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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:toll-like receptor signaling pathway
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Accession:GO:0002224 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
Comment:Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
Synonyms:exact_synonym: TLR signaling pathway;   toll-like receptor signalling pathway
 never_in_taxon: NCBITaxon:7215 ! Drosophila

GViewer not supported for the selected species.

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toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap3b1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO (PMID:20847273) MGI PMID:20847273 NCBI chrNW_004624869:2,459,370...2,741,529
Ensembl chrNW_004624869:2,459,947...2,741,328 		JBrowse link
G Bcl10 BCL10 immune signaling adaptor involved_in ISO (PMID:16831874) UniProt PMID:16831874 NCBI chrNW_004624742:12,210,333...12,222,533
Ensembl chrNW_004624742:12,210,360...12,221,759 		JBrowse link
G Cd86 CD86 molecule acts_upstream_of_or_within ISO (PMID:19734906) MGI PMID:19734906 NCBI chrNW_004624912:350,201...432,410
Ensembl chrNW_004624912:350,157...426,712 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30990796) Ensembl
MGI		 PMID:30990796 GO_REF:0000107 NCBI chrNW_004624767:20,519,054...20,525,311
Ensembl chrNW_004624767:20,519,313...20,524,554 		JBrowse link
G Irak3 interleukin 1 receptor associated kinase 3 ISO RGD PMID:27832756 RGD:34888235 NCBI chrNW_004624802:2,042,486...2,098,921
Ensembl chrNW_004624802:2,047,409...2,098,545 		JBrowse link
G LOC101703392 twinfilin-2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624730:6,004,706...6,020,876 JBrowse link
G LOC101707222 toll-like receptor 12 involved_in IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624764:16,546,107...16,548,950 JBrowse link
G Lrrc19 leucine rich repeat containing 19 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19679103) Ensembl
MGI		 PMID:19679103 GO_REF:0000107 NCBI chrNW_004624736:31,208,583...31,218,754
Ensembl chrNW_004624736:31,206,168...31,218,754 		JBrowse link
G Ly96 lymphocyte antigen 96 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624744:17,209,285...17,241,347
Ensembl chrNW_004624744:17,208,990...17,241,347 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 involved_in ISO (MGI:3761050|PMID:17906627) UniProt PMID:17906627 MGI:3761050 NCBI chrNW_004624807:4,726,511...4,774,945
Ensembl chrNW_004624807:4,724,234...4,796,143 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624730:4,446,815...4,492,753
Ensembl chrNW_004624730:4,446,850...4,476,630 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:23728777)
(PMID:25124037)		 MGI PMID:23728777 PMID:25124037 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
G Plcg2 phospholipase C gamma 2 involved_in ISO (MGI:3844414|PMID:19136564) ARUK-UCL PMID:19136564 MGI:3844414 NCBI chrNW_004624746:5,678,057...5,824,663
Ensembl chrNW_004624746:5,682,666...5,821,855 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 involved_in ISO (MGI:3761050|PMID:17906627) UniProt PMID:17906627 MGI:3761050 NCBI chrNW_004624829:4,978,181...5,087,493
Ensembl chrNW_004624829:4,983,282...5,087,485 		JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 involved_in ISO (PMID:12471095) UniProt PMID:12471095 NCBI chrNW_004624828:4,964,199...4,973,465
Ensembl chrNW_004624828:4,971,093...4,973,198 		JBrowse link
G Tifab TIFA inhibitor acts_upstream_of_negative_effect ISO (PMID:26458771) MGI PMID:26458771 NCBI chrNW_004624733:11,578,934...11,587,250 JBrowse link
G Tlr1 toll like receptor 1 involved_in ISO
IEA		 RGD
InterPro
TreeGrafter		 PMID:16973131 GO_REF:0000002 GO_REF:0000118 RGD:1643119 NCBI chrNW_004624840:7,287,772...7,349,282
Ensembl chrNW_004624840:7,287,781...7,290,162 		JBrowse link
G Tlr2 toll like receptor 2 involved_in IEA
ISO		 TreeGrafter
InterPro
UniProt
RGD		 PMID:16973131 PMID:18353287 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 RGD:1643119 RGD:5684896 NCBI chrNW_004624858:4,931,820...4,984,175
