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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phosphoramidon
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Accession:CHEBI:45353 term browser browse the term
Definition:A dipeptide isolated from the cultures of Streptomyces tanashiensis.
Synonyms:exact_synonym: N-(hydroxy{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}phosphoryl)-L-leucyl-L-tryptophan
 related_synonym: (2S)-2-{[(2S)-2-{[(S)-hydroxy{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}phosphoryl]amino}-4-methylpentanoyl]amino}-3-(1H-indol-3-yl)propanoic acid (non-preferred name);   Formula=C23H34N3O10P;   InChI=1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)/t12-,16-,17-,18-,19+,20+,23-/m0/s1;   InChIKey=ZPHBZEQOLSRPAK-XLCYBJAPSA-N;   N-(N-(((6-deoxy-alpha-L-mannopyranosyl)oxy)hydroxyphosphinyl)-L-leucyl)-L-tryptophan;   N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN;   SMILES=CC(C)C[C@H](NP(O)(=O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
 alt_id: CHEBI:8164
 xref: CAS:36357-77-4;   KEGG:C00563;   KNApSAcK:C00017972
 xref_mesh: MESH:C008890
 xref: PDBeChem:RDF;   PMID:1579051;   PMID:23988485;   PMID:24000822;   PMID:6363990;   PMID:7687732;   Reaxys:5368869;   Wikipedia:Phosphoramidon


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phosphoramidon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein] CTD PMID:15007106 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:15177934 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ece1 endothelin converting enzyme 1 multiple interactions
decreases activity		 EXP EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]; phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]; phosphoramidon inhibits the reaction [Indomethacin results in increased expression of ECE1 protein]
phosphoramidon decreases activity of recombinant Ece1 protein in COS cells		 CTD
RGD		 PMID:11145282 PMID:16280098 PMID:8034569 RGD:728596 NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions		 EXP phosphoramidon results in decreased expression of EDN1 protein
EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]; EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]]; phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]		 CTD PMID:11145282 PMID:16280098 PMID:16391412 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein]; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein] CTD PMID:15007106 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B increases expression EXP phosphoramidon results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form] CTD PMID:10070497 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Kel Kell metallo-endopeptidase (Kell blood group) multiple interactions ISO KEL protein alternative form binds to and affects the metabolism of phosphoramidon CTD PMID:15769748 NCBI chr 4:71,534,882...71,552,297
Ensembl chr 4:70,568,243...70,585,631 		JBrowse link
G Lep leptin decreases expression EXP phosphoramidon results in decreased expression of LEP protein CTD PMID:16391412 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:15177934 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15177934 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions EXP phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Nts neurotensin multiple interactions ISO phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15177934 NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Sell selectin L multiple interactions EXP phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form] CTD PMID:10070497 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [TAC1 protein co-treated with phosphoramidon] results in increased uptake of Oxygen CTD PMID:9808699 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19879
    role 19850
      biological role 19848
        biochemical role 19562
          metabolite 19550
            prokaryotic metabolite 18592
              bacterial metabolite 18592
                phosphoramidon 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19879
    subatomic particle 19877
      composite particle 19877
        hadron 19877
          baryon 19877
            nucleon 19877
              atomic nucleus 19877
                atom 19877
                  main group element atom 19816
                    p-block element atom 19816
                      chalcogen 19569
                        oxygen atom 19541
                          oxygen molecular entity 19541
                            hydroxides 19350
                              oxoacid 18798
                                pnictogen oxoacid 15022
                                  phosphorus oxoacid 14580
                                    phosphoric acids 13929
                                      phosphoric acid 13929
                                        phosphoric acid derivative 13840
                                          phosphate 13839
                                            organic phosphate 13839
                                              carbohydrate phosphate 1968
                                                phospho sugar 1813
                                                  aldose phosphate 1810
                                                    aldohexose phosphate 32
                                                      deoxyaldohexose phosphate 16
                                                        phosphoramidon 16
paths to the root