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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of low-density lipoprotein particle clearance
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Accession:GO:0010988 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.


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regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnpy2 canopy FGF signaling regulator 2 acts_upstream_of ISO (MGI:5427047|PMID:22378787) RGD PMID:22378787 MGI:5427047 NCBI chr 7:748,877...754,352
Ensembl chr 7:749,008...755,519 		JBrowse link
G Crp C-reactive protein IDA RGD PMID:8305421 RGD:9586002 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K acts_upstream_of
involved_in		 ISO
IEA		 (PMID:20371611)
GO_REF:0000107		 RGD
Ensembl		 PMID:20371611 GO_REF:0000107 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G LOC100359916 heterogeneous nuclear ribonucleoprotein K-like involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:58,668,326...58,670,222
Ensembl chr 5:58,668,327...58,670,220 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in ISO
IEA		 (PMID:12660231)
GO_REF:0000107		 RGD
Ensembl		 PMID:12660231 GO_REF:0000107 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
negative regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 IMP RGD PMID:23828271 RGD:12792253 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Apoc3 apolipoprotein C3 involved_in ISO
IBA
IEA		 (PMID:15778093)
GO_REF:0000033
GO_REF:0000118		 RGD
GO_Central
TreeGrafter		 PMID:15778093 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Csk C-terminal Src kinase IDA RGD PMID:10884975 RGD:5134370 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Il19 interleukin 19 involved_in ISO (MGI:6102526|PMID:28257760) RGD PMID:28257760 MGI:6102526 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473 		JBrowse link
G Khsrp KH-type splicing regulatory protein involved_in ISO RNAcentral:URS00004176D4_9606 (PMID:26523989) RGD PMID:26523989 NCBI chr 9:1,862,555...1,872,403
Ensembl chr 9:1,862,899...1,872,451 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO
IEA		 (PMID:17452316)
GO_REF:0000107		 RGD
Ensembl		 PMID:17452316 GO_REF:0000107 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Mir133a1 microRNA 133a-1 involved_in ISO (PMID:28257760) RGD PMID:28257760 NCBI chr18:1,885,082...1,885,168 JBrowse link
G Mir148a microRNA 148a involved_in ISO (PMID:26437365) RGD PMID:26437365 NCBI chr 4:80,333,762...80,333,858
Ensembl chr 4:80,333,762...80,333,858 		JBrowse link
G Mir17 microRNA 17 involved_in ISO (PMID:23285084) RGD PMID:23285084 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir185 microRNA 185 acts_upstream_of
involved_in		 ISO RNAcentral:URS00002367FA_9606|RNAcentral:URS00004176D4_9606 (PMID:24296663)
(PMID:26523989)		 RGD PMID:24296663 PMID:26523989 NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795 		JBrowse link
G Mir199a2 microRNA 199a-2 involved_in ISO (PMID:26163491) RGD PMID:26163491 NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063 		JBrowse link
G Mir27a microRNA 27a involved_in ISO (PMID:26318398) RGD PMID:26318398 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917 		JBrowse link
G Mir27b microRNA 27b involved_in ISO (PMID:26520906) RGD PMID:26520906 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Mir3582 microRNA 3582 involved_in ISO (PMID:28257760) RGD PMID:28257760 NCBI chr18:1,885,063...1,885,180
Ensembl chr18:1,885,063...1,885,180 		JBrowse link
G Mylip myosin regulatory light chain interacting protein involved_in ISO (MGI:3849777|PMID:19520913) RGD PMID:19520913 MGI:3849777 NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in ISO (PMID:17328821), (PMID:22848640) RGD PMID:17328821 PMID:22848640 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
positive regulation of low-density lipoprotein particle clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 involved_in ISO
IEA		 (PMID:22848640)
(MGI:5446858|PMID:22848640)
GO_REF:0000107		 RGD
Ensembl		 PMID:22848640 GO_REF:0000107 MGI:5446858 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 involved_in ISO
IEA		 (PMID:28257760)
GO_REF:0000107		 RGD
Ensembl		 PMID:28257760 GO_REF:0000107 NCBI chr 5:146,955,607...146,978,601
Ensembl chr 5:146,955,607...146,978,601 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6342648|PMID:31257031) RGD PMID:31257031 MGI:6342648 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    multicellular organismal process 8921
      plasma lipoprotein particle clearance 50
        regulation of lipoprotein particle clearance 32
          regulation of low-density lipoprotein particle clearance 24
            negative regulation of low-density lipoprotein particle clearance 16
            positive regulation of low-density lipoprotein particle clearance 3
Path 2
Term Annotations click to browse term
  biological_process 20413
    biological regulation 13755
      regulation of biological process 13322
        regulation of plasma lipoprotein particle levels 82
          plasma lipoprotein particle clearance 50
            regulation of lipoprotein particle clearance 32
              regulation of low-density lipoprotein particle clearance 24
                negative regulation of low-density lipoprotein particle clearance 16
                positive regulation of low-density lipoprotein particle clearance 3
paths to the root