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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:orciprenaline
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Accession:CHEBI:82719 term browser browse the term
Definition:A racemate composed of equimolar amounts of (R)- and (S)-orciprenaline. Used (as its sulfate salt) to relax the airway muscles and improve breathing for patients suffering from asthma or bronchitis.
Synonyms:exact_synonym: rac-5-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,3-diol
 related_synonym: (RS)-1-(3,5-Dihydroxyphenyl)-2-isopropylaminoethanol;   (RS)-orciprenaline;   3,5-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol;   Formula=C11H17NO3;   Metaproterenol;   orciprenalina;   orciprenalinum;   rac-5-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,3-diol;   rac-orciprenaline;   racemic orciprenaline
 xref: CAS:586-06-1;   DrugBank:DB00816;   HMDB:HMDB0014954;   KEGG:C07144;   KEGG:D08300
 xref_mesh: MESH:D009921
 xref: PMID:20221832;   PMID:21282332;   PMID:21410309;   PMID:23188641;   PMID:24085370;   PMID:345368;   PMID:368899;   PMID:4154486;   PMID:4671423;   PMID:4671739;   PMID:4727875;   PMID:4767625;   PMID:4806747;   PMID:5028606;   PMID:5049154;   PMID:5138661;   PMID:5450670;   PMID:5505816;   PMID:5505819;   PMID:5523085;   PMID:5537688;   PMID:5677872;   PMID:5841669;   PMID:7215898;   Reaxys:2807247;   Wikipedia:Orciprenaline


show annotations for term's descendants           Sort by:
orciprenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 multiple interactions
decreases expression
increases phosphorylation
affects expression
increases activity		 ISO [Metaproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Metaproterenol binds to and results in increased activity of ADRB2 protein
Metaproterenol results in decreased expression of ADRB2 protein
Metaproterenol results in increased phosphorylation of ADRB2 protein
Metaproterenol affects the expression of ADRB2 mRNA
Metaproterenol results in increased activity of ADRB2 protein		 CTD PMID:16980553 PMID:24705868 PMID:34601065 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Metaproterenol results in increased expression of BAX protein CTD PMID:15052282 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Metaproterenol results in increased expression of BCAT1 mRNA CTD PMID:23558518 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Metaproterenol results in decreased expression of BCL2 protein CTD PMID:15052282 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bnip1 BCL2 interacting protein 1 increases expression ISO Metaproterenol results in increased expression of BNIP1 protein CTD PMID:15052282 NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157 		JBrowse link
G Clu clusterin increases expression ISO Metaproterenol results in increased expression of CLU protein CTD PMID:15052282 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Metaproterenol results in increased expression of FABP3 protein CTD PMID:22878004 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Metaproterenol results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Metaproterenol results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Metaproterenol results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Metaproterenol results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Metaproterenol results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Metaproterenol results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Metaproterenol results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399 		JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Metaproterenol results in increased expression of SERPINE1 mRNA CTD PMID:23558518 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Metaproterenol results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Metaproterenol results in increased expression of SPP1 mRNA CTD PMID:23558518 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Metaproterenol results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Metaproterenol results in increased expression of TIMP1 mRNA CTD PMID:23558518 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnni3 troponin I3, cardiac type increases expression EXP Metaproterenol results in increased expression of TNNI3 protein CTD PMID:22878004 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Tnnt2 troponin T2, cardiac type increases expression EXP Metaproterenol results in increased expression of TNNT2 protein CTD PMID:22878004 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        anti-asthmatic agent 9300
          anti-asthmatic drug 8680
            orciprenaline 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        secondary amino compound 6829
                                          5-[1-hydroxy-2-(isopropanylamino)ethyl]benzene-1,3-diol 21
                                            (R)-orciprenaline 21
                                              orciprenaline 21
paths to the root