EPHB2 (EPH receptor B2) - Rat Genome Database

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Pathways
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Gene: EPHB2 (EPH receptor B2) Pan paniscus
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Symbol: EPHB2
Name: EPH receptor B2
RGD ID: 11895883
Description: ENCODES a protein that exhibits amyloid-beta binding (inferred); ATP binding (inferred); axon guidance receptor activity (inferred); INVOLVED IN animal organ morphogenesis (ortholog); axon guidance (ortholog); axonogenesis (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; syndecan signaling pathway; ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); Alzheimer's disease (ortholog); Anorectal Malformations (ortholog); FOUND IN cell surface (ortholog); dendrite (ortholog); dendritic spine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ephrin type-B receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21204,032,188 - 204,237,048 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11203,128,354 - 203,340,056 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,914,584 - 23,054,752 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,912,570 - 23,047,118 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
animal organ morphogenesis  (IEA,ISO)
axon guidance  (IEA,ISO)
axonal fasciculation  (IEA)
axonogenesis  (IEA,ISO)
B cell activation  (IEA)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
camera-type eye morphogenesis  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA,ISO)
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (ISO)
central nervous system projection neuron axonogenesis  (IEA,ISO)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
commissural neuron axon guidance  (IEA)
corpus callosum development  (IEA)
dendritic spine development  (IEA)
dendritic spine morphogenesis  (IEA,ISO)
ephrin receptor signaling pathway  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
hepatocyte growth factor receptor signaling pathway  (IEA)
hindbrain tangential cell migration  (ISO)
inner ear morphogenesis  (IEA)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
learning  (IEA,ISO)
learning or memory  (IEA)
macrophage colony-stimulating factor signaling pathway  (IEA)
negative regulation of axonogenesis  (IEA,ISO)
negative regulation of cell adhesion  (IEA)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA)
negative regulation of NMDA glutamate receptor activity  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of Ras protein signal transduction  (IEA)
neuron projection retraction  (IEA)
optic nerve morphogenesis  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (ISO)
phosphorylation  (ISO)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of B cell proliferation  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (IEA)
positive regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (IEA)
positive regulation of NMDA glutamate receptor activity  (ISO)
positive regulation of protein localization to cell surface  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of synapse assembly  (IEA,ISO)
positive regulation of synaptic plasticity  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
postsynaptic membrane assembly  (ISO)
protein phosphorylation  (ISO)
regulation of autophagosome assembly  (IEA,ISO)
regulation of axonogenesis  (IEA,ISO)
regulation of behavioral fear response  (ISO)
regulation of blood coagulation  (IEA)
regulation of body fluid levels  (IEA)
regulation of filopodium assembly  (ISO)
regulation of neuronal synaptic plasticity  (IEA,ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of synapse assembly  (IEA)
regulation of T-helper 17 type immune response  (ISO)
retinal ganglion cell axon guidance  (IEA,ISO)
roof of mouth development  (IEA)
system development  (IEA)
tight junction assembly  (ISO)
urogenital system development  (IEA)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)
vesicle-mediated intercellular transport  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EPHB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21204,032,188 - 204,237,048 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11203,128,354 - 203,340,056 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,914,584 - 23,054,752 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,912,570 - 23,047,118 (+)Ensemblpanpan1.1panPan2
EPHB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,710,838 - 22,921,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl122,710,839 - 22,921,500 (+)EnsemblGRCh38hg38GRCh38
GRCh37123,037,331 - 23,247,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,909,918 - 23,114,410 (+)NCBINCBI36Build 36hg18NCBI36
Celera121,361,651 - 21,563,983 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef121,351,920 - 21,485,793 (+)NCBIHuRef
CHM1_1123,149,831 - 23,354,155 (+)NCBICHM1_1
T2T-CHM13v2.0122,535,722 - 22,747,006 (+)NCBIT2T-CHM13v2.0
Ephb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394136,374,850 - 136,563,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4136,374,850 - 136,563,299 (-)EnsemblGRCm39 Ensembl
GRCm384136,647,536 - 136,836,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,647,539 - 136,835,988 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,209,523 - 136,391,850 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364135,925,684 - 136,108,011 (-)NCBIMGSCv36mm8
Celera4134,853,290 - 135,040,552 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.0NCBI
Ephb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,179,065 - 154,360,459 (-)NCBIGRCr8
