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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:insulin-like growth factor receptor signaling pathway
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Accession:GO:0048009 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to an insulin-like growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: IGF receptor signaling pathway;   IGF receptor signalling pathway


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insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193 		JBrowse link
G AR androgen receptor acts_upstream_of ISO (PMID:14676301) MGI PMID:14676301 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912 		JBrowse link
G ATXN1 ataxin 1 acts_upstream_of ISO (PMID:18216249) MGI PMID:18216249 NCBI chr35:15,458,498...15,863,829
Ensembl chr35:15,452,135...15,649,747 		JBrowse link
G ATXN7 ataxin 7 acts_upstream_of ISO (PMID:18216249) MGI PMID:18216249 NCBI chr20:27,226,957...27,335,327
Ensembl chr20:27,224,375...27,333,445 		JBrowse link
G COL6A1 collagen type VI alpha 1 chain involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28043812) Ensembl
MGI		 PMID:28043812 GO_REF:0000107 NCBI chr31:39,301,718...39,319,895
Ensembl chr31:39,301,748...39,448,062 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (PMID:12865332) MGI PMID:12865332 NCBI chr17:37,886,397...37,950,671
Ensembl chr17:37,886,601...37,949,812 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17183314) Ensembl
MGI		 PMID:17183314 GO_REF:0000107 NCBI chr 1:110,130,353...110,146,660
Ensembl chr 1:110,130,481...110,146,602 		JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18545656) Ensembl
MGI		 PMID:18545656 GO_REF:0000107 NCBI chr 1:110,173,781...110,191,612
Ensembl chr 1:110,173,715...110,190,125 		JBrowse link
G GHR growth hormone receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:67,021,821...67,245,499
Ensembl chr 4:67,022,252...67,290,473 		JBrowse link
G GHSR growth hormone secretagogue receptor involved_in
acts_upstream_of		 IEA
ISO		 (PMID:15070777) Ensembl
MGI		 PMID:15070777 GO_REF:0000107 NCBI chr34:36,691,132...36,694,304
Ensembl chr34:36,690,224...36,694,312 		JBrowse link
G GIGYF1 GRB10 interacting GYF protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12771153) Ensembl
TreeGrafter
MGI		 PMID:12771153 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:9,018,749...9,032,258
Ensembl chr 6:9,020,415...9,113,368 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19744960) Ensembl
TreeGrafter
MGI		 PMID:19744960 GO_REF:0000107 GO_REF:0000118 NCBI chr25:44,317,540...44,453,761
Ensembl chr25:44,317,517...44,452,064 		JBrowse link
G GRB10 growth factor receptor bound protein 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12771153) Ensembl
MGI		 PMID:12771153 GO_REF:0000107 NCBI chr18:1,890,689...2,014,836
Ensembl chr18:1,890,792...2,014,839 		JBrowse link
G GRB2 growth factor receptor bound protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:5,108,128...5,182,091
Ensembl chr 9:5,117,164...5,180,296 		JBrowse link
G IGF1 insulin like growth factor 1 involved_in
acts_upstream_of_or_within		 ISO
ISS
IEA
IBA		 (PMID:12805218) RGD
UniProt
Ensembl
GO_Central
TreeGrafter
MGI		 PMID:12805218 PMID:16083987 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:1580473 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794 		JBrowse link
G IGF1R insulin like growth factor 1 receptor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387 		JBrowse link
G IGF2 insulin like growth factor 2 involved_in ISO (PMID:29348399)
(PMID:9281335)		 MGI PMID:9281335 PMID:29348399 NCBI chr18:46,294,036...46,311,982
Ensembl chr18:46,294,019...46,311,982 		JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 acts_upstream_of ISO (PMID:16024235) MGI PMID:16024235 NCBI chr37:23,575,265...23,596,970
Ensembl chr37:23,579,841...23,596,870 		JBrowse link
G IRS1 insulin receptor substrate 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:39,624,554...39,687,991 JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:30,683,192...30,760,479
Ensembl chr30:30,683,107...30,760,479 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 involved_in ISO (PMID:21699731) MGI PMID:21699731 NCBI chr20:55,465,460...55,487,629
