Cd36 (CD36 molecule (CD36 blood group)) - Rat Genome Database

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Gene: Cd36 (CD36 molecule (CD36 blood group)) Heterocephalus glaber
Analyze
Symbol: Cd36
Name: CD36 molecule (CD36 blood group) (Ensembl:CD36 molecule)
RGD ID: 18927771
Description: ENCODES a protein that exhibits oleic acid binding (ortholog); transforming growth factor beta binding (ortholog); INVOLVED IN apoptotic cell clearance (ortholog); cell-cell adhesion via plasma-membrane adhesion molecules (ortholog); cellular response to bacterial lipopeptide (ortholog); PARTICIPATES IN retinol metabolic pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alcoholic Fatty Liver (ortholog); allergic contact dermatitis (ortholog); FOUND IN apical part of cell (ortholog); caveola (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CD36 molecule; Platelet glycoprotein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473929,407,568 - 29,441,333 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473929,341,620 - 29,441,232 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Alcoholic Fatty Liver  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
blood platelet disease  (ISO)
brain ischemia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cerebral malaria  (ISO)
chronic myeloid leukemia  (ISO)
colitis  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
endometriosis  (ISO)
epilepsy  (ISO)
essential thrombocythemia  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
glucose intolerance  (ISO)
granulomatosis with polyangiitis  (ISO)
Hematoma  (ISO)
hemolytic-uremic syndrome  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
inclusion body myositis  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Knee Osteoarthritis  (ISO)
liver cirrhosis  (ISO)
macular degeneration  (ISO)
malaria  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Mycobacterium Infections  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
nephrosis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
pemphigus  (ISO)
Penetrating Wounds  (ISO)
Plaque, Atherosclerotic  (ISO)
platelet-type bleeding disorder 10  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
polycystic ovary syndrome  (ISO)
polycythemia vera  (ISO)
primary immunodeficiency disease  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
Reperfusion Injury  (ISO)
Retroperitoneal Fibrosis  (ISO)
rheumatic heart disease  (ISO)
Sepsis  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Staphylococcal Infections  (ISO)
steatotic liver disease  (ISO)
Tachycardia  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid fibril formation  (IEA)
amyloid-beta clearance by cellular catabolic process  (IEA)
apoptotic cell clearance  (IEA,ISO)
cell adhesion  (IEA)
cell surface receptor signaling pathway  (IEA)
cell-cell adhesion via plasma-membrane adhesion molecules  (ISO)
cellular response to amyloid-beta  (IEA)
cellular response to bacterial lipopeptide  (IEA,ISO)
cellular response to diacyl bacterial lipopeptide  (IEA)
cellular response to hydroperoxide  (IEA)
cellular response to insulin stimulus  (ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to lipoteichoic acid  (IEA,ISO)
cellular response to low-density lipoprotein particle stimulus  (IEA)
cellular response to oxidative stress  (IEA)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA)
cGMP-mediated signaling  (IEA)
cholesterol import  (IEA)
cholesterol transport  (IEA)
defense response to Gram-positive bacterium  (IEA,ISO)
digestive tract development  (ISO)
eating behavior  (ISO)
energy homeostasis  (IEA)
fatty acid metabolic process  (ISO)
fatty acid oxidation  (ISO)
fatty acid transport  (IEA,ISO)
intestinal absorption  (IEA)
intestinal cholesterol absorption  (IEA)
lipid storage  (IEA)
lipid transport  (IEA)
lipid transport across blood-brain barrier  (IEA)
lipoprotein transport  (IEA)
long-chain fatty acid import across plasma membrane  (IEA)
long-chain fatty acid import into cell  (IEA)
long-chain fatty acid metabolic process  (ISO)
long-chain fatty acid transport  (IEA,ISO)
low-density lipoprotein particle clearance  (IEA)
low-density lipoprotein particle mediated signaling  (IEA)
MAPK cascade  (IEA,ISO)
maternal placenta development  (ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of gene expression  (IEA)
negative regulation of protein import into nucleus  (IEA)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
nitric oxide-cGMP-mediated signaling  (IEA)
oxidised low-density lipoprotein particle clearance  (IEA)
phagocytosis, recognition  (IEA,ISO)
plasma lipoprotein particle clearance  (IEA)
positive regulation of blood coagulation  (IEA)
positive regulation of blood microparticle formation  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell-matrix adhesion  (IEA)
positive regulation of cholesterol storage  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA)
positive regulation of NLRP3 inflammasome complex assembly  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phagocytosis  (ISO)
positive regulation of phagocytosis, engulfment  (IEA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA)
positive regulation of reactive oxygen species metabolic process  (IEA)
positive regulation of triglyceride metabolic process  (ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
receptor internalization  (IEA)
receptor-mediated endocytosis  (IEA)
regulation of action potential  (IEA)
regulation of protein-containing complex assembly  (IEA)
regulation of removal of superoxide radicals  (IEA)
regulation of toll-like receptor signaling pathway  (IEA)
response to activity  (ISO)
response to bacterium  (IEA,ISO)
response to estradiol  (ISO)
response to fatty acid  (IEA)
response to growth hormone  (ISO)
response to linoleic acid  (IEA)
response to lipid  (IEA)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to stilbenoid  (IEA)
response to vitamin B3  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of taste  (IEA)
short-chain fatty acid transport  (IEA)
triglyceride metabolic process  (ISO)
triglyceride transport  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Cd36
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473929,407,568 - 29,441,333 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473929,341,620 - 29,441,232 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CD36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38780,602,207 - 80,679,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl780,369,575 - 80,679,277 (+)EnsemblGRCh38hg38GRCh38
GRCh37780,231,523 - 80,308,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36780,069,459 - 80,144,262 (+)NCBINCBI36Build 36hg18NCBI36
Build 34779,912,607 - 79,950,974NCBI
Celera774,932,098 - 75,009,206 (+)NCBICelera
Cytogenetic Map7q21.11NCBI
HuRef774,834,319 - 74,911,371 (+)NCBIHuRef
CHM1_1780,162,020 - 80,239,042 (+)NCBICHM1_1
T2T-CHM13v2.0781,853,488 - 81,930,588 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2779,562,929 - 79,640,010 (+)NCBI
Cd36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39517,986,680 - 18,093,828 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl517,986,688 - 18,093,799 (-)EnsemblGRCm39 Ensembl
GRCm38517,781,690 - 17,888,959 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl517,781,690 - 17,888,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv37517,287,508 - 17,394,777 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36517,293,840 - 17,347,520 (-)NCBIMGSCv36mm8
Celera514,757,802 - 14,864,361 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map58.11NCBI
Cd36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8418,209,088 - 18,302,142 (+)NCBIGRCr8
mRatBN7.2417,317,343 - 17,410,084 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl417,354,466 - 17,513,903 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx422,477,636 - 22,533,306 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0418,290,445 - 18,348,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0416,675,588 - 16,731,247 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0414,150,309 - 14,191,498 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl414,001,761 - 14,249,749 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0414,125,297 - 14,166,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4413,534,582 - 13,554,416 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera412,880,238 - 12,941,086 (+)NCBICelera
Cytogenetic Map4q11NCBI
Cd36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554105,003,668 - 5,075,313 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554105,003,720 - 5,120,903 (-)NCBIChiLan1.0ChiLan1.0
CD36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2698,337,667 - 98,528,488 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17146,740,194 - 146,795,378 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0772,566,478 - 72,643,517 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1786,228,856 - 86,305,865 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl786,265,114 - 86,305,865 (+)Ensemblpanpan1.1panPan2
CD36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11820,299,808 - 20,375,856 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1820,339,050 - 20,372,639 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1820,015,595 - 20,045,069 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01820,745,564 - 20,821,666 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1820,542,818 - 20,821,688 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11820,418,233 - 20,447,673 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01819,970,682 - 20,000,166 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01820,626,442 - 20,655,919 (+)NCBIUU_Cfam_GSD_1.0
Cd36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511862,188,852 - 62,269,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936810758,182 - 838,365 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936810791,823 - 838,303 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl999,605,181 - 99,782,105 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1999,685,748 - 99,782,296 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29110,037,583 - 110,106,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD36
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12168,214,875 - 68,309,336 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2168,216,201 - 68,268,669 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604235,654,688 - 35,734,209 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Sequence