Ensembl chrNW_004624858:4,979,485...4,981,833 		JBrowse link
G Tlr3 toll like receptor 3 involved_in ISO
IEA		 RGD
InterPro
Ensembl
TreeGrafter		 PMID:16973131 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1643119 NCBI chrNW_004624769:16,925,969...16,945,250
Ensembl chrNW_004624769:16,925,984...16,941,196 		JBrowse link
G Tlr4 toll like receptor 4 involved_in ISO
IEA		 RGD
InterPro
Ensembl		 PMID:16973131 GO_REF:0000002 GO_REF:0000107 RGD:1643119 NCBI chrNW_004624760:17,596,516...17,608,955
Ensembl chrNW_004624760:17,598,630...17,609,120 		JBrowse link
G Tlr5 toll like receptor 5 involved_in IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624835:5,495,723...5,503,462
Ensembl chrNW_004624835:5,500,461...5,503,034 		JBrowse link
G Tlr6 toll like receptor 6 ISO RGD PMID:16973131 PMID:18353287 RGD:1643119 RGD:5684896 NCBI chrNW_004624840:7,323,022...7,349,334 JBrowse link
G Tlr7 toll like receptor 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624882:1,375,216...1,379,705 JBrowse link
G Tlr8 toll like receptor 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624882:1,240,519...1,247,311
Ensembl chrNW_004624882:1,240,626...1,312,468 		JBrowse link
G Traf3 TNF receptor associated factor 3 involved_in ISO (MGI:4839450|PMID:16306937) UniProt PMID:16306937 MGI:4839450 NCBI chrNW_004624734:1,728,353...1,820,345
Ensembl chrNW_004624734:1,728,255...1,786,010 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16415873) InterPro
MGI		 PMID:16415873 GO_REF:0000002 NCBI chrNW_004624767:18,859,990...18,869,083
Ensembl chrNW_004624767:18,860,017...18,868,581 		JBrowse link
MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrfip2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) MGI PMID:19265123 NCBI chrNW_004624788:15,158,920...15,294,785 JBrowse link
MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:14660645) UniProt PMID:14660645 NCBI chrNW_004624776:7,858,400...7,862,716
Ensembl chrNW_004624776:7,793,259...7,863,184 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) BHF-UCL PMID:16148103 NCBI chrNW_004624889:2,736,727...2,746,333 JBrowse link
G Myd88 MYD88 innate immune signal transduction adaptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12872135)
(PMID:12719478)
(PMID:14764662)		 Ensembl
MGI
InterPro		 PMID:12719478 PMID:12872135 PMID:14764662 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004624731:2,677,259...2,681,408
Ensembl chrNW_004624731:2,677,290...2,681,489 		JBrowse link
G Tlr2 toll like receptor 2 acts_upstream_of_or_within ISO (PMID:12719478) MGI PMID:12719478 NCBI chrNW_004624858:4,931,820...4,984,175
Ensembl chrNW_004624858:4,979,485...4,981,833 		JBrowse link
G Tlr4 toll like receptor 4 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624760:17,596,516...17,608,955
Ensembl chrNW_004624760:17,598,630...17,609,120 		JBrowse link
G Tlr6 toll like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584)
(PMID:20037584)		 ARUK-UCL
ComplexPortal		 PMID:20037584 MGI:4438693 NCBI chrNW_004624840:7,323,022...7,349,334 JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 involved_in ISO (MGI:5305352|PMID:22011580) UniProt PMID:22011580 MGI:5305352 NCBI chrNW_004624733:40,964,020...41,006,381 JBrowse link
MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrfip2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) MGI PMID:19265123 NCBI chrNW_004624788:15,158,920...15,294,785 JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 acts_upstream_of_or_within ISO (PMID:12872135)
(PMID:12855817)		 MGI PMID:12855817 PMID:12872135 NCBI chrNW_004624828:4,964,199...4,973,465
Ensembl chrNW_004624828:4,971,093...4,973,198 		JBrowse link
G Tnip3 TNFAIP3 interacting protein 3 involved_in ISO (PMID:17088249) UniProt PMID:17088249 NCBI chrNW_004624777:1,124,389...1,222,450
Ensembl chrNW_004624777:1,124,204...1,158,324 		JBrowse link
negative regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a CD300a molecule involved_in ISO (PMID:22043923) UniProt PMID:22043923 NCBI chrNW_004624801:4,404,376...4,420,836
