MAPKAPK3 (MAPK activated protein kinase 3) - Rat Genome Database

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Gene: MAPKAPK3 (MAPK activated protein kinase 3) Sus scrofa
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Symbol: MAPKAPK3
Name: MAPK activated protein kinase 3
RGD ID: 14204896
Description: ENCODES a protein that exhibits ATP binding (inferred); calcium-dependent protein serine/threonine kinase activity (inferred); calmodulin binding (inferred); INVOLVED IN intracellular signal transduction (inferred); macropinocytosis (inferred); response to cytokine (inferred); PARTICIPATES IN p38 MAPK signaling pathway; ASSOCIATED WITH Bacteremia (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAP kinase-activated protein kinase 3; mitogen-activated protein kinase-activated protein kinase 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1333,097,393 - 33,125,818 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11333,097,329 - 33,125,820 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21336,318,931 - 36,348,176 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:19921547   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAPKAPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1333,097,393 - 33,125,818 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11333,097,329 - 33,125,820 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21336,318,931 - 36,348,176 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPKAPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,611,520 - 50,649,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,611,520 - 50,649,291 (+)EnsemblGRCh38hg38GRCh38
GRCh37350,649,308 - 50,686,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,629,605 - 50,661,723 (+)NCBINCBI36Build 36hg18NCBI36
Build 34350,629,604 - 50,661,723NCBI
Celera350,627,403 - 50,659,525 (+)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef350,705,224 - 50,742,794 (+)NCBIHuRef
CHM1_1350,601,533 - 50,638,951 (+)NCBICHM1_1
T2T-CHM13v2.0350,641,158 - 50,679,247 (+)NCBIT2T-CHM13v2.0
Mapkapk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,132,125 - 107,167,082 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,132,126 - 107,167,076 (-)EnsemblGRCm39 Ensembl
GRCm389107,254,927 - 107,289,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,254,927 - 107,289,877 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,157,258 - 107,192,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,113,028 - 107,147,978 (-)NCBIMGSCv36mm8
Celera9106,860,944 - 106,896,004 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.98NCBI
Mapkapk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,808,429 - 116,842,228 (-)NCBIGRCr8
mRatBN7.28107,929,754 - 107,963,638 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,929,762 - 107,963,568 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,556,431 - 113,590,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,755,606 - 111,789,192 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,598,393 - 109,631,978 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,012,126 - 116,046,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,012,121 - 116,045,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,368,430 - 115,402,297 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,497,626 - 112,531,778 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,517,080 - 112,551,233 (-)NCBI
Celera8107,239,457 - 107,273,298 (-)NCBICelera
Cytogenetic Map8q32NCBI
Mapkapk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,392,539 - 2,420,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,392,539 - 2,419,219 (+)NCBIChiLan1.0ChiLan1.0
MAPKAPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,597,068 - 50,629,342 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,601,850 - 50,634,117 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,542,547 - 50,574,817 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,779,906 - 51,812,124 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,779,912 - 51,812,124 (+)Ensemblpanpan1.1panPan2
MAPKAPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12038,731,492 - 38,759,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2038,732,397 - 38,758,494 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,649,808 - 38,677,437 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,084,740 - 39,112,355 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,084,740 - 39,112,232 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,452,657 - 38,480,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02038,856,269 - 38,883,882 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,136,177 - 39,163,793 (-)NCBIUU_Cfam_GSD_1.0
