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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aquaretic
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Accession:CHEBI:194423 term browser browse the term
Definition:A class of diuretics which promote aquaresis (the excretion of water without electrolyte loss).
Synonyms:related_synonym: aquaretic agent;   aquaretic agents;   aquaretics
 xref: PMID:12107918;   PMID:17430186;   PMID:21088744;   PMID:24853354;   PMID:28194573;   PMID:28652798;   PMID:29259382;   PMID:36156485;   PMID:8738740;   PMID:8998673;   Wikipedia:Aquaretic


show annotations for term's descendants           Sort by:
demeclocycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline CTD PMID:19362101 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Demeclocycline CTD PMID:19362101 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
mozavaptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr2 arginine vasopressin receptor 2 multiple interactions EXP mozavaptan binds to and results in decreased activity of AVPR2 protein CTD PMID:12646291 NCBI chr  X:151,633,501...151,636,155
Ensembl chr  X:151,633,522...151,635,989 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO mozavaptan affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
satavaptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases phosphorylation EXP Satavaptan decreases phosphorylation of Map3k7 protein in inner medullary collecting duct RGD PMID:24259510 RGD:401827158 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
tolvaptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCB11 protein; tolvaptan results in decreased activity of ABCB11 protein CTD PMID:23956101 PMID:26507107 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC2 protein CTD PMID:26507107 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC3 protein CTD PMID:26507107 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC4 protein CTD PMID:26507107 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Alb albumin decreases expression ISO Tolvaptan results in decreased expression of ALB protein CTD PMID:33022361 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Tolvaptan results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Tolvaptan results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Mir122 microRNA 122 increases export ISO tolvaptan results in increased export of MIR122 CTD PMID:29029277 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases activity ISO tolvaptan metabolite results in decreased activity of SLC10A1 protein CTD PMID:26507107 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO tolvaptan results in increased expression of SLPI mRNA; tolvaptan results in increased expression of SLPI protein CTD PMID:28115652 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 multiple interactions ISO Cyclosporine promotes the reaction [SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan]; SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan CTD PMID:26660633 NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        pharmaceutical 19550
          drug 19550
            diuretic 4108
              aquaretic 17
                Mozavaptane hydrochloride 0
                conivaptan + 0
                conivaptan hydrochloride 0
                demeclocycline + 3
                demeclocycline hydrochloride 0
                mozavaptan 2
                satavaptan 1
                tolvaptan + 11
paths to the root