Ensembl chrNW_004624801:4,404,262...4,421,097 		JBrowse link
G Cd300lf CD300 molecule like family member f involved_in ISO (PMID:22043923) UniProt PMID:22043923 NCBI chrNW_004624801:4,573,010...4,587,632
Ensembl chrNW_004624801:4,573,010...4,587,592 		JBrowse link
negative regulation of MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sarm1 sterile alpha and TIR motif containing 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624786:974,785...1,001,810
Ensembl chrNW_004624786:974,876...997,956 		JBrowse link
negative regulation of toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin beta 2 involved_in ISO (MGI:3662828|PMID:16378096) UniProt PMID:16378096 MGI:3662828 NCBI chrNW_004624786:8,568,102...8,576,445
Ensembl chrNW_004624786:8,568,198...8,577,914 		JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in ISO (PMID:20829348) UniProt PMID:20829348 NCBI chrNW_004624828:6,313,165...6,322,837
Ensembl chrNW_004624828:6,313,867...6,322,764 		JBrowse link
G Gpr108 G protein-coupled receptor 108 involved_in ISO (MGI:6220977|PMID:30332431) UniProt PMID:30332431 MGI:6220977 NCBI chrNW_004624828:3,805,151...3,812,113
Ensembl chrNW_004624828:3,805,366...3,812,055 		JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:5896692|PMID:28039360) UniProt PMID:28039360 MGI:5896692 NCBI chrNW_004624786:9,938,384...9,941,210
Ensembl chrNW_004624786:9,938,384...9,941,235 		JBrowse link
G Irak3 interleukin 1 receptor associated kinase 3 involved_in ISO (MGI:2183694|PMID:12150927) BHF-UCL PMID:12150927 MGI:2183694 NCBI chrNW_004624802:2,042,486...2,098,921
Ensembl chrNW_004624802:2,047,409...2,098,545 		JBrowse link
G Irf4 interferon regulatory factor 4 acts_upstream_of_or_within ISO (PMID:16236719) MGI PMID:16236719 NCBI chrNW_004624756:23,917,111...23,931,482
Ensembl chrNW_004624756:23,918,323...23,931,501 		JBrowse link
G Lgr4 leucine rich repeat containing G protein-coupled receptor 4 involved_in ISO (MGI:5499954|PMID:23589304) UniProt PMID:23589304 MGI:5499954 NCBI chrNW_004624766:17,110,809...17,147,585
Ensembl chrNW_004624766:17,112,909...17,147,785 		JBrowse link
G Lrrc14 leucine rich repeat containing 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624735:12,337,564...12,345,260 JBrowse link
G Nfkbil1 NFKB inhibitor like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624754:24,639,757...24,652,059
Ensembl chrNW_004624754:24,639,860...24,649,968 		JBrowse link
G Nlrp6 NLR family pyrin domain containing 6 acts_upstream_of_or_within ISO (PMID:22763455) MGI PMID:22763455 NCBI chrNW_004624766:22,143,405...22,150,903 JBrowse link
G Otud4 OTU deubiquitinase 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624853:4,091,591...4,145,344
Ensembl chrNW_004624853:4,091,316...4,140,201 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 involved_in ISO (MGI:4821539|PMID:20584979) UniProt PMID:20584979 MGI:4821539 NCBI chrNW_004624824:279,893...383,220
Ensembl chrNW_004624824:293,374...383,156 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5487531|PMID:20728433) UniProt PMID:20728433 MGI:5487531 NCBI chrNW_004624737:8,021,478...8,154,543
Ensembl chrNW_004624737:8,022,836...8,154,422 		JBrowse link
G Rnf115 ring finger protein 115 involved_in ISO (PMID:35343654) UniProt PMID:35343654 NCBI chrNW_004624772:17,099,593...17,196,258
Ensembl chrNW_004624772:17,104,189...17,196,326 		JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase acid like 3B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624764:11,785,739...11,807,351
Ensembl chrNW_004624764:11,785,640...11,807,084 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase involved_in ISO (MGI:3773763|PMID:18083102) UniProt PMID:18083102 MGI:3773763 NCBI chrNW_004624804:8,711,487...8,729,025
Ensembl chrNW_004624804:8,710,821...8,728,072 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon involved_in ISO (PMID:35343654) UniProt PMID:35343654 NCBI chrNW_004624786:4,080,650...4,135,200
