Slc9a2 (solute carrier family 9 (sodium/hydrogen exchanger), member 2) - Rat Genome Database

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Gene: Slc9a2 (solute carrier family 9 (sodium/hydrogen exchanger), member 2) Mus musculus
Analyze
Symbol: Slc9a2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 2
RGD ID: 11318
MGI Page MGI
Description: Enables sodium:proton antiporter activity. Involved in epithelial cell differentiation and regulation of intracellular pH. Acts upstream of or within protein localization; regulation of pH; and sodium ion transport. Located in apical plasma membrane. Is expressed in genitourinary system and skeleton. Orthologous to human SLC9A2 (solute carrier family 9 member A2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2210416H12Rik; 4932415O19Rik; AV333884; MGC124408; MGC124410; Na(+)/H(+) exchanger 2; NHE; NHE-2; NHE2; sodium/hydrogen exchanger; sodium/hydrogen exchanger 2; solute carrier family 9 member 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,720,872 - 40,808,045 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,719,734 - 40,808,433 (+)EnsemblGRCm39 Ensembl
GRCm38140,681,712 - 40,768,885 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,680,574 - 40,769,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,738,557 - 40,825,730 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36140,626,258 - 40,713,431 (+)NCBIMGSCv36mm8
Celera140,497,312 - 40,580,915 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map119.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8199403   PMID:8824815   PMID:9107685   PMID:9502765   PMID:9590530   PMID:10349636   PMID:10506152   PMID:10666041   PMID:10666043   PMID:10772659   PMID:10841524   PMID:11042159  
PMID:11076861   PMID:11099134   PMID:11139574   PMID:11254504   PMID:11358967   PMID:11553519   PMID:11705743   PMID:11960774   PMID:12195293   PMID:12477932   PMID:12493726   PMID:12836026  
PMID:12842825   PMID:14962844   PMID:15604231   PMID:15800055   PMID:16141072   PMID:16141073   PMID:16690903   PMID:16870707   PMID:17890222   PMID:18269914   PMID:18287398   PMID:18287559  
PMID:18719001   PMID:19521566   PMID:20026617   PMID:21252044   PMID:21267068   PMID:21491542   PMID:21873635   PMID:21900251   PMID:22683701   PMID:23676500   PMID:23677982   PMID:24018950  
PMID:24233434   PMID:27390324   PMID:29694915   PMID:30073618   PMID:34985202  


Genomics

Comparative Map Data
Slc9a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,720,872 - 40,808,045 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,719,734 - 40,808,433 (+)EnsemblGRCm39 Ensembl
GRCm38140,681,712 - 40,768,885 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,680,574 - 40,769,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,738,557 - 40,825,730 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36140,626,258 - 40,713,431 (+)NCBIMGSCv36mm8
Celera140,497,312 - 40,580,915 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map119.66NCBI
SLC9A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382102,619,553 - 102,711,355 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2102,619,553 - 102,711,355 (+)EnsemblGRCh38hg38GRCh38
GRCh372103,236,012 - 103,327,814 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,602,598 - 102,694,241 (+)NCBINCBI36Build 36hg18NCBI36
Build 342102,694,683 - 102,786,325NCBI
Celera297,437,331 - 97,528,969 (+)NCBICelera
Cytogenetic Map2q12.1NCBI
HuRef297,000,460 - 97,092,035 (+)NCBIHuRef
CHM1_12103,240,476 - 103,332,120 (+)NCBICHM1_1
T2T-CHM13v2.02103,078,521 - 103,170,032 (+)NCBIT2T-CHM13v2.0
Slc9a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,427,612 - 50,510,043 (+)NCBIGRCr8
mRatBN7.2942,932,001 - 43,014,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,931,346 - 43,014,444 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx951,431,897 - 51,514,356 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,554,607 - 56,637,069 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,832,669 - 54,915,087 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,386,581 - 47,491,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,386,626 - 47,491,907 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0947,069,252 - 47,174,869 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,832,184 - 39,916,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,864,431 - 39,917,653 (+)NCBI
Celera940,674,586 - 40,756,808 (+)NCBICelera
RH 3.4 Map9416.79RGD
Cytogenetic Map9q22NCBI
Slc9a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554708,083,641 - 8,137,372 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554708,083,737 - 8,137,372 (+)NCBIChiLan1.0ChiLan1.0
SLC9A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21224,998,994 - 25,089,855 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A25,001,759 - 25,092,620 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A99,112,174 - 99,202,890 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A103,716,909 - 103,808,140 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A103,717,055 - 103,806,141 (+)Ensemblpanpan1.1panPan2
SLC9A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,334,417 - 40,394,438 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,338,284 - 40,394,470 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1040,259,042 - 40,355,812 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01041,199,202 - 41,296,164 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1041,204,618 - 41,296,196 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11040,914,179 - 41,010,959 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01041,194,951 - 41,291,464 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01041,387,298 - 41,484,088 (-)NCBIUU_Cfam_GSD_1.0
Slc9a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629289,792,543 - 89,876,241 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367131,256,692 - 1,342,229 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367131,256,678 - 1,340,338 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl351,535,798 - 51,623,057 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1351,535,798 - 51,623,003 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2353,962,479 - 54,047,324 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,274,887 - 6,368,183 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041173,959,230 - 174,051,533 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc9a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247497,100,607 - 7,189,494 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247497,100,585 - 7,188,744 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc9a2
3457 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:208
Interacting mature miRNAs:240
Transcripts:ENSMUST00000027231
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2555019158273271Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12603916060039160Mouse
1301756Pgia1_mproteoglycan induced arthritis 1 (mouse)Not determined11906535153065454Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
1301073Orch5_mautoimmune orchitis resistance 5 (mouse)Not determined11906535153065454Mouse
1301240Sluc15_msusceptibility to lung cancer 15 (mouse)Not determined11906535153065454Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
12880407V125Dq2_mvitamin D active form serum level QTL 2 (mouse)11933908153339081Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1967344243673601Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11134048245340482Mouse

