RGD Reference Report - Activation of the nociceptin/orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the rat. - Rat Genome Database

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Activation of the nociceptin/orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the rat.

Authors: Fedeli, A  Policani, F  Ubaldi, M  Cippitelli, A  Massi, M  Ciccocioppo, R 
Citation: Fedeli A, etal., Peptides. 2006 Dec;27(12):3284-91. Epub 2006 Oct 16.
RGD ID: 5131264
Pubmed: PMID:17050037   (View Abstract at PubMed)
DOI: DOI:10.1016/j.peptides.2006.09.001   (Journal Full-text)

Central injection of Nociceptin/Orphanin FQ (N/OFQ), inhibits the anorectic effect of corticotropin-relasing factor (CRF) and stress in rats. Recently, Urocortin II (Ucn II) and Urocortin III (Ucn III), two selective CRF(2) receptor agonists, have been identified. Here, we investigated the effect of intracerebroventricular (ICV) injection of 0.25, 0.75, 1.50 or 3 nmol/rat of Ucn II or Ucn III on food and water intake in food deprived rats. The effect of N/OFQ on Ucn II and UCNIII-induced anorexia was also studied. Results showed a greater inhibition of food consumption by Ucn II than Ucn III. Pretreatment with N/OFQ (0.25-2.0 nmol/rat) did not block the effects of Ucn II and UCNIII. Conversely, injection of N/OFQ (0.25-2.0 nmol/rat) blocked the anorectic effect of CRF (0.1 nmol/rat). These findings suggest that N/OFQ selectively prevent the anorectic effect mediated by activation of the CRF(1) receptor system.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CRHR2HumanAnorexia  ISOCrhr2 (Rattus norvegicus) RGD 
Crhr2RatAnorexia  IDA  RGD 
Crhr2MouseAnorexia  ISOCrhr2 (Rattus norvegicus) RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Crhr2Ratnegative regulation of feeding behavior  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crhr2  (corticotropin releasing hormone receptor 2)

Genes (Mus musculus)
Crhr2  (corticotropin releasing hormone receptor 2)

Genes (Homo sapiens)
CRHR2  (corticotropin releasing hormone receptor 2)


Additional Information