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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of toll-like receptor signaling pathway
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Accession:GO:0034122 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
Synonyms:exact_synonym: negative regulation of TLR signaling pathway;   negative regulation of toll-like receptor signalling pathway


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negative regulation of toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO (MGI:3662828|PMID:16378096) RGD PMID:16378096 MGI:3662828 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in ISO (PMID:20829348) RGD PMID:20829348 NCBI chr 7:8,391,396...8,397,219
Ensembl chr 7:8,391,397...8,396,829
JBrowse link
G Gpr108 G protein-coupled receptor 108 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:6220977|PMID:30332431)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:30332431 GO_REF:0000024 GO_REF:0000107 MGI:6220977 NCBI chr 9:2,120,740...2,131,771
Ensembl chr 9:2,120,744...2,132,572
JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:5896692|PMID:28039360) RGD PMID:28039360 MGI:5896692 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in ISO (MGI:2183694|PMID:12150927) RGD PMID:12150927 MGI:2183694 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
G Irf4 interferon regulatory factor 4 acts_upstream_of_or_within ISO MGI:2387941 (MGI:3608246|PMID:16236719) RGD PMID:16236719 MGI:3608246 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 involved_in ISS
ISO
GO_REF:0000024
(MGI:5499954|PMID:23589304)
UniProt
RGD
PMID:23589304 GO_REF:0000024 MGI:5499954 NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899
JBrowse link
G Lrrc14 leucine rich repeat containing 14 involved_in ISO
IEA
ISS
(PMID:27426725)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:27426725 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:108,430,779...108,437,118
Ensembl chr 7:108,430,792...108,437,111
JBrowse link
G Nfkbil1 NFKB inhibitor like 1 involved_in ISO
IBA
ISS
(PMID:20829348)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20829348 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:3,589,974...3,608,348
Ensembl chr20:3,590,642...3,605,616
JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 acts_upstream_of_or_within ISO MGI:5085850 (MGI:5432950|PMID:22763455) RGD PMID:22763455 MGI:5432950 NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113
JBrowse link
G Otud4 OTU deubiquitinase 4 involved_in IBA
ISO
PMID:21873635
(MGI:6120140|PMID:29395066)
(PMID:29395066)
RGD PMID:29395066 PMID:21873635 MGI:6120140, RGD:13792537 NCBI chr19:28,236,713...28,279,815
Ensembl chr19:28,236,713...28,279,815
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 involved_in ISO (MGI:4821539|PMID:20584979) RGD PMID:20584979 MGI:4821539 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5487531|PMID:20728433) RGD PMID:20728433 MGI:5487531 NCBI chr 1:240,090,859...240,245,007
Ensembl chr 1:240,093,065...240,204,828
JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B involved_in ISO (MGI:5689225|PMID:26095358) RGD PMID:26095358 MGI:5689225 NCBI chr 5:144,944,618...144,966,703
Ensembl chr 5:144,944,636...144,966,720
JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (PMID:17128265) RGD PMID:17128265 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase involved_in IEA
ISO
ISS
GO_REF:0000107
UniProtKB:Q00993|UniProtKB:Q60805 (MGI:3773763|PMID:18083102)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:18083102 GO_REF:0000024 GO_REF:0000107 MGI:3773763 NCBI chr 3:106,777,686...106,797,154
Ensembl chr 3:106,777,635...106,797,142
JBrowse link
negative regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule involved_in ISO (PMID:22043923) RGD PMID:22043923 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link
G Cd300lf Cd300 molecule-like family member F involved_in ISS
ISO
GO_REF:0000024
(PMID:22043923)
UniProt
RGD
PMID:22043923 GO_REF:0000024 NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041
JBrowse link
negative regulation of MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sarm1 sterile alpha and TIR motif containing 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:63,369,456...63,393,016
Ensembl chr10:63,369,456...63,392,822
JBrowse link
negative regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 involved_in ISO (MGI:5490396|PMID:23609450) RGD PMID:23609450 MGI:5490396 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO
GO_REF:0000024
(MGI:4456928|PMID:20385881)
UniProt
RGD
PMID:20385881 GO_REF:0000024 MGI:4456928 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (PMID:26599367)
(MGI:6162316|PMID:26599367)
RGD PMID:26599367 MGI:6162316 NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO MGI:2680581 (MGI:3050756|PMID:15220916) RGD PMID:15220916 MGI:3050756 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Tlr6 toll-like receptor 6 involved_in ISO ComplexPortal:CPX-1134|UniProtKB:O60603 (PMID:22198949) RGD PMID:22198949 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6695864|PMID:31134514) RGD PMID:31134514 MGI:6695864 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
negative regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19865078) RGD PMID:19865078 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (PMID:15474016) RGD PMID:15474016 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Ubqln1 ubiquilin 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5619743|PMID:21695056)
Ensembl
RGD
PMID:21695056 GO_REF:0000107 MGI:5619743 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090
JBrowse link
negative regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 involved_in ISO (MGI:5490396|PMID:23609450) RGD PMID:23609450 MGI:5490396 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529
JBrowse link
