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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17beta-estradiol 17-glucosiduronic acid
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Accession:CHEBI:791 term browser browse the term
Definition:A steroid glucosiduronic acid that consists of 17beta-estradiol having a beta-glucuronyl residue attached at position 17 via a glycosidic linkage.
Synonyms:exact_synonym: 3-hydroxyestra-1,3,5(10)-trien-17beta-yl beta-D-glucopyranosiduronic acid
 related_synonym: 17beta-Estradiol 17-(beta-D-glucuronide);   17beta-Estradiol glucuronide;   Formula=C24H32O8;   Glucuronosylestradiol;   InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1;   InChIKey=MTKNDAQYHASLID-QXYWQCSFSA-N;   Oestradiol-17beta-glucuronide;   SMILES=[H][C@]12CC[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21)O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O;   estra-1,3,5(10)-triene-3,17beta-diol 17-D-glucuronoside
 xref: CAS:1806-98-0;   HMDB:HMDB0010317;   KEGG:C11237;   LIPID_MAPS_instance:LMST05010015;   LIPID_MAPS_instance:LMST05010025
 xref_mesh: MESH:C025483
 xref: PMID:11812141;   PMID:11837698;   PMID:12527806;   PMID:12751626;   PMID:14567633;   PMID:15537867;   PMID:15608133;   PMID:20124397;   PMID:20360303;   PMID:20374298;   Reaxys:64569
 cyclic_relationship: is_conjugate_acid_of CHEBI:82961



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17beta-estradiol 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8b ATP-binding cassette, sub-family A member 8b increases uptake
multiple interactions
ISO ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide
Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; dofequidar inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; ochratoxin A inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Verapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:12379217 NCBI chr11:109,823,016...109,886,642
Ensembl chr11:109,823,016...109,886,671
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity
multiple interactions
affects localization
decreases secretion
ISO estradiol-17 beta-glucuronide results in decreased activity of ABCB11 protein
estradiol-17 beta-glucuronide affects the localization of and affects the activity of ABCB11 protein; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]
estradiol-17 beta-glucuronide results in decreased secretion of ABCB11 protein
CTD PMID:10869290 PMID:12702498 PMID:12893835 PMID:15763547 PMID:18972403 More... NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A affects response to substance
increases transport
multiple interactions
ISO ABCB1 affects the susceptibility to estradiol-17 beta-glucuronide
ABCB1 results in increased transport of estradiol-17 beta-glucuronide
Daunorubicin inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol 17-glucuronide inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]
CTD PMID:9794924 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 affects export EXP ABCB4 protein affects the export of estradiol-17 beta-glucuronide CTD PMID:11302927 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 affects transport
increases transport
increases uptake
multiple interactions
increases export
ISO ABCC1 protein affects the transport of estradiol-17 beta-glucuronide
ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide; ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide
ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide
[Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Quercetin affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]
ABCC1 protein results in increased export of estradiol-17 beta-glucuronide
CTD PMID:11278867 PMID:11306701 PMID:15459206 PMID:18336795 PMID:21918036 More... NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 affects export
multiple interactions
affects transport
affects response to substance
increases transport
affects localization
decreases secretion
ISO ABCC2 protein affects the export of estradiol-17 beta-glucuronide
[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Bile Acids and Salts promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide promotes the reaction [ABCC2 protein affects the transport of Bile Acids and Salts]; estradiol-17 beta-glucuronide results in decreased activity of and affects the localization of ABCC2 protein; Ethinyl Estradiol metabolite promotes the reaction [ABCC2 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Indomethacin promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Penicillin G promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; sulfanitran promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]
ABCC2 protein affects the susceptibility to estradiol-17 beta-glucuronide
ABCC2 protein modified form results in increased transport of estradiol-17 beta-glucuronide; ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide
abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; AG 1879 inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Bucladesine inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; CL 387785 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; EGF protein inhibits the reaction [Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]; EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein; Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Glycyrrhetinic Acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]
estradiol-17 beta-glucuronide results in decreased secretion of ABCC2 protein
CTD PMID:11500505 PMID:12029626 PMID:12642476 PMID:12702498 PMID:12702717 More... NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 affects transport
increases activity
increases transport
multiple interactions
ISO ABCC3 protein affects the transport of estradiol-17 beta-glucuronide
estradiol-17 beta-glucuronide results in increased activity of ABCC3 protein
ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide
Bile Acids and Salts inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Ethinyl Estradiol metabolite promotes the reaction [ABCC3 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Indomethacin inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; resveratrol metabolite promotes the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]; resveratrol-4'-O-glucuronide inhibits the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]
