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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:steroid glucosiduronic acid
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Accession:CHEBI:26763 term browser browse the term
Synonyms:related_synonym: steroid glucosiduronic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:136637


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17beta-estradiol 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 increases uptake
multiple interactions
ISO ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide
Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; dofequidar inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; ochratoxin A inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Verapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:12379217 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
decreases secretion
affects localization
multiple interactions
EXP estradiol-17 beta-glucuronide results in decreased activity of ABCB11 protein
estradiol-17 beta-glucuronide results in decreased secretion of ABCB11 protein
estradiol-17 beta-glucuronide affects the localization of ABCB11 protein
estradiol-17 beta-glucuronide affects the localization of and affects the activity of ABCB11 protein; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]
CTD PMID:10869290, PMID:12702498, PMID:12893835, PMID:15763547, PMID:18972403, PMID:20815017, PMID:29090346 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
multiple interactions
increases transport
ISO
EXP
ABCB1 affects the susceptibility to estradiol-17 beta-glucuronide
Daunorubicin inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol 17-glucuronide inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]
CTD PMID:9794924 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 affects export ISO ABCB4 protein affects the export of estradiol-17 beta-glucuronide CTD PMID:11302927 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects transport
increases export
multiple interactions
increases uptake
increases transport
ISO ABCC1 protein affects the transport of estradiol-17 beta-glucuronide
ABCC1 protein results in increased export of estradiol-17 beta-glucuronide
[Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Quercetin affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]
ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide; ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide
CTD PMID:11278867, PMID:11306701, PMID:15459206, PMID:18336795, PMID:21918036, PMID:27297967 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
decreases secretion
affects localization
affects transport
multiple interactions
increases transport
affects response to substance
ISO
EXP
ABCC2 protein affects the export of estradiol-17 beta-glucuronide
estradiol-17 beta-glucuronide results in decreased secretion of ABCC2 protein
estradiol-17 beta-glucuronide affects the localization of ABCC2 protein
ABCC2 protein affects the transport of estradiol-17 beta-glucuronide
abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; AG 1879 inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Bucladesine inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; CL 387785 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; EGF protein inhibits the reaction [Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]; EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein; Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Glycyrrhetinic Acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]
ABCC2 protein modified form results in increased transport of estradiol-17 beta-glucuronide; ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide
ABCC2 protein affects the susceptibility to estradiol-17 beta-glucuronide
[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Bile Acids and Salts promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide promotes the reaction [ABCC2 protein affects the transport of Bile Acids and Salts]; estradiol-17 beta-glucuronide results in decreased activity of and affects the localization of ABCC2 protein; Ethinyl Estradiol metabolite promotes the reaction [ABCC2 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Indomethacin promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Penicillin G promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; sulfanitran promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:11500505, PMID:12029626, PMID:12642476, PMID:12702498, PMID:12702717, PMID:12704183, PMID:12893835, PMID:14722317, PMID:15652233, PMID:15846474, PMID:15901800, PMID:15904671, PMID:17463180, PMID:18180276, PMID:18436619, PMID:18972403, PMID:19628752, PMID:20815017, PMID:25813982, PMID:29052767, PMID:29090346, PMID:32003934 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects transport
multiple interactions
increases transport
increases activity
ISO ABCC3 protein affects the transport of estradiol-17 beta-glucuronide
Bile Acids and Salts inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Ethinyl Estradiol metabolite promotes the reaction [ABCC3 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Indomethacin inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; resveratrol metabolite promotes the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]; resveratrol-4'-O-glucuronide inhibits the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]
estradiol-17 beta-glucuronide results in increased activity of ABCC3 protein
CTD PMID:12704183, PMID:14722317, PMID:17569508, PMID:19114588 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases transport
affects export
increases export
ISO ABCC4 protein results in increased transport of estradiol-17 beta-glucuronide
ABCC4 gene SNP affects the export of estradiol-17 beta-glucuronide
ABCC4 protein results in increased export of estradiol-17 beta-glucuronide
CTD PMID:11856762, PMID:27659809 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases transport