Ensembl chrNW_004624786:4,080,427...4,135,459 		JBrowse link
positive regulation of toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdi1 GDP dissociation inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624946:902,831...908,815
Ensembl chrNW_004624946:902,461...909,613 		JBrowse link
G Lrch4 leucine rich repeats and calponin homology domain containing 4 involved_in ISO (MGI:3615854|PMID:16449650) UniProt PMID:16449650 MGI:3615854 NCBI chrNW_004624740:16,491,804...16,503,682
Ensembl chrNW_004624740:16,491,837...16,503,491 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5487531|PMID:20728433) UniProt PMID:20728433 MGI:5487531 NCBI chrNW_004624737:8,021,478...8,154,543
Ensembl chrNW_004624737:8,022,836...8,154,422 		JBrowse link
regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf1 interferon regulatory factor 1 involved_in ISO (MGI:3691368|PMID:17018642) UniProt PMID:17018642 MGI:3691368 NCBI chrNW_004624733:39,596,565...39,603,428
Ensembl chrNW_004624733:39,596,501...39,603,526 		JBrowse link
G Irf7 interferon regulatory factor 7 involved_in ISO (MGI:3575992|PMID:15800576) UniProt PMID:15800576 MGI:3575992 NCBI chrNW_004624766:21,850,211...21,853,189 JBrowse link
regulation of MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf7 interferon regulatory factor 7 involved_in ISO (MGI:3575992|PMID:15800576) UniProt PMID:15800576 MGI:3575992 NCBI chrNW_004624766:21,850,211...21,853,189 JBrowse link
regulation of toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO (PMID:20037584) ARUK-UCL PMID:20037584 NCBI chrNW_004624745:13,904,912...14,159,374
Ensembl chrNW_004624745:13,902,577...14,159,372 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624739:29,341,620...29,441,232
Ensembl chrNW_004624739:29,407,568...29,441,333 		JBrowse link
G Esr1 estrogen receptor 1 acts_upstream_of_or_within ISO (PMID:22659029) MGI PMID:22659029 NCBI chrNW_004624785:6,164,507...6,601,302
Ensembl chrNW_004624785:6,164,379...6,601,326 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624742:5,260,651...5,271,908
Ensembl chrNW_004624742:5,261,537...5,270,695 		JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (MGI:6158883|PMID:20616063) UniProt PMID:20616063 MGI:6158883 NCBI chrNW_004624839:4,908,861...5,000,218
Ensembl chrNW_004624839:4,908,639...5,000,677 		JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624762:25,427,519...25,448,180
Ensembl chrNW_004624762:25,430,926...25,448,114 		JBrowse link
TIRAP-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:11544529) BHF-UCL PMID:11544529 NCBI chrNW_004624812:433,540...445,517
Ensembl chrNW_004624812:439,319...446,646 		JBrowse link
toll-like receptor TLR1:TLR2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scimp SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624786:8,975,216...8,982,825
Ensembl chrNW_004624786:8,974,587...9,007,986 		JBrowse link
toll-like receptor TLR6:TLR2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr2 toll like receptor 2 involved_in ISO (PMID:23626692) ComplexPortal PMID:23626692 NCBI chrNW_004624858:4,931,820...4,984,175
Ensembl chrNW_004624858:4,979,485...4,981,833 		JBrowse link
G Tlr6 toll like receptor 6 involved_in ISO (PMID:23626692) ComplexPortal PMID:23626692 NCBI chrNW_004624840:7,323,022...7,349,334 JBrowse link
TRAM-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101722352 TIR domain-containing adapter molecule 2 involved_in ISO (PMID:22685567)
(PMID:19412184)		 UniProt PMID:19412184 PMID:22685567 NCBI chrNW_004624733:6,304,454...6,341,827 JBrowse link
G Prkce protein kinase C epsilon involved_in ISO (MGI:3652658|PMID:16757566) UniProt PMID:16757566 MGI:3652658 NCBI chrNW_004624738:27,118,764...27,630,733
Ensembl chrNW_004624738:27,118,145...27,627,606 		JBrowse link
G Rab11fip2 RAB11 family interacting protein 2 involved_in ISO (PMID:30883606) UniProt PMID:30883606 NCBI chrNW_004624737:28,633,815...28,675,773
Ensembl chrNW_004624737:28,634,079...28,686,886 		JBrowse link
