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G |
Abca8b |
ATP-binding cassette, sub-family A member 8b |
increases uptake multiple interactions |
ISO |
ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; dofequidar inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; ochratoxin A inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Verapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] |
CTD |
PMID:12379217 |
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NCBI chr11:109,823,016...109,886,642
Ensembl chr11:109,823,016...109,886,671
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G |
Abcb11 |
ATP-binding cassette, sub-family B member 11 |
decreases activity multiple interactions affects localization decreases secretion |
ISO |
estradiol-17 beta-glucuronide results in decreased activity of ABCB11 protein estradiol-17 beta-glucuronide affects the localization of and affects the activity of ABCB11 protein; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein] estradiol-17 beta-glucuronide results in decreased secretion of ABCB11 protein |
CTD |
PMID:10869290 PMID:12702498 PMID:12893835 PMID:15763547 PMID:18972403 PMID:20815017 PMID:29090346 More...
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NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
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G |
Abcb1a |
ATP-binding cassette, sub-family B member 1A |
affects response to substance increases transport multiple interactions |
ISO |
ABCB1 affects the susceptibility to estradiol-17 beta-glucuronide ABCB1 results in increased transport of estradiol-17 beta-glucuronide Daunorubicin inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol 17-glucuronide inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide] |
CTD |
PMID:9794924 |
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NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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G |
Abcb4 |
ATP-binding cassette, sub-family B member 4 |
affects export |
EXP |
ABCB4 protein affects the export of estradiol-17 beta-glucuronide |
CTD |
PMID:11302927 |
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NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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G |
Abcc1 |
ATP-binding cassette, sub-family C member 1 |
affects transport increases transport increases uptake multiple interactions increases export |
ISO |
ABCC1 protein affects the transport of estradiol-17 beta-glucuronide ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide; ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide [Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Quercetin affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide] ABCC1 protein results in increased export of estradiol-17 beta-glucuronide |
CTD |
PMID:11278867 PMID:11306701 PMID:15459206 PMID:18336795 PMID:21918036 PMID:27297967 More...
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NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
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G |
Abcc2 |
ATP-binding cassette, sub-family member 2 |
affects export multiple interactions affects transport affects response to substance increases transport affects localization decreases secretion |
ISO |
ABCC2 protein affects the export of estradiol-17 beta-glucuronide [Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Bile Acids and Salts promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide promotes the reaction [ABCC2 protein affects the transport of Bile Acids and Salts]; estradiol-17 beta-glucuronide results in decreased activity of and affects the localization of ABCC2 protein; Ethinyl Estradiol metabolite promotes the reaction [ABCC2 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Indomethacin promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Penicillin G promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; sulfanitran promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide] ABCC2 protein affects the susceptibility to estradiol-17 beta-glucuronide ABCC2 protein modified form results in increased transport of estradiol-17 beta-glucuronide; ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; AG 1879 inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Bucladesine inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; CL 387785 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; EGF protein inhibits the reaction [Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]; EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein; Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Glycyrrhetinic Acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein] estradiol-17 beta-glucuronide results in decreased secretion of ABCC2 protein |
CTD |
PMID:11500505 PMID:12029626 PMID:12642476 PMID:12702498 PMID:12702717 PMID:12704183 PMID:12893835 PMID:14722317 PMID:15652233 PMID:15846474 PMID:15901800 PMID:15904671 PMID:17463180 PMID:18180276 PMID:18436619 PMID:18972403 PMID:19628752 PMID:20815017 PMID:25813982 PMID:29052767 PMID:29090346 PMID:32003934 More...