Ensembl chr20:55,465,212...55,487,641 		JBrowse link
G MAP2K5 mitogen-activated protein kinase kinase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:31,665,032...31,920,792
Ensembl chr30:31,664,564...31,920,751 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 involved_in ISO (PMID:14997210) MGI PMID:14997210 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha involved_in ISO (PMID:11784871)
(PMID:26872540)		 MGI PMID:11784871 PMID:26872540 NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:9440811 GO_REF:0000107 RGD:1625263 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970 		JBrowse link
G PLCB1 phospholipase C beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:13,337,285...13,996,218
Ensembl chr24:13,322,296...13,995,539 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:5,892,839...5,972,672
Ensembl chr20:5,892,834...5,972,090 		JBrowse link
G SHC1 SHC adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,501,829...42,509,613
Ensembl chr 7:42,500,185...42,508,276 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:31,007,940...31,181,569
Ensembl chr17:31,009,257...31,142,063 		JBrowse link
negative regulation of insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATXN1 ataxin 1 acts_upstream_of_or_within ISO (PMID:18216249) MGI PMID:18216249 NCBI chr35:15,458,498...15,863,829
Ensembl chr35:15,452,135...15,649,747 		JBrowse link
G ATXN7 ataxin 7 acts_upstream_of_or_within ISO (PMID:18216249) MGI PMID:18216249 NCBI chr20:27,226,957...27,335,327
Ensembl chr20:27,224,375...27,333,445 		JBrowse link
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:15,199,667...15,211,509
Ensembl chr24:15,200,291...15,212,217 		JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,089,429...23,202,176
Ensembl chr12:23,089,459...23,202,348 		JBrowse link
G CILP cartilage intermediate layer protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:29,573,072...29,587,601
Ensembl chr30:29,573,184...29,650,883 		JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16024235) Ensembl
MGI		 PMID:16024235 GO_REF:0000107 NCBI chr37:23,575,265...23,596,970
Ensembl chr37:23,579,841...23,596,870 		JBrowse link
G INPPL1 inositol polyphosphate phosphatase like 1 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:12933696 GO_REF:0000118 RGD:1626126 NCBI chr21:25,900,308...25,914,527
Ensembl chr21:25,900,900...25,915,577 		JBrowse link
G MIR29C-2 microRNA mir-29c-2 involved_in ISO (PMID:26045889), (PMID:26175848) BHF-UCL PMID:26045889 PMID:26175848 NCBI chr 7:6,651,339...6,651,396 JBrowse link
G NKX3-1 NK3 homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19258508) Ensembl
MGI		 PMID:19258508 GO_REF:0000107 NCBI chr25:33,815,343...33,817,465
Ensembl chr25:33,815,095...33,817,474 		JBrowse link
G TRIM72 tripartite motif containing 72 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23965929) Ensembl
MGI		 PMID:23965929 GO_REF:0000107 NCBI chr 6:17,031,175...17,053,399
Ensembl chr 6:17,031,913...17,039,556 		JBrowse link
positive regulation of insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor acts_upstream_of_or_within ISO (PMID:14676301) MGI PMID:14676301 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912 		JBrowse link
G CDH3 cadherin 3 involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 (PMID:22696062) Ensembl
UniProt		 PMID:22696062 GO_REF:0000107 NCBI chr 5:80,864,859...80,912,136
Ensembl chr 5:80,863,661...80,913,019 		JBrowse link
G GHSR growth hormone secretagogue receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15070777) Ensembl
MGI		 PMID:15070777 GO_REF:0000107 NCBI chr34:36,691,132...36,694,304
Ensembl chr34:36,690,224...36,694,312 		JBrowse link
G IFT88 intraflagellar transport 88 acts_upstream_of_or_within ISO (PMID:19596798) MGI PMID:19596798 NCBI chr25:17,414,965...17,551,405
Ensembl chr25:17,414,965...17,551,266 		JBrowse link
G IGF1 insulin like growth factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794 		JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16675541) Ensembl
MGI		 PMID:16675541 GO_REF:0000107 NCBI chr16:1,021,855...1,027,604
Ensembl chr16:1,021,972...1,026,392 		JBrowse link
G IGFBP4 insulin like growth factor binding protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16675541) Ensembl
