NLGN2 (neuroligin 2) - Rat Genome Database

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Gene: NLGN2 (neuroligin 2) Pan paniscus
Analyze
Symbol: NLGN2
Name: neuroligin 2
RGD ID: 11885073
Description: ENCODES a protein that exhibits cell adhesion molecule binding (inferred); identical protein binding (inferred); neurexin family protein binding (inferred); INVOLVED IN gephyrin clustering involved in postsynaptic density assembly (ortholog); insulin metabolic process (ortholog); jump response (ortholog); ASSOCIATED WITH common variable immunodeficiency (ortholog); congenital myasthenic syndrome 2A (ortholog); dyskeratosis congenita (ortholog); FOUND IN axon (ortholog); cell surface (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuroligin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,001,795 - 15,016,817 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,967,475 - 16,982,617 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,438,853 - 7,454,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,425,927 - 7,438,504 (+)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell adhesion  (IEA)
chemical synaptic transmission  (IEA)
gephyrin clustering involved in postsynaptic density assembly  (IEA,ISO)
inhibitory synapse assembly  (IEA)
insulin metabolic process  (ISO)
jump response  (ISO)
locomotory exploration behavior  (IEA)
modulation of chemical synaptic transmission  (IEA,ISO)
neuromuscular process controlling balance  (IEA)
neuron cell-cell adhesion  (IEA)
neurotransmitter-gated ion channel clustering  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of excitatory postsynaptic potential  (IEA)
positive regulation of inhibitory postsynaptic potential  (IEA)
positive regulation of insulin secretion  (ISO)
positive regulation of protein localization to synapse  (ISO)
positive regulation of synapse assembly  (ISO)
positive regulation of synaptic transmission, GABAergic  (IEA)
positive regulation of synaptic transmission, glutamatergic  (IEA)
positive regulation of synaptic vesicle clustering  (IEA)
positive regulation of t-SNARE clustering  (ISO)
postsynaptic density protein 95 clustering  (IEA)
postsynaptic membrane assembly  (IEA)
postsynaptic specialization assembly  (IEA)
presynapse assembly  (IEA,ISO)
presynaptic membrane assembly  (IEA)
protein localization to cell surface  (IEA,ISO)
protein localization to synapse  (IEA)
regulation of presynapse assembly  (ISO)
regulation of respiratory gaseous exchange by nervous system process  (IEA,ISO)
sensory perception of pain  (IEA)
social behavior  (ISO)
synapse assembly  (ISO)
synapse organization  (ISO)
synaptic transmission, GABAergic  (IEA,ISO)
synaptic vesicle endocytosis  (IEA)
terminal button organization  (ISO)
thigmotaxis  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NLGN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,001,795 - 15,016,817 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,967,475 - 16,982,617 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,438,853 - 7,454,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,425,927 - 7,438,504 (+)NCBIpanpan1.1PanPan1.1panPan2
NLGN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,404,653 - 7,419,860 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,404,874 - 7,419,860 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,311,164 - 7,323,179 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,252,226 - 7,263,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 34177,252,225 - 7,263,903NCBI
Celera177,337,380 - 7,349,064 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,205,598 - 7,217,206 (+)NCBIHuRef
CHM1_1177,320,590 - 7,332,275 (+)NCBICHM1_1
T2T-CHM13v2.0177,308,683 - 7,323,908 (+)NCBIT2T-CHM13v2.0
Nlgn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,713,949 - 69,728,610 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,713,948 - 69,728,610 (-)EnsemblGRCm39 Ensembl
GRCm381169,823,123 - 69,837,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,823,122 - 69,837,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,636,625 - 69,648,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,639,318 - 69,651,044 (-)NCBIMGSCv36mm8
Celera1177,384,083 - 77,395,807 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.89NCBI
Nlgn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,042,175 - 55,056,578 (-)NCBIGRCr8
mRatBN7.21054,544,461 - 54,557,854 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,544,588 - 54,558,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,206,968 - 59,220,379 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,695,535 - 58,708,946 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,203,207 - 54,216,624 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,431,586 - 56,444,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,431,573 - 56,444,847 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,176,705 - 56,189,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,646,081 - 56,678,060 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,659,705 - 56,691,680 (-)NCBI
Celera1053,698,870 - 53,712,041 (-)NCBICelera
Cytogenetic Map10q24NCBI
Nlgn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,504,974 - 9,520,059 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,504,974 - 9,520,059 (-)NCBIChiLan1.0ChiLan1.0
NLGN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,338,602 - 32,351,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,340,335 - 32,352,412 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,476,574 - 32,491,676 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,444,141 - 32,459,248 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,446,860 - 32,457,104 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,409,378 - 32,424,482 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,368,131 - 32,383,214 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,545,377 - 32,560,482 (+)NCBIUU_Cfam_GSD_1.0
Nlgn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,218,152 - 47,230,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595692,334 - 704,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595692,340 - 704,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLGN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,781,510 - 6,796,304 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,784,642 - 6,794,419 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,612,269 - 14,627,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlgn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,022,717 - 10,034,624 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,019,307 - 10,034,624 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_034941433   ⟹   XP_034797324
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21915,001,796 - 15,016,817 (+)NCBI
NHGRI_mPanPan11716,967,478 - 16,982,617 (+)NCBI
Mhudiblu_PPA_v0177,438,972 - 7,454,014 (+)NCBI
RefSeq Acc Id: XM_034941435   ⟹   XP_034797326
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21915,001,796 - 15,016,817 (+)NCBI
NHGRI_mPanPan11716,967,478 - 16,982,617 (+)NCBI
Mhudiblu_PPA_v0177,438,972 - 7,454,014 (+)NCBI
RefSeq Acc Id: XM_034941436   ⟹   XP_034797327
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21915,001,796 - 15,016,817 (+)NCBI
NHGRI_mPanPan11716,969,963 - 16,982,617 (+)NCBI
Mhudiblu_PPA_v0177,441,348 - 7,454,014 (+)NCBI
RefSeq Acc Id: XM_034941437   ⟹   XP_034797328
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21915,001,795 - 15,016,817 (+)NCBI
NHGRI_mPanPan11716,967,475 - 16,982,617 (+)NCBI
Mhudiblu_PPA_v0177,438,853 - 7,454,014 (+)NCBI
RefSeq Acc Id: XM_063598930   ⟹   XP_063455000
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21915,004,784 - 15,016,817 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034797328   ⟸   XM_034941437
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034797326   ⟸   XM_034941435
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034797324   ⟸   XM_034941433
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034797327   ⟸   XM_034941436
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063455000   ⟸   XM_063598930
- Peptide Label: isoform X1
Protein Domains
Carboxylesterase type B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039960 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000057123.1 UniProtKB/TrEMBL
  ENSPPAT00000057127.1 UniProtKB/TrEMBL
  ENSPPAT00000057129.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/TrEMBL
  Nlgn UniProtKB/TrEMBL
NCBI Gene NLGN2 ENTREZGENE
PANTHER NEUROLIGIN UniProtKB/TrEMBL
  PTHR43903:SF3 UniProtKB/TrEMBL
Pfam COesterase UniProtKB/TrEMBL
PRINTS NEUROLIGIN UniProtKB/TrEMBL
PROSITE CARBOXYLESTERASE_B_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A2R9BX28_PANPA UniProtKB/TrEMBL
  A0A2R9BX36_PANPA UniProtKB/TrEMBL
  A0A2R9BXR1_PANPA UniProtKB/TrEMBL