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ONTOLOGY REPORT - ANNOTATIONS

Term:low-density lipoprotein particle clearance
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Accession:GO:0034383 term browser browse the term
Definition:The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
Synonyms:exact_synonym: LDL clearance


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low-density lipoprotein particle clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646 		JBrowse link
G APOB apolipoprotein B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:117,250,096...117,316,200
Ensembl chr 3:117,250,096...117,316,200 		JBrowse link
G CD36 CD36 molecule involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105 		JBrowse link
G COMMD1 copper metabolism domain containing 1 acts_upstream_of_or_within ISO (PMID:26965651) MGI PMID:26965651 NCBI chr 3:79,770,315...79,913,969
Ensembl chr 3:79,770,463...79,913,975 		JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 involved_in ISO (PMID:18175806) BHF-UCL PMID:18175806 NCBI chr 9:10,032,163...10,066,082
Ensembl chr 9:10,032,128...10,068,437 		JBrowse link
G EHD1 EH domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:7,299,295...7,321,580
Ensembl chr 2:7,298,208...7,321,576 		JBrowse link
G LDLR low density lipoprotein receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26965651) Ensembl
MGI		 PMID:26965651 GO_REF:0000107 NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,827 		JBrowse link
G LDLRAP1 low density lipoprotein receptor adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:83,030,629...83,054,387
Ensembl chr 6:83,030,702...83,054,377 		JBrowse link
G LIPC lipase C, hepatic type ISO RGD PMID:8071607 RGD:2308769 NCBI chr 1:113,433,684...113,604,139
Ensembl chr 1:113,433,687...113,583,963 		JBrowse link
G SCARB1 scavenger receptor class B member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568 		JBrowse link
G WASHC1 WASH complex subunit 1 acts_upstream_of_or_within ISO (PMID:26965651) MGI PMID:26965651 NCBI chr 5:67,395,737...67,412,408
Ensembl chr 5:67,394,875...67,412,431 		JBrowse link
negative regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 ISO RGD PMID:23828271 RGD:12792253 NCBI chr 2:41,666,974...41,754,624
Ensembl chr 2:41,666,909...41,754,620 		JBrowse link
G APOC3 apolipoprotein C3 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:44,211,171...44,213,538
Ensembl chr 9:44,211,194...44,213,533 		JBrowse link
G CSK C-terminal Src kinase ISO RGD PMID:10884975 RGD:5134370 NCBI chr 7:58,736,473...58,755,034
Ensembl chr 7:58,736,531...58,755,260 		JBrowse link
G IL19 interleukin 19 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:67,469,519...67,479,597
Ensembl chr 9:67,469,524...67,479,813 		JBrowse link
G KHSRP KH-type splicing regulatory protein involved_in ISO (PMID:26523989) BHF-UCL PMID:26523989 NCBI chr 2:72,656,951...72,668,854
Ensembl chr 2:72,656,752...72,668,964 		JBrowse link
G LDLR low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,827 		JBrowse link
G MIR133A-1 microRNA mir-133a-1 involved_in ISO (PMID:28257760) BHF-UCL PMID:28257760 NCBI chr17:61,904,781...61,904,883
Ensembl chr17:61,904,781...61,904,883 		JBrowse link
G MIR133A-2 microRNA mir-133a-2 involved_in ISO (PMID:28257760) BHF-UCL PMID:28257760 NCBI chr 6:106,998,899...106,998,971
Ensembl chr 6:106,998,896...106,998,982 		JBrowse link
G MIR148A microRNA mir-148a involved_in ISO (PMID:26437365) BHF-UCL PMID:26437365 NCBI chr18:46,415,213...46,415,280
Ensembl chr18:46,415,202...46,415,281 		JBrowse link
G MIR17 microRNA mir-17 involved_in ISO (PMID:23285084) ARUK-UCL PMID:23285084 NCBI chr11:60,734,656...60,734,732
Ensembl chr11:60,734,656...60,734,732 		JBrowse link
G MIR185 microRNA mir-185 acts_upstream_of
involved_in		 ISO (PMID:24296663)
(PMID:26523989)		 BHF-UCL PMID:24296663 PMID:26523989 NCBI chr14:51,449,903...51,449,978
Ensembl chr14:51,449,903...51,449,978 		JBrowse link
G MIR199A-1 microRNA mir-199a-1 involved_in ISO (PMID:26163491) BHF-UCL PMID:26163491 NCBI chr 9:114,533,783...114,533,858
Ensembl chr 9:114,533,777...114,533,880 		JBrowse link
G MIR199A-2 microRNA mir-199a-2 involved_in ISO (PMID:26163491) BHF-UCL PMID:26163491 NCBI chr 2:69,558,051...69,558,130
Ensembl chr 2:69,558,050...69,558,131 		JBrowse link
G MIR27A microRNA mir-27a involved_in ISO (PMID:26318398) BHF-UCL PMID:26318398 NCBI chr 2:65,308,294...65,308,375
Ensembl chr 2:65,308,294...65,308,375 		JBrowse link
G MIR27B microRNA mir-27b involved_in ISO (PMID:26520906) BHF-UCL PMID:26520906 NCBI chr10:27,079,963...27,080,042
Ensembl chr10:27,079,954...27,080,056 		JBrowse link
G MYLIP myosin regulatory light chain interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:12,117,240...12,137,934
Ensembl chr 7:12,117,240...12,137,925 		JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:157,388,370...157,409,620
Ensembl chr 6:157,388,372...157,409,551 		JBrowse link
positive regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA2 annexin A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:111,588,721...111,635,064
Ensembl chr 1:111,588,306...111,635,059 		JBrowse link
G LDLRAP1 low density lipoprotein receptor adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:83,030,629...83,054,387
Ensembl chr 6:83,030,702...83,054,377 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:31257031) ARUK-UCL PMID:31257031 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNPY2 canopy FGF signaling regulator 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:22378787) Ensembl
BHF-UCL		 PMID:22378787 GO_REF:0000107 NCBI chr 5:21,707,834...21,711,292
Ensembl chr 5:21,707,834...21,711,292 		JBrowse link
G CRP C-reactive protein, pentraxin-related ISO RGD PMID:8305421 RGD:9586002 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218 		JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K acts_upstream_of ISO (PMID:20371611) BHF-UCL PMID:20371611 NCBI chr10:30,975,639...30,987,955
Ensembl chr10:30,975,702...30,987,956 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,294...83,684,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17667
    multicellular organismal process 8668
      plasma lipoprotein particle clearance 47
        low-density lipoprotein particle clearance 33
          negative regulation of low-density lipoprotein particle clearance 17
          positive regulation of low-density lipoprotein particle clearance 3
          regulation of low-density lipoprotein particle clearance + 24
Path 2
Term Annotations click to browse term
  biological_process 17667
    biological regulation 12821
      regulation of biological process 12448
        regulation of plasma lipoprotein particle levels 79
          plasma lipoprotein particle clearance 47
            low-density lipoprotein particle clearance 33
              negative regulation of low-density lipoprotein particle clearance 17
              positive regulation of low-density lipoprotein particle clearance 3
              regulation of low-density lipoprotein particle clearance + 24
paths to the root