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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of toll-like receptor signaling pathway
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Accession:GO:0034122 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway.
Synonyms:exact_synonym: negative regulation of TLR signaling pathway;   negative regulation of toll-like receptor signalling pathway


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negative regulation of toll-like receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 ISO (MGI:MGI:3662828|PMID:16378096) RGD PMID:16378096 MGI:MGI:3662828 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Cactin cactin, spliceosome C complex subunit ISO (PMID:20829348) RGD PMID:20829348 NCBI chr 7:11,258,526...11,266,509
Ensembl chr 7:11,261,201...11,266,630
JBrowse link
G Gps2 G protein pathway suppressor 2 ISO (MGI:MGI:5896692|PMID:28039360) RGD PMID:28039360 MGI:MGI:5896692 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO (MGI:MGI:2183694|PMID:12150927) RGD PMID:12150927 MGI:MGI:2183694 NCBI chr 7:64,922,830...64,982,224
Ensembl chr 7:64,923,615...64,982,281
JBrowse link
G Irf4 interferon regulatory factor 4 ISO MGI:MGI:2387941 (MGI:MGI:3608246|PMID:16236719) RGD PMID:16236719 MGI:MGI:3608246 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 ISO
ISS
(MGI:MGI:5499954|PMID:23589304)
GO_REF:0000024
RGD
UniProt
PMID:23589304 GO_REF:0000024, MGI:MGI:5499954 NCBI chr 3:101,051,960...101,152,119
Ensembl chr 3:101,051,955...101,152,119
JBrowse link
G Lrrc14 leucine rich repeat containing 14 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:27426725)
Ensembl
UniProt
RGD
PMID:27426725 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:117,773,219...117,779,555
Ensembl chr 7:117,773,230...117,779,505
JBrowse link
G Nfkbil1 NFKB inhibitor like 1 ISO
IBA
ISS
(PMID:20829348)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20829348, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:4,823,590...4,839,202
Ensembl chr20:4,822,935...4,839,202
JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 ISO MGI:MGI:5085850 (MGI:MGI:5432950|PMID:22763455) RGD PMID:22763455 MGI:MGI:5432950 NCBI chr 1:213,676,954...213,683,114
Ensembl chr 1:213,686,046...213,691,943
JBrowse link
G Otud4 OTU deubiquitinase 4 ISO
IBA
(PMID:29395066)
PMID:21873635
(MGI:MGI:6120140|PMID:29395066)
RGD PMID:29395066, PMID:21873635 MGI:MGI:6120140, RGD:13792537 NCBI chr19:31,895,753...31,942,509
Ensembl chr19:31,899,087...31,942,180
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO (MGI:MGI:4821539|PMID:20584979) RGD PMID:20584979 MGI:MGI:4821539 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 ISO (MGI:MGI:5487531|PMID:20728433) RGD PMID:20728433 MGI:MGI:5487531 NCBI chr 1:260,527,344...260,679,132
Ensembl chr 1:260,527,781...260,638,915
JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B ISO (MGI:MGI:5689225|PMID:26095358) RGD PMID:26095358 MGI:MGI:5689225 NCBI chr 5:150,925,150...150,946,994
Ensembl chr 5:150,925,370...150,949,931
JBrowse link
G Tlr9 toll-like receptor 9 ISO (PMID:17128265) RGD PMID:17128265 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
UniProtKB:Q00993|UniProtKB:Q60805 (MGI:MGI:3773763|PMID:18083102)
Ensembl
UniProt
RGD
PMID:18083102 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3773763 NCBI chr 3:111,597,102...111,616,142
Ensembl chr 3:111,597,102...111,616,142
JBrowse link
negative regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule ISO (PMID:22043923) RGD PMID:22043923 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
G Cd300lf Cd300 molecule-like family member F ISO
ISS
(PMID:22043923)
GO_REF:0000024
RGD
UniProt
PMID:22043923 GO_REF:0000024 NCBI chr10:103,669,781...103,690,584
Ensembl chr10:103,670,028...103,687,425
JBrowse link
negative regulation of MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sarm1 sterile alpha and TIR motif containing 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:65,742,343...65,766,050
