EPHB2 (EPH receptor B2) - Rat Genome Database

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Gene: EPHB2 (EPH receptor B2) Pan paniscus
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Symbol: EPHB2
Name: EPH receptor B2
RGD ID: 11895883
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); axon guidance receptor activity (ortholog); ephrin receptor activity (ortholog); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); axon guidance (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; syndecan signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anorectal Malformations (ortholog); Candidemia (ortholog); FOUND IN axon (ortholog); cell surface (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: ephrin type-B receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,914,584 - 23,054,752 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,912,570 - 23,047,118 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ morphogenesis  (ISO)
axon guidance  (ISO)
axonal fasciculation  (ISO)
B cell activation  (ISO)
camera-type eye morphogenesis  (ISO)
cell morphogenesis  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (ISO)
central nervous system projection neuron axonogenesis  (ISO)
commissural neuron axon guidance  (ISO)
corpus callosum development  (ISO)
dendritic spine development  (ISO)
dendritic spine morphogenesis  (ISO)
ephrin receptor signaling pathway  (ISO)
hindbrain tangential cell migration  (ISO)
inner ear morphogenesis  (ISO)
learning  (ISO)
learning or memory  (ISO)
negative regulation of axonogenesis  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of NMDA glutamate receptor activity  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of Ras protein signal transduction  (ISO)
neuron projection retraction  (ISO)
optic nerve morphogenesis  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
phosphorylation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of NMDA glutamate receptor activity  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of synaptic plasticity  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
postsynaptic membrane assembly  (ISO)
protein phosphorylation  (ISO)
regulation of axonogenesis  (ISO)
regulation of behavioral fear response  (ISO)
regulation of blood coagulation  (ISO)
regulation of body fluid levels  (ISO)
regulation of filopodium assembly  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of synapse assembly  (ISO)
regulation of T-helper 17 type immune response  (ISO)
retinal ganglion cell axon guidance  (ISO)
roof of mouth development  (ISO)
tight junction assembly  (ISO)
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (ISO)
urogenital system development  (ISO)
vesicle-mediated intercellular transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
EPHB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,914,584 - 23,054,752 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,912,570 - 23,047,118 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBIMhudiblu_PPA_v0panPan3
EPHB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl122,710,839 - 22,921,500 (+)EnsemblGRCh38hg38GRCh38
GRCh38122,710,770 - 22,921,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37123,037,331 - 23,247,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,909,918 - 23,114,410 (+)NCBINCBI36hg18NCBI36
Celera121,361,651 - 21,563,983 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef121,351,920 - 21,485,793 (+)NCBIHuRef
CHM1_1123,149,831 - 23,354,155 (+)NCBICHM1_1
Ephb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394136,374,850 - 136,563,637 (-)NCBIGRCm39mm39
GRCm39 Ensembl4136,374,850 - 136,563,299 (-)Ensembl
GRCm384136,647,536 - 136,836,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,647,539 - 136,835,988 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,209,523 - 136,391,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv364135,925,684 - 136,108,011 (-)NCBImm8
Celera4134,853,290 - 135,040,552 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.0NCBI
Ephb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25148,889,574 - 149,077,027 (-)NCBI
Rnor_6.0 Ensembl5155,022,493 - 155,204,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05155,024,478 - 155,143,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05158,789,192 - 158,907,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05156,786,985 - 156,811,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45155,423,035 - 155,605,384 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5147,297,353 - 147,415,432 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ephb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,844,713 - 2,980,445 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,844,713 - 2,986,790 (+)NCBIChiLan1.0ChiLan1.0
EPHB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,427,112 - 76,551,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,428,203 - 76,612,786 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,932,009 - 73,056,438 (-)NCBI
ROS_Cfam_1.0276,986,320 - 77,110,768 (-)NCBI
UMICH_Zoey_3.1273,807,403 - 73,931,772 (-)NCBI
UNSW_CanFamBas_1.0274,815,673 - 74,940,002 (-)NCBI
UU_Cfam_GSD_1.0275,819,294 - 75,943,710 (-)NCBI
Ephb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505842,251,873 - 42,378,453 (+)NCBI
SpeTri2.0NW_0049364748,109,800 - 8,203,106 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,649,143 - 80,843,567 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,649,098 - 80,849,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,689,973 - 74,878,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120109,747,883 - 109,954,936 (-)NCBI
ChlSab1.1 Ensembl20109,746,925 - 109,890,777 (-)Ensembl
Vero_WHO_p1.0NW_0236660336,358,996 - 6,570,523 (+)NCBI
Ephb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247647,421,818 - 7,599,800 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000042320   ⟹   ENSPPAP00000019552
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl122,912,570 - 23,047,118 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042322   ⟹   ENSPPAP00000019554
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl122,912,570 - 23,016,223 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042325   ⟹   ENSPPAP00000019557
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl122,913,767 - 23,045,852 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042337   ⟹   ENSPPAP00000019569
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl122,914,900 - 23,024,653 (+)Ensembl
RefSeq Acc Id: XM_034957849   ⟹   XP_034813740
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBI
RefSeq Acc Id: XM_034957854   ⟹   XP_034813745
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBI
RefSeq Acc Id: XM_034957860   ⟹   XP_034813751
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0121,895,962 - 22,101,474 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034813740 (Get FASTA)   NCBI Sequence Viewer  
  XP_034813745 (Get FASTA)   NCBI Sequence Viewer  
  XP_034813751 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034813740   ⟸   XM_034957849
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034813745   ⟸   XM_034957854
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034813751   ⟸   XM_034957860
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000019554   ⟸   ENSPPAT00000042322
RefSeq Acc Id: ENSPPAP00000019557   ⟸   ENSPPAT00000042325
RefSeq Acc Id: ENSPPAP00000019552   ⟸   ENSPPAT00000042320
RefSeq Acc Id: ENSPPAP00000019569   ⟸   ENSPPAT00000042337


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032919 Ensembl, ENTREZGENE
NCBI Gene EPHB2 ENTREZGENE