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ONTOLOGY REPORT - ANNOTATIONS

Term:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
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Accession:GO:0043162 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.
Synonyms:exact_synonym: ubiquitin-dependent protein breakdown via the multivesicular body pathway;   ubiquitin-dependent protein catabolic process via the MVB pathway;   ubiquitin-dependent protein catabolism via the MVB pathway;   ubiquitin-dependent protein degradation via the multivesicular body pathway


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ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp1a charged multivesicular body protein 1A involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436 		JBrowse link
G Chmp1b charged multivesicular body protein 1B involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr18:60,740,349...60,742,879 JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452 		JBrowse link
G Chmp2b charged multivesicular body protein 2B involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr11:3,337,478...3,364,015
Ensembl chr11:3,337,494...3,385,181 		JBrowse link
G Chmp3 charged multivesicular body protein 3 involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr 4:103,576,453...103,622,566
Ensembl chr 4:103,576,515...103,623,959 		JBrowse link
G Chmp4b charged multivesicular body protein 4B involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr 3:143,170,859...143,211,376
Ensembl chr 3:143,170,902...143,210,844 		JBrowse link
G Chmp4c charged multivesicular body protein 4C involved_in ISO
IEA		 (PMID:17984323)
GO_REF:0000107		 RGD
Ensembl		 PMID:17984323 GO_REF:0000107 NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668 		JBrowse link
G Chmp5 charged multivesicular body protein 5 involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr 5:56,081,385...56,098,529
Ensembl chr 5:56,081,343...56,098,529 		JBrowse link
G Chmp6 charged multivesicular body protein 6 involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640 		JBrowse link
G Chmp7 charged multivesicular body protein 7 involved_in ISO (PMID:17984323) RGD PMID:17984323 NCBI chr15:44,790,983...44,806,216
Ensembl chr15:44,790,996...44,806,216 		JBrowse link
G Hdac6 histone deacetylase 6 acts_upstream_of_or_within ISO MGI:3776868 (PMID:17785525) RGD PMID:17785525 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase involved_in ISO
IEA		 (PMID:20086093)
GO_REF:0000107		 RGD
Ensembl		 PMID:20086093 GO_REF:0000107 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951 		JBrowse link
G Plaa phospholipase A2, activating protein involved_in ISS
ISO		 GO_REF:0000024
(MGI:5883825|PMID:28413018)		 UniProt
RGD		 PMID:28413018 GO_REF:0000024 MGI:5883825 NCBI chr 5:109,428,600...109,460,373
Ensembl chr 5:109,428,265...109,460,282 		JBrowse link
G Ptpn23 protein tyrosine phosphatase, non-receptor type 23 involved_in ISO
IEA
ISS		 (PMID:21757351)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:21757351 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:110,360,804...110,383,271
Ensembl chr 8:110,360,804...110,383,271 		JBrowse link
G Rnf115 ring finger protein 115 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 2:184,262,087...184,329,839
Ensembl chr 2:184,262,371...184,329,823 		JBrowse link
G Rnf126 ring finger protein 126 involved_in ISO (PMID:23418353) RGD PMID:23418353 NCBI chr 7:9,939,359...9,946,963
Ensembl chr 7:9,938,229...9,946,738 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO
ISS
IEA		 (PMID:15611048), (PMID:21757351)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:15611048 PMID:21757351 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554 		JBrowse link
G Ubap1 ubiquitin-associated protein 1 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000002
(PMID:21757351)		 UniProt
GO_Central
InterPro
RGD		 PMID:21757351 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:56,520,722...56,561,153
Ensembl chr 5:56,520,743...56,561,152 		JBrowse link
G Ubap1l ubiquitin associated protein 1-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:65,877,488...65,897,593
Ensembl chr 8:65,884,729...65,897,593 		JBrowse link
G Vps28 VPS28 subunit of ESCRT-I involved_in ISO
IEA
ISS		 (PMID:21757351)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:21757351 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:108,341,989...108,345,837
Ensembl chr 7:108,341,989...108,345,837 		JBrowse link
G Vps37a VPS37A subunit of ESCRT-I involved_in ISO
IBA		 (PMID:21757351)
GO_REF:0000033		 RGD
GO_Central		 PMID:21757351 GO_REF:0000033 NCBI chr16:51,736,170...51,775,384
Ensembl chr16:51,737,481...51,775,390 		JBrowse link
G Vps37b VPS37B subunit of ESCRT-I involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:32,560,047...32,589,015
Ensembl chr12:32,560,047...32,589,014 		JBrowse link
G Vps37c VPS37C subunit of ESCRT-I involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:207,336,694...207,362,295
Ensembl chr 1:207,336,731...207,362,289 		JBrowse link
G Vps37d VPS37D subunit of ESCRT-I involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:21,609,210...21,614,669
Ensembl chr12:21,609,182...21,614,659 		JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A involved_in ISO
IEA		 (PMID:22547407)
GO_REF:0000107		 RGD
Ensembl		 PMID:22547407 GO_REF:0000107 NCBI chr19:34,934,999...34,948,888
Ensembl chr19:34,934,961...34,948,887 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO (PMID:22547407) RGD PMID:22547407 NCBI chr13:22,907,105...22,932,200
Ensembl chr13:22,907,109...22,932,229 		JBrowse link
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn23 protein tyrosine phosphatase, non-receptor type 23 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:110,360,804...110,383,271
Ensembl chr 8:110,360,804...110,383,271 		JBrowse link
G Snf8 SNF8 subunit of ESCRT-II involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:80,984,337...80,996,724
Ensembl chr10:80,984,363...80,996,734 		JBrowse link
G Stam signal transducing adaptor molecule involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:77,120,235...77,166,173
Ensembl chr17:77,120,158...77,166,467 		JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:86,196,062...86,201,606
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Vps28 VPS28 subunit of ESCRT-I involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,341,989...108,345,837
Ensembl chr 7:108,341,989...108,345,837 		JBrowse link
G Vps36 vacuolar protein sorting 36 homolog involved_in IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr16:69,810,404...69,834,789
Ensembl chr16:69,808,193...69,834,810 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11456
      primary metabolic process 10015
        protein metabolic process 4605
          proteolysis 1537
            proteolysis involved in protein catabolic process 795
              modification-dependent protein catabolic process 626
                ubiquitin-dependent protein catabolic process 611
                  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 30
                    protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 6
Path 2
Term Annotations click to browse term
  biological_process 19692
    metabolic process 11456
      catabolic process 2751
        organic substance catabolic process 2307
          macromolecule catabolic process 1534
            protein catabolic process 1065
              proteolysis involved in protein catabolic process 795
                modification-dependent protein catabolic process 626
                  ubiquitin-dependent protein catabolic process 611
                    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 30
                      protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 6
paths to the root