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ONTOLOGY REPORT - ANNOTATIONS

Term:metal cation:proton antiporter activity
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Accession:GO:0051139 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in).
Synonyms:exact_synonym: metal ion:hydrogen antiporter activity;   metal ion:proton antiporter activity
 xref: reactome:R-HSA-435171 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages"


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metal cation:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 enables IDA
IBA
ISO		 (MGI:7484270|PMID:9730978) UniProt
GO_Central
MGI		 PMID:9730978 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:7484270 NCBI chr 1:74,414,318...74,429,974
Ensembl chr 1:74,414,354...74,425,221 		JBrowse link
calcium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ghitm growth hormone inducible transmembrane protein enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr14:36,842,401...36,857,279
Ensembl chr14:36,842,049...36,857,229 		JBrowse link
G Letm1 leucine zipper-EF-hand containing transmembrane protein 1 enables IDA
ISO
IMP		 (MGI:5897526|PMID:27669901)
(MGI:5643854|PMID:23716663)		 UniProt
MGI		 PMID:23716663 PMID:27669901 GO_REF:0000119 MGI:4834177 MGI:5643854 MGI:5897526 NCBI chr 5:33,897,017...33,940,061
Ensembl chr 5:33,897,017...33,940,161 		JBrowse link
L-asparagine, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a3 solute carrier family 38, member 3 enables IDA
ISO		 (MGI:7310198|PMID:16249471) UniProt
MGI		 PMID:16249471 GO_REF:0000096 MGI:4417868 MGI:7310198 NCBI chr 9:107,528,353...107,546,167
Ensembl chr 9:107,527,833...107,546,729 		JBrowse link
L-glutamine, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a3 solute carrier family 38, member 3 enables IDA
ISO		 (MGI:7310198|PMID:16249471), (MGI:7310199|PMID:18689705) UniProt
MGI		 PMID:16249471 PMID:18689705 GO_REF:0000096 MGI:4417868 MGI:7310198 MGI:7310199 NCBI chr 9:107,528,353...107,546,167
Ensembl chr 9:107,527,833...107,546,729 		JBrowse link
G Slc38a5 solute carrier family 38, member 5 enables IDA
ISO		 (MGI:7310198|PMID:16249471), (MGI:7310199|PMID:18689705) UniProt
MGI		 PMID:16249471 PMID:18689705 GO_REF:0000096 MGI:4417868 MGI:7310198 MGI:7310199 NCBI chr  X:8,137,620...8,146,418
Ensembl chr  X:8,137,372...8,146,418 		JBrowse link
L-histidine, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a3 solute carrier family 38, member 3 enables IDA
ISO		 (MGI:7310200|PMID:15899884) UniProt
MGI		 PMID:15899884 GO_REF:0000096 MGI:4417868 MGI:7310200 NCBI chr 9:107,528,353...107,546,167
Ensembl chr 9:107,527,833...107,546,729 		JBrowse link
lithium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc9b2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:135,013,083...135,048,606
Ensembl chr 3:135,013,461...135,051,148 		JBrowse link
neutral amino acid, sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a5 solute carrier family 38, member 5 enables ISO MGI GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr  X:8,137,620...8,146,418
Ensembl chr  X:8,137,372...8,146,418 		JBrowse link
potassium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc17a6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 enables IDA
ISO		 (MGI:6838939|PMID:25433636) UniProt
MGI		 PMID:25433636 GO_REF:0000096 MGI:4417868 MGI:6838939 NCBI chr 7:51,271,578...51,320,874
Ensembl chr 7:51,271,754...51,320,867 		JBrowse link
G Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 enables ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 7:44,813,345...44,825,563
Ensembl chr 7:44,813,373...44,825,566 		JBrowse link
G Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 4:133,097,022...133,151,013
Ensembl chr 4:133,097,017...133,151,013 		JBrowse link
G Slc9a2 solute carrier family 9 (sodium/hydrogen exchanger), member 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:40,720,872...40,808,045
