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ONTOLOGY REPORT - ANNOTATIONS

Term:stress-activated MAPK cascade
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Accession:GO:0051403 term browser browse the term
Definition:A MAPK cascade that starts with the activation of a stress-activated MAP kinase cascade.
Synonyms:exact_synonym: stress-activated MAPK signaling pathway;   stress-activated MAPK signalling pathway;   stress-activated MAPKKK cascade;   stress-activated MAPKKK signaling pathway;   stress-activated MAPKKK signalling pathway
 narrow_synonym: MAPK11 cascade;   MAPK12 cascade;   MAPK13 cascade
 broad_synonym: SAPK cascade
 related_synonym: MAPK14 cascade


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stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:21367774 RGD:5129174 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G CARD9 caspase recruitment domain family member 9 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:17187069) Ensembl
MGI		 PMID:17187069 GO_REF:0000107
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15213232) Ensembl
MGI		 PMID:15213232 GO_REF:0000107 NCBI chr 7:42,218,016...42,332,523
Ensembl chr 7:42,218,290...42,332,518 		JBrowse link
G CRYAB crystallin alpha B ISO RGD PMID:18420382 RGD:2303631 NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,506...39,643,530 		JBrowse link
G DUSP10 dual specificity phosphatase 10 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:19696743) Ensembl
MGI		 PMID:19696743 GO_REF:0000107 NCBI chr10:10,866,446...10,905,852
Ensembl chr10:10,866,448...10,905,857 		JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:10,891,445...11,018,617
Ensembl chr12:10,894,966...11,018,641 		JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:71,299,010...71,308,432
Ensembl chr 2:71,298,325...71,308,124 		JBrowse link
G MAP3K13 mitogen-activated protein kinase kinase kinase 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:123,176,077...123,357,551
Ensembl chr13:123,176,188...123,352,775 		JBrowse link
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:79,174,444...79,378,520
Ensembl chr15:79,173,033...79,380,993 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:27,380,143...27,600,500
Ensembl chr 1:27,380,142...27,600,493 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:58,482,046...58,548,087
Ensembl chr 1:58,481,956...58,548,057 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 involved_in ISO (PMID:11096076) CAFA PMID:11096076 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK11 mitogen-activated protein kinase 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:420,848...428,103
Ensembl chr 5:421,798...428,101 		JBrowse link
G MAPK13 mitogen-activated protein kinase 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:31,880,643...31,889,586
Ensembl chr 7:31,880,638...31,889,455 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 involved_in ISO
IEA		 RGD
Ensembl		 PMID:16407200 GO_REF:0000107 RGD:1580544 NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 acts_upstream_of ISO (PMID:18261938) MGI PMID:18261938 NCBI chr18:42,464,667...42,509,135
Ensembl chr18:42,432,050...42,512,264 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chr 6:34,132,127...34,167,446
Ensembl chr 6:34,130,938...34,177,534 		JBrowse link
G PBK PDZ binding kinase involved_in
acts_upstream_of		 IEA
ISO		 (PMID:21715333) Ensembl
MGI		 PMID:21715333 GO_REF:0000107 NCBI chr14:11,543,657...11,577,286
Ensembl chr14:11,543,603...11,566,702 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:11894097)
(PMID:11894098), (PMID:18261938)		 Ensembl
MGI		 PMID:11894097 PMID:11894098 PMID:18261938 GO_REF:0000107 NCBI chr 4:47,026,558...47,075,133
Ensembl chr 4:47,027,098...47,074,704 		JBrowse link
G TAOK2 TAO kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:18,178,347...18,198,092
Ensembl chr 3:18,177,737...18,198,085 		JBrowse link
G TLR4 toll like receptor 4 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
negative regulation of stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUSP10 dual specificity phosphatase 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19696743) Ensembl
MGI		 PMID:19696743 GO_REF:0000107 NCBI chr10:10,866,446...10,905,852
Ensembl chr10:10,866,448...10,905,857 		JBrowse link
