2,4-Dihydroxybenzophenone - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	2,4-Dihydroxybenzophenone	go back to main search page
Accession:	CHEBI:34240	browse the term
Definition:	A benzophenone that has formula C13H10O3.
Synonyms:	related_synonym:	Formula=C13H10O3; InChI=1S/C13H10O3/c14-10-6-7-11(12(15)8-10)13(16)9-4-2-1-3-5-9/h1-8,14-15H; InChIKey=ZXDDPOHVAMWLBH-UHFFFAOYSA-N; SMILES=Oc1ccc(C(=O)c2ccccc2)c(O)c1
	xref:	CAS:131-56-6; KEGG:C14215
	xref_mesh:	MESH:C121479

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Genes (20)

2,4-Dihydroxybenzophenone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

affects binding
multiple interactions

2,4-dihydroxybenzophenone binds to AR protein
2,4-dihydroxybenzophenone analog binds to and results in decreased activity of AR protein; 2,4-dihydroxybenzophenone binds to and results in decreased activity of AR protein

PMID:14565775 PMID:33684284

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

cyclin D1

increases expression
multiple interactions

2,4-dihydroxybenzophenone results in increased expression of CCND1 mRNA; 2,4-dihydroxybenzophenone results in increased expression of CCND1 protein
fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of CCND1 mRNA]; fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of CCND1 protein]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cadherin 1

decreases expression
multiple interactions

2,4-dihydroxybenzophenone results in decreased expression of CDH1 protein
fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in decreased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

increases expression
multiple interactions

2,4-dihydroxybenzophenone results in increased expression of CDH2 protein
fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of CDH2 protein]

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase inhibitor 1A

decreases expression

2,4-dihydroxybenzophenone results in decreased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

estrogen receptor 1

increases expression
affects binding
multiple interactions

2,4-dihydroxybenzophenone analog results in increased expression of ESR1 mRNA
2,4-dihydroxybenzophenone binds to ESR1 protein
2,4-dihydroxybenzophenone binds to and results in increased activity of ESR1 protein; 2,4-dihydroxybenzophenone inhibits the reaction [Estradiol binds to ESR1 protein]

PMID:11823001 PMID:16079615 PMID:18973785 PMID:19913605 PMID:33049310

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases expression
multiple interactions
affects binding

2,4-dihydroxybenzophenone analog results in increased expression of ESR2 mRNA
2,4-dihydroxybenzophenone binds to and results in increased activity of ESR2 protein
2,4-dihydroxybenzophenone binds to ESR2 protein

PMID:16079615 PMID:18973785 PMID:19913605 PMID:33049310

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

filaggrin

multiple interactions
affects response to substance

[FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in increased secretion of Testosterone

NCBI chr 2:178,884,793...178,912,986

G

follicle stimulating hormone subunit beta

multiple interactions

[FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in decreased secretion of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases activity

2,4-dihydroxybenzophenone results in decreased activity of HSD3B1 protein

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

decreases activity

2,4-dihydroxybenzophenone results in decreased activity of HSD3B2 protein

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

kallikrein 1-related peptidase C10

decreases expression

2,4-dihydroxybenzophenone analog results in decreased expression of KLK3 mRNA

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

NK3 homeobox 1

decreases expression

2,4-dihydroxybenzophenone analog results in decreased expression of NKX3-1 mRNA

NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

2,4-dihydroxybenzophenone binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases activity

2,4-dihydroxybenzophenone results in increased activity of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

sex hormone binding globulin

affects binding

2,4-dihydroxybenzophenone binds to SHBG protein

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

snail family transcriptional repressor 1

increases expression
multiple interactions

2,4-dihydroxybenzophenone results in increased expression of SNAI1 protein
fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI1 protein]

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

increases expression
multiple interactions

2,4-dihydroxybenzophenone results in increased expression of SNAI2 protein
fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI2 protein]

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

trefoil factor 1

increases expression
multiple interactions

2,4-dihydroxybenzophenone results in increased expression of TFF1 mRNA
[oxybenzone co-treated with 2,4-dihydroxybenzophenone co-treated with octylmethoxycinnamate co-treated with enzacamene] results in increased expression of TFF1 mRNA; [oxybenzone co-treated with 2,4-dihydroxybenzophenone] results in increased expression of TFF1 mRNA

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

thyroid peroxidase

decreases activity

2,4-dihydroxybenzophenone results in decreased activity of TPO protein

NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19890
chemical entity	19867
group	19820
inorganic group	19417
oxo group	18920
organic oxo compound	18920
carbonyl compound	18920
ketone	17269
aromatic ketone	12454
benzophenones	1297
2,4-Dihydroxybenzophenone	20
Path 2
Term	Annotations
CHEBI ontology	19890
subatomic particle	19867
composite particle	19888
hadron	19888
baryon	19888
nucleon	19867
atomic nucleus	19888
atom	19888
main group element atom	19806
p-block element atom	19806
carbon group element atom	19746
carbon atom	19743
organic molecular entity	19743
heteroorganic entity	19502
organochalcogen compound	19264
organooxygen compound	19180
carbonyl compound	18920
ketone	17269
aromatic ketone	12454
benzophenones	1297
2,4-Dihydroxybenzophenone	20

paths to the root