CRHR2 (corticotropin releasing hormone receptor 2) - Rat Genome Database

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Gene: CRHR2 (corticotropin releasing hormone receptor 2) Sus scrofa
Analyze
Symbol: CRHR2
Name: corticotropin releasing hormone receptor 2
RGD ID: 14100500
Description: ENCODES a protein that exhibits corticotropin-releasing hormone receptor activity (ortholog); hormone activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN actin filament organization (ortholog); catecholamine biosynthetic process (ortholog); cellular response to glucocorticoid stimulus (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Anorexia (ortholog); anxiety disorder (ortholog); asthma (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell body fiber (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: corticotropin-releasing factor receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,251,749 - 42,295,467 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,251,755 - 42,296,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,648,683 - 46,651,308 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IBA)
catecholamine biosynthetic process  (ISO)
cell surface receptor signaling pathway  (IEA)
cellular response to corticotropin-releasing hormone stimulus  (IEA)
cellular response to glucocorticoid stimulus  (ISO)
cerebellum development  (ISO)
epithelial cell differentiation  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
gastric motility  (ISO)
hormone-mediated signaling pathway  (IEA)
hypothalamus development  (ISO)
long-term synaptic potentiation  (IBA,ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of calcium ion import  (ISO)
negative regulation of defecation  (ISO)
negative regulation of epinephrine secretion  (ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of follicle-stimulating hormone secretion  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
negative regulation of luteinizing hormone secretion  (ISO)
negative regulation of norepinephrine secretion  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of cAMP/PKA signal transduction  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of serotonin secretion  (ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
skeletal muscle tissue growth  (ISO)

Cellular Component
axon  (ISO)
axon terminus  (IBA,ISO)
cell body fiber  (ISO)
dendrite  (IBA,ISO)
membrane  (IEA)
neuronal cell body  (ISO)
perikaryon  (ISO)
plasma membrane  (IBA,IEA)
varicosity  (ISO)

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:19926814   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CRHR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,251,749 - 42,295,467 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,251,755 - 42,296,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,648,683 - 46,651,308 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRHR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38730,651,942 - 30,700,103 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl730,651,942 - 30,700,129 (-)EnsemblGRCh38hg38GRCh38
GRCh37730,691,558 - 30,739,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,659,388 - 30,688,665 (-)NCBINCBI36Build 36hg18NCBI36
Build 34730,465,439 - 30,495,136NCBI
Celera730,682,041 - 30,711,309 (-)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef730,573,396 - 30,621,616 (-)NCBIHuRef
CHM1_1730,691,838 - 30,739,995 (-)NCBICHM1_1
T2T-CHM13v2.0730,789,546 - 30,837,766 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2730,741,211 - 30,789,281 (-)NCBI
Crhr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39655,067,033 - 55,110,001 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl655,067,034 - 55,110,001 (-)EnsemblGRCm39 Ensembl
GRCm38655,090,048 - 55,133,016 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,090,049 - 55,133,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv37655,040,042 - 55,082,966 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36655,019,665 - 55,062,550 (-)NCBIMGSCv36mm8
Celera655,625,289 - 55,668,208 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.33NCBI
Crhr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,553,163 - 85,596,203 (-)NCBIGRCr8
mRatBN7.2484,222,897 - 84,265,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,224,002 - 84,265,904 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx489,447,028 - 89,474,226 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,222,449 - 85,249,647 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,634,840 - 83,661,994 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,286,371 - 85,329,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,286,372 - 85,329,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04149,943,615 - 149,986,646 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,839,822 - 83,867,017 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1484,085,174 - 84,112,370 (+)NCBI
Celera479,091,140 - 79,118,337 (-)NCBICelera
Cytogenetic Map4q24NCBI
Crhr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541031,828,506 - 31,875,100 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541031,830,333 - 31,874,384 (-)NCBIChiLan1.0ChiLan1.0
CRHR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2635,458,742 - 35,511,867 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1783,785,811 - 83,836,595 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0731,265,619 - 31,313,902 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1731,386,026 - 31,434,220 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,386,026 - 31,434,220 (-)Ensemblpanpan1.1panPan2
CRHR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,366,849 - 43,414,398 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,368,340 - 43,415,142 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1442,799,432 - 42,846,743 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01443,307,910 - 43,355,188 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1443,305,381 - 43,355,288 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11443,423,758 - 43,471,041 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01443,099,719 - 43,147,031 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01443,461,123 - 43,508,563 (-)NCBIUU_Cfam_GSD_1.0
Crhr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511887,689,367 - 87,736,056 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364786,899,017 - 6,947,790 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364786,901,098 - 6,947,719 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRHR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,703,637 - 27,738,873 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2127,708,113 - 27,739,116 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604276,965,555 - 77,000,544 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crhr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624739114,342 - 161,044 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624739114,383 - 161,010 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CRHR2
1547 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
1 2 18 1 5 5 18