CTD PMID:12704183 PMID:14722317 PMID:17569508 PMID:19114588 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 increases transport
increases export
affects export
ISO ABCC4 protein results in increased transport of estradiol-17 beta-glucuronide
ABCC4 protein results in increased export of estradiol-17 beta-glucuronide
ABCC4 gene SNP affects the export of estradiol-17 beta-glucuronide
CTD PMID:11856762 PMID:27659809 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases transport
multiple interactions
ISO ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide
Glycyrrhetinic Acid inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]; lapatinib inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]
CTD PMID:18436619 PMID:18829547 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation
ISO tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein] CTD PMID:29090346 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Aqp8 aquaporin 8 decreases expression ISO estradiol-17 beta-glucuronide results in decreased expression of AQP8 protein CTD PMID:17110522 NCBI chr 7:123,061,517...123,067,226
Ensembl chr 7:123,061,514...123,067,227
JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]] CTD PMID:25813982 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:25813982 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of ESR1 protein CTD PMID:25813982 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Hgf hepatocyte growth factor multiple interactions
increases uptake
ISO [HGF protein results in increased expression of SLCO1A1 protein] which results in increased uptake of estradiol-17 beta-glucuronide; ochratoxin A inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; SLCO1A1 protein affects the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150
JBrowse link
G Igf1r insulin-like growth factor I receptor multiple interactions
increases phosphorylation
ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of IGF1R protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein] CTD PMID:29090346 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
JBrowse link
G Ocln occludin affects localization ISO estradiol-17 beta-glucuronide affects the localization of OCLN protein CTD PMID:17463180 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
affects localization
ISO Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of PRKCA protein] CTD PMID:18972403 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 multiple interactions
affects transport
ISO estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]
SLC22A8 protein affects the transport of estradiol-17 beta-glucuronide
CTD PMID:11306713 PMID:15319347 NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 affects uptake
increases uptake
EXP SLCO1A1 protein affects the uptake of estradiol-17 beta-glucuronide
SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide
CTD PMID:21561886 PMID:34619012 NCBI chr 6:141,853,007...141,892,688
Ensembl chr 6:141,853,008...141,892,688
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects uptake
increases uptake
multiple interactions
EXP
ISO
SLCO1A4 protein affects the uptake of estradiol-17 beta-glucuronide
SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide
Bile Acids and Salts inhibits the reaction [SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:19464309 PMID:21561886 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925
JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions
increases import
increases uptake
affects response to substance
ISO
EXP
2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; pentabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]
Bile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]
SLCO1B2 protein affects the susceptibility to estradiol-17 beta-glucuronide
CTD PMID:18180276 PMID:18296417 PMID:19464309 PMID:20176623 PMID:32003934 More... NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372
JBrowse link
G Src Rous sarcoma oncogene multiple interactions ISO estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein] CTD PMID:25813982 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
JBrowse link
G Tjp1 tight junction protein 1 affects localization ISO estradiol-17 beta-glucuronide affects the localization of TJP1 protein CTD PMID:17463180 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
JBrowse link

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  CHEBI ontology 22205
    role 22190
      application 21776
        pharmaceutical 21190
          drug 21190
            protective agent 18630
              geroprotector 17729
                17beta-estradiol 11289
                  17beta-estradiol 17-glucosiduronic acid 24
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  CHEBI ontology 22205
    subatomic particle 22197
      composite particle 22197
        hadron 22197
          baryon 22197
            nucleon 22169
              atomic nucleus 22197
                atom 22197
                  main group element atom 22131
                    p-block element atom 22131
                      carbon group element atom 21928
                        carbon atom 21854
                          organic molecular entity 21854
                            heteroorganic entity 21512
                              organochalcogen compound 21001
                                organooxygen compound 20845
                                  carbohydrates and carbohydrate derivatives 16049
                                    carbohydrate 16049
                                      carbohydrate derivative 14779
                                        glycosyl compound 13169
                                          glycoside 11880
                                            glycosiduronic acid 197
                                              glucosiduronic acid 197
                                                steroid glucosiduronic acid 27
                                                  17beta-estradiol 17-glucosiduronic acid 24
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