EEF2K (eukaryotic elongation factor 2 kinase)

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Gene: EEF2K (eukaryotic elongation factor 2 kinase) Pan paniscus

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Symbol:

EEF2K

Name:

eukaryotic elongation factor 2 kinase

RGD ID:

11834130

Description:

ENCODES a protein that exhibits elongation factor-2 kinase activity (ortholog); translation regulator activity (ortholog); INVOLVED IN cellular response to anoxia (ortholog); cellular response to brain-derived neurotrophic factor stimulus (ortholog); cellular response to calcium ion (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN dendritic spine (ortholog); glutamatergic synapse (ortholog); postsynaptic density (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	16	27,571,678 - 27,654,230 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	16,443,579 - 16,526,061 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	22,518,150 - 22,598,735 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	22,537,518 - 22,596,091 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

autistic disorder (ISO)

genetic disease (ISO)

lung adenocarcinoma (ISO)

mitochondrial complex III deficiency nuclear type 5 (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to anoxia (ISO)

cellular response to brain-derived neurotrophic factor stimulus (ISO)

cellular response to calcium ion (ISO)

cellular response to cAMP (ISO)

cellular response to insulin stimulus (ISO)

negative regulation of apoptotic process (ISO)

phosphorylation (IEA)

positive regulation of dendritic spine morphogenesis (ISO)

positive regulation of endocytosis (ISO)

positive regulation of synapse assembly (ISO)

protein autophosphorylation (IEA)

protein phosphorylation (IEA)

regulation of protein autophosphorylation (IEA)

regulation of translation at postsynapse (ISO)

response to ischemia (ISO)

response to prolactin (ISO)

Cellular Component

dendritic spine (ISO)

glutamatergic synapse (ISO)

postsynaptic density (ISO)

Molecular Function

ATP binding (IEA)

calcium ion binding (IEA)

calmodulin binding (IEA)

elongation factor-2 kinase activity (IEA,ISO)

kinase activity (IEA)

nucleotide binding (IEA)

protein serine/threonine kinase activity (IEA)

transferase activity (IEA)

translation regulator activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

References

Genomics

Comparative Map Data

EEF2K
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	16	27,571,678 - 27,654,230 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	16,443,579 - 16,526,061 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	22,518,150 - 22,598,735 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	22,537,518 - 22,596,091 (+)	Ensembl	panpan1.1		panPan2

EEF2K
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	22,206,278 - 22,288,738 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	22,206,278 - 22,288,738 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	22,217,599 - 22,300,059 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	22,125,093 - 22,207,567 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	22,125,256 - 22,205,452	NCBI
Celera	16	20,997,480 - 21,079,953 (+)	NCBI		Celera
Cytogenetic Map	16	p12.2	NCBI
HuRef	16	20,462,336 - 20,544,660 (+)	NCBI		HuRef
CHM1_1	16	22,091,272 - 22,173,735 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	21,928,475 - 22,010,936 (-)	NCBI		T2T-CHM13v2.0

Eef2k
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	120,442,080 - 120,506,441 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	120,442,054 - 120,506,673 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	120,842,642 - 120,907,219 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	120,842,831 - 120,907,450 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	127,986,397 - 128,047,515 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	120,634,032 - 120,695,150 (+)	NCBI		MGSCv36	mm8
Celera	7	120,755,613 - 120,816,599 (+)	NCBI		Celera
Cytogenetic Map	7	F2	NCBI

Eef2k
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	175,393,119 - 175,454,452 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	175,393,154 - 175,455,164 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	183,753,768 - 183,794,993 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	190,939,743 - 190,980,965 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	183,625,310 - 183,666,539 (+)	NCBI	Rnor_WKY
Rnor_6.0	1	190,780,211 - 190,839,926 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	190,780,236 - 190,842,324 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	197,704,669 - 197,766,058 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	179,712,404 - 179,754,345 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	179,832,738 - 179,895,924 (+)	NCBI
Celera	1	173,143,531 - 173,184,040 (+)	NCBI		Celera
Cytogenetic Map	1	q36	NCBI

Eef2k
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955493	865,830 - 922,765 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955493	865,830 - 922,765 (+)	NCBI	ChiLan1.0	ChiLan1.0

EEF2K
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	23,368,296 - 23,433,853 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	23,371,546 - 23,433,929 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	24,863,141 - 24,928,560 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	23,506,671 - 23,572,566 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	23,506,218 - 23,572,676 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	23,308,900 - 23,374,695 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	23,218,207 - 23,280,831 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	23,600,299 - 23,665,719 (-)	NCBI		UU_Cfam_GSD_1.0

Eef2k
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	119,053,057 - 119,105,538 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	7,160,134 - 7,207,377 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936501	7,160,134 - 7,205,231 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EEF2K
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	23,887,125 - 23,956,373 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	23,887,120 - 23,980,231 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	24,287,297 - 24,412,626 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EEF2K
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	19,871,669 - 19,957,471 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	19,871,310 - 19,957,395 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	9,911,761 - 9,997,341 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eef2k
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	7,606,655 - 7,666,206 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	7,606,576 - 7,668,771 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_034939879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034939880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_004666789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000052010 ⟹ ENSPPAP00000029162

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	16	22,537,518 - 22,596,091 (+)	Ensembl

RefSeq Acc Id:

XM_034939879 ⟹ XP_034795770

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1	16	27,571,678 - 27,654,230 (+)	NCBI
Mhudiblu_PPA_v0	16	16,443,579 - 16,526,061 (-)	NCBI

RefSeq Acc Id:

XM_034939880 ⟹ XP_034795771

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1	16	27,581,112 - 27,654,230 (+)	NCBI
Mhudiblu_PPA_v0	16	16,444,481 - 16,511,609 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_034795770	(Get FASTA)	NCBI Sequence Viewer
	XP_034795771	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_034795770 ⟸ XM_034939879

RefSeq Acc Id:

XP_034795771 ⟸ XM_034939880

RefSeq Acc Id:

ENSPPAP00000029162 ⟸ ENSPPAT00000052010

Protein Domains

Alpha-type protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000037581	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000029162.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000052010.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.10	UniProtKB/TrEMBL
	MHCK/EF2 kinase	UniProtKB/TrEMBL
InterPro	eEF-2K	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	MHCK_EF2_kinase	UniProtKB/TrEMBL
	Sel1-like	UniProtKB/TrEMBL
	TPR-like_helical_dom_sf	UniProtKB/TrEMBL
NCBI Gene	EEF2K	ENTREZGENE
PANTHER	EUKARYOTIC ELONGATION FACTOR 2 KINASE	UniProtKB/TrEMBL
	EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED	UniProtKB/TrEMBL
Pfam	Alpha_kinase	UniProtKB/TrEMBL
	Sel1	UniProtKB/TrEMBL
PIRSF	Elongation_factor_2_kinase	UniProtKB/TrEMBL
PROSITE	ALPHA_KINASE	UniProtKB/TrEMBL
SMART	Alpha_kinase	UniProtKB/TrEMBL
Superfamily-SCOP	HCP-like	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	A0A2R9BL84_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - PID (archival)