Ensembl chr10:65,742,343...65,766,050
JBrowse link
negative regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 ISO (MGI:MGI:5490396|PMID:23609450) RGD PMID:23609450 MGI:MGI:5490396 NCBI chr15:93,612,968...93,622,322
Ensembl chr15:93,612,971...93,622,358
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO
ISS
(MGI:MGI:4456928|PMID:20385881)
GO_REF:0000024
RGD
UniProt
PMID:20385881 GO_REF:0000024, MGI:MGI:4456928 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Mfhas1 malignant fibrous histiocytoma amplified sequence 1 ISO (PMID:26599367)
(MGI:MGI:6162316|PMID:26599367)
RGD PMID:26599367 MGI:MGI:6162316 NCBI chr16:60,120,457...60,208,550
Ensembl chr16:60,128,201...60,208,462
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO MGI:MGI:2680581 (MGI:MGI:3050756|PMID:15220916) RGD PMID:15220916 MGI:MGI:3050756 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Tlr6 toll-like receptor 6 ISO ComplexPortal:CPX-1134|UniProtKB:O60603 (PMID:22198949) RGD PMID:22198949 NCBI chr14:45,024,351...45,041,188
Ensembl chr14:45,024,351...45,046,446
JBrowse link
negative regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 ISO (PMID:19865078) RGD PMID:19865078 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO (PMID:15474016) RGD PMID:15474016 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Ubqln1 ubiquilin 1 ISO
IEA
(MGI:MGI:5619743|PMID:21695056)
GO_REF:0000107
RGD
Ensembl
PMID:21695056 GO_REF:0000107, MGI:MGI:5619743 NCBI chr17:6,840,441...6,878,842
Ensembl chr17:6,840,463...6,878,844
JBrowse link
negative regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 ISO (MGI:MGI:5490396|PMID:23609450) RGD PMID:23609450 MGI:MGI:5490396 NCBI chr15:93,612,968...93,622,322
Ensembl chr15:93,612,971...93,622,358
JBrowse link
G Bpifb1 BPI fold containing family B, member 1 ISO
IBA
IEA
(PMID:21900486)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:21900486, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:149,668,099...149,702,399
Ensembl chr 3:149,668,102...149,702,399
JBrowse link
G Dab2ip DAB2 interacting protein IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:19948740)
Ensembl
UniProt
RGD
PMID:19948740 GO_REF:0000024, GO_REF:0000107 NCBI chr 3:14,889,263...15,060,286
Ensembl chr 3:14,889,510...15,060,286
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO
ISS
(MGI:MGI:4456928|PMID:20385881)
GO_REF:0000024
RGD
UniProt
PMID:20385881 GO_REF:0000024, MGI:MGI:4456928 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Mfhas1 malignant fibrous histiocytoma amplified sequence 1 ISO (PMID:28609714) RGD PMID:28609714 NCBI chr16:60,120,457...60,208,550
Ensembl chr16:60,128,201...60,208,462
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 ISO
IEA
(PMID:18511497)
GO_REF:0000107
RGD
Ensembl
PMID:18511497 GO_REF:0000107 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
JBrowse link
G Rab7b Rab7b, member RAS oncogene family ISO (MGI:MGI:3834524|PMID:17395780) RGD PMID:17395780 MGI:MGI:3834524 NCBI chr13:48,456,143...48,483,714
Ensembl chr13:48,455,923...48,482,138
JBrowse link
G Ticam2 toll-like receptor adaptor molecule 2 ISO (PMID:19412184) RGD PMID:19412184 NCBI chr18:40,555,106...40,572,569
Ensembl chr18:40,555,106...40,572,241
JBrowse link
negative regulation of toll-like receptor 5 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfaip3 TNF alpha induced protein 3 ISO (MGI:MGI:4943853|PMID:19912257) RGD PMID:19912257 MGI:MGI:4943853 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
negative regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gramd4 GRAM domain containing 4 ISO
IBA
(MGI:MGI:6274965|PMID:25917084)
PMID:21873635
RGD PMID:25917084, PMID:21873635 MGI:MGI:6274965, RGD:13792537 NCBI chr 7:126,939,819...127,013,455
Ensembl chr 7:126,939,925...127,013,486
JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S IEA
ISO