multiple interactions
ISO ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide
Glycyrrhetinic Acid inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]; lapatinib inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]
CTD PMID:18436619, PMID:18829547 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein
tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein]
CTD PMID:29090346 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aqp8 aquaporin 8 decreases expression EXP estradiol-17 beta-glucuronide results in decreased expression of AQP8 protein CTD PMID:17110522 NCBI chr 1:193,424,818...193,430,665
Ensembl chr 1:193,424,812...193,430,676
JBrowse link
G Egf epidermal growth factor multiple interactions EXP EGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]] CTD PMID:25813982 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:25813982 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of ESR1 protein CTD PMID:25813982 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Hgf hepatocyte growth factor multiple interactions
increases uptake
EXP [HGF protein results in increased expression of SLCO1A1 protein] which results in increased uptake of estradiol-17 beta-glucuronide; ochratoxin A inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; SLCO1A1 protein affects the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases phosphorylation
EXP 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of IGF1R protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein] CTD PMID:29090346 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Ocln occludin affects localization EXP estradiol-17 beta-glucuronide affects the localization of OCLN protein CTD PMID:17463180 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
affects localization
EXP Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of PRKCA protein] CTD PMID:18972403 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
affects transport
EXP
ISO
estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]
SLC22A8 protein affects the transport of estradiol-17 beta-glucuronide
CTD PMID:11306713, PMID:15319347 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects uptake
increases uptake
multiple interactions
ISO
EXP
SLCO1A4 protein affects the uptake of estradiol-17 beta-glucuronide
SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide
Bile Acids and Salts inhibits the reaction [SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:19464309, PMID:21561886 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases uptake
increases import
multiple interactions
affects response to substance
EXP
ISO
SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide
SLCO1B3 results in increased import of estradiol-17 beta-glucuronide
2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; pentabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]
SLCO1B2 protein affects the susceptibility to estradiol-17 beta-glucuronide
Bile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:18180276, PMID:18296417, PMID:19464309, PMID:20176623, PMID:32003934, PMID:32305507 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein] CTD PMID:25813982 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tjp1 tight junction protein 1 affects localization EXP estradiol-17 beta-glucuronide affects the localization of TJP1 protein CTD PMID:17463180 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
17beta-estradiol 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity EXP estradiol-3-glucuronide results in decreased activity of ABCB11 protein CTD PMID:10869290 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Kl Klotho multiple interactions
increases hydrolysis
ISO estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estradiol-3-glucuronide
CTD PMID:14701853 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
Aldosterone 18-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases chemical synthesis
ISO alclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; cicloprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Diflunisal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Fenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ibuprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Indomethacin inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketorolac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Naproxen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; pirprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide] CTD PMID:19740398 NCBI chr14:22,597,103...22,619,968 JBrowse link
androsterone 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions ISO androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
estriol 16-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:9794924 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
estriol 3-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions
increases hydrolysis
ISO estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
KL protein results in increased hydrolysis of estriol 3-glucuronide
CTD PMID:14701853 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
estrone 3-O-(beta-D-glucuronide) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho increases hydrolysis
multiple interactions
ISO KL protein results in increased hydrolysis of estrone-3-glucuronide
estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
CTD PMID:14701853 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
testosterone 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions ISO testosterone glucuronate inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          carbon atom 19597
            organic molecular entity 19597
              lipid 17059
                steroid 12800
                  steroid glucosiduronic acid 25
                    (2S,3S,4R,5S,6R)-6-(\{3-[(1R,3aS,3bR,9aR,9bS,11aS)-1-hydroxy-9a,11a-dimethyl-7-oxo-2H,3H,3aH,3bH,8H,9H,9bH,10H,11H-cyclopenta[a]phenanthren-1-yl]propanoyl\}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid 0