Ensembl Acc Id: ENSHGLT00000012056   ⟹   ENSHGLP00000011924
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473929,407,568 - 29,441,333 (+)Ensembl
RefSeq Acc Id: XM_004839755   ⟹   XP_004839812
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473929,408,101 - 29,441,232 (+)NCBI
RefSeq Acc Id: XM_013070345   ⟹   XP_012925799
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473929,370,982 - 29,441,232 (+)NCBI
RefSeq Acc Id: XM_013070346   ⟹   XP_012925800
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473929,341,620 - 29,441,232 (+)NCBI
RefSeq Acc Id: XM_021253985   ⟹   XP_021109644
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473929,408,099 - 29,441,232 (+)NCBI
RefSeq Acc Id: XM_021253986   ⟹   XP_021109645
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473929,371,017 - 29,441,232 (+)NCBI
RefSeq Acc Id: XP_012925800   ⟸   XM_013070346
- Peptide Label: isoform X1
- UniProtKB: G5BVU5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012925799   ⟸   XM_013070345
- Peptide Label: isoform X1
- UniProtKB: G5BVU5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021109645   ⟸   XM_021253986
- Peptide Label: isoform X1
- UniProtKB: G5BVU5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021109644   ⟸   XM_021253985
- Peptide Label: isoform X2
- UniProtKB: G5BVU5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004839812   ⟸   XM_004839755
- Peptide Label: isoform X1
- UniProtKB: G5BVU5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000011924   ⟸   ENSHGLT00000012056


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008538 Ensembl, ENTREZGENE
  ENSHGLG00100008827 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000012056 ENTREZGENE
  ENSHGLT00100012016 UniProtKB/TrEMBL
  ENSHGLT00100012018 UniProtKB/TrEMBL
InterPro CD36/SCARB1/SNMP1 UniProtKB/TrEMBL
  CD36_fam UniProtKB/TrEMBL
KEGG Report hgl:101703900 UniProtKB/TrEMBL
NCBI Gene Cd36 ENTREZGENE
PANTHER PTHR11923 UniProtKB/TrEMBL
  PTHR11923:SF12 UniProtKB/TrEMBL
Pfam CD36 UniProtKB/TrEMBL
PRINTS CD36ANTIGEN UniProtKB/TrEMBL
  CD36FAMILY UniProtKB/TrEMBL
UniProt G5BVU5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-01-30 Cd36  CD36 molecule (CD36 blood group)  Cd36  CD36 molecule  Symbol and/or name change 5135510 APPROVED