GO_REF:0000107
(PMID:26231120)
Ensembl
RGD
PMID:26231120 GO_REF:0000107 NCBI chr 9:10,585,360...10,646,205
Ensembl chr 9:10,603,813...10,645,939
JBrowse link
G Rab7b Rab7b, member RAS oncogene family ISO (MGI:MGI:4355098|PMID:19587007) RGD PMID:19587007 MGI:MGI:4355098 NCBI chr13:48,456,143...48,483,714
Ensembl chr13:48,455,923...48,482,138
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    signaling 7588
      negative regulation of signaling 1403
        negative regulation of signal transduction 1243
          negative regulation of toll-like receptor signaling pathway 33
            negative regulation of MyD88-dependent toll-like receptor signaling pathway 2
            negative regulation of MyD88-independent toll-like receptor signaling pathway 1
            negative regulation of toll-like receptor 1 signaling pathway 0
            negative regulation of toll-like receptor 10 signaling pathway 0
            negative regulation of toll-like receptor 11 signaling pathway 0
            negative regulation of toll-like receptor 12 signaling pathway 0
            negative regulation of toll-like receptor 13 signaling pathway 0
            negative regulation of toll-like receptor 15 signaling pathway 0
            negative regulation of toll-like receptor 2 signaling pathway 5
            negative regulation of toll-like receptor 21 signaling pathway 0
            negative regulation of toll-like receptor 3 signaling pathway 3
            negative regulation of toll-like receptor 4 signaling pathway 8
            negative regulation of toll-like receptor 5 signaling pathway 1
            negative regulation of toll-like receptor 6 signaling pathway 0
            negative regulation of toll-like receptor 7 signaling pathway 0
            negative regulation of toll-like receptor 8 signaling pathway 0
            negative regulation of toll-like receptor 9 signaling pathway 3
            suppression by virus of host toll-like receptor signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            regulation of signal transduction 2997
              regulation of pattern recognition receptor signaling pathway 94
                regulation of toll-like receptor signaling pathway 64
                  negative regulation of toll-like receptor signaling pathway 33
                    negative regulation of MyD88-dependent toll-like receptor signaling pathway 2
                    negative regulation of MyD88-independent toll-like receptor signaling pathway 1
                    negative regulation of toll-like receptor 1 signaling pathway 0
                    negative regulation of toll-like receptor 10 signaling pathway 0
                    negative regulation of toll-like receptor 11 signaling pathway 0
                    negative regulation of toll-like receptor 12 signaling pathway 0
                    negative regulation of toll-like receptor 13 signaling pathway 0
                    negative regulation of toll-like receptor 15 signaling pathway 0
                    negative regulation of toll-like receptor 2 signaling pathway 5
                    negative regulation of toll-like receptor 21 signaling pathway 0
                    negative regulation of toll-like receptor 3 signaling pathway 3
                    negative regulation of toll-like receptor 4 signaling pathway 8
                    negative regulation of toll-like receptor 5 signaling pathway 1
                    negative regulation of toll-like receptor 6 signaling pathway 0
                    negative regulation of toll-like receptor 7 signaling pathway 0
                    negative regulation of toll-like receptor 8 signaling pathway 0
                    negative regulation of toll-like receptor 9 signaling pathway 3
                    suppression by virus of host toll-like receptor signaling pathway 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.