mRatBN7.25148,889,574 - 149,077,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,897,246 - 149,077,059 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5151,593,352 - 151,774,684 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05153,367,634 - 153,548,972 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05153,349,643 - 153,530,963 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,024,478 - 155,143,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,022,493 - 155,204,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05156,786,985 - 156,811,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05158,789,192 - 158,907,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45155,423,035 - 155,605,384 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5147,297,353 - 147,415,432 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ephb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,844,713 - 2,980,445 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,844,713 - 2,986,790 (+)NCBIChiLan1.0ChiLan1.0
EPHB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,427,112 - 76,551,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,428,203 - 76,612,786 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,932,009 - 73,056,438 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,986,320 - 77,110,768 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,985,696 - 77,172,430 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,807,403 - 73,931,772 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,815,673 - 74,940,002 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,819,294 - 75,943,710 (-)NCBIUU_Cfam_GSD_1.0
Ephb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505842,251,873 - 42,378,453 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364748,109,031 - 8,203,106 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364748,109,800 - 8,203,106 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,650,740 - 80,843,567 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,649,098 - 80,849,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,689,973 - 74,878,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120109,747,883 - 109,954,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20109,746,925 - 109,890,777 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660336,358,996 - 6,570,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ephb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247647,421,862 - 7,593,482 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247647,421,818 - 7,599,800 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000042320   ⟹   ENSPPAP00000019552
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl122,912,570 - 23,047,118 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042322   ⟹   ENSPPAP00000019554
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl122,912,570 - 23,016,223 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042325   ⟹   ENSPPAP00000019557
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl122,913,767 - 23,045,852 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042337   ⟹   ENSPPAP00000019569
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl122,914,900 - 23,024,653 (+)Ensembl
RefSeq Acc Id: XM_034957849   ⟹   XP_034813740
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21204,032,188 - 204,237,048 (-)NCBI
NHGRI_mPanPan11203,128,354 - 203,340,056 (-)NCBI
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBI
RefSeq Acc Id: XM_034957854   ⟹   XP_034813745
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21204,032,188 - 204,237,047 (-)NCBI
NHGRI_mPanPan11203,128,354 - 203,340,055 (-)NCBI
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBI
RefSeq Acc Id: XM_034957860   ⟹   XP_034813751
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21204,032,188 - 204,236,999 (-)NCBI
NHGRI_mPanPan11203,135,184 - 203,339,983 (-)NCBI
Mhudiblu_PPA_v0121,895,962 - 22,101,474 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034813740 (Get FASTA)   NCBI Sequence Viewer  
  XP_034813745 (Get FASTA)   NCBI Sequence Viewer  
  XP_034813751 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000019552.1
  ENSPPAP00000019554.1
  ENSPPAP00000019557.1
  ENSPPAP00000019569.1
RefSeq Acc Id: XP_034813740   ⟸   XM_034957849
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AQB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034813745   ⟸   XM_034957854
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AQB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034813751   ⟸   XM_034957860
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AQB9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000019554   ⟸   ENSPPAT00000042322
Ensembl Acc Id: ENSPPAP00000019557   ⟸   ENSPPAT00000042325
Ensembl Acc Id: ENSPPAP00000019552   ⟸   ENSPPAT00000042320
Ensembl Acc Id: ENSPPAP00000019569   ⟸   ENSPPAT00000042337
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032919 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000042320.1 UniProtKB/TrEMBL
  ENSPPAT00000042322.1 UniProtKB/TrEMBL
  ENSPPAT00000042325.1 UniProtKB/TrEMBL
  ENSPPAT00000042337.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/TrEMBL
  EphB2_rcpt_lig-bd UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/TrEMBL
  Ephrin_rcpt_TKs UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/TrEMBL
NCBI Gene EPHB2 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/TrEMBL
  EPHRIN TYPE-B RECEPTOR 2 UniProtKB/TrEMBL
Pfam EphA2_TM UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
PIRSF TyrPK_ephrin_receptor UniProtKB/TrEMBL
PRINTS FNTYPEIII UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE EPH_LBD UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART EPH_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A2R9AQB7_PANPA UniProtKB/TrEMBL
  A0A2R9AQB9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AX16_PANPA UniProtKB/TrEMBL
  A0A2R9AX28_PANPA UniProtKB/TrEMBL