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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:monochlorobiphenyl
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Accession:CHEBI:36717 term browser browse the term
Definition:A chlorobiphenyl carrying a single chloro substituent at unspecified position.
Synonyms:exact_synonym: chloro-1,1'-biphenyl
 related_synonym: Formula=C12H9Cl;   chlorobiphenyl;   chlorodiphenyl;   diphenylchloride
 xref: CAS:27323-18-8


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2-chlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 2-chlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO 2-chlorobiphenyl results in decreased activity of CYP1A2 protein CTD PMID:15916432 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 2-chlorobiphenyl analog results in increased activity of NR1I3 protein; 2-chlorobiphenyl results in increased activity of NR1I3 protein CTD PMID:26231822 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
3-chlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO 3-chlorobiphenyl analog results in increased activity of NR1I3 protein CTD PMID:26231822 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
4-chlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO 4-chlorobiphenyl results in decreased activity of CYP1A2 protein CTD PMID:15916432 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO 4-chlorobiphenyl metabolite results in increased expression of G6PD mRNA CTD PMID:25417049 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Hk2 hexokinase 2 increases expression ISO 4-chlorobiphenyl metabolite results in increased expression of HK2 mRNA CTD PMID:25417049 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases response to substance EXP MAPK1 protein modified form results in increased susceptibility to 4-chlorobiphenyl analog CTD PMID:19631230 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases response to substance EXP MAPK3 protein modified form results in increased susceptibility to 4-chlorobiphenyl analog CTD PMID:19631230 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Pkm pyruvate kinase M1/2 increases expression ISO 4-chlorobiphenyl metabolite results in increased expression of PKM mRNA CTD PMID:25417049 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases oxidation		 ISO [PTGS2 protein results in increased oxidation of 4-chlorobiphenyl metabolite] which results in increased chemical synthesis of Quinones CTD PMID:19105592 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sdhc succinate dehydrogenase complex subunit C decreases expression ISO 4-chlorobiphenyl metabolite results in decreased expression of SDHC mRNA CTD PMID:25417049 NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253 		JBrowse link
G Sdhd succinate dehydrogenase complex subunit D decreases expression ISO 4-chlorobiphenyl metabolite results in decreased expression of SDHD mRNA CTD PMID:25417049 NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression		 ISO 4-chlorobiphenyl metabolite results in decreased expression of and results in decreased activity of SOD2 protein
4-chlorobiphenyl metabolite results in decreased expression of SOD2 mRNA		 CTD PMID:20163859 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein results in increased sulfation of 4-chlorobiphenyl metabolite CTD PMID:23584369 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions
affects binding		 ISO 4-chlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]
4-chlorobiphenyl metabolite binds to SULT2A1 protein		 CTD PMID:24508592 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Ttr transthyretin multiple interactions ISO 4-chlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein] CTD PMID:23584369 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      molecular entity 19806
        polyatomic entity 19764
          molecule 19670
            cyclic compound 19486
              ring assembly 9171
                biphenyls 6245
                  chlorobiphenyl 6017
                    monochlorobiphenyl 15
                      2-chlorobiphenyl 3
                      3-chlorobiphenyl 1
                      4-chlorobiphenyl + 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            organic hydride 18669
                              organic fundamental parent 18669
                                hydrocarbon 18415
                                  halohydrocarbon 15686
                                    chlorohydrocarbon 11285
                                      chloroarene 6017
                                        chlorobiphenyl 6017
                                          monochlorobiphenyl 15
                                            2-chlorobiphenyl 3
                                            3-chlorobiphenyl 1
                                            4-chlorobiphenyl + 13
paths to the root