G FOXM1 forkhead box M1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:67,246,219...67,263,215
Ensembl chr 5:67,245,694...67,263,211
Ensembl chr 5:67,245,694...67,263,211 		JBrowse link
G FOXO1 forkhead box O1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473 		JBrowse link
G IGBP1 immunoglobulin binding protein 1 involved_in ISO (PMID:17438131) UniProt PMID:17438131 NCBI chr  X:56,173,773...56,206,121 JBrowse link
G LOC100739163 glutathione S-transferase P-like involved_in ISO (MGI:5009411|PMID:16023107) BHF-UCL PMID:16023107 MGI:5009411 NCBI chr 2:4,978,761...4,982,233 JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor involved_in ISS UniProt GO_REF:0000024 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078 		JBrowse link
G PBK PDZ binding kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21715333) Ensembl
MGI		 PMID:21715333 GO_REF:0000107 NCBI chr14:11,543,657...11,577,286
Ensembl chr14:11,543,603...11,566,702 		JBrowse link
G PPIA peptidylprolyl isomerase A involved_in ISS UniProt GO_REF:0000024 NCBI chr18:50,563,130...50,566,857 JBrowse link
G QARS1 glutaminyl-tRNA synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:31,715,686...31,723,200
Ensembl chr13:31,715,689...31,723,197 		JBrowse link
positive regulation of stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARL6IP5 ADP ribosylation factor like GTPase 6 interacting protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:50,509,777...50,538,004
Ensembl chr13:50,509,519...50,538,966 		JBrowse link
G CARD9 caspase recruitment domain family member 9 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17187069) MGI
Ensembl		 PMID:17187069 GO_REF:0000107
G CLEC7A C-type lectin domain containing 7A involved_in ISO (MGI:5803730|PMID:27288407) UniProt PMID:27288407 MGI:5803730 NCBI chr 5:61,832,910...61,846,441
Ensembl chr 5:61,832,954...61,846,434 		JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO RGD PMID:19211730 RGD:5130956 NCBI chr18:42,251,755...42,296,457
Ensembl chr18:42,251,749...42,295,467 		JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:103,041,029...103,096,741
Ensembl chr 3:103,041,221...103,096,738 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:17161379 RGD:5508698 NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,224...84,402,957 		JBrowse link
G IGFBP6 insulin like growth factor binding protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:18,352,884...18,357,225
Ensembl chr 5:18,352,400...18,357,225 		JBrowse link
G IL1A interleukin 1 alpha ISO RGD PMID:15671867 RGD:1358666 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119 		JBrowse link
G IL26 interleukin 26 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:32,568,189...32,583,278
Ensembl chr 5:32,568,023...32,583,239 		JBrowse link
G INAVA innate immunity activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:23,392,202...23,414,318
Ensembl chr10:23,392,099...23,412,712 		JBrowse link
G KLHDC10 kelch domain containing 10 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr18:18,667,377...18,723,090
Ensembl chr18:18,667,365...18,723,067 		JBrowse link
G LOC110258578 interleukin-1 beta-like ISO RGD PMID:12629164 PMID:15671867 RGD:1358666 RGD:1626685
G MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 ISO RGD PMID:12024021 RGD:2302280 NCBI chr 5:120,575...131,060
Ensembl chr 5:120,580...130,939 		JBrowse link
G MID1 midline 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:7,235,386...7,906,049
Ensembl chr  X:7,237,942...7,620,011 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 acts_upstream_of_or_within ISO (PMID:18261938) MGI PMID:18261938 NCBI chr18:42,464,667...42,509,135
Ensembl chr18:42,432,050...42,512,264 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17187069)
(PMID:18261938)		 MGI
Ensembl		 PMID:17187069 PMID:18261938 GO_REF:0000107 NCBI chr 6:34,132,127...34,167,446
Ensembl chr 6:34,130,938...34,177,534 		JBrowse link
G PDCD10 programmed cell death 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:106,517,408...106,558,959
Ensembl chr13:106,517,432...106,558,895 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894098), (PMID:18261938)
(PMID:11894097)		 Ensembl
MGI		 PMID:11894097 PMID:11894098 PMID:18261938 GO_REF:0000107 NCBI chr 4:47,026,558...47,075,133
