PCSK9 (proprotein convertase subtilisin/kexin type 9) - Rat Genome Database
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Gene: PCSK9 (proprotein convertase subtilisin/kexin type 9) Sus scrofa
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Symbol: PCSK9
Name: proprotein convertase subtilisin/kexin type 9
RGD ID: 13861039
Description: ENCODES a protein that exhibits apolipoprotein binding (inferred); apolipoprotein receptor binding (inferred); low-density lipoprotein particle binding (inferred); INVOLVED IN cholesterol homeostasis (ortholog); cholesterol metabolic process (ortholog); kidney development (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Coronary Disease (ortholog); familial hypercholesterolemia (ortholog); FOUND IN cytoplasm (ortholog); extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: proprotein convertase subtilisin/kexin type 9
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6157,388,372 - 157,409,604 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16157,388,370 - 157,409,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26145,451,983 - 145,473,336 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
cellular response to insulin stimulus  (IEA)
cellular response to starvation  (IEA)
cholesterol homeostasis  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
kidney development  (IEA,ISO)
lipoprotein metabolic process  (IEA,ISO)
liver development  (IEA,ISO)
low-density lipoprotein particle receptor catabolic process  (IEA)
low-density lipoprotein receptor particle metabolic process  (ISO)
lysosomal transport  (IEA)
negative regulation of low-density lipoprotein particle clearance  (IEA)
negative regulation of low-density lipoprotein particle receptor binding  (IEA)
negative regulation of low-density lipoprotein receptor activity  (IEA)
negative regulation of receptor recycling  (IEA)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (IEA)
negative regulation of signaling receptor activity  (IEA)
negative regulation of sodium ion transmembrane transporter activity  (IEA)
neurogenesis  (ISO)
neuron differentiation  (IEA)
phospholipid metabolic process  (IEA,ISO)
positive regulation of low-density lipoprotein particle receptor catabolic process  (IEA)
positive regulation of neuron apoptotic process  (IEA)
positive regulation of receptor internalization  (IEA)
protein autoprocessing  (IEA,ISO)
protein processing  (ISO)
proteolysis  (IEA)
regulation of low-density lipoprotein particle receptor catabolic process  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of signaling receptor activity  (ISO)
triglyceride metabolic process  (IEA,ISO)

References
Additional References at PubMed
PMID:29175268   PMID:32560445  


Genomics

Comparative Map Data
PCSK9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6157,388,372 - 157,409,604 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16157,388,370 - 157,409,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26145,451,983 - 145,473,336 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl155,039,548 - 55,064,852 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl155,039,447 - 55,064,852 (+)EnsemblGRCh38hg38GRCh38
GRCh38155,039,548 - 55,064,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37155,505,221 - 55,530,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,277,808 - 55,303,111 (+)NCBINCBI36hg18NCBI36
Build 34155,217,240 - 55,242,544NCBI
Celera153,792,769 - 53,818,130 (+)NCBI
Cytogenetic Map1p32.3NCBI
HuRef153,618,200 - 53,643,557 (+)NCBIHuRef
CHM1_1155,621,314 - 55,646,685 (+)NCBICHM1_1
Pcsk9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394106,299,531 - 106,321,522 (-)NCBIGRCm39mm39
GRCm39 Ensembl4106,299,526 - 106,321,526 (-)Ensembl
GRCm384106,442,334 - 106,464,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4106,442,329 - 106,464,329 (-)EnsemblGRCm38mm10GRCm38
MGSCv374106,114,939 - 106,136,930 (-)NCBIGRCm37mm9NCBIm37
MGSCv364105,940,274 - 105,974,961 (-)NCBImm8
Celera4104,803,009 - 104,824,874 (-)NCBICelera
Cytogenetic Map4C7NCBI
Pcsk9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25121,211,278 - 121,233,688 (-)NCBI
Rnor_6.0 Ensembl5126,031,368 - 126,053,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05126,031,368 - 126,053,726 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05129,878,797 - 129,900,625 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45127,501,476 - 127,524,289 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15127,507,768 - 127,529,490 (-)NCBI
Celera5119,960,965 - 119,983,199 (-)NCBICelera
Cytogenetic Map5q34NCBI
Pcsk9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554644,425,435 - 4,439,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554644,424,583 - 4,439,805 (-)NCBIChiLan1.0ChiLan1.0
PCSK9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1155,911,016 - 55,943,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl155,911,016 - 55,936,456 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0154,323,036 - 54,355,397 (+)NCBIMhudiblu_PPA_v0panPan3
PCSK9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1554,197,211 - 54,210,724 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha554,264,679 - 54,280,339 (-)NCBI
ROS_Cfam_1.0554,383,361 - 54,399,016 (-)NCBI
UMICH_Zoey_3.1554,380,525 - 54,396,181 (-)NCBI
UNSW_CanFamBas_1.0554,270,491 - 54,282,704 (-)NCBI
UU_Cfam_GSD_1.0554,658,929 - 54,672,888 (-)NCBI
Pcsk9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440505869,116,048 - 69,144,955 (+)NCBI
SpeTri2.0NW_0049365226,271,339 - 6,300,202 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK9
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12077,893,574 - 77,921,076 (-)NCBI
ChlSab1.1 Ensembl2077,893,590 - 77,918,613 (-)Ensembl
Pcsk9
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248624,873,457 - 4,895,836 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system nervous system
High
Medium
Low 1
Below cutoff 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000029382   ⟹   ENSSSCP00000023105
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6157,388,372 - 157,409,604 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000052183   ⟹   ENSSSCP00000053893
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6157,388,372 - 157,409,604 (-)Ensembl
RefSeq Acc Id: XM_005653438   ⟹   XP_005653495
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16157,388,370 - 157,409,620 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005653495 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005653495   ⟸   XM_005653438
- Sequence:
RefSeq Acc Id: ENSSSCP00000023105   ⟸   ENSSSCT00000029382
RefSeq Acc Id: ENSSSCP00000053893   ⟸   ENSSSCT00000052183
Protein Domains
Inhibitor I9   PCSK9_C1   PCSK9_C2   PCSK9_C3   Peptidase_S8


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000025020 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000023105 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000053893 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000029382 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000052183 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.80 UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/TrEMBL
InterPro PCSK9_C UniProtKB/TrEMBL
  PCSK9_C2 UniProtKB/TrEMBL
  PCSK9_C3 UniProtKB/TrEMBL
  PCSK9_ProteinaseK-like UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/TrEMBL
  S8pro/Inhibitor_I9 UniProtKB/TrEMBL
  S8pro/Inhibitor_I9_sf UniProtKB/TrEMBL
NCBI Gene PCSK9 ENTREZGENE
Pfam Inhibitor_I9 UniProtKB/TrEMBL
  PCSK9_C1 UniProtKB/TrEMBL
  PCSK9_C2 UniProtKB/TrEMBL
  PCSK9_C3 UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/TrEMBL
PRINTS SUBTILISIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52743 UniProtKB/TrEMBL
UniProt A0A287BBJ9_PIG UniProtKB/TrEMBL
  I3LGB2_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91234 ENTREZGENE