protein that exhibits chromatin binding (ortholog); dynein complex binding (ortholog); G-quadruplex RNA binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); cellular response to DNA damage stimulus (ortholog); cellular response to hydroxyurea (ortholog); ASSOCIATED WITH anxiety disorder (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); Cajal body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: fragile X mental retardation 1; fragile X mental retardation protein 1; fragile X mental retardation protein 1 homolog; synaptic functional regulator FMR1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X147,366,713 - 147,405,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX147,365,748 - 147,405,321 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X136,937,889 - 136,976,828 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterograde axonal transport  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to hydroxyurea  (ISO)
cellular response to monosodium glutamate  (ISO)
cellular response to potassium ion  (ISO)
cellular response to UV  (ISO)
cellular response to virus  (ISO)
central nervous system development  (ISO)
dendritic spine development  (ISO)
detection of mechanical stimulus involved in sensory perception  (ISO)
excitatory chemical synaptic transmission  (ISO)
glutamate receptor signaling pathway  (ISO)
inhibitory chemical synaptic transmission  (ISO)
modulation by host of viral RNA genome replication  (ISO)
mRNA transport  (ISO)
negative regulation of cytoplasmic translation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of long-term synaptic depression  (ISO)
negative regulation of mRNA catabolic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of protein processing  (ISO)
negative regulation of receptor internalization  (ISO)
negative regulation of synaptic vesicle exocytosis  (ISO)
negative regulation of translation  (ISO)
negative regulation of translational initiation  (ISO)
negative regulation of voltage-gated calcium channel activity  (ISO)
ovarian follicle development  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gene silencing by miRNA  (ISO)
positive regulation of histone phosphorylation  (ISO)
positive regulation of intracellular transport of viral material  (ISO)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of long-term synaptic depression  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of mRNA binding  (ISO)
positive regulation of proteasomal protein catabolic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of response to DNA damage stimulus  (ISO)
positive regulation of synaptic transmission  (ISO)
positive regulation of translation  (ISO)
regulation of alternative mRNA splicing, via spliceosome  (ISO)
regulation of dendritic spine development  (ISO)
regulation of filopodium assembly  (ISO)
regulation of gene silencing by miRNA  (ISO)
regulation of modification of synaptic structure  (ISO)
regulation of mRNA stability  (ISO)
regulation of neuronal action potential  (ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of translation at postsynapse, modulating synaptic transmission  (ISO)
regulation of translation at presynapse, modulating synaptic transmission  (ISO)
response to activity  (ISO)
response to cocaine  (ISO)
response to electrical stimulus  (ISO)
response to gonadotropin  (ISO)
response to interleukin-1  (ISO)
response to interleukin-17  (ISO)
response to light stimulus  (ISO)
social behavior  (ISO)
transmission of nerve impulse  (ISO)