TRIF-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule involved_in ISO (PMID:36232715) UniProt PMID:36232715 NCBI chrNW_004624736:9,991,851...10,017,047
Ensembl chrNW_004624736:9,996,156...10,013,814 		JBrowse link
G Cd300lf CD300 molecule like family member f involved_in ISO (PMID:22043923) UniProt PMID:22043923 NCBI chrNW_004624801:4,573,010...4,587,632
Ensembl chrNW_004624801:4,573,010...4,587,592 		JBrowse link
G Cd40 CD40 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624790:8,475,640...8,485,927
Ensembl chrNW_004624790:8,476,158...8,485,856 		JBrowse link
G Irf3 interferon regulatory factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624832:4,611,445...4,616,319
Ensembl chrNW_004624832:4,612,374...4,616,276 		JBrowse link
G LOC101722352 TIR domain-containing adapter molecule 2 involved_in IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624733:6,304,454...6,341,827 JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 involved_in ISO (MGI:3718934|PMID:17658277)
(PMID:25636800)		 ParkinsonsUK-UCL
CACAO		 PMID:17658277 PMID:25636800 MGI:3718934 NCBI chrNW_004624828:4,964,199...4,973,465
Ensembl chrNW_004624828:4,971,093...4,973,198 		JBrowse link
G Tlr4 toll like receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624760:17,596,516...17,608,955
Ensembl chrNW_004624760:17,598,630...17,609,120 		JBrowse link
G Tlr6 toll like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chrNW_004624840:7,323,022...7,349,334 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    immune system process 2103
      activation of immune response 460
        activation of innate immune response 253
          innate immune response-activating signaling pathway 237
            pattern recognition receptor signaling pathway 235
              toll-like receptor signaling pathway 69
                MyD88-dependent toll-like receptor signaling pathway + 12
                MyD88-independent toll-like receptor signaling pathway + 14
                TIRAP-dependent toll-like receptor signaling pathway + 1
                negative regulation of toll-like receptor signaling pathway + 20
                positive regulation of toll-like receptor signaling pathway + 3
                regulation of toll-like receptor signaling pathway + 30
                toll-like receptor 21 signaling pathway + 0
                toll-like receptor TLR1:TLR2 signaling pathway 1
                toll-like receptor TLR6:TLR2 signaling pathway 2
Path 2
Term Annotations click to browse term
  biological_process 15093
    response to stimulus 8161
      response to biotic stimulus 1361
        response to external biotic stimulus 1317
          response to other organism 1314
            defense response to other organism 906
              defense response to symbiont 802
                innate immune response 664
                  regulation of innate immune response 371
                    positive regulation of innate immune response 309
                      activation of innate immune response 253
                        innate immune response-activating signaling pathway 237
                          pattern recognition receptor signaling pathway 235
                            toll-like receptor signaling pathway 69
                              MyD88-dependent toll-like receptor signaling pathway + 12
                              MyD88-independent toll-like receptor signaling pathway + 14
                              TIRAP-dependent toll-like receptor signaling pathway + 1
                              negative regulation of toll-like receptor signaling pathway + 20
                              positive regulation of toll-like receptor signaling pathway + 3
                              regulation of toll-like receptor signaling pathway + 30
                              toll-like receptor 21 signaling pathway + 0
                              toll-like receptor TLR1:TLR2 signaling pathway 1
                              toll-like receptor TLR6:TLR2 signaling pathway 2
paths to the root