Ensembl chr 4:47,027,098...47,074,704 		JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:51,772,635...51,794,107
Ensembl chr12:51,773,448...51,794,104 		JBrowse link
G SEMA4C semaphorin 4C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:56,750,745...56,760,835
Ensembl chr 3:56,750,760...56,760,828 		JBrowse link
G STK25 serine/threonine kinase 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:140,144,334...140,154,361
Ensembl chr15:140,144,336...140,154,366 		JBrowse link
G TAOK1 TAO kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:45,597,067...45,750,117
Ensembl chr12:45,597,072...45,744,356 		JBrowse link
G TAOK2 TAO kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:18,178,347...18,198,092
Ensembl chr 3:18,177,737...18,198,085 		JBrowse link
G TAOK3 TAO kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:34,322,016...34,514,234
Ensembl chr14:34,409,070...34,513,025 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,539...8,390,341 		JBrowse link
G TLR4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
regulation of stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FAS Fas cell surface death receptor involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G GREM1 gremlin 1, DAN family BMP antagonist NOT|involved_in ISO (MGI:5318033|PMID:12135612) BHF-UCL PMID:12135612 MGI:5318033 NCBI chr 1:136,617,041...136,629,293
Ensembl chr 1:136,617,105...136,629,292 		JBrowse link
G LOC100627067 tumor necrosis factor receptor superfamily member 26-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:2,163,609...2,177,107 JBrowse link
G LOC100739163 glutathione S-transferase P-like involved_in ISO (MGI:5009198|PMID:10945608) BHF-UCL PMID:10945608 MGI:5009198 NCBI chr 2:4,978,761...4,982,233 JBrowse link
G LOC102158193 tumor necrosis factor receptor superfamily member 6-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:2,186,250...2,198,845 JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 involved_in IEA UniProt GO_REF:0000117 NCBI chr 1:164,381,892...164,469,313
Ensembl chr 1:164,381,845...164,471,226 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 involved_in IEA UniProt GO_REF:0000117 NCBI chr 2:74,626,739...74,651,352
Ensembl chr 2:74,626,783...74,651,348 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 involved_in IEA UniProt GO_REF:0000117 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 involved_in IEA UniProt GO_REF:0000117 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G NBR1 NBR1 autophagy cargo receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:19,755,733...19,789,014
Ensembl chr12:19,755,738...19,788,960 		JBrowse link
G PRDX1 peroxiredoxin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16880205) Ensembl
MGI		 PMID:16880205 GO_REF:0000107 NCBI chr 6:165,847,390...165,859,918
Ensembl chr 6:165,824,395...165,861,442 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:53,374,559...53,394,172
Ensembl chr 9:53,375,644...53,394,165 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17806
    response to stimulus 10061
      response to stress 4007
        cellular response to stress 1949
          stress-activated protein kinase signaling cascade 66
            stress-activated MAPK cascade 59
              cell wall integrity MAPK cascade + 0
              filamentous growth MAPK cascade 0
              negative regulation of stress-activated MAPK cascade + 9
              positive regulation of stress-activated MAPK cascade + 26
              regulation of stress-activated MAPK cascade + 46
Path 2
Term Annotations click to browse term
  biological_process 17806
    biological regulation 12905
      regulation of biological process 12538
        regulation of cellular process 12040
          signal transduction 6963
            intracellular signal transduction 2737
              intracellular signaling cassette 1933
                MAPK cascade 794
                  stress-activated MAPK cascade 59
                    cell wall integrity MAPK cascade + 0
                    filamentous growth MAPK cascade 0
                    negative regulation of stress-activated MAPK cascade + 9
                    positive regulation of stress-activated MAPK cascade + 26
                    regulation of stress-activated MAPK cascade + 46
paths to the root