Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:toll-like receptor 2 signaling pathway
go back to main search page
Accession:GO:0034134 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to toll-like receptor 2.
Synonyms:exact_synonym: TLR2 signaling pathway;   toll-like receptor 2 signalling pathway


show annotations for term's descendants           Sort by:
toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:14660645) RGD PMID:14660645 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:10383454)
(PMID:10549626)
GO_REF:0000033		 RGD
GO_Central		 PMID:10383454 PMID:10549626 GO_REF:0000033 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Lgals9 galectin 9 NOT|involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of ISO MGI:2680581 (PMID:15220916) RGD PMID:15220916 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (PMID:22187460) RGD PMID:22187460 NCBI chr 1:240,090,854...240,245,007
Ensembl chr 1:240,093,065...240,204,828 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO (PMID:11894098) RGD PMID:11894098 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Tlr2 toll-like receptor 2 involved_in ISO (PMID:17128265) RGD PMID:17128265 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 involved_in IBA
ISO		 GO_REF:0000033
(PMID:16633345)		 GO_Central
RGD		 PMID:16633345 GO_REF:0000033 NCBI chr14:76,228,350...76,245,553
Ensembl chr14:76,228,371...76,275,265 		JBrowse link
negative regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 involved_in ISO (PMID:23609450) RGD PMID:23609450 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(PMID:20385881)		 UniProt
RGD		 PMID:20385881 GO_REF:0000024 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (PMID:26599367) RGD PMID:26599367 NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO MGI:2680581 (PMID:15220916) RGD PMID:15220916 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Tlr6 toll-like receptor 6 involved_in ISO ComplexPortal:CPX-1134|UniProtKB:O60603 (PMID:22198949) RGD PMID:22198949 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:31134514) RGD PMID:31134514 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
positive regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyba cytochrome b-245 alpha chain involved_in ISO
IEA		 (PMID:22423966)
GO_REF:0000107		 RGD
Ensembl		 PMID:22423966 GO_REF:0000107 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19865078) RGD PMID:19865078 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:16267105) RGD PMID:16267105 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (PMID:26599367), (PMID:28471450) RGD PMID:26599367 PMID:28471450 NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743 		JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 involved_in ISO
ISS		 (PMID:28471450)
GO_REF:0000024		 RGD
UniProt		 PMID:28471450 GO_REF:0000024 NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:19509286) RGD PMID:19509286 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432 		JBrowse link
G Tlr1 toll-like receptor 1 involved_in ISO ComplexPortal:CPX-1134|UniProtKB:O60603 (PMID:22198949) RGD PMID:22198949 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    immune system process 3002
      activation of immune response 576
        immune response-activating signaling pathway 494
          immune response-activating cell surface receptor signaling pathway 302
            innate immune response activating cell surface receptor signaling pathway 90
              cell surface pattern recognition receptor signaling pathway 78
                cell surface toll-like receptor signaling pathway 72
                  toll-like receptor 2 signaling pathway 18
                    MyD88-dependent toll-like receptor 2 signaling pathway 0
                    negative regulation of toll-like receptor 2 signaling pathway 6
                    positive regulation of toll-like receptor 2 signaling pathway 7
                    regulation of toll-like receptor 2 signaling pathway + 12
Path 2
Term Annotations click to browse term
  biological_process 20069
    response to stimulus 10792
      response to external stimulus 2751
        response to external biotic stimulus 1863
          response to other organism 1859
            defense response to other organism 1311
              defense response to symbiont 1177
                innate immune response 1005
                  regulation of innate immune response 480
                    positive regulation of innate immune response 386
                      activation of innate immune response 314
                        innate immune response-activating signaling pathway 287
                          innate immune response activating cell surface receptor signaling pathway 90
                            cell surface pattern recognition receptor signaling pathway 78
                              cell surface toll-like receptor signaling pathway 72
                                toll-like receptor 2 signaling pathway 18
                                  MyD88-dependent toll-like receptor 2 signaling pathway 0
                                  negative regulation of toll-like receptor 2 signaling pathway 6
                                  positive regulation of toll-like receptor 2 signaling pathway 7
                                  regulation of toll-like receptor 2 signaling pathway + 12
paths to the root