Ensembl chr 1:40,719,734...40,808,433 		JBrowse link
G Slc9a3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 enables IBA GO_Central GO_REF:0000033 NCBI chr13:74,234,374...74,317,561
Ensembl chr13:74,269,576...74,317,561 		JBrowse link
G Slc9a4 solute carrier family 9 (sodium/hydrogen exchanger), member 4 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:40,619,146...40,670,188
Ensembl chr 1:40,619,241...40,669,885 		JBrowse link
G Slc9a5 solute carrier family 9 (sodium/hydrogen exchanger), member 5 enables IBA GO_Central GO_REF:0000033 NCBI chr 8:106,074,782...106,095,979
Ensembl chr 8:106,075,475...106,096,513 		JBrowse link
G Slc9a6 solute carrier family 9 (sodium/hydrogen exchanger), member 6 enables IDA
IBA		 (MGI:7387161|PMID:17005858) UniProt
GO_Central		 PMID:17005858 GO_REF:0000033 MGI:7387161 NCBI chr  X:55,654,921...55,709,590
Ensembl chr  X:55,655,117...55,709,590 		JBrowse link
G Slc9a7 solute carrier family 9 (sodium/hydrogen exchanger), member 7 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr  X:19,965,090...20,158,274
Ensembl chr  X:19,971,993...20,158,046 		JBrowse link
G Slc9a8 solute carrier family 9 (sodium/hydrogen exchanger), member 8 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:167,261,678...167,318,920
Ensembl chr 2:167,263,632...167,318,920 		JBrowse link
G Slc9a9 solute carrier family 9 (sodium/hydrogen exchanger), member 9 enables IDA
IBA		 (MGI:7387161|PMID:17005858) UniProt
GO_Central		 PMID:17005858 GO_REF:0000033 MGI:7387161 NCBI chr 9:94,551,945...95,112,505
Ensembl chr 9:94,551,962...95,112,498 		JBrowse link
G Slc9c1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 enables IBA GO_Central GO_REF:0000033 NCBI chr16:45,355,629...45,427,364
Ensembl chr16:45,355,672...45,427,364 		JBrowse link
G Tmco3 transmembrane and coiled-coil domains 3 enables IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 8:13,333,214...13,372,924
Ensembl chr 8:13,338,190...13,372,924 		JBrowse link
sodium:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chp1 calcineurin-like EF hand protein 1 enables ISO
IMP		 (PMID:34108458)
(PMID:23904602)		 MGI PMID:23904602 PMID:34108458 NCBI chr 2:119,378,172...119,417,505
Ensembl chr 2:119,378,178...119,417,508 		JBrowse link
G Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 enables ISO
IBA
IMP
IDA		 (PMID:23677982)
(PMID:10666043)
(PMID:15090545)		 MGI
GO_Central
RGD		 PMID:10666043 PMID:15090545 PMID:16002403 PMID:23677982 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1581387 NCBI chr 4:133,097,022...133,151,013
Ensembl chr 4:133,097,017...133,151,013 		JBrowse link
G Slc9a2 solute carrier family 9 (sodium/hydrogen exchanger), member 2 enables ISO
IBA
IDA		 (PMID:10666043) MGI
GO_Central
RGD		 PMID:7683411 PMID:10666043 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:729996 NCBI chr 1:40,720,872...40,808,045
Ensembl chr 1:40,719,734...40,808,433 		JBrowse link
G Slc9a3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 enables ISO
IDA
IBA		 (PMID:10666043) MGI
GO_Central
RGD		 PMID:10666043 PMID:11880335 PMID:12907430 PMID:15265811 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1581380 RGD:1625070 RGD:737665 NCBI chr13:74,234,374...74,317,561
Ensembl chr13:74,269,576...74,317,561 		JBrowse link
G Slc9a4 solute carrier family 9 (sodium/hydrogen exchanger), member 4 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000096 MGI:4417868 NCBI chr 1:40,619,146...40,670,188
Ensembl chr 1:40,619,241...40,669,885 		JBrowse link
G Slc9a5 solute carrier family 9 (sodium/hydrogen exchanger), member 5 enables ISO
IBA		 MGI
GO_Central
RGD		 PMID:9933642 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:634199 NCBI chr 8:106,074,782...106,095,979
Ensembl chr 8:106,075,475...106,096,513 		JBrowse link
G Slc9a6 solute carrier family 9 (sodium/hydrogen exchanger), member 6 enables IDA
