LDLRAP1 (low density lipoprotein receptor adaptor protein 1) - Rat Genome Database
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Gene: LDLRAP1 (low density lipoprotein receptor adaptor protein 1) Sus scrofa
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Symbol: LDLRAP1
Name: low density lipoprotein receptor adaptor protein 1
RGD ID: 13978269
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); clathrin binding (ortholog); signaling adaptor activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); positive regulation of receptor-mediated endocytosis (ortholog); receptor-mediated endocytosis (ortholog); ASSOCIATED WITH autosomal recessive hypercholesterolemia (ortholog); familial hypercholesterolemia (ortholog); Hypercholesterolemia (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); early endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: low density lipoprotein receptor adapter protein 1; low-density lipoprotein adaptor protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl683,030,701 - 83,054,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1683,030,629 - 83,054,387 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2676,601,373 - 76,625,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:19544207  


Genomics

Comparative Map Data
LDLRAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl683,030,701 - 83,054,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1683,030,629 - 83,054,387 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2676,601,373 - 76,625,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LDLRAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl125,543,580 - 25,568,886 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl125,543,606 - 25,568,886 (+)EnsemblGRCh38hg38GRCh38
GRCh38125,543,588 - 25,590,400 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37125,870,097 - 25,895,377 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,742,663 - 25,767,964 (+)NCBINCBI36hg18NCBI36
Celera124,265,963 - 24,291,423 (+)NCBI
Cytogenetic Map1p36.11NCBI
HuRef124,124,497 - 24,149,801 (+)NCBIHuRef
CHM1_1125,983,497 - 26,008,795 (+)NCBICHM1_1
Ldlrap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394134,468,865 - 134,495,342 (-)NCBIGRCm39mm39
GRCm39 Ensembl4134,468,865 - 134,495,335 (-)Ensembl
GRCm384134,741,554 - 134,768,032 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4134,741,554 - 134,768,024 (-)EnsemblGRCm38mm10GRCm38
MGSCv374134,301,327 - 134,323,919 (-)NCBIGRCm37mm9NCBIm37
MGSCv364134,017,498 - 134,040,023 (-)NCBImm8
Celera4132,929,656 - 132,952,236 (-)NCBICelera
Cytogenetic Map4D3NCBI
Ldlrap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25146,955,607 - 146,978,601 (-)NCBI
Rnor_6.0 Ensembl5152,966,591 - 152,987,211 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05152,964,294 - 152,987,286 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05156,742,863 - 156,765,855 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45153,504,535 - 153,527,523 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5145,368,945 - 145,391,939 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ldlrap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554525,081,556 - 5,095,182 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554525,081,919 - 5,102,349 (+)NCBIChiLan1.0ChiLan1.0
LDLRAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1125,871,874 - 25,920,550 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl125,878,358 - 25,903,336 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0124,809,535 - 24,852,394 (+)NCBIMhudiblu_PPA_v0panPan3
LDLRAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl274,341,036 - 74,364,162 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1274,340,272 - 74,363,929 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ldlrap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647410,196,228 - 10,219,137 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LDLRAP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120107,207,363 - 107,232,237 (-)NCBI
Ldlrap1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247649,675,917 - 9,699,597 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 2 5
Low 9 3 3 3 2 18 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003942   ⟹   ENSSSCP00000003851
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl683,030,726 - 83,054,376 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000071367   ⟹   ENSSSCP00000066253
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl683,030,701 - 83,054,381 (+)Ensembl
RefSeq Acc Id: XM_003127708   ⟹   XP_003127756
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1683,030,629 - 83,054,387 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095594   ⟹   XP_020951253
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1683,030,630 - 83,054,387 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003127756 (Get FASTA)   NCBI Sequence Viewer  
  XP_020951253 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABU48613 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003127756   ⟸   XM_003127708
- Peptide Label: isoform X1
- UniProtKB: F1STU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020951253   ⟸   XM_021095594
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000003851   ⟸   ENSSSCT00000003942
RefSeq Acc Id: ENSSSCP00000066253   ⟸   ENSSSCT00000071367
Protein Domains
PID


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003549 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070026515 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000003851 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000066253 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070045031 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003942 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000071367 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070053151 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
KEGG Report ssc:100125967 UniProtKB/TrEMBL
NCBI Gene LDLRAP1 ENTREZGENE
Pfam PID UniProtKB/TrEMBL
  PID_2 UniProtKB/TrEMBL
PROSITE PID UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
UniProt A0A4X1VTR4_PIG UniProtKB/TrEMBL
  A0A5G2QWD8_PIG UniProtKB/TrEMBL
  A7UI08_PIG UniProtKB/TrEMBL
  F1STU0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:89674 ENTREZGENE