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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of insulin-like growth factor receptor signaling pathway
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Accession:GO:0043569 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
Synonyms:exact_synonym: down regulation of insulin-like growth factor receptor signaling pathway;   downregulation of insulin-like growth factor receptor signaling pathway;   negative regulation of IGF receptor signaling pathway;   negative regulation of IGF receptor signalling pathway;   negative regulation of insulin-like growth factor receptor signalling pathway
 narrow_synonym: inhibition of insulin-like growth factor receptor signaling pathway


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negative regulation of insulin-like growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn1 ataxin 1 ISO MGI:MGI:2429435 (MGI:MGI:3774689|PMID:18216249) RGD PMID:18216249 MGI:MGI:3774689 NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814
JBrowse link
G Atxn7 ataxin 7 ISO MGI:MGI:2651378 (MGI:MGI:3774689|PMID:18216249) RGD PMID:18216249 MGI:MGI:3774689 NCBI chr15:12,421,432...12,569,649
Ensembl chr15:12,425,175...12,513,931
JBrowse link
G Bmp2 bone morphogenetic protein 2 ISO
IEA
(PMID:19584291)
GO_REF:0000107
RGD
Ensembl
PMID:19584291 GO_REF:0000107 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp5 bone morphogenetic protein 5 ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:82,669,466...82,950,273
Ensembl chr 8:82,878,941...82,950,273
JBrowse link
G Cilp cartilage intermediate layer protein ISO (PMID:12746903) RGD PMID:12746903 NCBI chr 8:70,760,922...70,775,891
Ensembl chr 8:70,760,922...70,775,891
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 ISO (PMID:10766744)
(MGI:MGI:3589307|PMID:16024235)
RGD PMID:10766744, PMID:16024235 MGI:MGI:3589307 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IMP RGD PMID:12933696 RGD:1626126 NCBI chr 1:166,898,177...166,912,524
Ensembl chr 1:166,899,894...166,912,524
JBrowse link
G Nkx3-1 NK3 homeobox 1 ISO
ISS
(MGI:MGI:3839214|PMID:19258508)
GO_REF:0000024
RGD
UniProt
PMID:19258508 GO_REF:0000024, MGI:MGI:3839214 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Trim72 tripartite motif containing 72 ISO MGI:MGI:96432 (MGI:MGI:5602876|PMID:23965929) RGD PMID:23965929 MGI:MGI:5602876 NCBI chr 1:199,450,042...199,457,902
Ensembl chr 1:199,449,973...199,457,895
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    cellular process 18788
      signal transduction 7016
        negative regulation of signal transduction 1243
          negative regulation of insulin-like growth factor receptor signaling pathway 9
Path 2
Term Annotations click to browse term
  biological_process 20015
    biological regulation 13760
      regulation of biological process 13073
        regulation of cellular process 12563
          signal transduction 7016
            cell surface receptor signaling pathway 2783
              enzyme linked receptor protein signaling pathway 963
                transmembrane receptor protein tyrosine kinase signaling pathway 605
                  insulin-like growth factor receptor signaling pathway 40
                    regulation of insulin-like growth factor receptor signaling pathway 26
                      negative regulation of insulin-like growth factor receptor signaling pathway 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.