Markers in Region
AV333884  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38140,769,058 - 40,769,206UniSTSGRCm38
MGSCv37140,825,903 - 40,826,051UniSTSGRCm37
Celera140,581,088 - 40,581,236UniSTS
Cytogenetic Map1BUniSTS
cM Map120.4UniSTS
Whitehead/MRC_RH1623.44UniSTS
D1Mit172  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38140,712,756 - 40,712,897UniSTSGRCm38
MGSCv37140,769,601 - 40,769,742UniSTSGRCm37
Celera140,524,670 - 40,524,811UniSTS
Cytogenetic Map1BUniSTS
cM Map121.6UniSTS
Whitehead Genetic120.8UniSTS
Whitehead/MRC_RH1633.56UniSTS
Whitehead_YAC1 UniSTS
Slc9a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1BUniSTS
cM Map120.4UniSTS
Slc9a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1BUniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000027231   ⟹   ENSMUSP00000027231
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl140,719,734 - 40,808,433 (+)Ensembl
GRCm38.p6 Ensembl140,680,574 - 40,769,273 (+)Ensembl
RefSeq Acc Id: ENSMUST00000192294
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl140,794,916 - 40,796,231 (+)Ensembl
GRCm38.p6 Ensembl140,755,756 - 40,757,071 (+)Ensembl
RefSeq Acc Id: ENSMUST00000192345   ⟹   ENSMUSP00000142144
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl140,720,757 - 40,766,841 (+)Ensembl
GRCm38.p6 Ensembl140,681,597 - 40,727,681 (+)Ensembl
RefSeq Acc Id: NM_001033289   ⟹   NP_001028461
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,720,872 - 40,808,045 (+)NCBI
GRCm38140,681,712 - 40,768,885 (+)ENTREZGENE
MGSCv37140,738,557 - 40,825,730 (+)RGD
Celera140,497,312 - 40,580,915 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001028461   ⟸   NM_001033289
- Peptide Label: precursor
- UniProtKB: Q3ZAS0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027231   ⟸   ENSMUST00000027231
RefSeq Acc Id: ENSMUSP00000142144   ⟸   ENSMUST00000192345
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3ZAS0-F1-model_v2 AlphaFold Q3ZAS0 1-814 view protein structure

Promoters
RGD ID:6873574
Promoter ID:EPDNEW_M238
Type:initiation region
Name:Slc9a2_1
Description:Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),member 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38140,681,675 - 40,681,735EPDNEW
RGD ID:6818492
Promoter ID:MM_KWN:566
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:ENSMUST00000027231,   UC007AUM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36140,738,166 - 40,738,767 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105075 AgrOrtholog
Ensembl Genes ENSMUSG00000026062 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027231 ENTREZGENE
  ENSMUST00000027231.13 UniProtKB/Swiss-Prot
  ENSMUST00000192345.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.1330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1040 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cation/H_exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation/H_exchanger_CPA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/H_exchanger_2 UniProtKB/TrEMBL
  NaH_exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHE-2/4 UniProtKB/Swiss-Prot
  NHE_CaM-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:226999 UniProtKB/Swiss-Prot
MGD MGI:105075 ENTREZGENE
NCBI Gene 226999 ENTREZGENE
PANTHER Cation/H_exchanger_cons-reg UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SODIUM/HYDROGEN EXCHANGER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Na_H_Exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEXCaM_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc9a2 PhenoGen
PRINTS NAHEXCHNGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAHEXCHNGR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q3TM63_MOUSE UniProtKB/TrEMBL
  Q3ZAS0 ENTREZGENE
  Q9WUJ4_MOUSE UniProtKB/TrEMBL
  SL9A2_MOUSE UniProtKB/Swiss-Prot