IGFBP3 (insulin like growth factor binding protein 3) - Rat Genome Database

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Gene: IGFBP3 (insulin like growth factor binding protein 3) Canis lupus familiaris
Analyze
Symbol: IGFBP3
Name: insulin like growth factor binding protein 3
RGD ID: 12224708
Description: ENCODES a protein that exhibits insulin-like growth factor II binding (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); cellular response to Thyroglobulin triiodothyronine (ortholog); female pregnancy (ortholog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH acoustic neuroma (ortholog); Acute-Phase Reaction (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular space (ortholog); heterochromatin (ortholog); insulin-like growth factor binary complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: insulin-like growth factor-binding protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,021,855 - 1,027,604 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,021,972 - 1,026,392 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha161,797,939 - 1,804,689 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,008,571 - 1,015,327 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,008,253 - 1,015,330 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.116999,220 - 1,005,969 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.016934,846 - 941,592 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.016233,123 - 239,875 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
Acute-Phase Reaction  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
Barrett's esophagus  (ISO)
beta thalassemia  (ISO)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (ISO)
Burns  (ISO)
cervix uteri carcinoma in situ  (ISO)
Closed Head Injuries  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
Down syndrome  (ISO)
Dwarfism  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Endotoxemia  (ISO)
epidermolysis bullosa dystrophica  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fetal Growth Retardation  (ISO)
Fetal Macrosomia  (ISO)
genetic disease  (ISO)
high grade glioma  (ISO)
ichthyosis  (ISO)
impotence  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
Malocclusion  (ISO)
McCune Albright syndrome  (ISO)
Metabolic Bone Diseases  (ISO)
myeloid leukemia  (ISO)
Myocardial Ischemia  (ISO)
obesity  (ISO)
ornithine carbamoyltransferase deficiency  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Ovarian Neoplasms  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
primary progressive multiple sclerosis  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
retinopathy of prematurity  (ISO)
rheumatoid arthritis  (ISO)
Spinal Fractures  (ISO)
Spontaneous Abortions  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
tonsillitis  (ISO)
transitional cell carcinoma  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:20406781   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IGFBP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,021,855 - 1,027,604 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,021,972 - 1,026,392 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha161,797,939 - 1,804,689 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,008,571 - 1,015,327 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,008,253 - 1,015,330 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.116999,220 - 1,005,969 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.016934,846 - 941,592 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.016233,123 - 239,875 (-)NCBIUU_Cfam_GSD_1.0
IGFBP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38745,912,245 - 45,921,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl745,912,245 - 45,921,874 (-)EnsemblGRCh38hg38GRCh38
GRCh37745,951,844 - 45,960,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,918,369 - 45,927,396 (-)NCBINCBI36Build 36hg18NCBI36
Build 34745,725,189 - 45,734,057NCBI
Celera746,050,761 - 46,059,785 (-)NCBICelera
Cytogenetic Map7p12.3NCBI
HuRef745,836,799 - 45,845,824 (-)NCBIHuRef
CHM1_1745,956,047 - 45,965,072 (-)NCBICHM1_1
T2T-CHM13v2.0746,073,961 - 46,082,986 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2745,991,173 - 46,000,198 (-)NCBI
Igfbp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39117,156,086 - 7,165,498 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl117,156,086 - 7,163,923 (-)EnsemblGRCm39 Ensembl
GRCm38117,206,086 - 7,215,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,206,086 - 7,213,923 (-)EnsemblGRCm38mm10GRCm38
MGSCv37117,106,089 - 7,113,926 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36117,108,384 - 7,113,834 (-)NCBIMGSCv36mm8
Celera117,681,286 - 7,689,161 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.75NCBI
Igfbp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81486,270,208 - 86,277,944 (-)NCBIGRCr8
mRatBN7.21482,056,347 - 82,064,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1482,056,347 - 82,064,083 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1486,457,400 - 86,465,160 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,697,249 - 87,705,011 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01484,145,931 - 84,153,669 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01487,457,647 - 87,465,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1487,457,647 - 87,465,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,091,987 - 81,099,675 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,959,153 - 87,967,085 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11487,978,297 - 87,986,223 (-)NCBI
