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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases activity multiple interactions |
ISO |
metolachlor results in increased activity of ABCB1 protein ABCB1 protein affects the reaction [metolachlor results in increased susceptibility to Paclitaxel] |
CTD |
PMID:18433974 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Ar |
androgen receptor |
affects binding multiple interactions |
EXP ISO |
metolachlor binds to AR protein metolachlor inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] |
CTD |
PMID:14565775 PMID:33049310 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
metolachlor results in decreased expression of CCNA2 mRNA |
CTD |
PMID:23084262 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases activity |
ISO |
metolachlor results in increased activity of CYP19A1 protein |
CTD |
PMID:16996190 |
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NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases activity multiple interactions |
ISO |
metolachlor results in increased activity of CYP1A1 protein [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to metolachlor |
CTD |
PMID:10813365 PMID:16608219 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases activity |
ISO |
metolachlor results in increased activity of CYP1A2 protein |
CTD |
PMID:10813365 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases activity |
EXP |
metolachlor results in increased activity of CYP2B1 protein |
CTD |
PMID:10813365 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions increases metabolic processing |
ISO |
[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to metolachlor; CYP2B6 protein results in increased degradation of and results in decreased susceptibility to metolachlor; CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to metolachlor CYP2B6 protein results in increased metabolism of metolachlor |
CTD |
PMID:11133395 PMID:15853388 PMID:16277416 PMID:16608219 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions |
ISO |
[CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to metolachlor |
CTD |
PMID:16608219 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression increases metabolic processing |
ISO |
metolachlor results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased metabolism of metolachlor |
CTD |
PMID:11133395 PMID:16565514 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Dio1 |
iodothyronine deiodinase 1 |
decreases activity |
ISO |
metolachlor results in decreased activity of DIO1 protein |
CTD |
PMID:29228274 |
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NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
metolachlor binds to and results in increased activity of ESR1 protein |
CTD |
PMID:33049310 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
metolachlor binds to and results in increased activity of ESR2 protein |
CTD |
PMID:33049310 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Fshb |
follicle stimulating hormone subunit beta |
increases expression |
EXP |
metolachlor results in increased expression of FSHB protein |
CTD |
PMID:23724293 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Hnrnph1 |
heterogeneous nuclear ribonucleoprotein H1 |
multiple interactions |
ISO |
[Herbicides results in increased abundance of metolachlor] which affects the methylation of HNRNPH1 gene |
CTD |
PMID:34516295 |
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NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases activity |
ISO |
metolachlor results in increased activity of NFE2L2 protein |
CTD |
PMID:20143881 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity |
ISO |
metolachlor binds to and results in increased activity of NR1I2 protein metolachlor results in increased activity of NR1I2 protein |
CTD |
PMID:16565514 PMID:21115097 PMID:28728110 PMID:33049310 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Odf2 |
outer dense fiber of sperm tails 2 |
multiple interactions |
ISO |
[Herbicides results in increased abundance of metolachlor] which affects the methylation of ODF2 gene |
CTD |
PMID:34516295 |
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NCBI chr 3:13,160,981...13,207,223
Ensembl chr 3:13,161,494...13,206,985
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
metolachlor binds to and results in increased activity of PPARG protein |
CTD |
PMID:33049310 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Rpp21 |
ribonuclease P/MRP subunit p21 |
multiple interactions |
ISO |
[Herbicides results in increased abundance of metolachlor] which affects the methylation of RPP21 gene |
CTD |
PMID:34516295 |
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NCBI chr20:2,018,170...2,020,100
Ensembl chr20:2,018,147...2,020,106
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G |
Sntg2 |
syntrophin, gamma 2 |
multiple interactions |
ISO |
[Herbicides results in increased abundance of metolachlor] which affects the methylation of SNTG2 gene |
CTD |
PMID:34516295 |
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NCBI chr 6:46,801,893...47,003,390
Ensembl chr 6:46,801,377...47,003,372
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