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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium stibogluconate
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Accession:CHEBI:28148 term browser browse the term
Definition:A D-gluconate adduct of indefinite composition containing between 30 and 34% of antimony(V), calculated with reference to dried and methanol-free substance. It is used as a treatment for leishmaniasis.
Synonyms:exact_synonym: trisodium 1-{[3-carboxylato-5-(1,2-dihydroxyethyl)-1-hydroxy-2,6,7-trioxa-1lambda(5)-stibabicyclo[2.2.1]hept-1-yl]oxy}-5-(1,2-dihydroxyethyl)-1-oxido-2,6,7-trioxa-1lambda(5)-stibabicyclo[2.2.1]heptane-3-carboxylate--water (1/9)
 related_synonym: Antimony (V) derivative of sodium gluconate;   Antimony sodium gluconate;   Formula=C12H17O17Sb2.9H2O.3Na;   Formula=C12H35Na3O26Sb2;   InChI=1S/2C6H9O7.3Na.10H2O.2O.2Sb/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;;;;;;;;;;;;/h2*2-5,7-8H,1H2,(H,12,13);;;;10*1H2;;;;/q2*-3;3*+1;;;;;;;;;;;;-1;+3;+4/p-3/t2*2-,3-,4+,5-;;;;;;;;;;;;;;;;;/m11................./s1;   InChIKey=YQDGWZZYGYKDLR-UZVLBLASSA-K;   Myostibin;   Pentostam;   SMILES=O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[H][C@@]1(O[Sb]2(O)(O[C@@H](C([O-])=O)[C@@]1([H])O2)O[Sb]12([O-])O[C@@H](C([O-])=O)[C@@]([H])(O1)[C@]([H])(O2)[C@H](O)CO)[C@H](O)CO;   Stibanate;   Stibanose;   Stibatin;   Stibinol;   estibogluconato sodico;   natrii stibogluconas;   stibogluconate de sodium;   trisodium 1-{[3-carboxylato-5-(1,2-dihydroxyethyl)-1-hydroxy-2,6,7-trioxa-1lambda(5)-stibabicyclo[2.2.1]hept-1-yl]oxy}-5-(1,2-dihydroxyethyl)-1-oxido-2,6,7-trioxa-1lambda(5)-stibabicyclo[2.2.1]heptane-3-carboxylate nonahydrate
 alt_id: CHEBI:26716;   CHEBI:9181;   MESH:D000967
 xref: CAS:16037-91-5;   DrugBank:DB05630;   KEGG:C07638;   KEGG:D00582
 xref_mesh: MESH:D000967


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sodium stibogluconate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Lovastatin results in decreased activity of ABCC1 protein] which results in increased susceptibility to Antimony Sodium Gluconate CTD PMID:18056276 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Antimony Sodium Gluconate results in decreased expression of BCL6 protein CTD PMID:27546522 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Antimony Sodium Gluconate results in decreased expression of CCL2 mRNA CTD PMID:20102417 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Epo erythropoietin decreases expression ISO Antimony Sodium Gluconate results in decreased expression of EPO mRNA; Antimony Sodium Gluconate results in decreased expression of EPO protein CTD PMID:9531339 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Icam1 intercellular adhesion molecule 1 affects response to substance ISO ICAM1 protein affects the susceptibility to Antimony Sodium Gluconate CTD PMID:11035738 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma affects response to substance
multiple interactions
decreases expression		 ISO IFNG protein affects the susceptibility to Antimony Sodium Gluconate
[IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL10 mRNA; [IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL4 mRNA; [IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of IL12B mRNA; [IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of NOS2 mRNA; IFNG protein affects the reaction [IL10RA protein affects the susceptibility to Antimony Sodium Gluconate]
[Antimony Sodium Gluconate co-treated with Amphotericin B] results in increased expression of IFNG protein
Antimony Sodium Gluconate results in decreased expression of IFNG mRNA		 CTD PMID:9234779 PMID:9498473 PMID:10603400 PMID:12870129 PMID:17911647 More... NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Antimony Sodium Gluconate results in increased expression of IFNGR1 mRNA; Antimony Sodium Gluconate results in increased expression of IFNGR1 protein CTD PMID:12803856 NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:14,333,187...14,351,785 		JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
affects response to substance		 ISO Antimony Sodium Gluconate results in decreased expression of IL10 mRNA
[Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of IL10 protein
[IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL10 mRNA
IL10 protein affects the susceptibility to Antimony Sodium Gluconate		 CTD PMID:9234779 PMID:9498473 PMID:12379707 PMID:17911647 PMID:20102417 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions
affects response to substance		 ISO IFNG protein affects the reaction [IL10RA protein affects the susceptibility to Antimony Sodium Gluconate] CTD PMID:12379707 PMID:12870129 NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:45,563,137...45,578,061 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO [IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of IL12B mRNA CTD PMID:9234779 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Antimony Sodium Gluconate results in decreased expression of IL1B mRNA CTD PMID:20102417 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
affects response to substance		 ISO [IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL4 mRNA
Antimony Sodium Gluconate results in decreased expression of IL4 mRNA
IL4 protein affects the susceptibility to Antimony Sodium Gluconate		 CTD PMID:7960131 PMID:9234779 PMID:11069076 PMID:20102417 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Antimony Sodium Gluconate results in increased expression of ITGAM protein CTD PMID:12399974 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of NOS2 mRNA CTD PMID:9234779 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 decreases activity ISO Antimony Sodium Gluconate results in decreased activity of PTPN6 protein CTD PMID:12399974 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of TGFB1 protein CTD PMID:17911647 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Antimony Sodium Gluconate results in decreased expression of TNF mRNA CTD PMID:20102417 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf18 TNF receptor superfamily member 18 increases response to substance ISO TNFRSF18 protein results in increased susceptibility to Antimony Sodium Gluconate CTD PMID:20139272 NCBI chr 5:171,901,734...171,904,578
Ensembl chr 5:166,618,969...166,622,353 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression ISO Antimony Sodium Gluconate results in decreased expression of TNFRSF1A protein CTD PMID:7844400 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B decreases expression ISO Antimony Sodium Gluconate results in decreased expression of TNFRSF1B protein CTD PMID:7844400 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      application 19713
        pharmaceutical 19549
          drug 19549
            antineoplastic agent 17838
              sodium stibogluconate 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic ion 11457
                              organic anion 6856
                                carboxylic acid anion 2501
                                  carbohydrate acid anion 21
                                    aldonate 21
                                      hexonate 21
                                        gluconates 21
                                          D-gluconate adduct 21
                                            sodium stibogluconate 20
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