IBA		 (MGI:7387161|PMID:17005858) UniProt
GO_Central		 PMID:17005858 GO_REF:0000033 MGI:7387161 NCBI chr  X:55,654,921...55,709,590
Ensembl chr  X:55,655,117...55,709,590 		JBrowse link
G Slc9a7 solute carrier family 9 (sodium/hydrogen exchanger), member 7 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr  X:19,965,090...20,158,274
Ensembl chr  X:19,971,993...20,158,046 		JBrowse link
G Slc9a8 solute carrier family 9 (sodium/hydrogen exchanger), member 8 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr 2:167,261,678...167,318,920
Ensembl chr 2:167,263,632...167,318,920 		JBrowse link
G Slc9a9 solute carrier family 9 (sodium/hydrogen exchanger), member 9 enables IDA
IBA		 (MGI:7387161|PMID:17005858) UniProt
GO_Central		 PMID:17005858 GO_REF:0000033 MGI:7387161 NCBI chr 9:94,551,945...95,112,505
Ensembl chr 9:94,551,962...95,112,498 		JBrowse link
G Slc9b2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:135,013,083...135,048,606
Ensembl chr 3:135,013,461...135,051,148 		JBrowse link
G Slc9c1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 enables TAS
IBA		 Reactome
GO_Central		 GO_REF:0000033 Reactome:R-MMU-2872452 NCBI chr16:45,355,629...45,427,364
Ensembl chr16:45,355,672...45,427,364 		JBrowse link
zinc:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc30a1 solute carrier family 30 (zinc transporter), member 1 enables ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 1:191,638,810...191,645,359
Ensembl chr 1:191,638,879...191,645,359 		JBrowse link
G Slc30a2 solute carrier family 30 (zinc transporter), member 2 enables IC
ISO		 (MGI:7339315|PMID:21289295) UniProt
MGI		 PMID:21289295 GO_REF:0000119 MGI:4834177 MGI:7339315 NCBI chr 4:134,070,357...134,081,795
Ensembl chr 4:134,070,492...134,081,795 		JBrowse link
G Slc30a5 solute carrier family 30 (zinc transporter), member 5 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:100,939,153...100,969,988
Ensembl chr13:100,939,156...100,969,935 		JBrowse link
G Slc30a6 solute carrier family 30 (zinc transporter), member 6 NOT|enables ISO (PMID:19366695) UniProt PMID:19366695 NCBI chr17:74,702,573...74,731,225
Ensembl chr17:74,702,603...74,731,216 		JBrowse link
G Slc30a8 solute carrier family 30 (zinc transporter), member 8 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:52,158,949...52,199,194
Ensembl chr15:52,158,949...52,199,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28831
    transporter activity 1198
      transmembrane transporter activity 1108
        monoatomic ion transmembrane transporter activity 733
          monoatomic cation transmembrane transporter activity 604
            proton transmembrane transporter activity 143
              metal cation:proton antiporter activity 25
                calcium:proton antiporter activity 2
                lithium:proton antiporter activity 1
                manganese:proton antiporter activity 0
                potassium:proton antiporter activity 13
                sodium:proton antiporter activity + 14
                zinc:proton antiporter activity 5
Path 2
Term Annotations click to browse term
  molecular_function 28831
    transporter activity 1198
      transmembrane transporter activity 1108
        monoatomic ion transmembrane transporter activity 733
          monoatomic cation transmembrane transporter activity 604
            metal ion transmembrane transporter activity 444
              metal cation:monoatomic cation antiporter activity 40
                metal cation:proton antiporter activity 25
                  calcium:proton antiporter activity 2
                  lithium:proton antiporter activity 1
                  manganese:proton antiporter activity 0
                  potassium:proton antiporter activity 13
                  sodium:proton antiporter activity + 14
                  zinc:proton antiporter activity 5
paths to the root