Mapkapk3 (MAPK activated protein kinase 3) - Rat Genome Database

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Gene: Mapkapk3 (MAPK activated protein kinase 3) Heterocephalus glaber
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Symbol: Mapkapk3
Name: MAPK activated protein kinase 3
RGD ID: 18928459
Description: ENCODES a protein that exhibits 3-phosphoinositide-dependent protein kinase activity (inferred); AMP-activated protein kinase activity (inferred); ATP binding (inferred); INVOLVED IN macropinocytosis (ortholog); peptidyl-serine phosphorylation (ortholog); response to cytokine (ortholog); PARTICIPATES IN p38 MAPK signaling pathway; ASSOCIATED WITH Bacteremia (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MAP kinase-activated protein kinase 3; mitogen-activated protein kinase-activated protein kinase 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,446,850 - 4,476,630 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,446,815 - 4,492,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mapkapk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,446,850 - 4,476,630 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,446,815 - 4,492,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MAPKAPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,611,520 - 50,649,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,611,520 - 50,649,291 (+)EnsemblGRCh38hg38GRCh38
GRCh37350,649,308 - 50,686,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,629,605 - 50,661,723 (+)NCBINCBI36Build 36hg18NCBI36
Build 34350,629,604 - 50,661,723NCBI
Celera350,627,403 - 50,659,525 (+)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef350,705,224 - 50,742,794 (+)NCBIHuRef
CHM1_1350,601,533 - 50,638,951 (+)NCBICHM1_1
T2T-CHM13v2.0350,641,158 - 50,679,247 (+)NCBIT2T-CHM13v2.0
Mapkapk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,132,125 - 107,167,082 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,132,126 - 107,167,076 (-)EnsemblGRCm39 Ensembl
GRCm389107,254,927 - 107,289,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,254,927 - 107,289,877 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,157,258 - 107,192,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,113,028 - 107,147,978 (-)NCBIMGSCv36mm8
Celera9106,860,944 - 106,896,004 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.98NCBI
Mapkapk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,808,429 - 116,842,228 (-)NCBIGRCr8
mRatBN7.28107,929,754 - 107,963,638 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,929,762 - 107,963,568 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,556,431 - 113,590,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,755,606 - 111,789,192 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,598,393 - 109,631,978 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,012,126 - 116,046,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,012,121 - 116,045,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,368,430 - 115,402,297 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,497,626 - 112,531,778 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,517,080 - 112,551,233 (-)NCBI
Celera8107,239,457 - 107,273,298 (-)NCBICelera
Cytogenetic Map8q32NCBI
Mapkapk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,392,539 - 2,420,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,392,539 - 2,419,219 (+)NCBIChiLan1.0ChiLan1.0
MAPKAPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,597,068 - 50,629,342 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,601,850 - 50,634,117 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,542,547 - 50,574,817 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,779,906 - 51,812,124 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,779,912 - 51,812,124 (+)Ensemblpanpan1.1panPan2
MAPKAPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12038,731,492 - 38,759,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2038,732,397 - 38,758,494 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,649,808 - 38,677,437 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,084,740 - 39,112,355 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,084,740 - 39,112,232 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,452,657 - 38,480,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02038,856,269 - 38,883,882 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,136,177 - 39,163,793 (-)NCBIUU_Cfam_GSD_1.0
Mapkapk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,369,894 - 65,399,362 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365292,130,252 - 2,160,313 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365292,130,421 - 2,159,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPKAPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1333,097,393 - 33,125,818 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11333,097,329 - 33,125,820 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21336,318,931 - 36,348,176 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPKAPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,998,774 - 12,036,477 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041154,949,436 - 154,982,394 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000017343   ⟹   ENSHGLP00000017170
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247304,446,850 - 4,476,630 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000017344   ⟹   ENSHGLP00000017171
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247304,447,234 - 4,475,106 (+)Ensembl
RefSeq Acc Id: XM_004834158   ⟹   XP_004834215
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247304,446,815 - 4,492,753 (+)NCBI
RefSeq Acc Id: XM_004834159   ⟹   XP_004834216
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247304,446,815 - 4,492,753 (+)NCBI
RefSeq Acc Id: XM_013070408   ⟹   XP_012925862
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247304,446,815 - 4,492,753 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004834215 (Get FASTA)   NCBI Sequence Viewer  
  XP_004834216 (Get FASTA)   NCBI Sequence Viewer  
  XP_012925862 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB14846 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000017170
RefSeq Acc Id: XP_004834215   ⟸   XM_004834158
- Peptide Label: isoform X1
- UniProtKB: G5BZT6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004834216   ⟸   XM_004834159
- Peptide Label: isoform X2
- UniProtKB: G5BZT6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012925862   ⟸   XM_013070408
- Peptide Label: isoform X3
- UniProtKB: G5BZT6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000017171   ⟸   ENSHGLT00000017344
Ensembl Acc Id: ENSHGLP00000017170   ⟸   ENSHGLT00000017343


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012299 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000017343 ENTREZGENE
Gene3D-CATH MAP kinase activated protein kinase 2 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CDPK_Ser/Thr_kinases UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MAPKAPK_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Mapkapk3 ENTREZGENE
PANTHER MAP KINASE-ACTIVATED PROTEIN KINASE 3 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt G5BZT6 ENTREZGENE, UniProtKB/TrEMBL