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NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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G |
Abcc3 |
ATP-binding cassette, sub-family C member 3 |
affects transport increases activity increases transport multiple interactions |
ISO |
ABCC3 protein affects the transport of estradiol-17 beta-glucuronide estradiol-17 beta-glucuronide results in increased activity of ABCC3 protein ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide Bile Acids and Salts inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Ethinyl Estradiol metabolite promotes the reaction [ABCC3 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Indomethacin inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; resveratrol metabolite promotes the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]; resveratrol-4'-O-glucuronide inhibits the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide] |
CTD |
PMID:12704183 PMID:14722317 PMID:17569508 PMID:19114588 |
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NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
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G |
Abcc4 |
ATP-binding cassette, sub-family C member 4 |
increases transport increases export affects export |
ISO |
ABCC4 protein results in increased transport of estradiol-17 beta-glucuronide ABCC4 protein results in increased export of estradiol-17 beta-glucuronide ABCC4 gene SNP affects the export of estradiol-17 beta-glucuronide |
CTD |
PMID:11856762 PMID:27659809 |
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NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 (Junior blood group) |
increases transport multiple interactions |
ISO |
ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide Glycyrrhetinic Acid inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]; lapatinib inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide] |
CTD |
PMID:18436619 PMID:18829547 |
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NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
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G |
Akt1 |
thymoma viral proto-oncogene 1 |
multiple interactions increases phosphorylation |
ISO |
tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:29090346 |
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NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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G |
Aqp8 |
aquaporin 8 |
decreases expression |
ISO |
estradiol-17 beta-glucuronide results in decreased expression of AQP8 protein |
CTD |
PMID:17110522 |
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NCBI chr 7:123,061,517...123,067,226
Ensembl chr 7:123,061,514...123,067,227
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
EGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]] |
CTD |
PMID:25813982 |
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NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein] |
CTD |
PMID:25813982 |
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NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
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G |
Esr1 |
estrogen receptor 1 (alpha) |
multiple interactions |
ISO |
estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of ESR1 protein |
CTD |
PMID:25813982 |
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NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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G |
Hgf |
hepatocyte growth factor |
multiple interactions increases uptake |
ISO |
[HGF protein results in increased expression of SLCO1A1 protein] which results in increased uptake of estradiol-17 beta-glucuronide; ochratoxin A inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; SLCO1A1 protein affects the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] |
CTD |
PMID:18031729 |
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NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150
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G |
Igf1r |
insulin-like growth factor I receptor |
multiple interactions increases phosphorylation |
ISO |
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of IGF1R protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein] |
CTD |
PMID:29090346 |
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NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
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G |
Ocln |
occludin |
affects localization |
ISO |
estradiol-17 beta-glucuronide affects the localization of OCLN protein |
CTD |
PMID:17463180 |
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NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226
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G |
Prkca |
protein kinase C, alpha |
multiple interactions affects localization |
ISO |
Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of PRKCA protein] |
CTD |
PMID:18972403 |
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NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
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G |
Slc22a8 |
solute carrier family 22 (organic anion transporter), member 8 |
multiple interactions affects transport |
ISO |
estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine] SLC22A8 protein affects the transport of estradiol-17 beta-glucuronide |
CTD |
PMID:11306713 PMID:15319347 |
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NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199
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G |
Slco1a1 |
solute carrier organic anion transporter family, member 1a1 |
affects uptake increases uptake |
EXP |
SLCO1A1 protein affects the uptake of estradiol-17 beta-glucuronide SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide |
CTD |
PMID:21561886 PMID:34619012 |
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NCBI chr 6:141,853,007...141,892,688
Ensembl chr 6:141,853,008...141,892,688
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
affects uptake increases uptake multiple interactions |
EXP ISO |
SLCO1A4 protein affects the uptake of estradiol-17 beta-glucuronide SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide Bile Acids and Salts inhibits the reaction [SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide] |
CTD |
PMID:19464309 PMID:21561886 |
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NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925
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G |
Slco1b2 |
solute carrier organic anion transporter family, member 1b2 |
multiple interactions increases import increases uptake affects response to substance |
ISO EXP |
2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; pentabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide] Bile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide] SLCO1B2 protein affects the susceptibility to estradiol-17 beta-glucuronide |
CTD |
PMID:18180276 PMID:18296417 PMID:19464309 PMID:20176623 PMID:32003934 PMID:32305507 PMID:34619012 More...
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NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372
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G |
Src |
Rous sarcoma oncogene |
multiple interactions |
ISO |
estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein] |
CTD |
PMID:25813982 |
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NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
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G |
Tjp1 |
tight junction protein 1 |
affects localization |
ISO |
estradiol-17 beta-glucuronide affects the localization of TJP1 protein |
CTD |
PMID:17463180 |
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NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
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