References

Genomics

Comparative Map Data
FMR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X147,366,713 - 147,405,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX147,365,748 - 147,405,321 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X136,937,889 - 136,976,828 (+)NCBIMhudiblu_PPA_v0panPan3
FMR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX147,911,919 - 147,951,125 (+)EnsemblGRCh38hg38GRCh38
GRCh38X147,911,919 - 147,951,125 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X146,993,437 - 147,032,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X146,801,201 - 146,840,303 (+)NCBINCBI36hg18NCBI36
Build 34X146,699,054 - 146,738,157NCBI
CeleraX147,345,446 - 147,384,585 (+)NCBI
Cytogenetic MapXq27.3NCBI
HuRefX135,963,879 - 135,993,282 (+)NCBIHuRef
CHM1_1X146,904,323 - 146,943,501 (+)NCBICHM1_1
Fmr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X67,722,142 - 67,761,569 (+)NCBIGRCm39mm39
GRCm39 EnsemblX67,722,147 - 67,761,569 (+)Ensembl
GRCm38X68,678,536 - 68,717,963 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX68,678,541 - 68,717,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X65,931,730 - 65,971,138 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X51,835,932 - 51,875,340 (+)NCBImm8
MGSCv36X64,939,220 - 64,978,628 (+)NCBImm8
Cytogenetic MapXA7.1NCBI
cM MapX34.83NCBI
Fmr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X147,240,239 - 147,278,057 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX147,240,301 - 147,278,050 (+)Ensembl
Rnor_6.0X154,684,924 - 154,722,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX154,684,935 - 154,722,314 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01150,408,220 - 150,445,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X154,756,031 - 154,793,782 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X154,829,463 - 154,867,215 (+)NCBI
Celera1134,092,390 - 134,130,141 (-)NCBICelera
Cytogenetic MapXq37NCBI
Fmr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955498566,688 - 595,360 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955498566,741 - 594,837 (+)NCBIChiLan1.0ChiLan1.0
FMR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X116,249,079 - 116,287,008 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX116,249,142 - 116,321,439 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX102,141,952 - 102,179,858 (+)NCBI
ROS_Cfam_1.0X118,308,237 - 118,346,144 (+)NCBI
UMICH_Zoey_3.1X115,421,122 - 115,459,027 (+)NCBI
UNSW_CanFamBas_1.0X117,632,687 - 117,670,590 (+)NCBI
UU_Cfam_GSD_1.0X117,359,050 - 117,396,958 (+)NCBI
Fmr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X114,286,773 - 114,324,847 (+)NCBI
SpeTri2.0NW_0049365131,290,038 - 1,327,850 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FMR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX120,361,229 - 120,399,835 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X120,361,232 - 120,400,282 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X137,792,642 - 137,831,753 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X122,635,383 - 122,674,298 (+)NCBIChlSab1.1chlSab2
ChlSab1.1X122,635,383 - 122,674,298 (+)NCBIChlSab1.1chlSab2
ChlSab1.1X122,635,383 - 122,674,298 (+)NCBIChlSab1.1chlSab2
ChlSab1.1X122,635,383 - 122,674,298 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX122,635,439 - 122,674,355 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606560,266,278 - 60,318,872 (+)NCBIVero_WHO_p1.0
Fmr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624883645,524 - 681,705 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000061854   ⟹   ENSPPAP00000038945
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX147,365,748 - 147,405,321 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000061858   ⟹   ENSPPAP00000038949
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX147,365,748 - 147,405,321 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000061883   ⟹   ENSPPAP00000038974
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX147,366,744 - 147,403,036 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000061887   ⟹   ENSPPAP00000038978
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX147,366,744 - 147,387,969 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000061891   ⟹   ENSPPAP00000038982
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX147,366,744 - 147,379,595 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000061893   ⟹   ENSPPAP00000038984
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX147,366,744 - 147,367,336 (+)Ensembl
RefSeq Acc Id: XM_003806816   ⟹   XP_003806864
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,405,327 (+)NCBI
Mhudiblu_PPA_v0X136,937,935 - 136,976,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003806817   ⟹   XP_003806865
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,405,268 (+)NCBI
Mhudiblu_PPA_v0X136,937,971 - 136,976,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003806818   ⟹   XP_003806866
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,405,268 (+)NCBI
Mhudiblu_PPA_v0X136,937,889 - 136,976,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008957796   ⟹   XP_008956044
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,403,050 (+)NCBI
Mhudiblu_PPA_v0X136,937,971 - 136,976,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008957799   ⟹   XP_008956047
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,405,327 (+)NCBI
Mhudiblu_PPA_v0X136,937,971 - 136,976,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008957813   ⟹   XP_008956061
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,403,050 (+)NCBI
Mhudiblu_PPA_v0X136,937,971 - 136,976,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008957819   ⟹   XP_008956067
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,405,327 (+)NCBI
Mhudiblu_PPA_v0X136,937,971 - 136,976,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008957822   ⟹   XP_008956070
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,405,327 (+)NCBI
Mhudiblu_PPA_v0X136,937,970 - 136,976,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008957826   ⟹   XP_008956074
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,403,050 (+)NCBI
Mhudiblu_PPA_v0X136,937,971 - 136,976,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008957838   ⟹   XP_008956086
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,402,833 (+)NCBI
Mhudiblu_PPA_v0X136,937,971 - 136,974,360 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008957845   ⟹   XP_008956093
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,405,327 (+)NCBI
Mhudiblu_PPA_v0X136,937,971 - 136,976,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014343569   ⟹   XP_014199055
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1X147,366,713 - 147,399,100 (+)NCBI
Mhudiblu_PPA_v0X136,937,971 - 136,970,522 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_003806864   ⟸   XM_003806816
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008956047   ⟸   XM_008957799
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008956067   ⟸   XM_008957819
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008956070   ⟸   XM_008957822
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_008956093   ⟸   XM_008957845
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_003806866   ⟸   XM_003806818
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_003806865   ⟸   XM_003806817
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008956044   ⟸   XM_008957796
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008956061   ⟸   XM_008957813
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008956074   ⟸   XM_008957826
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_008956086   ⟸   XM_008957838
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_014199055   ⟸   XM_014343569
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: ENSPPAP00000038982   ⟸   ENSPPAT00000061891
RefSeq Acc Id: ENSPPAP00000038984   ⟸   ENSPPAT00000061893
RefSeq Acc Id: ENSPPAP00000038949   ⟸   ENSPPAT00000061858
RefSeq Acc Id: ENSPPAP00000038945   ⟸   ENSPPAT00000061854
RefSeq Acc Id: ENSPPAP00000038978   ⟸   ENSPPAT00000061887
RefSeq Acc Id: ENSPPAP00000038974   ⟸   ENSPPAT00000061883


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041836 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000038945 ENTREZGENE
  ENSPPAP00000038949 ENTREZGENE
  ENSPPAP00000038974 ENTREZGENE
NCBI Gene FMR1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-27 FMR1  FMRP translational regulator 1  FMR1  fragile X mental retardation 1  Symbol and/or name change 5135510 APPROVED