                    (3a,5b,7a,12a)-24-[(carboxymethyl)amino]-1,12-dihydroxy-24-oxocholan-3-yl-b-D-Glucopyranosiduronic acid 0
                    11-Oxo-androsterone glucuronide 0
                    11-beta-Hydroxyandrosterone-3-glucuronide 0
                    11alpha-hydroxyprogesterone 11-glucosiduronic acid 0
                    16-epiestriol 16-O-(beta-D-glucuronide) 0
                    16-epiestriol 3-O-(beta-D-glucuronide) 0
                    16alpha-hydroxyestrone 16-O-(beta-D-glucuronide) 0
                    16alpha-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                    17-Hydroxyandrostane-3-glucuronide 0
                    17-epiestriol 16-O-(beta-D-glucuronide) 0
                    17-epiestriol 17-O-(beta-D-glucuronide) 0
                    17-epiestriol 3-O-(beta-D-glucuronide) 0
                    17alpha-(N-acetyl-D-glucosaminyl)estradiol 3-glucosiduronic acid 0
                    17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucuronoside 0
                    17alpha-estradiol 17-O-(beta-D-glucuronide) 0
                    17alpha-estradiol 3-glucosiduronic acid 0
                    17beta-Estradiol-3-(beta-D-glucuronide) 17-sulfate 0
                    17beta-estradiol 17-glucosiduronic acid 23
                    17beta-estradiol 3-glucosiduronic acid 2
                    17beta-estradiol 3-sulfate 17-(beta-D-glucosiduronic acid) 0
                    2-hydroxy-17beta-estradiol 2-O-(beta-D-glucuronide) 0
                    2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                    2-hydroxyestrone 2-O-(beta-D-glucuronide) 0
                    2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                    2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                    2-methoxyestrone 3-O-(beta-D-glucuronide) 0
                    3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
                    4-androsten-17beta-ol-3-one glucosiduronate 0
                    4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                    4-hydroxy-17beta-estradiol 4-O-(beta-D-glucuronide) 0
                    4-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                    4-hydroxyestrone 4-O-(beta-D-glucuronide) 0
                    4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                    4-methoxyestrone 3-O-(beta-D-glucuronide) 0
                    5alpha-androstane-3alpha,17beta-diol 17-glucosiduronic acid 0
                    5alpha-androstane-3beta,17beta-diol 17-O-(beta-D-glucuronide) 0
                    5alpha-dihydrotestosterone 17-O-(beta-D-glucuronide) 0
                    5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronide] 0
                    6-dehydrotestosterone 17-glucosiduronic acid 0
                    Aldosterone 18-glucuronide 1
                    Pregnanediol-3-glucuronide 0
                    Tetrahydroaldosterone-3-glucuronide 0
                    androsterone 3-glucosiduronic acid 1
                    bile alcohol glucuronide 0
                    calcidiol 25-O-(beta-D-glucuronide) 0
                    calcidiol 3-O-(beta-D-glucuronide) 0
                    calcitriol 25-O-(beta-D-glucuronide) 0
                    chenodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                    chenodeoxycholic acid 3-O-(beta-D-glucuronide) 0
                    cholic acid 24-O-(beta-D-glucuronide) 0
                    cholic acid glucuronide 0
                    dehydroisoandrosterone 3-glucuronide 0
                    deoxycholic acid 24-O-(beta-D-glucuronide) 0
                    deoxycholic acid 3-glucuronide 0
                    epitestosterone 17-O-(beta-D-glucuronide) 0
                    estriol 16-O-(beta-D-glucuronide) 1
                    estriol 3-O-(beta-D-glucuronide) 1
                    estrone 3-O-(beta-D-glucuronide) 1
                    etiocholanolone 3-glucuronide 0
                    hyocholic acid 24-O-(beta-D-glucuronide) 0
                    hyocholic acid 6-O-(beta-D-glucuronide) 0
                    hyodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                    hyodeoxycholic acid 6-O-(beta-D-glucuronide) 0
                    lithocholic acid 24-O-(beta-D-glucuronide) 0
                    lithocholic acid 3-O-(beta-D-glucuronide) 0
                    testosterone 17-glucosiduronic acid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            heteroorganic entity 19184
                              organochalcogen compound 18894
                                organooxygen compound 18816
                                  carbohydrates and carbohydrate derivatives 12191
                                    carbohydrate 12191
                                      carbohydrate derivative 11814
                                        glycosyl compound 10856
                                          glycoside 9209
                                            glycosiduronic acid 140
                                              glucosiduronic acid 140
                                                steroid glucosiduronic acid 25
                                                  (2S,3S,4R,5S,6R)-6-(\{3-[(1R,3aS,3bR,9aR,9bS,11aS)-1-hydroxy-9a,11a-dimethyl-7-oxo-2H,3H,3aH,3bH,8H,9H,9bH,10H,11H-cyclopenta[a]phenanthren-1-yl]propanoyl\}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid 0
                                                  (3a,5b,7a,12a)-24-[(carboxymethyl)amino]-1,12-dihydroxy-24-oxocholan-3-yl-b-D-Glucopyranosiduronic acid 0
                                                  11-Oxo-androsterone glucuronide 0
                                                  11-beta-Hydroxyandrosterone-3-glucuronide 0
                                                  11alpha-hydroxyprogesterone 11-glucosiduronic acid 0
