MIR185 (microRNA mir-185) - Rat Genome Database

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Gene: MIR185 (microRNA mir-185) Sus scrofa
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Symbol: MIR185 (Ensembl: ssc-mir-185)
Name: microRNA mir-185 (Ensembl:ssc-mir-185)
RGD ID: 14061266
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA 185; ssc-mir-185
RGD Orthologs
Human
Mouse
Rat
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,449,903 - 51,449,978 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,449,903 - 51,449,978 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,086,524 - 55,086,599 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cholesterol  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cholesterol homeostasis  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of (R)-mevalonic acid biosynthetic process  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of B cell activation  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cholesterol biosynthetic process  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fatty acid biosynthetic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of high-density lipoprotein particle clearance  (ISO)
negative regulation of low-density lipoprotein particle clearance  (ISO)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (ISO)
negative regulation of response to drug  (ISO)
negative regulation of signal transduction  (ISO)
negative regulation of transmembrane transport  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane  (ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
regulation of SMAD protein signal transduction  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:18548309   PMID:19917043   PMID:21312241   PMID:24499489   PMID:37858158  


Genomics

Comparative Map Data
MIR185
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,449,903 - 51,449,978 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,449,903 - 51,449,978 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,086,524 - 55,086,599 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIR185
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,033,139 - 20,033,220 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,033,139 - 20,033,220 (+)EnsemblGRCh38hg38GRCh38
GRCh372220,020,662 - 20,020,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,400,661 - 18,400,742 (+)NCBINCBI36Build 36hg18NCBI36
Celera223,871,865 - 3,871,946 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,641,080 - 3,641,161 (+)NCBIHuRef
CHM1_12220,020,370 - 20,020,451 (+)NCBICHM1_1
T2T-CHM13v2.02220,410,752 - 20,410,833 (+)NCBIT2T-CHM13v2.0
Mir185
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,145,265 - 18,145,329 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,145,265 - 18,145,329 (-)EnsemblGRCm39 Ensembl
GRCm381618,327,401 - 18,327,465 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,327,401 - 18,327,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,327,494 - 18,327,558 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1618,900,146 - 18,900,210 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.35NCBI
Mir185
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,169,028 - 96,169,107 (+)NCBIGRCr8
mRatBN7.21182,664,716 - 82,664,795 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,664,716 - 82,664,795 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,393,107 - 91,393,186 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,054,335 - 84,054,414 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,107,847 - 83,107,926 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,812,702 - 86,812,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,812,702 - 86,812,781 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,906,640 - 89,906,719 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1181,441,729 - 81,441,808 (+)NCBICelera
Cytogenetic Map11q23NCBI
MIR185
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,296,014 - 29,296,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,296,004 - 29,296,079 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,254,692 - 29,254,747 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,699,896 - 30,699,951 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12628,747,758 - 28,747,813 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,373,121 - 28,373,176 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,458,129 - 29,458,184 (-)NCBIUU_Cfam_GSD_1.0


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
mesenchyme
nervous system
2 1 2 1

Sequence


Ensembl Acc Id: ENSSSCT00000021279
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1451,449,903 - 51,449,978 (+)Ensembl
RefSeq Acc Id: NR_035369
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11451,449,903 - 51,449,978 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000019684 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000021279 ENTREZGENE
miRBase MI0008218 ENTREZGENE
NCBI Gene MIR185 ENTREZGENE
RNAcentral URS00004176D4 RNACentral
  URS000075E069 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR185  microRNA mir-185    microRNA 185  Symbol and/or name change 5135510 APPROVED