Mapkapk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,369,894 - 65,399,362 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365292,130,252 - 2,160,313 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365292,130,421 - 2,159,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPKAPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,998,774 - 12,036,477 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041154,949,436 - 154,982,394 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapkapk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,446,850 - 4,476,630 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,446,815 - 4,492,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAPKAPK3
397 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 4 3 5 2 3 2 3
Low 2 20 2 1
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000012495   ⟹   ENSSSCP00000012169
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1333,097,393 - 33,125,818 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000064542   ⟹   ENSSSCP00000039920
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1333,097,408 - 33,125,814 (+)Ensembl
RefSeq Acc Id: NM_001143717   ⟹   NP_001137189
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11333,097,408 - 33,125,820 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005669545   ⟹   XP_005669602
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11333,097,329 - 33,125,820 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005669602   ⟸   XM_005669545
- Peptide Label: isoform X1
- UniProtKB: B8XSJ7 (UniProtKB/TrEMBL),   A0A4X1SIW7 (UniProtKB/TrEMBL),   F1SJ16 (UniProtKB/TrEMBL),   A0A8D0KE59 (UniProtKB/TrEMBL),   A0A8D0QBE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001137189   ⟸   NM_001143717
- UniProtKB: B8XSJ7 (UniProtKB/TrEMBL),   A0A4X1SIW7 (UniProtKB/TrEMBL),   F1SJ16 (UniProtKB/TrEMBL),   A0A8D0KE59 (UniProtKB/TrEMBL),   A0A8D0QBE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000039920   ⟸   ENSSSCT00000064542
RefSeq Acc Id: ENSSSCP00000012169   ⟸   ENSSSCT00000012495
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011415 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005038032 UniProtKB/TrEMBL
  ENSSSCG00015080435 UniProtKB/TrEMBL
  ENSSSCG00025068887 UniProtKB/TrEMBL
  ENSSSCG00030050123 UniProtKB/TrEMBL
  ENSSSCG00035071654 UniProtKB/TrEMBL
  ENSSSCG00040075803 UniProtKB/TrEMBL
  ENSSSCG00045030271 UniProtKB/TrEMBL
  ENSSSCG00050029690 UniProtKB/TrEMBL
  ENSSSCG00055004118 UniProtKB/TrEMBL
  ENSSSCG00060071969 UniProtKB/TrEMBL
  ENSSSCG00065067364 UniProtKB/TrEMBL
  ENSSSCG00070001211 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012495.5 UniProtKB/TrEMBL
  ENSSSCT00000064542 ENTREZGENE
  ENSSSCT00000064542.3 UniProtKB/TrEMBL
  ENSSSCT00005060952.1 UniProtKB/TrEMBL
  ENSSSCT00015109359.1 UniProtKB/TrEMBL
  ENSSSCT00025094943.1 UniProtKB/TrEMBL
  ENSSSCT00030069903.1 UniProtKB/TrEMBL
  ENSSSCT00035096946.1 UniProtKB/TrEMBL
  ENSSSCT00040105327.1 UniProtKB/TrEMBL
  ENSSSCT00045051713.1 UniProtKB/TrEMBL
  ENSSSCT00050039948.1 UniProtKB/TrEMBL
  ENSSSCT00055008142.1 UniProtKB/TrEMBL
  ENSSSCT00060098376.1 UniProtKB/TrEMBL
  ENSSSCT00065092517.1 UniProtKB/TrEMBL
  ENSSSCT00070002379.1 UniProtKB/TrEMBL
  ENSSSCT00070002392.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1170.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAPKAPK_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100233192 UniProtKB/TrEMBL
NCBI Gene MAPKAPK3 ENTREZGENE
PANTHER MAP KINASE-ACTIVATED PROTEIN KINASE 3 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A4X1SIW7 ENTREZGENE, UniProtKB/TrEMBL
  A0A5K1UJP6_PIG UniProtKB/TrEMBL
  A0A8D0KE59 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0QBE3 ENTREZGENE, UniProtKB/TrEMBL
  B8XSJ7 ENTREZGENE, UniProtKB/TrEMBL
  F1SJ16 ENTREZGENE
UniProt Secondary F1SJ16 UniProtKB/TrEMBL
VGNC ID VGNC:90012 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 MAPKAPK3  MAPK activated protein kinase 3    mitogen-activated protein kinase-activated protein kinase 3  Symbol and/or name change 5135510 APPROVED