                                                  16-epiestriol 16-O-(beta-D-glucuronide) 0
                                                  16-epiestriol 3-O-(beta-D-glucuronide) 0
                                                  16alpha-hydroxyestrone 16-O-(beta-D-glucuronide) 0
                                                  16alpha-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                                  17-Hydroxyandrostane-3-glucuronide 0
                                                  17-epiestriol 16-O-(beta-D-glucuronide) 0
                                                  17-epiestriol 17-O-(beta-D-glucuronide) 0
                                                  17-epiestriol 3-O-(beta-D-glucuronide) 0
                                                  17alpha-(N-acetyl-D-glucosaminyl)estradiol 3-glucosiduronic acid 0
                                                  17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucuronoside 0
                                                  17alpha-estradiol 17-O-(beta-D-glucuronide) 0
                                                  17alpha-estradiol 3-glucosiduronic acid 0
                                                  17beta-Estradiol-3-(beta-D-glucuronide) 17-sulfate 0
                                                  17beta-estradiol 17-glucosiduronic acid 23
                                                  17beta-estradiol 3-glucosiduronic acid 2
                                                  17beta-estradiol 3-sulfate 17-(beta-D-glucosiduronic acid) 0
                                                  2-hydroxy-17beta-estradiol 2-O-(beta-D-glucuronide) 0
                                                  2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                                                  2-hydroxyestrone 2-O-(beta-D-glucuronide) 0
                                                  2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                                  2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                                                  2-methoxyestrone 3-O-(beta-D-glucuronide) 0
                                                  3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
                                                  4-androsten-17beta-ol-3-one glucosiduronate 0
                                                  4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                                                  4-hydroxy-17beta-estradiol 4-O-(beta-D-glucuronide) 0
                                                  4-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                                  4-hydroxyestrone 4-O-(beta-D-glucuronide) 0
                                                  4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
                                                  4-methoxyestrone 3-O-(beta-D-glucuronide) 0
                                                  5alpha-androstane-3alpha,17beta-diol 17-glucosiduronic acid 0
                                                  5alpha-androstane-3beta,17beta-diol 17-O-(beta-D-glucuronide) 0
                                                  5alpha-dihydrotestosterone 17-O-(beta-D-glucuronide) 0
                                                  5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronide] 0
                                                  6-dehydrotestosterone 17-glucosiduronic acid 0
                                                  Aldosterone 18-glucuronide 1
                                                  Pregnanediol-3-glucuronide 0
                                                  Tetrahydroaldosterone-3-glucuronide 0
                                                  androsterone 3-glucosiduronic acid 1
                                                  bile alcohol glucuronide 0
                                                  calcidiol 25-O-(beta-D-glucuronide) 0
                                                  calcidiol 3-O-(beta-D-glucuronide) 0
                                                  calcitriol 25-O-(beta-D-glucuronide) 0
                                                  chenodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                                                  chenodeoxycholic acid 3-O-(beta-D-glucuronide) 0
                                                  cholic acid 24-O-(beta-D-glucuronide) 0
                                                  cholic acid glucuronide 0
                                                  dehydroisoandrosterone 3-glucuronide 0
                                                  deoxycholic acid 24-O-(beta-D-glucuronide) 0
                                                  deoxycholic acid 3-glucuronide 0
                                                  epitestosterone 17-O-(beta-D-glucuronide) 0
                                                  estriol 16-O-(beta-D-glucuronide) 1
                                                  estriol 3-O-(beta-D-glucuronide) 1
                                                  estrone 3-O-(beta-D-glucuronide) 1
                                                  etiocholanolone 3-glucuronide 0
                                                  hyocholic acid 24-O-(beta-D-glucuronide) 0
                                                  hyocholic acid 6-O-(beta-D-glucuronide) 0
                                                  hyodeoxycholic acid 24-O-(beta-D-glucuronide) 0
                                                  hyodeoxycholic acid 6-O-(beta-D-glucuronide) 0
                                                  lithocholic acid 24-O-(beta-D-glucuronide) 0
                                                  lithocholic acid 3-O-(beta-D-glucuronide) 0
                                                  testosterone 17-glucosiduronic acid 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.