MGI		 PMID:16675541 GO_REF:0000107 NCBI chr 9:22,168,241...22,182,272
Ensembl chr 9:22,126,470...22,182,518 		JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 acts_upstream_of_or_within ISO (PMID:16675541) MGI PMID:16675541 NCBI chr37:23,575,265...23,596,970
Ensembl chr37:23,579,841...23,596,870 		JBrowse link
G MYORG myogenesis regulating glycosidase (putative) involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19706595) Ensembl
MGI		 PMID:19706595 GO_REF:0000107 NCBI chr11:51,070,088...51,077,595
Ensembl chr11:51,071,707...51,073,851 		JBrowse link
G PHIP pleckstrin homology domain interacting protein involved_in ISO (MGI:3723572|PMID:17636024) UniProt PMID:17636024 MGI:3723572 NCBI chr12:39,899,738...40,015,795
Ensembl chr12:39,904,603...40,032,194 		JBrowse link
G WNT1 Wnt family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:5,588,151...5,592,254
Ensembl chr27:5,574,940...5,592,060 		JBrowse link
regulation of insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GHRHR growth hormone releasing hormone receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7390396), (PMID:7679139) Ensembl
MGI		 PMID:7390396 PMID:7679139 GO_REF:0000107 NCBI chr14:43,626,862...43,638,737
Ensembl chr14:43,626,845...43,638,753 		JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:1,037,169...1,040,996
Ensembl chr16:1,037,162...1,167,094 		JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr37:23,553,227...23,569,321
Ensembl chr37:23,559,501...23,569,312 		JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:1,021,855...1,027,604
Ensembl chr16:1,021,972...1,026,392 		JBrowse link
G IGFBP4 insulin like growth factor binding protein 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:22,168,241...22,182,272
Ensembl chr 9:22,126,470...22,182,518 		JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr37:23,575,265...23,596,970
Ensembl chr37:23,579,841...23,596,870 		JBrowse link
G IGFBP6 insulin like growth factor binding protein 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr27:2,063,548...2,067,366
Ensembl chr27:1,989,772...2,067,298 		JBrowse link
G LOC119864970 insulin-like growth factor-binding protein 2 involved_in IEA TreeGrafter GO_REF:0000118
G POU1F1 POU class 1 homeobox 1 acts_upstream_of_or_within ISO (PMID:7390396) MGI PMID:7390396 NCBI chr31:769,454...788,761
Ensembl chr31:769,487...787,626 		JBrowse link
G RAPGEFL1 Rap guanine nucleotide exchange factor like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:22,385,970...22,399,584
Ensembl chr 9:22,387,786...22,394,887 		JBrowse link
G ZFAND2B zinc finger AN1-type containing 2B involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,757,454...25,760,366
Ensembl chr37:25,757,669...25,760,132 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17925
    cellular process 16910
      signal transduction 6317
        cell surface receptor signaling pathway 2807
          enzyme-linked receptor protein signaling pathway 1041
            cell surface receptor protein tyrosine kinase signaling pathway 654
              insulin-like growth factor receptor signaling pathway 53
                negative regulation of insulin-like growth factor receptor signaling pathway 10
                positive regulation of insulin-like growth factor receptor signaling pathway 11
                regulation of insulin-like growth factor receptor signaling pathway + 28
Path 2
Term Annotations click to browse term
  biological_process 17925
    biological regulation 12446
      regulation of biological process 12082
        signaling 6866
          signal transduction 6317
            cell surface receptor signaling pathway 2807
              enzyme-linked receptor protein signaling pathway 1041
                cell surface receptor protein tyrosine kinase signaling pathway 654
                  insulin-like growth factor receptor signaling pathway 53
                    negative regulation of insulin-like growth factor receptor signaling pathway 10
                    positive regulation of insulin-like growth factor receptor signaling pathway 11
                    regulation of insulin-like growth factor receptor signaling pathway + 28
paths to the root