Sequence


Ensembl Acc Id: ENSSSCT00000054973   ⟹   ENSSSCP00000034621
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1842,251,749 - 42,295,464 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000057070   ⟹   ENSSSCP00000056907
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1842,266,243 - 42,295,467 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000073139   ⟹   ENSSSCP00000072675
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1842,251,807 - 42,295,466 (+)Ensembl
RefSeq Acc Id: NM_001144118   ⟹   NP_001137590
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11842,266,426 - 42,294,563 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021078456   ⟹   XP_020934115
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11842,251,755 - 42,296,457 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021078457   ⟹   XP_020934116
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11842,251,783 - 42,296,457 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021078458   ⟹   XP_020934117
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11842,266,250 - 42,296,457 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021078459   ⟹   XP_020934118
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11842,251,821 - 42,296,457 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020934115   ⟸   XM_021078456
- Peptide Label: isoform X1
- UniProtKB: A0A8D0Z8N4 (UniProtKB/TrEMBL),   A0A286ZSJ2 (UniProtKB/TrEMBL),   A0A8D1DPX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020934116   ⟸   XM_021078457
- Peptide Label: isoform X2
- UniProtKB: A0A8D1DPX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020934118   ⟸   XM_021078459
- Peptide Label: isoform X4
- UniProtKB: A0A8D0JAC2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020934117   ⟸   XM_021078458
- Peptide Label: isoform X3
- UniProtKB: A0A8D0QAE6 (UniProtKB/TrEMBL),   A0A287BK61 (UniProtKB/TrEMBL),   A0A8D1TVT9 (UniProtKB/TrEMBL),   A0A8D2BYR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001137590   ⟸   NM_001144118
- UniProtKB: B8Q4Z9 (UniProtKB/TrEMBL),   A0A480TFX2 (UniProtKB/TrEMBL),   A0A8D1IXK6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000034621   ⟸   ENSSSCT00000054973
Ensembl Acc Id: ENSSSCP00000072675   ⟸   ENSSSCT00000073139
Ensembl Acc Id: ENSSSCP00000056907   ⟸   ENSSSCT00000057070
Protein Domains
G-protein coupled receptors family 2 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000033514 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005023207 UniProtKB/TrEMBL
  ENSSSCG00015077614 UniProtKB/TrEMBL
  ENSSSCG00025075975 UniProtKB/TrEMBL
  ENSSSCG00030002960 UniProtKB/TrEMBL
  ENSSSCG00035025330 UniProtKB/TrEMBL
  ENSSSCG00040018851 UniProtKB/TrEMBL
  ENSSSCG00045033149 UniProtKB/TrEMBL
  ENSSSCG00050021075 UniProtKB/TrEMBL
  ENSSSCG00055005128 UniProtKB/TrEMBL
  ENSSSCG00065008429 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000054973 ENTREZGENE
  ENSSSCT00000054973.3 UniProtKB/TrEMBL
  ENSSSCT00000057070 ENTREZGENE
  ENSSSCT00000057070.3 UniProtKB/TrEMBL
  ENSSSCT00000073139.1 UniProtKB/TrEMBL
  ENSSSCT00005037111.1 UniProtKB/TrEMBL
  ENSSSCT00015104865.1 UniProtKB/TrEMBL
  ENSSSCT00015105147.1 UniProtKB/TrEMBL
  ENSSSCT00025105049.1 UniProtKB/TrEMBL
  ENSSSCT00030003811.1 UniProtKB/TrEMBL
  ENSSSCT00030003896.1 UniProtKB/TrEMBL
  ENSSSCT00035033344.1 UniProtKB/TrEMBL
  ENSSSCT00035033360.1 UniProtKB/TrEMBL
  ENSSSCT00040025454.1 UniProtKB/TrEMBL
  ENSSSCT00045058707.1 UniProtKB/TrEMBL
  ENSSSCT00050028470.1 UniProtKB/TrEMBL
  ENSSSCT00050028479.1 UniProtKB/TrEMBL
  ENSSSCT00055010065.1 UniProtKB/TrEMBL
  ENSSSCT00065011298.1 UniProtKB/TrEMBL
  ENSSSCT00065011316.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1240.10 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_2 UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  GPCR_2_CRF2_rcpt UniProtKB/TrEMBL
  GPCR_2_CRF_rcpt UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/TrEMBL
KEGG Report ssc:100240719 UniProtKB/TrEMBL
NCBI Gene CRHR2 ENTREZGENE
PANTHER CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2 UniProtKB/TrEMBL
  PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/TrEMBL
  HRM UniProtKB/TrEMBL
PRINTS CRFRECEPTOR UniProtKB/TrEMBL
  CRFRECEPTOR2 UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
SMART HormR UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
  SSF111418 UniProtKB/TrEMBL
UniProt A0A286ZSJ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BK61 ENTREZGENE, UniProtKB/TrEMBL
  A0A480TFX2 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2RDV9_PIG UniProtKB/TrEMBL
  A0A8D0JAC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0QAE6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Z8N4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1DPX2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IXK6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1TVT9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2BYR9 ENTREZGENE, UniProtKB/TrEMBL
  B8Q4Z9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:86994 ENTREZGENE