G Bpifb1 BPI fold containing family B, member 1 involved_in IEA
ISO
IBA
GO_REF:0000107
(PMID:21900486)
PMID:21873635
Ensembl
RGD
PMID:21900486 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:142,672,995...142,706,258
Ensembl chr 3:142,672,995...142,706,256
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19948740)
UniProt
Ensembl
RGD
PMID:19948740 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO
GO_REF:0000024
(MGI:4456928|PMID:20385881)
UniProt
RGD
PMID:20385881 GO_REF:0000024 MGI:4456928 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (PMID:28609714) RGD PMID:28609714 NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in ISO
IEA
(PMID:18511497)
GO_REF:0000107
RGD
Ensembl
PMID:18511497 GO_REF:0000107 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Rab7b Rab7b, member RAS oncogene family involved_in ISO (MGI:3834524|PMID:17395780) RGD PMID:17395780 MGI:3834524 NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581
JBrowse link
G Ticam2 toll-like receptor adaptor molecule 2 involved_in ISO (PMID:19412184) RGD PMID:19412184 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6152919|PMID:29407460), (MGI:6695864|PMID:31134514) RGD PMID:29407460 PMID:31134514 MGI:6152919 MGI:6695864 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
negative regulation of toll-like receptor 5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (MGI:4943853|PMID:19912257) RGD PMID:19912257 MGI:4943853 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
negative regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gramd4 GRAM domain containing 4 involved_in IBA
ISO
PMID:21873635
(MGI:6274965|PMID:25917084)
RGD PMID:25917084 PMID:21873635 MGI:6274965, RGD:13792537 NCBI chr 7:117,150,398...117,224,056
Ensembl chr 7:117,150,374...117,224,053
JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S involved_in ISO
IEA
(PMID:26231120)
GO_REF:0000107
RGD
Ensembl
PMID:26231120 GO_REF:0000107 NCBI chr 9:1,245,408...1,307,015
Ensembl chr 9:1,245,410...1,306,947
JBrowse link
G Rab7b Rab7b, member RAS oncogene family involved_in ISO (MGI:4355098|PMID:19587007) RGD PMID:19587007 MGI:4355098 NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    signaling 7460
      negative regulation of signaling 1405
        negative regulation of signal transduction 1264
          negative regulation of toll-like receptor signaling pathway 35
            negative regulation of MyD88-dependent toll-like receptor signaling pathway 2
            negative regulation of MyD88-independent toll-like receptor signaling pathway 1
            negative regulation of toll-like receptor 1 signaling pathway 0
            negative regulation of toll-like receptor 10 signaling pathway 0
            negative regulation of toll-like receptor 11 signaling pathway 0
            negative regulation of toll-like receptor 12 signaling pathway 0
            negative regulation of toll-like receptor 13 signaling pathway 0
            negative regulation of toll-like receptor 15 signaling pathway 0
            negative regulation of toll-like receptor 2 signaling pathway 6
            negative regulation of toll-like receptor 21 signaling pathway 0
            negative regulation of toll-like receptor 3 signaling pathway 3
            negative regulation of toll-like receptor 4 signaling pathway 9
            negative regulation of toll-like receptor 5 signaling pathway 1
            negative regulation of toll-like receptor 6 signaling pathway 0
            negative regulation of toll-like receptor 7 signaling pathway 0
            negative regulation of toll-like receptor 8 signaling pathway 0
            negative regulation of toll-like receptor 9 signaling pathway 3
            suppression by virus of host toll-like receptor signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        regulation of cellular process 12228
          signal transduction 6882
            immune response-regulating signaling pathway 494
              pattern recognition receptor signaling pathway 169
                toll-like receptor signaling pathway 117
                  regulation of toll-like receptor signaling pathway 69
                    negative regulation of toll-like receptor signaling pathway 35
                      negative regulation of MyD88-dependent toll-like receptor signaling pathway 2
                      negative regulation of MyD88-independent toll-like receptor signaling pathway 1
                      negative regulation of toll-like receptor 1 signaling pathway 0
                      negative regulation of toll-like receptor 10 signaling pathway 0
                      negative regulation of toll-like receptor 11 signaling pathway 0
                      negative regulation of toll-like receptor 12 signaling pathway 0
                      negative regulation of toll-like receptor 13 signaling pathway 0
                      negative regulation of toll-like receptor 15 signaling pathway 0
                      negative regulation of toll-like receptor 2 signaling pathway 6
                      negative regulation of toll-like receptor 21 signaling pathway 0
                      negative regulation of toll-like receptor 3 signaling pathway 3
                      negative regulation of toll-like receptor 4 signaling pathway 9
                      negative regulation of toll-like receptor 5 signaling pathway 1
                      negative regulation of toll-like receptor 6 signaling pathway 0
                      negative regulation of toll-like receptor 7 signaling pathway 0
                      negative regulation of toll-like receptor 8 signaling pathway 0
                      negative regulation of toll-like receptor 9 signaling pathway 3
                      suppression by virus of host toll-like receptor signaling pathway 0
paths to the root