Celera1481,130,767 - 81,138,473 (-)NCBICelera
RH 3.4 Map14598.5RGD
Cytogenetic Map14q21NCBI
Igfbp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554566,795,604 - 6,800,845 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554566,795,560 - 6,802,147 (+)NCBIChiLan1.0ChiLan1.0
IGFBP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2650,797,505 - 50,806,866 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1799,122,231 - 99,131,164 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0746,564,234 - 46,573,145 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1746,681,856 - 46,690,240 (-)NCBIpanpan1.1PanPan1.1panPan2
Igfbp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118101,299,235 - 101,306,540 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647820,510,137 - 20,518,306 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647820,511,490 - 20,518,251 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,003,022 - 50,010,690 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,002,921 - 50,009,425 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21854,851,168 - 54,855,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap18q24NCBI
IGFBP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12112,905,309 - 12,914,199 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2112,905,280 - 12,914,205 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660629,622,694 - 9,631,602 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247406,877,348 - 6,886,512 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247406,878,818 - 6,886,512 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IGFBP3
56 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 16 6 4 6 6 6 6
Low 5 6 2 6 12 8 4
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000019522   ⟹   ENSCAFP00000018107
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl161,021,972 - 1,026,392 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845019908   ⟹   ENSCAFP00845015594
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl161,008,253 - 1,015,330 (+)Ensembl
RefSeq Acc Id: XM_003639557   ⟹   XP_003639605
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1161,021,855 - 1,027,604 (+)NCBI
Dog10K_Boxer_Tasha161,797,939 - 1,804,689 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038496912   ⟹   XP_038352840
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.116999,220 - 1,005,969 (+)NCBI
RefSeq Acc Id: XM_038559248   ⟹   XP_038415176
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.016233,123 - 239,875 (-)NCBI
RefSeq Acc Id: XM_038623218   ⟹   XP_038479146
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.016934,846 - 941,592 (+)NCBI
RefSeq Acc Id: XM_038688953   ⟹   XP_038544881
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0161,008,571 - 1,015,327 (+)NCBI
RefSeq Acc Id: XP_003639605   ⟸   XM_003639557
- UniProtKB: A0A8C0L739 (UniProtKB/TrEMBL),   A0A8C0N3M9 (UniProtKB/TrEMBL),   A0A8I3N8K1 (UniProtKB/TrEMBL),   A0A8C0R4Q4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000018107   ⟸   ENSCAFT00000019522
RefSeq Acc Id: XP_038352840   ⟸   XM_038496912
RefSeq Acc Id: XP_038479146   ⟸   XM_038623218
RefSeq Acc Id: XP_038544881   ⟸   XM_038688953
- UniProtKB: A0A8C0L739 (UniProtKB/TrEMBL),   A0A8C0N3M9 (UniProtKB/TrEMBL),   A0A8I3N8K1 (UniProtKB/TrEMBL),   A0A8C0R4Q4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415176   ⟸   XM_038559248
- UniProtKB: A0A8C0L739 (UniProtKB/TrEMBL),   A0A8C0N3M9 (UniProtKB/TrEMBL),   A0A8C0R4Q4 (UniProtKB/TrEMBL),   A0A8I3N8K1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845015594   ⟸   ENSCAFT00845019908
Promoters
RGD ID:13686021
Promoter ID:EPDNEW_C4088
Type:single initiation site
Name:IGFBP3_1
Description:insulin like growth factor binding protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1161,021,846 - 1,021,906EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012294 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011519 UniProtKB/TrEMBL
  ENSCAFG00040007912 UniProtKB/TrEMBL
  ENSCAFG00845011212 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019522.5 UniProtKB/TrEMBL
  ENSCAFT00030021405.1 UniProtKB/TrEMBL
  ENSCAFT00040014779.1 UniProtKB/TrEMBL
  ENSCAFT00845019908 ENTREZGENE
  ENSCAFT00845019908.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.40.20 UniProtKB/TrEMBL
  4.10.800.10 UniProtKB/TrEMBL
InterPro Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  IGFBP-3 UniProtKB/TrEMBL
  IGFBP-like UniProtKB/TrEMBL
  IGFBP_1-6_chordata UniProtKB/TrEMBL
  Insulin_GF-bd_Cys-rich_CS UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/TrEMBL
NCBI Gene IGFBP3 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN UniProtKB/TrEMBL
  PTHR11551:SF3 UniProtKB/TrEMBL
Pfam IGFBP UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/TrEMBL
PRINTS IGFBPFAMILY UniProtKB/TrEMBL
  IGFBPFAMILY3 UniProtKB/TrEMBL
PROSITE IGFBP_N_1 UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/TrEMBL
  THYROGLOBULIN_1_1 UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/TrEMBL
SMART SM00121 UniProtKB/TrEMBL
  SM00211 UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/TrEMBL
  SSF57610 UniProtKB/TrEMBL
UniProt A0A8C0L739 ENTREZGENE
  A0A8C0N3M9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R4Q4 ENTREZGENE
  A0A8I3N8K1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41904 ENTREZGENE